Incidental Mutation 'R4948:Lrp4'
| ID |
383554 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp4
|
| Ensembl Gene |
ENSMUSG00000027253 |
| Gene Name |
low density lipoprotein receptor-related protein 4 |
| Synonyms |
6430526J12Rik, Megf7, mdig |
| MMRRC Submission |
042545-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.781)
|
| Stock # |
R4948 (G1)
|
| Quality Score |
180 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
91287856-91344124 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 91316231 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Leucine
at position 783
(R783L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000028689
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028689]
|
| AlphaFold |
Q8VI56 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000028689
AA Change: R783L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000028689
Gene: ENSMUSG00000027253
AA Change: R783L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
LDLa
|
26 |
68 |
5.77e-10 |
SMART |
|
LDLa
|
70 |
107 |
4.05e-14 |
SMART |
|
LDLa
|
109 |
145 |
1.9e-10 |
SMART |
|
LDLa
|
147 |
184 |
1.51e-13 |
SMART |
|
LDLa
|
190 |
227 |
6.83e-12 |
SMART |
|
LDLa
|
230 |
267 |
2.45e-13 |
SMART |
|
LDLa
|
269 |
306 |
6.32e-16 |
SMART |
|
LDLa
|
311 |
351 |
3.24e-13 |
SMART |
|
EGF
|
357 |
394 |
1.4e0 |
SMART |
|
EGF_CA
|
395 |
434 |
1.05e-8 |
SMART |
|
LY
|
460 |
502 |
7.01e-10 |
SMART |
|
LY
|
503 |
545 |
4.41e-16 |
SMART |
|
LY
|
546 |
589 |
1.04e-12 |
SMART |
|
LY
|
590 |
632 |
5.07e-16 |
SMART |
|
LY
|
633 |
674 |
3.12e-7 |
SMART |
|
EGF
|
701 |
737 |
9.27e-1 |
SMART |
|
LY
|
765 |
807 |
7.29e-8 |
SMART |
|
LY
|
808 |
850 |
1.92e-16 |
SMART |
|
LY
|
851 |
894 |
3.05e-10 |
SMART |
|
LY
|
895 |
937 |
6.69e-16 |
SMART |
|
LY
|
938 |
979 |
8.71e-6 |
SMART |
|
EGF
|
1005 |
1044 |
1.64e-1 |
SMART |
|
LY
|
1073 |
1115 |
2.58e-8 |
SMART |
|
LY
|
1116 |
1158 |
1.57e-12 |
SMART |
|
LY
|
1159 |
1202 |
7.4e-9 |
SMART |
|
LY
|
1203 |
1245 |
9.39e-11 |
SMART |
|
LY
|
1246 |
1285 |
6.11e-1 |
SMART |
|
EGF
|
1312 |
1349 |
1.53e-1 |
SMART |
|
LY
|
1377 |
1419 |
4.42e-7 |
SMART |
|
LY
|
1420 |
1462 |
1.04e-12 |
SMART |
|
LY
|
1463 |
1506 |
2.11e-13 |
SMART |
|
LY
|
1507 |
1549 |
4.66e-15 |
SMART |
|
LY
|
1550 |
1590 |
2.02e-1 |
SMART |
|
EGF_like
|
1616 |
1649 |
5.79e1 |
SMART |
|
low complexity region
|
1674 |
1690 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1724 |
1746 |
N/A |
INTRINSIC |
|
low complexity region
|
1857 |
1870 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0720 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.3%
- 20x: 92.2%
|
| Validation Efficiency |
94% (103/109) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutations of this gene cause polysyndactyly. Additional phenotypes may include growth retardation, abnormal incisor development, kidney agenesis, and neonatal lethality associated with respiratory failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2610318N02Rik |
A |
T |
16: 16,936,154 (GRCm39) |
|
probably null |
Het |
| Adcy4 |
C |
T |
14: 56,016,486 (GRCm39) |
D322N |
probably damaging |
Het |
| Alas1 |
A |
T |
9: 106,124,077 (GRCm39) |
L27* |
probably null |
Het |
| Aldh1a7 |
A |
G |
19: 20,704,374 (GRCm39) |
V40A |
possibly damaging |
Het |
| Appbp2 |
A |
T |
