|Institutional Source||Beutler Lab|
|Gene Name||interferon lambda receptor 1|
|Synonyms||IFNLR1, Il28ra, CRF2-12|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R4938 (G1)|
|Chromosomal Location||135686287-135708181 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 135705282 bp|
|Amino Acid Change||Glutamic Acid to Glycine at position 343 (E343G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000074009 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000074408]|
|Predicted Effect||probably benign
AA Change: E343G
PolyPhen 2 Score 0.351 (Sensitivity: 0.90; Specificity: 0.89)
AA Change: E343G
|Meta Mutation Damage Score||0.036|
|Coding Region Coverage||
|Validation Efficiency||99% (74/75)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are viable and normal with respect to viral infection, however antiviral response evoked by TLRs are significantly reduced. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ifnlr1||
(F):5'- ATACCCAGTGGCAACCTTTCAG -3'
(R):5'- TGGAAGACCCAACTTCATCC -3'
(F):5'- AACCTTTCAGCCCAGTGG -3'
(R):5'- GACCCAACTTCATCCTTATATGAGG -3'