Incidental Mutation 'R4942:Vmn2r73'
ID 383194
Institutional Source Beutler Lab
Gene Symbol Vmn2r73
Ensembl Gene ENSMUSG00000070458
Gene Name vomeronasal 2, receptor 73
Synonyms EG620928
Accession Numbers
Essential gene? Probably non essential (E-score: 0.172) question?
Stock # R4942 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 85506755-85525146 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85519582 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 459 (Y459H)
Ref Sequence ENSEMBL: ENSMUSP00000076687 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077478]
AlphaFold D3Z7M3
Predicted Effect probably damaging
Transcript: ENSMUST00000077478
AA Change: Y459H

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000076687
Gene: ENSMUSG00000070458
AA Change: Y459H

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 465 1.4e-30 PFAM
Pfam:NCD3G 508 560 5.9e-21 PFAM
Pfam:7tm_3 590 827 4.4e-51 PFAM
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730522E02Rik A G 11: 25,720,472 (GRCm39) probably null Het
Adamts7 T C 9: 90,045,364 (GRCm39) S23P probably benign Het
Adamtsl1 T A 4: 86,259,451 (GRCm39) C824* probably null Het
Adgre1 A G 17: 57,713,903 (GRCm39) Y196C probably damaging Het
Arap1 A G 7: 101,051,009 (GRCm39) D542G possibly damaging Het
B3gat1 A G 9: 26,666,894 (GRCm39) D42G probably benign Het
Birc6 G A 17: 74,930,045 (GRCm39) A2412T probably damaging Het
Bnip5 T C 17: 29,122,232 (GRCm39) R420G probably benign Het
Bsn A G 9: 107,983,678 (GRCm39) Y3459H unknown Het
Cacnb1 T C 11: 97,893,809 (GRCm39) Y571C probably damaging Het
Cdk2ap2 G A 19: 4,147,508 (GRCm39) probably null Het
Cep57 A G 9: 13,724,723 (GRCm39) S265P probably damaging Het
Clca3a1 A G 3: 144,710,524 (GRCm39) I893T probably benign Het
Clca3a2 T A 3: 144,512,263 (GRCm39) E491V probably damaging Het
Cldn10 G A 14: 119,025,725 (GRCm39) G53S possibly damaging Het
Cobl A T 11: 12,204,185 (GRCm39) I832N probably damaging Het
Col9a2 T C 4: 120,910,316 (GRCm39) V487A possibly damaging Het
Cse1l C T 2: 166,771,714 (GRCm39) T325I probably damaging Het
Dlx6 A G 6: 6,863,468 (GRCm39) Q30R probably benign Het
Dnah8 T C 17: 30,948,116 (GRCm39) V1902A probably benign Het
Dusp8 A G 7: 141,635,965 (GRCm39) F542L possibly damaging Het
Emid1 T G 11: 5,079,430 (GRCm39) M323L probably benign Het
Ercc5 A G 1: 44,215,125 (GRCm39) D886G probably benign Het
Fam184b T C 5: 45,730,649 (GRCm39) E461G probably damaging Het
Fbn1 C A 2: 125,225,536 (GRCm39) C572F possibly damaging Het
Gigyf1 G T 5: 137,523,952 (GRCm39) V1041L possibly damaging Het
Grin3b A G 10: 79,811,556 (GRCm39) H714R probably damaging Het
Heatr1 A G 13: 12,428,391 (GRCm39) probably null Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Llgl1 C T 11: 60,600,394 (GRCm39) P581L probably benign Het
Lypd6b C A 2: 49,836,132 (GRCm39) H104Q probably benign Het
