Mutagenetix > Incidental Mutation

Incidental Mutation 'R4946:Dnah5'

383451

Institutional Source

Beutler Lab

Gene Symbol

Dnah5

Ensembl Gene

ENSMUSG00000022262

Gene Name

dynein, axonemal, heavy chain 5

Synonyms

Dnahc5, b2b3491Clo, b2b1154Clo, b2b1134Clo, b2b1565Clo, b2b1537Clo, Mdnah5

MMRRC Submission

042543-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.791) question?

Stock #

R4946 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

28203898-28472198 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 28326703 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 1971 (M1971V)

Ref Sequence

ENSEMBL: ENSMUSP00000069751 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067048]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000067048
AA Change: M1971V

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000069751
Gene: ENSMUSG00000022262
AA Change: M1971V

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	247	802	2.3e-163	PFAM
low complexity region	1077	1088	N/A	INTRINSIC
low complexity region	1113	1128	N/A	INTRINSIC
Pfam:DHC_N2	1399	1807	2.3e-134	PFAM
AAA	1972	2108	2e-3	SMART
AAA	2251	2424	4.3e-3	SMART
AAA	2579	2777	2.2e-3	SMART
low complexity region	2874	2889	N/A	INTRINSIC
Pfam:AAA_8	2914	3186	3.2e-70	PFAM
Pfam:MT	3198	3546	1e-44	PFAM
Pfam:AAA_9	3567	3792	1.4e-86	PFAM
low complexity region	3889	3899	N/A	INTRINSIC
Pfam:Dynein_heavy	3930	4618	4.4e-246	PFAM

Coding Region Coverage

1x: 99.0%
3x: 98.2%
10x: 96.0%
20x: 91.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a disruption in this gene display postnatal lethality, hydrocephalus, respiratory infections, situs inversus and ciliary immotility. [provided by MGI curators]

Allele List at MGI

All alleles(11) : Targeted(2) Gene trapped(1) Transgenic(1) Chemically induced(7)

