Incidental Mutation 'R0320:Tigd4'
ID 38270
Institutional Source Beutler Lab
Gene Symbol Tigd4
Ensembl Gene ENSMUSG00000047819
Gene Name tigger transposable element derived 4
Synonyms C130063O11Rik, Tigd4
MMRRC Submission 038530-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.161) question?
Stock # R0320 (G1)
Quality Score 204
Status Validated
Chromosome 3
Chromosomal Location 84500881-84504339 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 84502481 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 466 (V466E)
Ref Sequence ENSEMBL: ENSMUSP00000052320 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062623] [ENSMUST00000154148]
AlphaFold Q8BUZ3
Predicted Effect probably benign
Transcript: ENSMUST00000062623
AA Change: V466E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000052320
Gene: ENSMUSG00000047819
AA Change: V466E

DomainStartEndE-ValueType
Pfam:CENP-B_N 15 67 9e-14 PFAM
CENPB 81 146 5.52e-16 SMART
Pfam:DDE_1 211 375 4.9e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000154148
SMART Domains Protein: ENSMUSP00000116393
Gene: ENSMUSG00000102805

DomainStartEndE-ValueType
Arfaptin 1 227 7.15e-121 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.0%
Validation Efficiency 100% (71/71)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T C 14: 32,384,571 (GRCm39) T465A probably benign Het
A430110L20Rik T G 1: 181,054,987 (GRCm39) noncoding transcript Het
Aadacl4fm1 A T 4: 144,248,990 (GRCm39) H119L probably damaging Het
Abcb10 C T 8: 124,689,746 (GRCm39) R439Q probably benign Het
Abcb8 T C 5: 24,605,788 (GRCm39) S199P probably damaging Het
Adam8 C A 7: 139,566,355 (GRCm39) C556F probably damaging Het
Akap11 T C 14: 78,750,819 (GRCm39) T523A probably benign Het
Aldh3b1 T C 19: 3,968,999 (GRCm39) probably benign Het
Arhgap30 T A 1: 171,231,372 (GRCm39) W230R possibly damaging Het
Atp8b4 A G 2: 126,301,614 (GRCm39) I82T possibly damaging Het
Bptf A T 11: 106,963,645 (GRCm39) L1850I probably damaging Het
C4b C A 17: 34,952,135 (GRCm39) V1237L probably benign Het
Calu C A 6: 29,374,550 (GRCm39) probably benign Het
Cit C A 5: 116,117,504 (GRCm39) L1227M possibly damaging Het
Col4a1 C T 8: 11,292,782 (GRCm39) probably null Het
Cp T C 3: 20,029,012 (GRCm39) probably benign Het
Cpd T C 11: 76,731,273 (GRCm39) D311G possibly damaging Het
Ctc1 T A 11: 68,924,363 (GRCm39) S972T probably damaging Het
Dnah17 A G 11: 117,943,500 (GRCm39) F3201L possibly damaging Het
Dop1b C A 16: 93,607,035 (GRCm39) R2113S probably benign Het
Dym T A 18: 75,332,333 (GRCm39) D520E probably damaging Het
Eif5a G T 11: 69,808,305 (GRCm39) T64K probably benign Het
Flt3 A T 5: 147,306,389 (GRCm39) probably benign Het
Ints6 A T 14: 62,945,084 (GRCm39) Y415* probably null Het
Itga1 A G 13: 115,114,130 (GRCm39) probably benign Het
Itgae A G 11: 73,021,825 (GRCm39) H902R possibly damaging Het
Itprid1 T C 6: 55,953,432 (GRCm39) I916T probably damaging Het
Kdm5a T C 6: 120,366,581 (GRCm39) I406T probably benign Het
Lmx1a C T 1: 167,618,973 (GRCm39) Q111* probably null Het
Lrrc25 T C 8: 71,070,896 (GRCm39) Y226H probably benign Het
Mcam T A 9: 44,051,483 (GRCm39) N447K possibly damaging Het
Mcm10 A T 2: 5,008,897 (GRCm39) D357E probably benign Het
Nrip1 T C 16: 76,089,251 (GRCm39) T769A probably benign Het
Ofcc1 G C 13: 40,360,172 (GRCm39) Q286E probably benign Het
Or1e23 T G 11: 73,407,750 (GRCm39) I92L probably damaging Het
Or56b35 A T 7: 104,963,861 (GRCm39) I217F probably benign Het