Man1a A T 10: 53,809,586 (GRCm39) probably null Het
Megf6 A T 4: 154,338,277 (GRCm39) D449V probably damaging Het
Mtor T C 4: 148,556,599 (GRCm39) V1003A probably benign Het
Ncan C A 8: 70,552,944 (GRCm39) W1096L probably damaging Het
Ndor1 C T 2: 25,138,133 (GRCm39) probably null Het
Ndufaf1 T C 2: 119,490,547 (GRCm39) E171G possibly damaging Het
Nell1 T C 7: 49,770,397 (GRCm39) V152A possibly damaging Het
Nherf4 C A 9: 44,159,915 (GRCm39) G402* probably null Het
Nt5dc1 A T 10: 34,198,673 (GRCm39) V255E probably damaging Het
Or2a20 T A 6: 43,193,928 (GRCm39) F27Y probably damaging Het
Or2y1b A T 11: 49,208,375 (GRCm39) M1L probably null Het
Or52h7 A G 7: 104,214,212 (GRCm39) I261M probably benign Het
Or52z14 G A 7: 103,253,401 (GRCm39) R180H probably benign Het
Otud7a T C 7: 63,407,171 (GRCm39) I50T probably damaging Het
P2ry13 G A 3: 59,116,983 (GRCm39) T265I probably benign Het
Pde4d A G 13: 108,996,733 (GRCm39) S12G probably benign Het
Pigk C A 3: 152,450,154 (GRCm39) N219K probably damaging Het
Plcg1 T A 2: 160,595,509 (GRCm39) probably null Het
Psd2 A T 18: 36,111,717 (GRCm39) D114V probably damaging Het
Ptch1 A T 13: 63,672,884 (GRCm39) I770N probably benign Het
Ptprq A T 10: 107,524,290 (GRCm39) M481K probably benign Het
Rnf216 A C 5: 143,078,814 (GRCm39) M45R probably damaging Het
Rpsa T A 9: 119,960,129 (GRCm39) W231R probably benign Het
Ryr1 G T 7: 28,768,998 (GRCm39) T2797N probably damaging Het
Ryr3 A T 2: 112,666,602 (GRCm39) M1468K probably damaging Het
Slc6a7 A G 18: 61,137,589 (GRCm39) Y244H probably damaging Het
Slco6c1 T A 1: 97,009,049 (GRCm39) D462V probably damaging Het
Spata31d1b A T 13: 59,864,917 (GRCm39) E688D possibly damaging Het
Srpra G A 9: 35,126,766 (GRCm39) R508H probably benign Het
Tnrc18 A T 5: 142,773,737 (GRCm39) I181N unknown Het
Tnrc6a T C 7: 122,791,836 (GRCm39) F1785L probably damaging Het
Trio A T 15: 27,752,811 (GRCm39) D2174E probably benign Het
Ttn C T 2: 76,623,600 (GRCm39) V15326I probably damaging Het
Ubap2 T A 4: 41,245,461 (GRCm39) probably benign Het
Vmn2r113 C T 17: 23,177,321 (GRCm39) P702S probably damaging Het
Vmn2r66 A T 7: 84,656,980 (GRCm39) W142R probably damaging Het
Wsb2 C T 5: 117,515,550 (GRCm39) T385M probably damaging Het
Other mutations in Vmn2r73
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00158:Vmn2r73 APN 7 85,506,795 (GRCm39) missense
IGL01151:Vmn2r73 APN 7 85,507,086 (GRCm39) missense probably damaging 0.99
IGL01408:Vmn2r73 APN 7 85,521,455 (GRCm39) missense probably benign 0.45
IGL01505:Vmn2r73 APN 7 85,507,267 (GRCm39) nonsense probably null
IGL01731:Vmn2r73 APN 7 85,506,757 (GRCm39) makesense probably null
IGL01818:Vmn2r73 APN 7 85,519,109 (GRCm39) splice site probably benign
IGL02236:Vmn2r73 APN 7 85,521,902 (GRCm39) missense probably benign 0.00
IGL02265:Vmn2r73 APN 7 85,520,847 (GRCm39) missense probably benign 0.02
IGL02266:Vmn2r73 APN 7 85,525,007 (GRCm39) missense possibly damaging 0.52
IGL02276:Vmn2r73 APN 7 85,518,980 (GRCm39) critical splice donor site probably null
IGL02284:Vmn2r73 APN 7 85,507,123 (GRCm39) missense possibly damaging 0.92
IGL02380:Vmn2r73 APN 7 85,507,383 (GRCm39) missense probably benign 0.00
IGL02466:Vmn2r73 APN 7 85,522,084 (GRCm39) missense probably damaging 1.00
IGL03172:Vmn2r73 APN 7 85,507,495 (GRCm39) missense probably benign 0.01
IGL03179:Vmn2r73 APN 7 85,519,468 (GRCm39) missense probably benign 0.04
G1Funyon:Vmn2r73 UTSW 7 85,507,510 (GRCm39) missense probably benign 0.00
R0077:Vmn2r73 UTSW 7 85,525,075 (GRCm39) missense probably benign 0.00
R0311:Vmn2r73 UTSW 7 85,520,997 (GRCm39) missense probably benign
R0413:Vmn2r73 UTSW 7 85,521,087 (GRCm39) missense possibly damaging 0.68
R0494:Vmn2r73 UTSW 7 85,522,140 (GRCm39) missense probably benign
R1523:Vmn2r73 UTSW 7 85,519,486 (GRCm39) missense probably benign 0.02
R1618:Vmn2r73 UTSW 7 85,525,120 (GRCm39) nonsense probably null
R1667:Vmn2r73 UTSW 7 85,506,889 (GRCm39) missense probably benign 0.00
R1728:Vmn2r73 UTSW 7 85,507,086 (GRCm39) missense probably damaging 1.00
R1729:Vmn2r73 UTSW 7 85,507,086 (GRCm39) missense probably damaging 1.00
R1747:Vmn2r73 UTSW 7 85,507,375 (GRCm39) missense probably damaging 1.00
R1784:Vmn2r73 UTSW 7 85,507,086 (GRCm39) missense probably damaging 1.00
R2152:Vmn2r73 UTSW 7 85,506,936 (GRCm39) missense probably benign 0.03
R2395:Vmn2r73 UTSW 7 85,506,975 (GRCm39) missense probably damaging 1.00
R2415:Vmn2r73 UTSW 7 85,521,431 (GRCm39) missense probably damaging 1.00
R2926:Vmn2r73 UTSW 7 85,520,871 (GRCm39) missense probably benign 0.17
R3719:Vmn2r73 UTSW 7 85,519,582 (GRCm39) missense probably damaging 1.00
R3766:Vmn2r73 UTSW 7 85,521,198 (GRCm39) missense probably benign
R3838:Vmn2r73 UTSW 7 85,507,258 (GRCm39) missense probably benign 0.00
R3890:Vmn2r73 UTSW 7 85,507,144 (GRCm39) missense probably benign
R4030:Vmn2r73 UTSW 7 85,521,044 (GRCm39) missense possibly damaging 0.92
R4247:Vmn2r73 UTSW 7 85,521,883 (GRCm39) missense probably damaging 0.99
R4409:Vmn2r73 UTSW 7 85,520,768 (GRCm39) missense probably damaging 0.97
R4427:Vmn2r73 UTSW 7 85,506,981 (GRCm39) missense probably damaging 1.00
R4430:Vmn2r73 UTSW 7 85,519,449 (GRCm39) missense probably benign
R4552:Vmn2r73 UTSW 7 85,525,055 (GRCm39) missense probably benign 0.12
R4779:Vmn2r73 UTSW 7 85,520,923 (GRCm39) nonsense probably null
R4906:Vmn2r73 UTSW 7 85,506,829 (GRCm39) missense probably damaging 0.99
R5280:Vmn2r73 UTSW 7 85,507,155 (GRCm39) missense probably damaging 0.98
R5344:Vmn2r73 UTSW 7 85,525,046 (GRCm39) missense probably benign 0.00
R5478:Vmn2r73 UTSW 7 85,518,996 (GRCm39) missense probably damaging 1.00
R5527:Vmn2r73 UTSW 7 85,507,575 (GRCm39) missense possibly damaging 0.65
R5691:Vmn2r73 UTSW 7 85,507,299 (GRCm39) missense probably damaging 1.00
R5826:Vmn2r73 UTSW 7 85,524,956 (GRCm39) missense possibly damaging 0.77
R6018:Vmn2r73 UTSW 7 85,521,875 (GRCm39) missense possibly damaging 0.48
R6082:Vmn2r73 UTSW 7 85,507,429 (GRCm39) missense probably benign 0.00
R6111:Vmn2r73 UTSW 7 85,520,997 (GRCm39) missense probably benign
R6233:Vmn2r73 UTSW 7 85,519,099 (GRCm39) missense probably benign 0.00
R6278:Vmn2r73 UTSW 7 85,522,140 (GRCm39) missense probably benign
R6283:Vmn2r73 UTSW 7 85,521,049 (GRCm39) missense probably benign 0.00
R6307:Vmn2r73 UTSW 7 85,506,828 (GRCm39) missense probably damaging 1.00
R6413:Vmn2r73 UTSW 7 85,519,544 (GRCm39) nonsense probably null
R6782:Vmn2r73 UTSW 7 85,519,563 (GRCm39) missense probably benign 0.00
R6884:Vmn2r73 UTSW 7 85,507,213 (GRCm39) missense probably benign 0.05
R6921:Vmn2r73 UTSW 7 85,507,446 (GRCm39) missense probably benign 0.27
R7169:Vmn2r73 UTSW 7 85,507,663 (GRCm39) nonsense probably null
R7206:Vmn2r73 UTSW 7 85,522,075 (GRCm39) missense probably benign 0.03
R7311:Vmn2r73 UTSW 7 85,521,192 (GRCm39) missense possibly damaging 0.80
R7650:Vmn2r73 UTSW 7 85,521,147 (GRCm39) missense probably benign
R7811:Vmn2r73 UTSW 7 85,524,956 (GRCm39) missense possibly damaging 0.77
R8263:Vmn2r73 UTSW 7 85,507,619 (GRCm39) missense probably benign
R8301:Vmn2r73 UTSW 7 85,507,510 (GRCm39) missense probably benign 0.00
R8341:Vmn2r73 UTSW 7 85,507,128 (GRCm39) missense probably benign 0.01
R8500:Vmn2r73 UTSW 7 85,519,638 (GRCm39) missense probably benign 0.01
R8673:Vmn2r73 UTSW 7 85,521,902 (GRCm39) missense probably benign 0.01
R8719:Vmn2r73 UTSW 7 85,521,095 (GRCm39) missense probably damaging 0.96
R8783:Vmn2r73 UTSW 7 85,507,668 (GRCm39) missense probably damaging 0.96
R8828:Vmn2r73 UTSW 7 85,521,179 (GRCm39) missense probably damaging 0.98
R8860:Vmn2r73 UTSW 7 85,522,149 (GRCm39) splice site probably benign
R9002:Vmn2r73 UTSW 7 85,507,284 (GRCm39) missense probably benign 0.32
R9008:Vmn2r73 UTSW 7 85,521,904 (GRCm39) missense probably damaging 0.96
R9159:Vmn2r73 UTSW 7 85,521,931 (GRCm39) missense possibly damaging 0.90
R9180:Vmn2r73 UTSW 7 85,507,123 (GRCm39) missense probably benign 0.07
R9198:Vmn2r73 UTSW 7 85,518,987 (GRCm39) missense probably benign 0.01
R9329:Vmn2r73 UTSW 7 85,519,073 (GRCm39) missense probably benign
R9448:Vmn2r73 UTSW 7 85,522,027 (GRCm39) missense probably benign 0.00
R9463:Vmn2r73 UTSW 7 85,506,795 (GRCm39) missense
R9589:Vmn2r73 UTSW 7 85,519,659 (GRCm39) missense probably benign 0.03
X0023:Vmn2r73 UTSW 7 85,507,664 (GRCm39) missense probably benign 0.31
Z1176:Vmn2r73 UTSW 7 85,521,176 (GRCm39) missense probably damaging 0.99
Z1177:Vmn2r73 UTSW 7 85,521,480 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAAGTATTTATTCCATGGCAAAGC -3'
(R):5'- GTAAACCACATAGGGCTTTCATG -3'

Sequencing Primer
(F):5'- TTATTCCATGGCAAAGCAAAAAGG -3'
(R):5'- GCAAGAGACTATCAAGTACTTTTCC -3'
Posted On 2016-04-27