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8a	T	C	11: 109,977,300 (GRCm39)	D98G	probably damaging	Het
Adgre1	G	A	17: 57,750,918 (GRCm39)	V531I	probably benign	Het
Aldoart2	A	G	12: 55,612,801 (GRCm39)	Q242R	probably benign	Het
Ank2	A	T	3: 126,735,589 (GRCm39)		probably benign	Het
Ank3	C	T	10: 69,733,947 (GRCm39)	A737V	probably damaging	Het
Ankle2	A	G	5: 110,401,704 (GRCm39)	I789V	probably benign	Het
Ankrd13c	T	C	3: 157,711,410 (GRCm39)	V510A	probably damaging	Het
Arid1b	T	A	17: 5,393,118 (GRCm39)	M2216K	probably damaging	Het
Arrdc1	A	G	2: 24,815,860 (GRCm39)	V380A	probably benign	Het
B3galt1	C	A	2: 67,948,913 (GRCm39)	N209K	possibly damaging	Het
Cd300c2	A	T	11: 114,887,731 (GRCm39)	C224S	probably benign	Het
Cdk4	T	C	10: 126,900,759 (GRCm39)		probably null	Het
Cdk5rap1	T	C	2: 154,210,794 (GRCm39)	T115A	possibly damaging	Het
Clvs1	A	T	4: 9,281,831 (GRCm39)	R92*	probably null	Het
Cnga1	A	G	5: 72,762,107 (GRCm39)	V469A	probably damaging	Het
Ctns	A	G	11: 73,087,479 (GRCm39)	F16L	probably benign	Het
Dlg5	A	T	14: 24,204,429 (GRCm39)	C1299S	probably damaging	Het
Dnah3	T	A	7: 119,530,783 (GRCm39)	Y3690F	probably damaging	Het
Dpp8	T	C	9: 64,963,200 (GRCm39)	Y485H	probably benign	Het
Dsc2	T	C	18: 20,183,214 (GRCm39)	D68G	probably damaging	Het
Eeig2	A	G	3: 108,887,544 (GRCm39)	V240A	probably benign	Het
Elavl1	A	T	8: 4,351,752 (GRCm39)	D121E	probably benign	Het
Ermap	A	G	4: 119,040,505 (GRCm39)	V311A	probably damaging	Het
Fbxw11	C	T	11: 32,689,226 (GRCm39)	R437C	probably damaging	Het
Gas2l3	T	C	10: 89,249,634 (GRCm39)	M495V	probably benign	Het
Hacd1	C	T	2: 14,049,948 (GRCm39)		probably null	Het
Itgav	A	G	2: 83,619,327 (GRCm39)	R596G	probably benign	Het
Kars1	T	C	8: 112,728,352 (GRCm39)	H215R	possibly damaging	Het
Kif26a	G	A	12: 112,144,228 (GRCm39)	R1494H	probably damaging	Het
Klf12	G	A	14: 100,260,393 (GRCm39)	S112L	possibly damaging	Het
Krt77	T	C	15: 101,777,998 (GRCm39)	Y19C	unknown	Het
Lrrc4c	A	G	2: 97,460,834 (GRCm39)	T487A	probably benign	Het
Lrrn1	A	G	6: 107,545,851 (GRCm39)	M550V	probably benign	Het
Lsr	C	A	7: 30,657,634 (GRCm39)	R442L	probably benign	Het
Lysmd2	A	C	9: 75,542,728 (GRCm39)	T112P	probably damaging	Het
Mctp2	A	T	7: 71,909,017 (GRCm39)	S99T	probably benign	Het
Mettl4	A	G	17: 95,047,960 (GRCm39)	V227A	probably benign	Het
Mill2	T	A	7: 18,590,608 (GRCm39)		probably null	Het
Mpp3	T	C	11: 101,895,848 (GRCm39)	N476D	probably benign	Het
Mtmr6	C	T	14: 60,517,638 (GRCm39)	P83L	possibly damaging	Het
Myh3	T	C	11: 66,984,364 (GRCm39)	I1067T	probably benign	Het
Myh9	C	A	15: 77,657,540 (GRCm39)	Q1068H	probably damaging	Het
Narf	T	A	11: 121,141,179 (GRCm39)	H304Q	possibly damaging	Het
Nfatc2ip	G	T	7: 125,995,784 (GRCm39)	P35Q	possibly damaging	Het
Npas3	C	A	12: 54,112,618 (GRCm39)	P426Q	probably damaging	Het
Or10aa3	T	G	1: 173,878,400 (GRCm39)	S154A	possibly damaging	Het
Or4e1	G	A	14: 52,700,740 (GRCm39)	T242I	probably damaging	Het
Or4f4b	T	C	2: 111,314,311 (GRCm39)	Y207H	possibly damaging	Het
Or51i1	T	A	7: 103,671,219 (GRCm39)	Q102L	probably damaging	Het
Or5p5	A	G	7: 107,414,589 (GRCm39)	H266R	possibly damaging	Het
Pcdh10	A	T	3: 45,333,917 (GRCm39)	E77V	probably damaging	Het
Pcnt	C	T	10: 76,192,019 (GRCm39)	R2764Q	probably damaging	Het
Pgbd5	T	C	8: 125,097,324 (GRCm39)	D493G	possibly damaging	Het
Piezo2	G	T	18: 63,290,333 (GRCm39)	T142N	probably benign	Het
Plcb1	A	G	2: 135,187,015 (GRCm39)	I761V	probably benign	Het
Plekhg4	T	G	8: 106,108,628 (GRCm39)	D1196E	probably null	Het
Pparg	A	G	6: 115,427,989 (GRCm39)	K159E	probably damaging	Het
Psmb1	A	T	17: 15,718,478 (GRCm39)	M16K	probably benign	Het
Ptprq	T	C	10: 107,361,595 (GRCm39)	I2139V	probably benign	Het
Ralgapb	T	A	2: 158,282,887 (GRCm39)	S239T	probably damaging	Het
Serpina11	A	G	12: 103,950,923 (GRCm39)	V266A	probably damaging	Het
Sf3a2	C	G	10: 80,639,947 (GRCm39)		probably benign	Het
Smim18	T	C	8: 34,232,587 (GRCm39)	T11A	possibly damaging	Het
Snx6	G	A	12: 54,817,528 (GRCm39)	T7I	probably damaging	Het
Srcin1	T	A	11: 97,442,768 (GRCm39)	D75V	probably damaging	Het
Srsf12	T	A	4: 33,231,174 (GRCm39)	S223T	probably damaging	Het
Taf4b	G	T	18: 14,946,599 (GRCm39)	C474F	probably damaging	Het
Tango6	T	A	8: 107,444,722 (GRCm39)	C542*	probably null	Het
Tbc1d24	A	G	17: 24,427,510 (GRCm39)	S151P	possibly damaging	Het
Tssk6	T	C	8: 70,355,714 (GRCm39)	S253P	probably benign	Het
Ttc39c	G	A	18: 12,857,999 (GRCm39)	W300*	probably null	Het
Ttc6	T	A	12: 57,689,926 (GRCm39)	W539R	probably benign	Het
Ttn	T	C	2: 76,582,770 (GRCm39)	T22708A	probably damaging	Het
Ttn	C	A	2: 76,749,053 (GRCm39)	E3999*	probably null	Het
Vill	T	G	9: 118,897,508 (GRCm39)	L261R	probably damaging	Het
Vmn1r20	T	C	6: 57,409,159 (GRCm39)	S162P	probably damaging	Het
Zfp516	T	C	18: 82,974,219 (GRCm39)	I139T	probably benign	Het