Parp3 T A 9: 106,353,011 (GRCm39) N55I possibly damaging Het
Parp4 T C 14: 56,825,953 (GRCm39) probably null Het
Pilrb1 G A 5: 137,853,260 (GRCm39) T181I probably benign Het
Ppm1n A G 7: 19,012,281 (GRCm39) V317A probably damaging Het
Prdm2 A T 4: 142,905,921 (GRCm39) F55L probably damaging Het
Psd2 C T 18: 36,112,697 (GRCm39) R131C probably damaging Het
Ralgps1 A T 2: 33,031,027 (GRCm39) C570S possibly damaging Het
Scaf8 T C 17: 3,228,530 (GRCm39) S443P unknown Het
Setd5 A G 6: 113,088,442 (GRCm39) K190R probably damaging Het
Spsb4 T A 9: 96,878,161 (GRCm39) H54L probably damaging Het
St7l T A 3: 104,778,229 (GRCm39) L122* probably null Het
Stom C T 2: 35,211,646 (GRCm39) R125H probably damaging Het
Tmc3 A C 7: 83,257,027 (GRCm39) probably benign Het
Vcl C T 14: 21,035,692 (GRCm39) probably benign Het
Vmn1r168 G A 7: 23,240,767 (GRCm39) R208H probably benign Het
Vmn2r75 C A 7: 85,814,288 (GRCm39) V402L probably benign Het
Vps13b A T 15: 35,674,974 (GRCm39) H1698L probably damaging Het
Wnt16 T G 6: 22,297,992 (GRCm39) V286G possibly damaging Het
Xirp1 C A 9: 119,845,533 (GRCm39) V1117L probably benign Het
Zfp788 C T 7: 41,298,971 (GRCm39) H536Y probably damaging Het
Other mutations in Tigd4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01791:Tigd4 APN 3 84,502,052 (GRCm39) missense probably damaging 1.00
R0080:Tigd4 UTSW 3 84,501,452 (GRCm39) missense probably benign 0.19
R0347:Tigd4 UTSW 3 84,501,167 (GRCm39) missense probably damaging 1.00
R1875:Tigd4 UTSW 3 84,502,394 (GRCm39) missense probably benign 0.00
R1876:Tigd4 UTSW 3 84,501,242 (GRCm39) nonsense probably null
R2142:Tigd4 UTSW 3 84,501,670 (GRCm39) missense possibly damaging 0.95
R2258:Tigd4 UTSW 3 84,501,600 (GRCm39) missense probably benign 0.00
R2519:Tigd4 UTSW 3 84,501,221 (GRCm39) missense probably damaging 1.00
R2866:Tigd4 UTSW 3 84,501,259 (GRCm39) missense possibly damaging 0.48
R2867:Tigd4 UTSW 3 84,501,259 (GRCm39) missense possibly damaging 0.48
R2867:Tigd4 UTSW 3 84,501,259 (GRCm39) missense possibly damaging 0.48
R3974:Tigd4 UTSW 3 84,502,585 (GRCm39) missense possibly damaging 0.82
R4094:Tigd4 UTSW 3 84,501,947 (GRCm39) missense probably damaging 1.00
R4967:Tigd4 UTSW 3 84,502,460 (GRCm39) missense probably benign 0.03
R5155:Tigd4 UTSW 3 84,501,970 (GRCm39) missense possibly damaging 0.96
R5878:Tigd4 UTSW 3 84,501,749 (GRCm39) missense probably benign 0.09
R6174:Tigd4 UTSW 3 84,502,574 (GRCm39) missense probably benign 0.02
R6960:Tigd4 UTSW 3 84,501,423 (GRCm39) missense probably damaging 1.00
R7414:Tigd4 UTSW 3 84,501,128 (GRCm39) missense probably benign 0.37
R7445:Tigd4 UTSW 3 84,502,471 (GRCm39) missense probably benign 0.01
R7696:Tigd4 UTSW 3 84,502,224 (GRCm39) missense possibly damaging 0.89
R7810:Tigd4 UTSW 3 84,502,310 (GRCm39) missense possibly damaging 0.49
R8016:Tigd4 UTSW 3 84,501,971 (GRCm39) missense possibly damaging 0.46
R8489:Tigd4 UTSW 3 84,502,526 (GRCm39) missense probably benign
R8745:Tigd4 UTSW 3 84,501,874 (GRCm39) missense probably benign 0.03
R8872:Tigd4 UTSW 3 84,501,547 (GRCm39) missense probably benign
X0023:Tigd4 UTSW 3 84,501,164 (GRCm39) missense probably damaging 1.00
X0064:Tigd4 UTSW 3 84,501,785 (GRCm39) missense probably damaging 1.00
Z1176:Tigd4 UTSW 3 84,501,696 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGATGCTGCTGTTGCTCTTGACC -3'
(R):5'- CCCGAGGAAAAGTTACTGCTCTGC -3'

Sequencing Primer
(F):5'- TGACTGCCCATGCAGTG -3'
(R):5'- GCAGCCGAACAATACGTGAC -3'
Posted On 2013-05-23