11: 85,085,409 (GRCm39) |
I499K |
possibly damaging |
Het |
| B3gnt5 |
A |
C |
16: 19,587,894 (GRCm39) |
M38L |
probably benign |
Het |
| Brd8 |
A |
G |
18: 34,747,585 (GRCm39) |
V92A |
probably damaging |
Het |
| Btla |
A |
T |
16: 45,063,091 (GRCm39) |
E151D |
probably benign |
Het |
| Cd79b |
T |
A |
11: 106,203,687 (GRCm39) |
T67S |
probably benign |
Het |
| Cep192 |
A |
G |
18: 67,949,875 (GRCm39) |
R320G |
probably benign |
Het |
| Chad |
A |
C |
11: 94,456,528 (GRCm39) |
D202A |
probably damaging |
Het |
| Chil6 |
A |
G |
3: 106,295,988 (GRCm39) |
|
probably benign |
Het |
| Cpz |
T |
C |
5: 35,674,748 (GRCm39) |
E167G |
possibly damaging |
Het |
| Crisp2 |
T |
G |
17: 41,076,159 (GRCm39) |
H225P |
probably damaging |
Het |
| Cyp2c23 |
T |
C |
19: 44,010,138 (GRCm39) |
Y69C |
possibly damaging |
Het |
| Dcp1a |
T |
A |
14: 30,201,724 (GRCm39) |
L49H |
probably damaging |
Het |
| Dnah6 |
T |
A |
6: 73,030,672 (GRCm39) |
H3380L |
probably benign |
Het |
| Dnai3 |
T |
A |
3: 145,788,820 (GRCm39) |
K254* |
probably null |
Het |
| Dnm2 |
A |
G |
9: 21,415,829 (GRCm39) |
D721G |
possibly damaging |
Het |
| Dnpep |
G |
T |
1: 75,293,404 (GRCm39) |
T15K |
probably benign |
Het |
| Dock3 |
A |
T |
9: 106,868,354 (GRCm39) |
D643E |
probably damaging |
Het |
| Ear6 |
C |
T |
14: 52,091,573 (GRCm39) |
T40I |
possibly damaging |
Het |
| Fancm |
A |
G |
12: 65,137,748 (GRCm39) |
D313G |
probably damaging |
Het |
| Fbxw16 |
T |
A |
9: 109,267,415 (GRCm39) |
E272V |
probably damaging |
Het |
| Frmd4b |
T |
A |
6: 97,283,691 (GRCm39) |
E393D |
probably benign |
Het |
| Fryl |
T |
A |
5: 73,246,473 (GRCm39) |
M1100L |
probably benign |
Het |
| Gjd3 |
T |
C |
11: 102,691,247 (GRCm39) |
H252R |
probably damaging |
Het |
| Gm10518 |
T |
C |
1: 179,631,477 (GRCm39) |
|
probably benign |
Het |
| Gna14 |
A |
G |
19: 16,580,656 (GRCm39) |
M165V |
probably benign |
Het |
| Hells |
C |
A |
19: 38,923,966 (GRCm39) |
Q72K |
probably damaging |
Het |
| Herc1 |
A |
G |
9: 66,392,184 (GRCm39) |
I4031V |
probably benign |
Het |
| Hspa2 |
C |
T |
12: 76,452,761 (GRCm39) |
A485V |
probably damaging |
Het |
| Ighv1-54 |
T |
A |
12: 115,157,438 (GRCm39) |
I70F |
probably benign |
Het |
| Il20rb |
A |
T |
9: 100,343,592 (GRCm39) |
|
probably benign |
Het |
| Irag1 |
A |
G |
7: 110,487,236 (GRCm39) |
V498A |
probably damaging |
Het |
| Krt1 |
C |
A |
15: 101,754,376 (GRCm39) |
V625L |
unknown |
Het |
| Lamc3 |
T |
C |
2: 31,830,748 (GRCm39) |
I1495T |
probably benign |
Het |
| Larp6 |
A |
G |
9: 60,645,063 (GRCm39) |
E401G |
possibly damaging |
Het |
| Ldha |
A |
T |
7: 46,496,805 (GRCm39) |
H19L |
probably benign |
Het |
| Lrba |
A |
G |
3: 86,192,335 (GRCm39) |
N83S |
probably damaging |
Het |
| Lrrk2 |
T |
G |
15: 91,687,592 (GRCm39) |
I2227S |
probably benign |
Het |
| Lvrn |
T |
C |
18: 47,013,803 (GRCm39) |
L495P |
probably damaging |
Het |
| Macf1 |
T |
C |
4: 123,391,548 (GRCm39) |
N1077S |
probably damaging |
Het |
| Mboat1 |
A |
G |
13: 30,425,213 (GRCm39) |
T425A |
probably damaging |
Het |
| Mcam |
A |
G |
9: 44,047,863 (GRCm39) |
E36G |
probably damaging |
Het |
| Meis1 |
T |
A |
11: 18,966,308 (GRCm39) |
T22S |
probably benign |
Het |
| Micu1 |
A |
G |
10: 59,699,076 (GRCm39) |
K451R |
possibly damaging |
Het |
| Nat8 |
A |
T |
6: 85,807,505 (GRCm39) |