Other mutations in Dnah5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Dnah5	APN	15	28,272,488 (GRCm39)	missense	probably benign
IGL00331:Dnah5	APN	15	28,421,766 (GRCm39)	missense	probably damaging	1.00
IGL00519:Dnah5	APN	15	28,444,364 (GRCm39)	missense	probably benign	0.10
IGL00537:Dnah5	APN	15	28,458,848 (GRCm39)	critical splice donor site	probably null
IGL01102:Dnah5	APN	15	28,410,149 (GRCm39)	critical splice donor site	probably null
IGL01126:Dnah5	APN	15	28,302,545 (GRCm39)	missense	possibly damaging	0.85
IGL01154:Dnah5	APN	15	28,458,802 (GRCm39)	missense	possibly damaging	0.75
IGL01349:Dnah5	APN	15	28,295,059 (GRCm39)	splice site	probably benign
IGL01353:Dnah5	APN	15	28,233,418 (GRCm39)	missense	probably benign	0.00
IGL01372:Dnah5	APN	15	28,230,636 (GRCm39)	missense	probably benign	0.00
IGL01390:Dnah5	APN	15	28,411,686 (GRCm39)	missense	probably benign	0.00
IGL01446:Dnah5	APN	15	28,326,815 (GRCm39)	missense	probably damaging	1.00
IGL01472:Dnah5	APN	15	28,331,872 (GRCm39)	missense	probably damaging	1.00
IGL01485:Dnah5	APN	15	28,331,872 (GRCm39)	missense	probably damaging	1.00
IGL01568:Dnah5	APN	15	28,229,798 (GRCm39)	missense	probably benign	0.01
IGL01592:Dnah5	APN	15	28,236,783 (GRCm39)	missense	probably benign	0.01
IGL01594:Dnah5	APN	15	28,311,480 (GRCm39)	missense	possibly damaging	0.87
IGL01677:Dnah5	APN	15	28,367,928 (GRCm39)	missense	probably damaging	1.00
IGL01845:Dnah5	APN	15	28,449,315 (GRCm39)	missense	probably benign	0.06
IGL01904:Dnah5	APN	15	28,307,510 (GRCm39)	missense	probably benign	0.09
IGL01913:Dnah5	APN	15	28,313,899 (GRCm39)	missense	possibly damaging	0.50
IGL01950:Dnah5	APN	15	28,290,435 (GRCm39)	missense	probably null	1.00
IGL01963:Dnah5	APN	15	28,370,682 (GRCm39)	missense	probably benign	0.12
IGL02008:Dnah5	APN	15	28,343,698 (GRCm39)	missense	probably damaging	0.98
IGL02088:Dnah5	APN	15	28,459,264 (GRCm39)	critical splice acceptor site	probably null
IGL02090:Dnah5	APN	15	28,240,187 (GRCm39)	splice site	probably benign
IGL02114:Dnah5	APN	15	28,397,270 (GRCm39)	missense	probably damaging	0.97
IGL02135:Dnah5	APN	15	28,248,031 (GRCm39)	missense	possibly damaging	0.50
IGL02232:Dnah5	APN	15	28,299,386 (GRCm39)	missense	probably damaging	1.00
IGL02386:Dnah5	APN	15	28,340,527 (GRCm39)	missense	probably damaging	1.00
IGL02475:Dnah5	APN	15	28,219,296 (GRCm39)	missense	probably benign	0.09
IGL02626:Dnah5	APN	15	28,307,422 (GRCm39)	missense	possibly damaging	0.94
IGL02650:Dnah5	APN	15	28,289,193 (GRCm39)	splice site	probably benign
IGL02651:Dnah5	APN	15	28,350,768 (GRCm39)	missense	probably benign	0.05
IGL02652:Dnah5	APN	15	28,366,333 (GRCm39)	missense	probably damaging	0.99
IGL02670:Dnah5	APN	15	28,409,442 (GRCm39)	missense	probably damaging	1.00
IGL02697:Dnah5	APN	15	28,445,289 (GRCm39)	missense	probably benign	0.00
IGL02721:Dnah5	APN	15	28,234,389 (GRCm39)	critical splice acceptor site	probably null
IGL02858:Dnah5	APN	15	28,453,358 (GRCm39)	missense	possibly damaging	0.65
IGL02859:Dnah5	APN	15	28,383,771 (GRCm39)	missense	probably benign	0.01
IGL02945:Dnah5	APN	15	28,270,572 (GRCm39)	missense	probably benign	0.00
IGL02949:Dnah5	APN	15	28,272,331 (GRCm39)	missense	probably benign	0.32
IGL02971:Dnah5	APN	15	28,384,607 (GRCm39)	missense	probably damaging	1.00
IGL03017:Dnah5	APN	15	28,340,471 (GRCm39)	missense	possibly damaging	0.93
IGL03177:Dnah5	APN	15	28,295,545 (GRCm39)	missense	probably damaging	0.97
IGL03212:Dnah5	APN	15	28,290,309 (GRCm39)	missense	probably benign	0.08
IGL03224:Dnah5	APN	15	28,459,300 (GRCm39)	missense	probably damaging	1.00
IGL03231:Dnah5	APN	15	28,311,294 (GRCm39)	missense	probably damaging	1.00
IGL03273:Dnah5	APN	15	28,458,795 (GRCm39)	missense	probably damaging	0.98
IGL03294:Dnah5	APN	15	28,233,441 (GRCm39)	critical splice donor site	probably null
IGL03331:Dnah5	APN	15	28,420,086 (GRCm39)	missense	probably damaging	1.00
