Incidental Mutation 'R4948:Vmn2r85'
ID 383593
Institutional Source Beutler Lab
Gene Symbol Vmn2r85
Ensembl Gene ENSMUSG00000092048
Gene Name vomeronasal 2, receptor 85
Synonyms EG623734
MMRRC Submission 042545-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R4948 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 130253658-130266615 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 130254990 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 565 (E565K)
Ref Sequence ENSEMBL: ENSMUSP00000128792 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171811]
AlphaFold G3UW56
Predicted Effect probably damaging
Transcript: ENSMUST00000171811
AA Change: E565K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000128792
Gene: ENSMUSG00000092048
AA Change: E565K

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 77 425 9e-26 PFAM
Pfam:NCD3G 508 562 1.1e-18 PFAM
Pfam:7tm_3 595 831 3.7e-54 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.3%
  • 20x: 92.2%
Validation Efficiency 94% (103/109)
Allele List at MGI
Other mutations in this stock
Total: 100 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610318N02Rik A T 16: 16,936,154 (GRCm39) probably null Het
Adcy4 C T 14: 56,016,486 (GRCm39) D322N probably damaging Het
Alas1 A T 9: 106,124,077 (GRCm39) L27* probably null Het
Aldh1a7 A G 19: 20,704,374 (GRCm39) V40A possibly damaging Het
Appbp2 A T 11: 85,085,409 (GRCm39) I499K possibly damaging Het
B3gnt5 A C 16: 19,587,894 (GRCm39) M38L probably benign Het
Brd8 A G 18: 34,747,585 (GRCm39) V92A probably damaging Het
Btla A T 16: 45,063,091 (GRCm39) E151D probably benign Het
Cd79b T A 11: 106,203,687 (GRCm39) T67S probably benign Het
Cep192 A G 18: 67,949,875 (GRCm39) R320G probably benign Het
Chad A C 11: 94,456,528 (GRCm39) D202A probably damaging Het
Chil6 A G 3: 106,295,988 (GRCm39) probably benign Het
Cpz T C 5: 35,674,748 (GRCm39) E167G possibly damaging Het
Crisp2 T G 17: 41,076,159 (GRCm39) H225P probably damaging Het
Cyp2c23 T C 19: 44,010,138 (GRCm39) Y69C possibly damaging Het
Dcp1a T A 14: 30,201,724 (GRCm39) L49H probably damaging Het
Dnah6 T A 6: 73,030,672 (GRCm39) H3380L probably benign Het
Dnai3 T A 3: 145,788,820 (GRCm39) K254* probably null Het
Dnm2 A G 9: 21,415,829 (GRCm39) D721G possibly damaging Het
Dnpep G T 1: 75,293,404 (GRCm39) T15K probably benign Het
Dock3 A T 9: 106,868,354 (GRCm39) D643E probably damaging Het
Ear6 C T 14: 52,091,573 (GRCm39) T40I possibly damaging Het
Fancm A G 12: 65,137,748 (GRCm39) D313G probably damaging Het
Fbxw16 T A 9: 109,267,415 (GRCm39) E272V probably damaging Het
Frmd4b T A 6: 97,283,691 (GRCm39) E393D probably benign Het
Fryl T A 5: 73,246,473 (GRCm39) M1100L probably benign Het
Gjd3 T C 11: 102,691,247 (GRCm39) H252R probably damaging Het
Gm10518 T C 1: 179,631,477 (GRCm39) probably benign Het
Gna14 A G 19: 16,580,656 (GRCm39) M165V probably benign Het
Hells C A 19: 38,923,966 (GRCm39) Q72K probably damaging Het
Herc1 A G 9: 66,392,184 (GRCm39) I4031V probably benign Het
Hspa2 C T 12: 76,452,761 (GRCm39) A485V probably damaging Het
Ighv1-54 T A 12: 115,157,438 (GRCm39) I70F probably benign Het