D209E |
probably benign |
Het |
| Nek10 |
T |
A |
14: 14,860,986 (GRCm38) |
L513M |
possibly damaging |
Het |
| Nmral1 |
G |
A |
16: 4,534,274 (GRCm39) |
R56* |
probably null |
Het |
| Ofcc1 |
G |
A |
13: 40,168,864 (GRCm39) |
T841I |
probably damaging |
Het |
| Or10j27 |
A |
G |
1: 172,958,526 (GRCm39) |
V86A |
probably benign |
Het |
| Or5b99 |
A |
T |
19: 12,977,195 (GRCm39) |
T282S |
probably benign |
Het |
| Or5g25 |
T |
C |
2: 85,477,916 (GRCm39) |
I250V |
probably benign |
Het |
| Or5h24 |
G |
A |
16: 58,919,340 (GRCm39) |
T5I |
probably damaging |
Het |
| Palm3 |
A |
T |
8: 84,753,708 (GRCm39) |
R132* |
probably null |
Het |
| Pax2 |
A |
G |
19: 44,804,479 (GRCm39) |
Y272C |
probably damaging |
Het |
| Phc2 |
G |
A |
4: 128,616,908 (GRCm39) |
A394T |
probably benign |
Het |
| Phf2 |
C |
A |
13: 48,961,198 (GRCm39) |
G831C |
unknown |
Het |
| Pik3c2b |
G |
A |
1: 133,027,453 (GRCm39) |
|
probably null |
Het |
| Plin2 |
T |
A |
4: 86,580,228 (GRCm39) |
I178F |
probably benign |
Het |
| Pramel32 |
A |
T |
4: 88,547,185 (GRCm39) |
L162H |
probably damaging |
Het |
| Prdm14 |
T |
A |
1: 13,192,855 (GRCm39) |
I295F |
probably damaging |
Het |
| Psmd5 |
C |
T |
2: 34,760,795 (GRCm39) |
R47H |
probably benign |
Het |
| Ptchd3 |
T |
A |
11: 121,733,342 (GRCm39) |
I744K |
probably damaging |
Het |
| Ptrh1 |
T |
A |
2: 32,666,557 (GRCm39) |
|
probably benign |
Het |
| Rab6a |
A |
G |
7: 100,277,627 (GRCm39) |
D49G |
probably damaging |
Het |
| Radil |
A |
T |
5: 142,470,994 (GRCm39) |
D1062E |
probably benign |
Het |
| Robo2 |
A |
G |
16: 74,149,726 (GRCm39) |
V34A |
possibly damaging |
Het |
| Sall3 |
G |
A |
18: 81,014,626 (GRCm39) |
P1029S |
probably benign |
Het |
| Sec14l3 |
A |
G |
11: 4,018,101 (GRCm39) |
D127G |
possibly damaging |
Het |
| Sel1l2 |
A |
G |
2: 140,086,086 (GRCm39) |
Y502H |
probably damaging |
Het |
| Serpina1f |
A |
G |
12: 103,656,010 (GRCm39) |
V406A |
probably damaging |
Het |
| Sf3b3 |
T |
C |
8: 111,540,301 (GRCm39) |
D1040G |
probably damaging |
Het |
| Sgcd |
A |
G |
11: 46,870,262 (GRCm39) |
I233T |
possibly damaging |
Het |
| Slc15a3 |
A |
G |
19: 10,820,410 (GRCm39) |
Q9R |
probably benign |
Het |
| Slc25a46 |
A |
G |
18: 31,716,336 (GRCm39) |
F389L |
probably damaging |
Het |
| Slc26a2 |
G |
T |
18: 61,331,330 (GRCm39) |
C700* |
probably null |
Het |
| Slc4a7 |
A |
G |
14: 14,771,283 (GRCm38) |
Y671C |
possibly damaging |
Het |
| Slc5a10 |
A |
T |
11: 61,610,708 (GRCm39) |
I22N |
probably damaging |
Het |
| Slc5a9 |
C |
A |
4: 111,748,941 (GRCm39) |
|
probably null |
Het |
| Slc6a12 |
A |
G |
6: 121,332,281 (GRCm39) |
D205G |
probably benign |
Het |
| Tas2r115 |
G |
A |
6: 132,714,124 (GRCm39) |
H276Y |
probably damaging |
Het |
| Tdpoz4 |
T |
A |
3: 93,704,318 (GRCm39) |
I205N |
probably damaging |
Het |
| Tfeb |
C |
T |
17: 48,096,904 (GRCm39) |
T33I |
probably benign |
Het |
| Tgm3 |
A |
G |
2: 129,890,240 (GRCm39) |
T668A |
probably benign |
Het |
| Tnpo3 |
A |
G |
6: 29,582,259 (GRCm39) |
V201A |
probably benign |
Het |
| Tpcn1 |
T |
A |
5: 120,694,596 (GRCm39) |
M158L |
probably benign |
Het |
| Trim47 |
A |
C |
11: 115,996,918 (GRCm39) |
L612R |
probably damaging |
Het |
| Trmt10c |
A |
T |
16: 55,854,438 (GRCm39) |
L399* |
probably null |
Het |
| Trpm2 |
A |
T |
10: 77,753,626 (GRCm39) |