IGL03337:Dnah5	APN	15	28,290,287 (GRCm39)	missense	probably benign	0.10
IGL03367:Dnah5	APN	15	28,234,473 (GRCm39)	missense	possibly damaging	0.95
Firtel	UTSW	15	28,448,513 (GRCm39)	missense	possibly damaging	0.95
lowbar	UTSW	15	28,311,279 (GRCm39)	splice site	probably null
notherone	UTSW	15	28,340,552 (GRCm39)	missense	probably benign	0.13
scheffler	UTSW	15	28,438,237 (GRCm39)	splice site	probably benign
IGL02837:Dnah5	UTSW	15	28,269,546 (GRCm39)	missense	probably benign
P0008:Dnah5	UTSW	15	28,302,533 (GRCm39)	missense	probably damaging	1.00
P0014:Dnah5	UTSW	15	28,403,619 (GRCm39)	missense	probably damaging	1.00
PIT4687001:Dnah5	UTSW	15	28,383,723 (GRCm39)	missense	probably damaging	0.98
R0030:Dnah5	UTSW	15	28,451,663 (GRCm39)	missense	probably benign	0.34
R0087:Dnah5	UTSW	15	28,350,759 (GRCm39)	missense	probably damaging	1.00
R0099:Dnah5	UTSW	15	28,240,080 (GRCm39)	missense	probably damaging	1.00
R0102:Dnah5	UTSW	15	28,245,897 (GRCm39)	splice site	probably benign
R0102:Dnah5	UTSW	15	28,245,897 (GRCm39)	splice site	probably benign
R0104:Dnah5	UTSW	15	28,453,499 (GRCm39)	missense	possibly damaging	0.88
R0112:Dnah5	UTSW	15	28,263,825 (GRCm39)	missense	probably benign	0.00
R0122:Dnah5	UTSW	15	28,378,509 (GRCm39)	missense	probably damaging	1.00
R0126:Dnah5	UTSW	15	28,246,465 (GRCm39)	missense	probably benign	0.00
R0127:Dnah5	UTSW	15	28,295,071 (GRCm39)	missense	probably damaging	1.00
R0233:Dnah5	UTSW	15	28,333,216 (GRCm39)	missense	probably damaging	1.00
R0310:Dnah5	UTSW	15	28,299,256 (GRCm39)	missense	probably benign	0.19
R0386:Dnah5	UTSW	15	28,383,727 (GRCm39)	missense	probably damaging	1.00
R0421:Dnah5	UTSW	15	28,229,687 (GRCm39)	missense	possibly damaging	0.79
R0481:Dnah5	UTSW	15	28,383,745 (GRCm39)	missense	probably benign	0.31
R0514:Dnah5	UTSW	15	28,366,467 (GRCm39)	missense	probably damaging	1.00
R0609:Dnah5	UTSW	15	28,327,925 (GRCm39)	missense	probably benign
R0720:Dnah5	UTSW	15	28,314,007 (GRCm39)	missense	probably null	0.98
R0731:Dnah5	UTSW	15	28,311,289 (GRCm39)	missense	possibly damaging	0.78
R0747:Dnah5	UTSW	15	28,444,333 (GRCm39)	missense	possibly damaging	0.64
R0747:Dnah5	UTSW	15	28,444,332 (GRCm39)	missense	probably damaging	0.99
R0766:Dnah5	UTSW	15	28,448,633 (GRCm39)	missense	probably null	0.89
R0849:Dnah5	UTSW	15	28,263,745 (GRCm39)	missense	probably damaging	0.96
R1034:Dnah5	UTSW	15	28,302,617 (GRCm39)	missense	probably damaging	1.00
R1084:Dnah5	UTSW	15	28,343,598 (GRCm39)	missense	probably benign	0.01
R1148:Dnah5	UTSW	15	28,421,836 (GRCm39)	missense	probably damaging	1.00
R1148:Dnah5	UTSW	15	28,421,836 (GRCm39)	missense	probably damaging	1.00
R1200:Dnah5	UTSW	15	28,246,403 (GRCm39)	missense	possibly damaging	0.88
R1208:Dnah5	UTSW	15	28,327,877 (GRCm39)	missense	probably damaging	1.00
R1208:Dnah5	UTSW	15	28,327,877 (GRCm39)	missense	probably damaging	1.00
R1269:Dnah5	UTSW	15	28,238,657 (GRCm39)	missense	probably damaging	1.00
R1373:Dnah5	UTSW	15	28,314,064 (GRCm39)	splice site	probably benign
R1401:Dnah5	UTSW	15	28,402,059 (GRCm39)	missense	probably damaging	1.00
R1413:Dnah5	UTSW	15	28,370,555 (GRCm39)	missense	probably benign
R1430:Dnah5	UTSW	15	28,346,003 (GRCm39)	missense	probably benign	0.37
R1457:Dnah5	UTSW	15	28,403,688 (GRCm39)	critical splice donor site	probably null
R1468:Dnah5	UTSW	15	28,230,609 (GRCm39)	nonsense	probably null
R1468:Dnah5	UTSW	15	28,230,609 (GRCm39)	nonsense	probably null
R1560:Dnah5	UTSW	15	28,420,149 (GRCm39)	missense	probably damaging	1.00
R1568:Dnah5	UTSW	15	28,409,323 (GRCm39)	missense	probably damaging	0.98
R1574:Dnah5	UTSW	15	28,252,569 (GRCm39)	missense	probably benign	0.00
R1574:Dnah5	UTSW	15	28,252,569 (GRCm39)	missense	probably benign	0.00
R1603:Dnah5	UTSW	15	28,449,326 (GRCm39)	missense	probably benign	0.09
R1603:Dnah5	UTSW	15	28,295,131 (GRCm39)	splice site	probably benign
R1673:Dnah5	UTSW	15	28,290,294 (GRCm39)	missense	probably benign
R1755:Dnah5	UTSW	15	28,326,782 (GRCm39)	missense	probably damaging	0.99