Il20rb A T 9: 100,343,592 (GRCm39) probably benign Het
Irag1 A G 7: 110,487,236 (GRCm39) V498A probably damaging Het
Krt1 C A 15: 101,754,376 (GRCm39) V625L unknown Het
Lamc3 T C 2: 31,830,748 (GRCm39) I1495T probably benign Het
Larp6 A G 9: 60,645,063 (GRCm39) E401G possibly damaging Het
Ldha A T 7: 46,496,805 (GRCm39) H19L probably benign Het
Lrba A G 3: 86,192,335 (GRCm39) N83S probably damaging Het
Lrp4 G T 2: 91,316,231 (GRCm39) R783L probably benign Het
Lrrk2 T G 15: 91,687,592 (GRCm39) I2227S probably benign Het
Lvrn T C 18: 47,013,803 (GRCm39) L495P probably damaging Het
Macf1 T C 4: 123,391,548 (GRCm39) N1077S probably damaging Het
Mboat1 A G 13: 30,425,213 (GRCm39) T425A probably damaging Het
Mcam A G 9: 44,047,863 (GRCm39) E36G probably damaging Het
Meis1 T A 11: 18,966,308 (GRCm39) T22S probably benign Het
Micu1 A G 10: 59,699,076 (GRCm39) K451R possibly damaging Het
Nat8 A T 6: 85,807,505 (GRCm39) D209E probably benign Het
Nek10 T A 14: 14,860,986 (GRCm38) L513M possibly damaging Het
Nmral1 G A 16: 4,534,274 (GRCm39) R56* probably null Het
Ofcc1 G A 13: 40,168,864 (GRCm39) T841I probably damaging Het
Or10j27 A G 1: 172,958,526 (GRCm39) V86A probably benign Het
Or5b99 A T 19: 12,977,195 (GRCm39) T282S probably benign Het
Or5g25 T C 2: 85,477,916 (GRCm39) I250V probably benign Het
Or5h24 G A 16: 58,919,340 (GRCm39) T5I probably damaging Het
Palm3 A T 8: 84,753,708 (GRCm39) R132* probably null Het
Pax2 A G 19: 44,804,479 (GRCm39) Y272C probably damaging Het
Phc2 G A 4: 128,616,908 (GRCm39) A394T probably benign Het
Phf2 C A 13: 48,961,198 (GRCm39) G831C unknown Het
Pik3c2b G A 1: 133,027,453 (GRCm39) probably null Het
Plin2 T A 4: 86,580,228 (GRCm39) I178F probably benign Het
Pramel32 A T 4: 88,547,185 (GRCm39) L162H probably damaging Het
Prdm14 T A 1: 13,192,855 (GRCm39) I295F probably damaging Het
Psmd5 C T 2: 34,760,795 (GRCm39) R47H probably benign Het
Ptchd3 T A 11: 121,733,342 (GRCm39) I744K probably damaging Het
Ptrh1 T A 2: 32,666,557 (GRCm39) probably benign Het
Rab6a A G 7: 100,277,627 (GRCm39) D49G probably damaging Het
Radil A T 5: 142,470,994 (GRCm39) D1062E probably benign Het
Robo2 A G 16: 74,149,726 (GRCm39) V34A possibly damaging Het
Sall3 G A 18: 81,014,626 (GRCm39) P1029S probably benign Het
Sec14l3 A G 11: 4,018,101 (GRCm39) D127G possibly damaging Het
Sel1l2 A G 2: 140,086,086 (GRCm39) Y502H probably damaging Het
Serpina1f A G 12: 103,656,010 (GRCm39) V406A probably damaging Het
Sf3b3 T C 8: 111,540,301 (GRCm39) D1040G probably damaging Het
Sgcd A G 11: 46,870,262 (GRCm39) I233T possibly damaging Het
Slc15a3 A G 19: 10,820,410 (GRCm39) Q9R probably benign Het
Slc25a46 A G 18: 31,716,336 (GRCm39) F389L probably damaging Het
Slc26a2 G T 18: 61,331,330 (GRCm39) C700* probably null Het
Slc4a7 A G 14: 14,771,283 (GRCm38) Y671C possibly damaging Het
Slc5a10 A T 11: 61,610,708 (GRCm39) I22N probably damaging Het
Slc5a9 C A 4: 111,748,941 (GRCm39) probably null Het
Slc6a12 A G 6: 121,332,281 (GRCm39) D205G probably benign Het
Tas2r115 G A 6: 132,714,124 (GRCm39) H276Y probably damaging Het
Tdpoz4 T A 3: 93,704,318 (GRCm39) I205N probably damaging Het