S1293T |
probably benign |
Het |
| Ttn |
C |
T |
2: 76,582,941 (GRCm39) |
V22651I |
probably damaging |
Het |
| Tubgcp5 |
A |
G |
7: 55,455,871 (GRCm39) |
I300V |
probably benign |
Het |
| Uty |
T |
A |
Y: 1,136,883 (GRCm39) |
Q844L |
probably damaging |
Het |
| Vmn2r85 |
C |
T |
10: 130,254,990 (GRCm39) |
E565K |
probably damaging |
Het |
| Vmn2r97 |
T |
C |
17: 19,167,561 (GRCm39) |
V605A |
possibly damaging |
Het |
| Vwa3a |
T |
C |
7: 120,375,487 (GRCm39) |
V399A |
probably damaging |
Het |
| Wnk4 |
G |
A |
11: 101,159,107 (GRCm39) |
R508Q |
probably damaging |
Het |
| Zfp217 |
A |
G |
2: 169,961,130 (GRCm39) |
V399A |
probably damaging |
Het |
| Zfp616 |
T |
A |
11: 73,974,830 (GRCm39) |
N457K |
possibly damaging |
Het |
|
| Other mutations in Lrp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00225:Lrp4
|
APN |
2 |
91,325,371 (GRCm39) |
missense |
probably benign |
|
|
IGL00509:Lrp4
|
APN |
2 |
91,316,519 (GRCm39) |
splice site |
probably benign |
|
|
IGL01145:Lrp4
|
APN |
2 |
91,317,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01287:Lrp4
|
APN |
2 |
91,304,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01531:Lrp4
|
APN |
2 |
91,341,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01534:Lrp4
|
APN |
2 |
91,303,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01544:Lrp4
|
APN |
2 |
91,307,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01761:Lrp4
|
APN |
2 |
91,312,326 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01885:Lrp4
|
APN |
2 |
91,331,452 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01909:Lrp4
|
APN |
2 |
91,324,529 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02111:Lrp4
|
APN |
2 |
91,336,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02385:Lrp4
|
APN |
2 |
91,305,065 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02403:Lrp4
|
APN |
2 |
91,338,927 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02431:Lrp4
|
APN |
2 |
91,306,982 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02452:Lrp4
|
APN |
2 |
91,304,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02798:Lrp4
|
APN |
2 |
91,307,055 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02828:Lrp4
|
APN |
2 |
91,305,639 (GRCm39) |
missense |
probably benign |
|
|
IGL02832:Lrp4
|
APN |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02893:Lrp4
|
APN |
2 |
91,305,161 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
artiodactyl
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
bubalus
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
riverhorse
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wallow
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
F5770:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0137:Lrp4
|
UTSW |
2 |
91,325,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0265:Lrp4
|
UTSW |
2 |
91,321,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0368:Lrp4
|
UTSW |
2 |
91,308,079 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0531:Lrp4
|
UTSW |
2 |
91,305,523 (GRCm39) |
splice site |
probably benign |
|
|
R0827:Lrp4
|
UTSW |
2 |
91,325,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1029:Lrp4
|
UTSW |
2 |
91,317,372 (GRCm39) |
splice site |
probably benign |
|
|
R1183:Lrp4
|
UTSW |
2 |