R1785:Dnah5	UTSW	15	28,313,932 (GRCm39)	missense	probably damaging	1.00
R1786:Dnah5	UTSW	15	28,313,932 (GRCm39)	missense	probably damaging	1.00
R1789:Dnah5	UTSW	15	28,270,572 (GRCm39)	missense	probably benign	0.00
R1817:Dnah5	UTSW	15	28,246,546 (GRCm39)	nonsense	probably null
R1819:Dnah5	UTSW	15	28,246,546 (GRCm39)	nonsense	probably null
R1834:Dnah5	UTSW	15	28,409,270 (GRCm39)	missense	probably benign	0.00
R1855:Dnah5	UTSW	15	28,411,815 (GRCm39)	missense	possibly damaging	0.88
R1870:Dnah5	UTSW	15	28,331,859 (GRCm39)	nonsense	probably null
R1871:Dnah5	UTSW	15	28,331,859 (GRCm39)	nonsense	probably null
R1987:Dnah5	UTSW	15	28,343,737 (GRCm39)	missense	probably damaging	0.99
R1988:Dnah5	UTSW	15	28,343,737 (GRCm39)	missense	probably damaging	0.99
R1989:Dnah5	UTSW	15	28,343,737 (GRCm39)	missense	probably damaging	0.99
R2062:Dnah5	UTSW	15	28,366,416 (GRCm39)	missense	probably damaging	1.00
R2069:Dnah5	UTSW	15	28,312,534 (GRCm39)	splice site	probably null
R2121:Dnah5	UTSW	15	28,297,151 (GRCm39)	splice site	probably benign
R2128:Dnah5	UTSW	15	28,408,467 (GRCm39)	missense	probably benign	0.00
R2129:Dnah5	UTSW	15	28,408,467 (GRCm39)	missense	probably benign	0.00
R2151:Dnah5	UTSW	15	28,444,237 (GRCm39)	missense	probably damaging	1.00
R2159:Dnah5	UTSW	15	28,252,691 (GRCm39)	missense	probably benign	0.00
R2207:Dnah5	UTSW	15	28,343,817 (GRCm39)	missense	probably benign	0.11
R2231:Dnah5	UTSW	15	28,408,563 (GRCm39)	critical splice donor site	probably null
R2232:Dnah5	UTSW	15	28,408,563 (GRCm39)	critical splice donor site	probably null
R2282:Dnah5	UTSW	15	28,327,448 (GRCm39)	missense	probably damaging	0.99
R2305:Dnah5	UTSW	15	28,387,913 (GRCm39)	missense	probably benign	0.25
R2339:Dnah5	UTSW	15	28,314,028 (GRCm39)	missense	probably benign	0.00
R2437:Dnah5	UTSW	15	28,307,537 (GRCm39)	critical splice donor site	probably null
R2696:Dnah5	UTSW	15	28,278,722 (GRCm39)	missense	probably benign	0.00
R3156:Dnah5	UTSW	15	28,438,237 (GRCm39)	splice site	probably benign
R3431:Dnah5	UTSW	15	28,295,413 (GRCm39)	missense	probably benign	0.20
R3700:Dnah5	UTSW	15	28,387,937 (GRCm39)	missense	possibly damaging	0.72
R3724:Dnah5	UTSW	15	28,270,566 (GRCm39)	missense	probably benign	0.08
R3732:Dnah5	UTSW	15	28,409,268 (GRCm39)	missense	possibly damaging	0.64
R3872:Dnah5	UTSW	15	28,411,656 (GRCm39)	missense	possibly damaging	0.50
R4063:Dnah5	UTSW	15	28,421,144 (GRCm39)	missense	probably damaging	0.98
R4072:Dnah5	UTSW	15	28,340,444 (GRCm39)	nonsense	probably null
R4075:Dnah5	UTSW	15	28,293,937 (GRCm39)	missense	probably benign
R4245:Dnah5	UTSW	15	28,219,335 (GRCm39)	missense	probably benign
R4254:Dnah5	UTSW	15	28,438,248 (GRCm39)	missense	probably benign	0.07
R4255:Dnah5	UTSW	15	28,438,248 (GRCm39)	missense	probably benign	0.07
R4392:Dnah5	UTSW	15	28,289,375 (GRCm39)	missense	probably benign	0.19
R4552:Dnah5	UTSW	15	28,397,300 (GRCm39)	missense	probably benign	0.19
R4574:Dnah5	UTSW	15	28,367,909 (GRCm39)	missense	probably benign	0.05
R4577:Dnah5	UTSW	15	28,289,396 (GRCm39)	missense	probably benign	0.06
R4587:Dnah5	UTSW	15	28,304,745 (GRCm39)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,420,140 (GRCm39)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,402,099 (GRCm39)	missense	probably damaging	1.00
R4676:Dnah5	UTSW	15	28,295,406 (GRCm39)	missense	possibly damaging	0.65
R4707:Dnah5	UTSW	15	28,372,521 (GRCm39)	missense	probably damaging	0.97
R4754:Dnah5	UTSW	15	28,421,101 (GRCm39)	splice site	probably null
R4767:Dnah5	UTSW	15	28,270,620 (GRCm39)	missense	probably benign	0.02
R4857:Dnah5	UTSW	15	28,345,953 (GRCm39)	missense	probably benign	0.00
R4883:Dnah5	UTSW	15	28,343,784 (GRCm39)	missense	probably benign	0.00
R4889:Dnah5	UTSW	15	28,235,938 (GRCm39)	missense	probably benign	0.01
R4946:Dnah5	UTSW	15	28,388,050 (GRCm39)	missense	probably damaging	1.00
R4947:Dnah5	UTSW	15	28,272,518 (GRCm39)	missense	probably benign