Tfeb C T 17: 48,096,904 (GRCm39) T33I probably benign Het
Tgm3 A G 2: 129,890,240 (GRCm39) T668A probably benign Het
Tnpo3 A G 6: 29,582,259 (GRCm39) V201A probably benign Het
Tpcn1 T A 5: 120,694,596 (GRCm39) M158L probably benign Het
Trim47 A C 11: 115,996,918 (GRCm39) L612R probably damaging Het
Trmt10c A T 16: 55,854,438 (GRCm39) L399* probably null Het
Trpm2 A T 10: 77,753,626 (GRCm39) S1293T probably benign Het
Ttn C T 2: 76,582,941 (GRCm39) V22651I probably damaging Het
Tubgcp5 A G 7: 55,455,871 (GRCm39) I300V probably benign Het
Uty T A Y: 1,136,883 (GRCm39) Q844L probably damaging Het
Vmn2r97 T C 17: 19,167,561 (GRCm39) V605A possibly damaging Het
Vwa3a T C 7: 120,375,487 (GRCm39) V399A probably damaging Het
Wnk4 G A 11: 101,159,107 (GRCm39) R508Q probably damaging Het
Zfp217 A G 2: 169,961,130 (GRCm39) V399A probably damaging Het
Zfp616 T A 11: 73,974,830 (GRCm39) N457K possibly damaging Het
Other mutations in Vmn2r85
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01160:Vmn2r85 APN 10 130,254,690 (GRCm39) missense probably benign 0.22
IGL01298:Vmn2r85 APN 10 130,254,690 (GRCm39) missense probably benign 0.22
IGL01361:Vmn2r85 APN 10 130,254,690 (GRCm39) missense probably benign 0.22
IGL02185:Vmn2r85 APN 10 130,254,561 (GRCm39) missense probably benign 0.13
IGL02505:Vmn2r85 APN 10 130,261,449 (GRCm39) missense probably damaging 1.00
IGL02607:Vmn2r85 APN 10 130,262,290 (GRCm39) missense possibly damaging 0.89
IGL02755:Vmn2r85 APN 10 130,261,381 (GRCm39) missense probably damaging 0.98
IGL03188:Vmn2r85 APN 10 130,254,612 (GRCm39) missense probably benign 0.16
IGL03366:Vmn2r85 APN 10 130,262,328 (GRCm39) missense probably benign 0.00
IGL03397:Vmn2r85 APN 10 130,261,263 (GRCm39) missense probably damaging 1.00
PIT4445001:Vmn2r85 UTSW 10 130,261,572 (GRCm39) missense probably benign 0.00
R0066:Vmn2r85 UTSW 10 130,261,770 (GRCm39) missense probably damaging 1.00
R0128:Vmn2r85 UTSW 10 130,255,054 (GRCm39) splice site probably benign
R0130:Vmn2r85 UTSW 10 130,255,054 (GRCm39) splice site probably benign
R0503:Vmn2r85 UTSW 10 130,258,609 (GRCm39) missense probably damaging 1.00
R0827:Vmn2r85 UTSW 10 130,265,387 (GRCm39) missense possibly damaging 0.89
R1432:Vmn2r85 UTSW 10 130,261,155 (GRCm39) missense possibly damaging 0.74
R1521:Vmn2r85 UTSW 10 130,261,788 (GRCm39) missense probably damaging 0.99
R2029:Vmn2r85 UTSW 10 130,261,443 (GRCm39) nonsense probably null
R2034:Vmn2r85 UTSW 10 130,262,242 (GRCm39) splice site probably benign
R2852:Vmn2r85 UTSW 10 130,255,035 (GRCm39) missense probably benign 0.03
R2853:Vmn2r85 UTSW 10 130,255,035 (GRCm39) missense probably benign 0.03
R3084:Vmn2r85 UTSW 10 130,261,081 (GRCm39) missense probably benign 0.00
R3085:Vmn2r85 UTSW 10 130,261,081 (GRCm39) missense probably benign 0.00
R3430:Vmn2r85 UTSW 10 130,254,758 (GRCm39) missense probably damaging 0.97
R3694:Vmn2r85 UTSW 10 130,254,171 (GRCm39) missense probably damaging 0.99
R3932:Vmn2r85 UTSW 10 130,254,336 (GRCm39) missense probably damaging 1.00
R4207:Vmn2r85 UTSW 10 130,254,574 (GRCm39) missense probably damaging 1.00
R4628:Vmn2r85 UTSW 10 130,261,235 (GRCm39) missense probably benign 0.00
R4814:Vmn2r85 UTSW 10 130,254,567 (GRCm39) missense probably benign 0.12
R4951:Vmn2r85 UTSW 10 130,261,113 (GRCm39) missense probably damaging 1.00
R4959:Vmn2r85 UTSW 10 130,257,302 (GRCm39) missense probably damaging 1.00
R5336:Vmn2r85 UTSW 10 130,258,574 (GRCm39) missense possibly damaging 0.63
R5643:Vmn2r85 UTSW 10 130,262,343 (GRCm39) missense probably damaging 1.00
R6061:Vmn2r85 UTSW 10 130,261,531 (GRCm39) missense probably benign 0.09
R6115:Vmn2r85 UTSW 10 130,258,672 (GRCm39) missense probably damaging 1.00
R6190:Vmn2r85 UTSW 10 130,261,330 (GRCm39) missense possibly damaging 0.88
R6518:Vmn2r85 UTSW 10 130,265,281 (GRCm39) missense probably benign 0.00
R6533:Vmn2r85 UTSW 10 130,262,529 (GRCm39) missense probably benign 0.00
R6610:Vmn2r85 UTSW 10 130,261,838 (GRCm39) missense probably damaging 0.97
R6809:Vmn2r85 UTSW 10 130,261,795 (GRCm39) missense probably benign
R6962:Vmn2r85 UTSW 10 130,261,452 (GRCm39) missense probably damaging 0.99
R7075:Vmn2r85 UTSW 10 130,258,557 (GRCm39) missense probably benign 0.06
R7104:Vmn2r85 UTSW 10 130,262,376 (GRCm39) missense probably benign
R7424:Vmn2r85 UTSW 10 130,254,849 (GRCm39) missense probably damaging 1.00
R7516:Vmn2r85 UTSW 10 130,254,852 (GRCm39) missense probably damaging 1.00
R7537:Vmn2r85 UTSW 10 130,258,735 (GRCm39) missense probably benign 0.01
R7768:Vmn2r85 UTSW 10 130,254,562 (GRCm39) missense probably damaging 1.00
R7810:Vmn2r85 UTSW 10 130,261,081 (GRCm39) missense probably benign 0.00
R8078:Vmn2r85 UTSW 10 130,265,364 (GRCm39) nonsense probably null
R8115:Vmn2r85 UTSW 10 130,261,820 (GRCm39) missense probably benign 0.06
R8262:Vmn2r85 UTSW 10 130,254,738 (GRCm39) missense probably damaging 0.98
R8395:Vmn2r85 UTSW 10 130,261,797 (GRCm39) missense probably damaging 0.99
R8409:Vmn2r85 UTSW 10 130,261,257 (GRCm39) missense probably benign 0.16
R8547:Vmn2r85 UTSW 10 130,261,311 (GRCm39) missense probably damaging 1.00
R8875:Vmn2r85 UTSW 10 130,254,171 (GRCm39) missense probably damaging 0.99
R9035:Vmn2r85 UTSW 10 130,261,479 (GRCm39) missense probably benign
R9040:Vmn2r85 UTSW 10 130,254,311 (GRCm39) missense probably damaging 1.00
R9115:Vmn2r85 UTSW 10 130,254,153 (GRCm39) missense probably benign 0.00
R9182:Vmn2r85 UTSW 10 130,265,350 (GRCm39) missense probably benign 0.00
R9245:Vmn2r85 UTSW 10 130,261,534 (GRCm39) missense probably damaging 1.00
R9245:Vmn2r85 UTSW 10 130,255,033 (GRCm39) missense possibly damaging 0.92
R9405:Vmn2r85 UTSW 10 130,261,215 (GRCm39) missense probably damaging 0.99
R9502:Vmn2r85 UTSW 10 130,261,387 (GRCm39) missense probably damaging 0.99
R9520:Vmn2r85 UTSW 10 130,254,993 (GRCm39) missense probably benign
R9653:Vmn2r85 UTSW 10 130,261,694 (GRCm39) missense probably damaging 0.99
Z1176:Vmn2r85 UTSW 10 130,261,713 (GRCm39) missense probably damaging 0.99
Z1177:Vmn2r85 UTSW 10 130,254,776 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATGCAGTTATTGGCCTTCAC -3'
(R):5'- ATCTGTTCCCTCACAATGCATAGG -3'

Sequencing Primer
(F):5'- ATTGGCCTTCACAATGGGAGTATCC -3'
(R):5'- GTTAGTGGTTCCTACAGCAATAAGG -3'
Posted On 2016-04-27