91,307,864 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1587:Lrp4
|
UTSW |
2 |
91,306,650 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1693:Lrp4
|
UTSW |
2 |
91,322,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Lrp4
|
UTSW |
2 |
91,322,966 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1863:Lrp4
|
UTSW |
2 |
91,328,708 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1908:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1909:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1932:Lrp4
|
UTSW |
2 |
91,327,700 (GRCm39) |
nonsense |
probably null |
|
|
R1934:Lrp4
|
UTSW |
2 |
91,310,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2358:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2433:Lrp4
|
UTSW |
2 |
91,336,360 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2698:Lrp4
|
UTSW |
2 |
91,305,557 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2919:Lrp4
|
UTSW |
2 |
91,321,075 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3105:Lrp4
|
UTSW |
2 |
91,331,394 (GRCm39) |
missense |
probably benign |
|
|
R3709:Lrp4
|
UTSW |
2 |
91,320,811 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R3711:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3735:Lrp4
|
UTSW |
2 |
91,328,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3808:Lrp4
|
UTSW |
2 |
91,307,047 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3894:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3895:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4397:Lrp4
|
UTSW |
2 |
91,342,015 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4741:Lrp4
|
UTSW |
2 |
91,341,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5050:Lrp4
|
UTSW |
2 |
91,322,767 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5096:Lrp4
|
UTSW |
2 |
91,316,137 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5110:Lrp4
|
UTSW |
2 |
91,327,417 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5141:Lrp4
|
UTSW |
2 |
91,309,023 (GRCm39) |
splice site |
probably benign |
|
|
R5439:Lrp4
|
UTSW |
2 |
91,327,418 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5725:Lrp4
|
UTSW |
2 |
91,325,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5795:Lrp4
|
UTSW |
2 |
91,304,816 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5820:Lrp4
|
UTSW |
2 |
91,322,960 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5883:Lrp4
|
UTSW |
2 |
91,318,778 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5919:Lrp4
|
UTSW |
2 |
91,303,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Lrp4
|
UTSW |
2 |
91,342,029 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6080:Lrp4
|
UTSW |
2 |
91,332,345 (GRCm39) |
missense |
probably benign |
|
|
R6189:Lrp4
|
UTSW |
2 |
91,305,579 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6192:Lrp4
|
UTSW |
2 |
91,338,833 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6319:Lrp4
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Lrp4
|
UTSW |
2 |
91,324,174 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6479:Lrp4
|
UTSW |
2 |
91,317,429 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6500:Lrp4
|
UTSW |
2 |
91,322,765 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6643:Lrp4
|
UTSW |
2 |
91,332,340 (GRCm39) |
missense |
probably benign |
|
|
R6657:Lrp4
|
UTSW |
2 |