R5033:Dnah5	UTSW	15	28,421,824 (GRCm39)	missense	probably damaging	0.96
R5164:Dnah5	UTSW	15	28,408,438 (GRCm39)	missense	probably benign	0.00
R5175:Dnah5	UTSW	15	28,448,550 (GRCm39)	missense	probably damaging	1.00
R5182:Dnah5	UTSW	15	28,311,424 (GRCm39)	missense	probably damaging	0.99
R5187:Dnah5	UTSW	15	28,272,318 (GRCm39)	missense	probably benign	0.41
R5272:Dnah5	UTSW	15	28,350,811 (GRCm39)	missense	probably benign
R5308:Dnah5	UTSW	15	28,229,797 (GRCm39)	missense	possibly damaging	0.80
R5310:Dnah5	UTSW	15	28,311,474 (GRCm39)	missense	probably damaging	1.00
R5322:Dnah5	UTSW	15	28,384,390 (GRCm39)	missense	probably benign	0.41
R5398:Dnah5	UTSW	15	28,293,872 (GRCm39)	missense	probably benign
R5596:Dnah5	UTSW	15	28,343,754 (GRCm39)	missense	probably damaging	1.00
R5603:Dnah5	UTSW	15	28,420,078 (GRCm39)	missense	probably damaging	1.00
R5619:Dnah5	UTSW	15	28,302,581 (GRCm39)	missense	probably damaging	1.00
R5656:Dnah5	UTSW	15	28,421,210 (GRCm39)	missense	probably benign	0.03
R5741:Dnah5	UTSW	15	28,246,513 (GRCm39)	missense	probably benign	0.11
R5754:Dnah5	UTSW	15	28,402,014 (GRCm39)	missense	probably benign	0.01
R5763:Dnah5	UTSW	15	28,311,298 (GRCm39)	missense	probably damaging	1.00
R5824:Dnah5	UTSW	15	28,313,967 (GRCm39)	missense	probably benign	0.00
R5836:Dnah5	UTSW	15	28,383,738 (GRCm39)	missense	probably damaging	1.00
R5838:Dnah5	UTSW	15	28,290,341 (GRCm39)	missense	probably benign	0.00
R5864:Dnah5	UTSW	15	28,297,159 (GRCm39)	missense	possibly damaging	0.83
R5895:Dnah5	UTSW	15	28,234,599 (GRCm39)	splice site	probably null
R5896:Dnah5	UTSW	15	28,272,206 (GRCm39)	missense	probably benign
R5899:Dnah5	UTSW	15	28,448,513 (GRCm39)	missense	possibly damaging	0.95
R5905:Dnah5	UTSW	15	28,387,979 (GRCm39)	missense	probably damaging	1.00
R5924:Dnah5	UTSW	15	28,307,473 (GRCm39)	missense	probably benign	0.41
R5927:Dnah5	UTSW	15	28,335,864 (GRCm39)	missense	probably benign	0.00
R5929:Dnah5	UTSW	15	28,311,354 (GRCm39)	missense	probably damaging	1.00
R5929:Dnah5	UTSW	15	28,311,353 (GRCm39)	missense	probably benign	0.01
R5931:Dnah5	UTSW	15	28,453,425 (GRCm39)	missense	probably damaging	0.99
R5964:Dnah5	UTSW	15	28,458,730 (GRCm39)	missense	possibly damaging	0.49
R5975:Dnah5	UTSW	15	28,234,428 (GRCm39)	missense	probably damaging	1.00
R5993:Dnah5	UTSW	15	28,299,372 (GRCm39)	missense	probably benign	0.09
R6016:Dnah5	UTSW	15	28,328,030 (GRCm39)	missense	probably damaging	1.00
R6028:Dnah5	UTSW	15	28,387,979 (GRCm39)	missense	probably damaging	1.00
R6065:Dnah5	UTSW	15	28,230,614 (GRCm39)	missense	possibly damaging	0.47
R6117:Dnah5	UTSW	15	28,270,566 (GRCm39)	missense	probably damaging	0.99
R6143:Dnah5	UTSW	15	28,233,377 (GRCm39)	missense	probably benign	0.05
R6146:Dnah5	UTSW	15	28,459,331 (GRCm39)	missense	probably benign
R6154:Dnah5	UTSW	15	28,204,177 (GRCm39)	missense	probably benign	0.15
R6164:Dnah5	UTSW	15	28,378,489 (GRCm39)	missense	probably benign	0.08
R6266:Dnah5	UTSW	15	28,335,773 (GRCm39)	missense	possibly damaging	0.67
R6321:Dnah5	UTSW	15	28,372,557 (GRCm39)	missense	probably damaging	0.99
R6349:Dnah5	UTSW	15	28,238,657 (GRCm39)	missense	probably damaging	1.00
R6431:Dnah5	UTSW	15	28,349,970 (GRCm39)	missense	possibly damaging	0.52
R6467:Dnah5	UTSW	15	28,438,329 (GRCm39)	missense	probably benign	0.10
R6564:Dnah5	UTSW	15	28,367,891 (GRCm39)	missense	probably benign
R6607:Dnah5	UTSW	15	28,445,346 (GRCm39)	missense	possibly damaging	0.95
R6619:Dnah5	UTSW	15	28,409,266 (GRCm39)	missense	probably benign	0.03
R6633:Dnah5	UTSW	15	28,293,933 (GRCm39)	missense	probably benign	0.27
R6647:Dnah5	UTSW	15	28,403,633 (GRCm39)	missense	probably benign	0.02
R6782:Dnah5	UTSW	15	28,449,302 (GRCm39)	missense	possibly damaging	0.89
R6797:Dnah5	UTSW	15	28,233,384 (GRCm39)	nonsense	probably null
R6797:Dnah5	UTSW	15	28,451,609 (GRCm39)	missense	probably damaging	1.00
R6831:Dnah5	UTSW	15	28,411,661 (GRCm39)	missense	possibly damaging	0.88
R6849:Dnah5	UTSW	15	28,278,770 (GRCm39)	missense	probably benign	0.14
R6871:Dnah5	UTSW	15	28,229,786 (GRCm39)	missense	probably benign	0.32
R6936:Dnah5	UTSW	15	28,409,414 (GRCm39)	missense	probably damaging	1.00
R6943:Dnah5	UTSW	15	28,235,866 (GRCm39)	missense	probably damaging	1.00
R7030:Dnah5	UTSW	15	28,333,208 (GRCm39)	missense	probably benign	0.00
R7030:Dnah5	UTSW	15	28,238,738 (GRCm39)	missense	probably benign
R7032:Dnah5	UTSW	15	28,326,796 (GRCm39)	missense	probably damaging	1.00
R7063:Dnah5	UTSW	15	28,233,394 (GRCm39)	missense	probably benign	0.00
R7094:Dnah5	UTSW	15	28,453,482 (GRCm39)	missense	probably damaging	0.98
R7097:Dnah5	UTSW	15	28,453,410 (GRCm39)	missense	probably benign	0.00
R7126:Dnah5	UTSW	15	28,349,983 (GRCm39)	missense	probably benign	0.03
R7153:Dnah5	UTSW	15	28,365,668 (GRCm39)	splice site	probably null
R7209:Dnah5	UTSW	15	28,459,371 (GRCm39)	missense	possibly damaging	0.71
R7276:Dnah5	UTSW	15	28,367,984 (GRCm39)	missense	probably damaging	1.00
R7320:Dnah5	UTSW	15	28,270,616 (GRCm39)	missense	probably null	0.33
R7350:Dnah5	UTSW	15	28,235,965 (GRCm39)	critical splice donor site	probably null
R7380:Dnah5	UTSW	15	28,370,524 (GRCm39)	missense	probably damaging	1.00
R7438:Dnah5	UTSW	15	28,347,098 (GRCm39)	missense	probably damaging	0.99
R7499:Dnah5	UTSW	15	28,302,596 (GRCm39)	missense	probably damaging	1.00
R7513:Dnah5	UTSW	15	28,370,561 (GRCm39)	missense	probably benign
R7519:Dnah5	UTSW	15	28,390,629 (GRCm39)	missense	probably damaging	0.98
R7524:Dnah5	UTSW	15	28,297,212 (GRCm39)	missense	possibly damaging	0.50
R7556:Dnah5	UTSW	15	28,290,389 (GRCm39)	missense	probably null	0.43
R7570:Dnah5	UTSW	15	28,347,098 (GRCm39)	missense	probably damaging	1.00
R7585:Dnah5	UTSW	15	28,402,014 (GRCm39)	missense	probably benign	0.09
R7642:Dnah5	UTSW	15	28,248,125 (GRCm39)	critical splice donor site	probably null
R7670:Dnah5	UTSW	15	28,246,378 (GRCm39)	splice site	probably null
R7763:Dnah5	UTSW	15	28,314,001 (GRCm39)	missense	probably damaging	1.00
R7821:Dnah5	UTSW	15	28,411,678 (GRCm39)	missense	possibly damaging	0.89
R7826:Dnah5	UTSW	15	28,367,958 (GRCm39)	missense	probably damaging	1.00
R7872:Dnah5	UTSW	15	28,245,830 (GRCm39)	missense	probably damaging	0.99
R7889:Dnah5	UTSW	15	28,448,560 (GRCm39)	nonsense	probably null
R7919:Dnah5	UTSW	15	28,350,742 (GRCm39)	missense	probably damaging	1.00
R7920:Dnah5	UTSW	15	28,453,368 (GRCm39)	missense	probably benign	0.00
R7936:Dnah5	UTSW	15	28,345,983 (GRCm39)	missense	possibly damaging	0.64
R7996:Dnah5	UTSW	15	28,409,323 (GRCm39)	missense	probably damaging	0.98
R8063:Dnah5	UTSW	15	28,230,729 (GRCm39)	missense	probably benign
R8084:Dnah5	UTSW	15	28,388,099 (GRCm39)	missense	probably damaging	1.00
R8105:Dnah5	UTSW	15	28,372,548 (GRCm39)	missense	probably benign
R8114:Dnah5	UTSW	15	28,240,122 (GRCm39)	missense	probably benign	0.01
R8142:Dnah5	UTSW	15	28,384,519 (GRCm39)	missense	probably benign	0.36
R8153:Dnah5	UTSW	15	28,384,576 (GRCm39)	missense	probably damaging	1.00
R8161:Dnah5	UTSW	15	28,350,850 (GRCm39)	missense	possibly damaging	0.79
R8174:Dnah5	UTSW	15	28,311,279 (GRCm39)	splice site	probably null
R8187:Dnah5	UTSW	15	28,384,355 (GRCm39)	missense	probably damaging	1.00
R8194:Dnah5	UTSW	15	28,453,414 (GRCm39)	missense	probably damaging	0.99
R8280:Dnah5	UTSW	15	28,408,538 (GRCm39)	missense	probably benign	0.01
R8291:Dnah5	UTSW	15	28,263,743 (GRCm39)	missense	probably benign	0.03
R8324:Dnah5	UTSW	15	28,347,011 (GRCm39)	missense	probably damaging	1.00
R8347:Dnah5	UTSW	15	28,236,812 (GRCm39)	missense	possibly damaging	0.90
R8356:Dnah5	UTSW	15	28,444,469 (GRCm39)	missense	probably null	0.02
R8356:Dnah5	UTSW	15	28,444,313 (GRCm39)	missense	probably benign	0.03
R8361:Dnah5	UTSW	15	28,331,956 (GRCm39)	missense	probably damaging	0.98
R8375:Dnah5	UTSW	15	28,327,489 (GRCm39)	missense	probably benign	0.00
R8474:Dnah5	UTSW	15	28,247,978 (GRCm39)	missense	probably benign	0.00
R8481:Dnah5	UTSW	15	28,419,941 (GRCm39)	missense	probably benign	0.00
R8494:Dnah5	UTSW	15	28,345,977 (GRCm39)	missense	probably benign	0.32
R8495:Dnah5	UTSW	15	28,409,414 (GRCm39)	missense	probably damaging	0.97
R8519:Dnah5	UTSW	15	28,299,245 (GRCm39)	missense	probably benign	0.07
R8683:Dnah5	UTSW	15	28,289,367 (GRCm39)	missense	probably benign	0.00
R8739:Dnah5	UTSW	15	28,346,006 (GRCm39)	missense	probably benign	0.01
R8752:Dnah5	UTSW	15	28,290,365 (GRCm39)	missense	probably benign	0.00
R8784:Dnah5	UTSW	15	28,388,097 (GRCm39)	missense	probably benign	0.16
R8813:Dnah5	UTSW	15	28,229,719 (GRCm39)	missense	probably damaging	1.00
R8862:Dnah5	UTSW	15	28,459,502 (GRCm39)	splice site	probably benign
R8873:Dnah5	UTSW	15	28,219,334 (GRCm39)	missense	probably benign
R8885:Dnah5	UTSW	15	28,327,886 (GRCm39)	missense	probably damaging	1.00
R8901:Dnah5	UTSW	15	28,365,715 (GRCm39)	missense	possibly damaging	0.76
R9025:Dnah5	UTSW	15	28,409,412 (GRCm39)	missense	probably damaging	1.00
R9037:Dnah5	UTSW	15	28,248,104 (GRCm39)	missense	probably benign	0.05
R9057:Dnah5	UTSW	15	28,391,014 (GRCm39)	missense	probably damaging	1.00
R9059:Dnah5	UTSW	15	28,245,812 (GRCm39)	missense	probably benign
R9065:Dnah5	UTSW	15	28,293,936 (GRCm39)	missense	probably benign	0.09
R9098:Dnah5	UTSW	15	28,420,107 (GRCm39)	missense
R9118:Dnah5	UTSW	15	28,401,994 (GRCm39)	frame shift	probably null
R9149:Dnah5	UTSW	15	28,387,914 (GRCm39)	missense	probably benign	0.00
R9184:Dnah5	UTSW	15	28,340,552 (GRCm39)	missense	probably benign	0.13
R9205:Dnah5	UTSW	15	28,448,480 (GRCm39)	missense	possibly damaging	0.88
R9297:Dnah5	UTSW	15	28,204,054 (GRCm39)	start gained	probably benign
R9302:Dnah5	UTSW	15	28,240,032 (GRCm39)	missense	probably benign	0.03
R9310:Dnah5	UTSW	15	28,448,579 (GRCm39)	missense	probably damaging	1.00
R9318:Dnah5	UTSW	15	28,204,054 (GRCm39)	start gained	probably benign
R9405:Dnah5	UTSW	15	28,272,306 (GRCm39)	missense	probably benign
R9424:Dnah5	UTSW	15	28,272,286 (GRCm39)	missense	probably benign	0.01
R9467:Dnah5	UTSW	15	28,366,293 (GRCm39)	missense	possibly damaging	0.94
R9469:Dnah5	UTSW	15	28,421,146 (GRCm39)	missense	probably benign	0.06
R9548:Dnah5	UTSW	15	28,328,025 (GRCm39)	missense	possibly damaging	0.79
R9564:Dnah5	UTSW	15	28,290,422 (GRCm39)	missense	probably benign	0.04
R9576:Dnah5	UTSW	15	28,272,286 (GRCm39)	missense	probably benign	0.01
R9593:Dnah5	UTSW	15	28,236,774 (GRCm39)	missense	probably benign
R9644:Dnah5	UTSW	15	28,230,650 (GRCm39)	missense	probably damaging	0.98
R9655:Dnah5	UTSW	15	28,242,900 (GRCm39)	missense	probably benign
R9657:Dnah5	UTSW	15	28,410,089 (GRCm39)	missense	probably damaging	1.00
R9704:Dnah5	UTSW	15	28,247,965 (GRCm39)	missense	probably benign	0.00
R9797:Dnah5	UTSW	15	28,233,316 (GRCm39)	missense	probably benign	0.34
RF009:Dnah5	UTSW	15	28,204,165 (GRCm39)	missense	probably benign	0.00
X0011:Dnah5	UTSW	15	28,408,527 (GRCm39)	missense	probably benign	0.16
X0018:Dnah5	UTSW	15	28,269,500 (GRCm39)	missense	probably benign	0.00
X0022:Dnah5	UTSW	15	28,270,557 (GRCm39)	missense	probably benign	0.01
X0023:Dnah5	UTSW	15	28,384,454 (GRCm39)	missense	probably damaging	0.99
X0028:Dnah5	UTSW	15	28,470,623 (GRCm39)	missense	probably damaging	1.00
Z1088:Dnah5	UTSW	15	28,366,503 (GRCm39)	missense	probably null	0.10
Z1088:Dnah5	UTSW	15	28,384,376 (GRCm39)	missense	probably damaging	1.00
Z1177:Dnah5	UTSW	15	28,295,457 (GRCm39)	missense	probably damaging	0.98
Z1177:Dnah5	UTSW	15	28,270,549 (GRCm39)	missense	probably benign	0.00
Z1177:Dnah5	UTSW	15	28,270,500 (GRCm39)	missense	probably benign	0.32
Z1177:Dnah5	UTSW	15	28,387,909 (GRCm39)	missense	possibly damaging	0.72

Predicted Primers

PCR Primer
(F):5'- ACATGAGGACATTTGTCTTAGGATG -3'
(R):5'- GCTGCACTGACCATCCTAAG -3'

Sequencing Primer
(F):5'- TGTAGGTTTGCAAATTATCTATAGGG -3'
(R):5'- CTGATCTGAAATTTCTCAGTCACTG -3'

Posted On

2016-04-27