91,322,398 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6696:Lrp4
|
UTSW |
2 |
91,327,690 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6714:Lrp4
|
UTSW |
2 |
91,306,710 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6734:Lrp4
|
UTSW |
2 |
91,316,242 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6770:Lrp4
|
UTSW |
2 |
91,327,648 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6774:Lrp4
|
UTSW |
2 |
91,341,849 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6957:Lrp4
|
UTSW |
2 |
91,317,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6978:Lrp4
|
UTSW |
2 |
91,322,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7065:Lrp4
|
UTSW |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7142:Lrp4
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7219:Lrp4
|
UTSW |
2 |
91,322,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7237:Lrp4
|
UTSW |
2 |
91,303,528 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7387:Lrp4
|
UTSW |
2 |
91,306,959 (GRCm39) |
missense |
probably benign |
|
|
R7585:Lrp4
|
UTSW |
2 |
91,322,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7835:Lrp4
|
UTSW |
2 |
91,325,387 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7872:Lrp4
|
UTSW |
2 |
91,321,061 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7968:Lrp4
|
UTSW |
2 |
91,324,424 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8222:Lrp4
|
UTSW |
2 |
91,305,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8338:Lrp4
|
UTSW |
2 |
91,322,713 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8342:Lrp4
|
UTSW |
2 |
91,318,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8435:Lrp4
|
UTSW |
2 |
91,307,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8720:Lrp4
|
UTSW |
2 |
91,324,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8774:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8774-TAIL:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8792:Lrp4
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8913:Lrp4
|
UTSW |
2 |
91,331,785 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9017:Lrp4
|
UTSW |
2 |
91,324,397 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9062:Lrp4
|
UTSW |
2 |
91,303,925 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9118:Lrp4
|
UTSW |
2 |
91,308,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9640:Lrp4
|
UTSW |
2 |
91,316,296 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9649:Lrp4
|
UTSW |
2 |
91,338,914 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9708:Lrp4
|
UTSW |
2 |
91,342,076 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9748:Lrp4
|
UTSW |
2 |
91,316,116 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9776:Lrp4
|
UTSW |
2 |
91,316,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7580:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7581:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7582:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7583:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
X0021:Lrp4
|
UTSW |
2 |
91,331,407 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACCAGGTGTCACACAGGTG -3'
(R):5'- AGCAAAGTTTATCACTGTCTGC -3'
Sequencing Primer
(F):5'- CTGTCACCATTACTGGATTTAGAGC -3'
(R):5'- GCAAAGTTTATCACTGTCTGCACTCC -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation