Incidental Mutation 'R4967:Ncoa6'
| ID |
384081 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ncoa6
|
| Ensembl Gene |
ENSMUSG00000038369 |
| Gene Name |
nuclear receptor coactivator 6 |
| Synonyms |
ASC-2, RAP250, NRC, AIB3, ASC2, PRIP |
| MMRRC Submission |
042563-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4967 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
155232585-155315741 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 155263252 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Lysine
at position 394
(T394K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000118113
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043126]
[ENSMUST00000109669]
[ENSMUST00000109670]
[ENSMUST00000123293]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000043126
AA Change: T394K
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000045386
Gene: ENSMUSG00000038369
AA Change: T394K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
47 |
190 |
3.3e-55 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
450 |
597 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
636 |
793 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1564 |
N/A |
INTRINSIC |
|
low complexity region
|
1578 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1607 |
1618 |
N/A |
INTRINSIC |
|
low complexity region
|
1808 |
1825 |
N/A |
INTRINSIC |
|
low complexity region
|
1894 |
1908 |
N/A |
INTRINSIC |
|
low complexity region
|
2043 |
2053 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109669
AA Change: T394K
PolyPhen 2
Score 0.225 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000105294
Gene: ENSMUSG00000038369
AA Change: T394K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
45 |
195 |
2.6e-61 |
PFAM |
|
SCOP:d1lsha3
|
239 |
321 |
5e-3 |
SMART |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109670
AA Change: T394K
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000105295
Gene: ENSMUSG00000038369
AA Change: T394K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
45 |
195 |
3.6e-60 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
450 |
597 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
636 |
793 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1564 |
N/A |
INTRINSIC |
|
low complexity region
|
1578 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1607 |
1618 |
N/A |
INTRINSIC |
|
low complexity region
|
1808 |
1825 |
N/A |
INTRINSIC |
|
low complexity region
|
1894 |
1908 |
N/A |
INTRINSIC |
|
low complexity region
|
2043 |
2053 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000123293
AA Change: T394K
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000118113
Gene: ENSMUSG00000038369
AA Change: T394K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
45 |
195 |
2.4e-60 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
low complexity region
|
564 |
573 |
N/A |
INTRINSIC |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141928
|
| Meta Mutation Damage Score |
0.0857 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.7%
|
| Validation Efficiency |
100% (102/102) |
| MGI Phenotype |
PHENOTYPE: Homozygotes for targeted null mutations exhibit retarded embryonic growth and defects of the placenta, heart, liver, and nervous system. Mutants die around midgestation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930447C04Rik |
A |
T |
12: 72,956,502 (GRCm39) |
Y199* |
probably null |
Het |
| Adhfe1 |
A |
T |
1: 9,637,029 (GRCm39) |
I394F |
probably benign |
Het |
| Arhgap26 |
G |
T |
18: 39,379,893 (GRCm39) |
R485L |
probably damaging |
Het |
| Atat1 |
T |
A |
17: 36,212,467 (GRCm39) |
N231I |
probably damaging |
Het |
| B4galnt2 |
T |
C |
11: 95,760,100 (GRCm39) |
N309S |
probably benign |
Het |
| Bank1 |
A |
T |
3: 135,772,134 (GRCm39) |
F499I |
probably damaging |
Het |
| Bcl9l |
A |
G |
9: 44,416,365 (GRCm39) |
D146G |
possibly damaging |
Het |
| Bglap3 |
A |
T |
3: 88,283,671 (GRCm39) |
|
probably benign |
Het |
| Bscl2 |
C |
A |
19: 8,825,344 (GRCm39) |
T376K |
probably benign |
Het |
| Cercam |
A |
T |
2: 29,761,033 (GRCm39) |
|
probably null |
Het |
| Clec4f |
C |
T |
6: 83,633,012 (GRCm39) |
M1I |
probably null |
Het |
| Clec4n |
A |
T |
6: 123,209,066 (GRCm39) |
I14F |
probably benign |
Het |
| Cmya5 |
T |
C |
13: 93,227,093 (GRCm39) |
E2665G |
probably damaging |
Het |
| Cog4 |
T |
A |
8: 111,578,915 (GRCm39) |
|
probably null |
Het |
| Cubn |
A |
G |
2: 13,352,856 (GRCm39) |
F1961L |
probably benign |
Het |
| Cyp4a29 |
A |
T |
4: 115,104,196 (GRCm39) |
H88L |
probably benign |
Het |
| Dhdh |
A |
G |
7: 45,128,530 (GRCm39) |
L216P |
probably damaging |
Het |
| Dpp6 |
T |
C |
5: 27,871,509 (GRCm39) |
F544S |
probably damaging |
Het |
| Dthd1 |
C |
T |
5: 63,045,549 (GRCm39) |
T771I |
probably benign |
Het |
| Emc10 |
A |
G |
7: 44,142,612 (GRCm39) |
|
probably null |
Het |
| Fgg |
A |
T |
3: 82,920,072 (GRCm39) |
T284S |
probably benign |
Het |
| Gask1a |
C |
T |
9: 121,794,784 (GRCm39) |
R313W |
probably damaging |
Het |
| Gm3002 |
T |
A |
14: 3,824,737 (GRCm38) |
N24K |
probably damaging |
Het |
| Gm8674 |
G |
A |
13: 50,056,034 (GRCm39) |
|
noncoding transcript |
Het |
| Gpr63 |
G |
A |
4: 25,008,368 (GRCm39) |
W364* |
probably null |
Het |
| Hcn4 |
C |
G |
9: 58,767,111 (GRCm39) |
P891A |
unknown |
Het |
| Hcrtr1 |
A |
T |
4: 130,024,792 (GRCm39) |
F365I |
possibly damaging |
Het |
| Hmcn2 |
A |
G |
2: 31,244,176 (GRCm39) |
|
probably null |
Het |
| Hoxc5 |
T |
A |
15: 102,923,786 (GRCm39) |
L194H |
probably damaging |
Het |
| Ifna11 |
A |
G |
4: 88,738,287 (GRCm39) |
N31S |
probably null |
Het |
| Ikbke |
GCC |
G |
1: 131,203,004 (GRCm39) |
|
probably null |
Het |
| Iqgap2 |
A |
T |
13: 95,766,514 (GRCm39) |
D1496E |
probably benign |
Het |
| Kif28 |
G |
T |
1: 179,536,007 (GRCm39) |
Q556K |
probably damaging |
Het |
| Klhl42 |
C |
T |
6: 147,009,502 (GRCm39) |
T447I |
possibly damaging |
Het |
| Lrp1b |
A |
C |
2: 41,678,986 (GRCm39) |
D35E |
probably damaging |
Het |
| Lsm14b |
A |
G |
2: 179,675,692 (GRCm39) |
|
probably benign |
Het |
| Map3k1 |
T |
C |
13: 111,909,272 (GRCm39) |
E226G |
probably damaging |
Het |
| Map3k14 |
T |
A |
11: 103,130,357 (GRCm39) |
N187Y |
probably benign |
Het |
| Mcm6 |
A |
T |
1: 128,263,586 (GRCm39) |
V645E |
probably damaging |
Het |
| Mdh1b |
G |
T |
1: 63,759,022 (GRCm39) |
P190Q |
probably damaging |
Het |
| Meiob |
T |
G |
17: 25,037,353 (GRCm39) |
L77R |
probably damaging |
Het |
| Mrgpra3 |
A |
T |
7: 47,239,267 (GRCm39) |
F220I |
probably benign |
Het |
| Mrtfa |
C |
A |
15: 80,929,476 (GRCm39) |
|
probably benign |
Het |
| Mtor |
T |
A |
4: 148,575,817 (GRCm39) |
S1324T |
possibly damaging |
Het |
| Myot |
T |
A |
18: 44,487,995 (GRCm39) |
D437E |
possibly damaging |
Het |
| Nf1 |
T |
A |
11: 79,456,379 (GRCm39) |
|
probably null |
Het |
| Nup210 |
T |
A |
6: 91,013,451 (GRCm39) |
T1190S |
possibly damaging |
Het |
| Odf1 |
T |
A |
15: 38,226,652 (GRCm39) |
I184N |
probably damaging |
Het |
| Or10d1 |
C |
T |
9: 39,484,054 (GRCm39) |
C167Y |
probably damaging |
Het |
| Or13d1 |
T |
C |
4: 52,970,960 (GRCm39) |
V113A |
possibly damaging |
Het |
| Or1n1b |
A |
G |
2: 36,780,719 (GRCm39) |
I47T |
probably damaging |
Het |
| Or5k15 |
G |
T |
16: 58,709,957 (GRCm39) |
Q209K |
possibly damaging |
Het |
| Padi1 |
A |
G |
4: 140,572,901 (GRCm39) |
V21A |
probably benign |
Het |
| Pdzrn3 |
C |
T |
6: 101,128,551 (GRCm39) |
R705H |
probably damaging |
Het |
| Pik3cb |
T |
C |
9: 98,987,685 (GRCm39) |
I18V |
probably benign |
Het |
| Pmpca |
T |
C |
2: 26,280,320 (GRCm39) |
S117P |
probably damaging |
Het |
| Poteg |
T |
A |
8: 27,985,009 (GRCm39) |
|
probably benign |
Het |
| Pramel32 |
T |
C |
4: 88,547,432 (GRCm39) |
T80A |
probably damaging |
Het |
| Rab30 |
G |
A |
7: 92,478,771 (GRCm39) |
R72H |
probably damaging |
Het |
| Ramp2 |
T |
A |
11: 101,138,383 (GRCm39) |
|
probably null |
Het |
| Rbks |
G |
A |
5: 31,781,876 (GRCm39) |
T308I |
probably damaging |
Het |
| Rnf112 |
A |
G |
11: 61,343,752 (GRCm39) |
|
probably benign |
Het |
| Rnf38 |
G |
A |
4: 44,152,460 (GRCm39) |
P3S |
probably damaging |
Het |
| Sec16a |
A |
G |
2: 26,302,883 (GRCm39) |
S2344P |
probably benign |
Het |
| Slc16a8 |
C |
T |
15: 79,137,084 (GRCm39) |
V109M |
possibly damaging |
Het |
| Slc28a1 |
A |
T |
7: 80,791,757 (GRCm39) |
T308S |
possibly damaging |
Het |
| Slc39a3 |
T |
C |
10: 80,867,453 (GRCm39) |
T98A |
possibly damaging |
Het |
| Smarcc2 |
T |
C |
10: 128,319,049 (GRCm39) |
F731L |
probably damaging |
Het |
| Smc4 |
A |
G |
3: 68,925,572 (GRCm39) |
|
probably benign |
Het |
| Sparcl1 |
T |
G |
5: 104,240,776 (GRCm39) |
D216A |
probably damaging |
Het |
| Speg |
G |
A |
1: 75,364,513 (GRCm39) |
R192H |
probably damaging |
Het |
| Sspo |
T |
C |
6: 48,441,539 (GRCm39) |
L1892P |
probably damaging |
Het |
| Styxl2 |
A |
T |
1: 165,954,675 (GRCm39) |
V25E |
probably damaging |
Het |
| Tacc2 |
A |
G |
7: 130,225,678 (GRCm39) |
N807D |
probably damaging |
Het |
| Teddm1a |
A |
T |
1: 153,767,979 (GRCm39) |
K148* |
probably null |
Het |
| Tex15 |
T |
A |
8: 34,064,498 (GRCm39) |
D1309E |
probably benign |
Het |
| Thbs1 |
A |
T |
2: 117,945,259 (GRCm39) |
E277D |
probably benign |
Het |
| Ticrr |
G |
A |
7: 79,310,158 (GRCm39) |
R24Q |
probably damaging |
Het |
| Tigd4 |
A |
G |
3: 84,502,460 (GRCm39) |
E459G |
probably benign |
Het |
| Tln2 |
C |
A |
9: 67,262,407 (GRCm39) |
A615S |
probably damaging |
Het |
| Tmprss5 |
T |
C |
9: 49,026,817 (GRCm39) |
V410A |
probably damaging |
Het |
| Tnrc6a |
G |
T |
7: 122,789,095 (GRCm39) |
W1638L |
probably damaging |
Het |
| Tpr |
A |
G |
1: 150,285,810 (GRCm39) |
D424G |
probably damaging |
Het |
| Trim34a |
A |
T |
7: 103,910,271 (GRCm39) |
K358* |
probably null |
Het |
| Tssk5 |
T |
A |
15: 76,258,856 (GRCm39) |
D10V |
possibly damaging |
Het |
| Usp35 |
A |
C |
7: 96,962,782 (GRCm39) |
L470R |
probably damaging |
Het |
| Usp42 |
T |
C |
5: 143,701,119 (GRCm39) |
D968G |
possibly damaging |
Het |
| Utrn |
A |
G |
10: 12,331,164 (GRCm39) |
V2924A |
probably damaging |
Het |
| Wdtc1 |
C |
A |
4: 133,021,654 (GRCm39) |
A627S |
probably damaging |
Het |
| Xrra1 |
A |
G |
7: 99,555,730 (GRCm39) |
T366A |
probably damaging |
Het |
| Zfp712 |
T |
A |
13: 67,188,773 (GRCm39) |
K585* |
probably null |
Het |
| Zfp97 |
T |
A |
17: 17,365,393 (GRCm39) |
N297K |
probably damaging |
Het |
| Zfp97 |
G |
T |
17: 17,364,938 (GRCm39) |
E146* |
probably null |
Het |
|
| Other mutations in Ncoa6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00484:Ncoa6
|
APN |
2 |
155,248,128 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00849:Ncoa6
|
APN |
2 |
155,263,608 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL00933:Ncoa6
|
APN |
2 |
155,257,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00981:Ncoa6
|
APN |
2 |
155,248,099 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01420:Ncoa6
|
APN |
2 |
155,249,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02160:Ncoa6
|
APN |
2 |
155,263,003 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL03049:Ncoa6
|
APN |
2 |
155,260,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03194:Ncoa6
|
APN |
2 |
155,257,788 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03269:Ncoa6
|
APN |
2 |
155,248,409 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03299:Ncoa6
|
APN |
2 |
155,249,207 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03306:Ncoa6
|
APN |
2 |
155,247,427 (GRCm39) |
missense |
probably benign |
0.30 |
|
alcoa
|
UTSW |
2 |
155,244,584 (GRCm39) |
unclassified |
probably benign |
|
|
Aluminum
|
UTSW |
2 |
155,241,613 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
balboa
|
UTSW |
2 |
155,248,869 (GRCm39) |
missense |
probably benign |
0.05 |
|
mauna_loa
|
UTSW |
2 |
155,257,147 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4466001:Ncoa6
|
UTSW |
2 |
155,247,577 (GRCm39) |
missense |
probably benign |
|
|
R0011:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0014:Ncoa6
|
UTSW |
2 |
155,279,963 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0079:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0080:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0081:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0164:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0166:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0172:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0173:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0245:Ncoa6
|
UTSW |
2 |
155,233,131 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0284:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0285:Ncoa6
|
UTSW |
2 |
155,257,621 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0285:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0288:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0539:Ncoa6
|
UTSW |
2 |
155,257,617 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0652:Ncoa6
|
UTSW |
2 |
155,233,131 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0781:Ncoa6
|
UTSW |
2 |
155,253,440 (GRCm39) |
splice site |
probably benign |
|
|
R1053:Ncoa6
|
UTSW |
2 |
155,275,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1110:Ncoa6
|
UTSW |
2 |
155,253,440 (GRCm39) |
splice site |
probably benign |
|
|
R1420:Ncoa6
|
UTSW |
2 |
155,263,073 (GRCm39) |
nonsense |
probably null |
|
|
R1521:Ncoa6
|
UTSW |
2 |
155,257,142 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1541:Ncoa6
|
UTSW |
2 |
155,257,224 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1677:Ncoa6
|
UTSW |
2 |
155,244,584 (GRCm39) |
unclassified |
probably benign |
|
|
R1858:Ncoa6
|
UTSW |
2 |
155,263,559 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1954:Ncoa6
|
UTSW |
2 |
155,248,741 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1955:Ncoa6
|
UTSW |
2 |
155,248,741 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2040:Ncoa6
|
UTSW |
2 |
155,248,000 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2087:Ncoa6
|
UTSW |
2 |
155,248,079 (GRCm39) |
nonsense |
probably null |
|
|
R2159:Ncoa6
|
UTSW |
2 |
155,249,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2278:Ncoa6
|
UTSW |
2 |
155,249,570 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2696:Ncoa6
|
UTSW |
2 |
155,279,935 (GRCm39) |
missense |
probably benign |
0.45 |
|
R2891:Ncoa6
|
UTSW |
2 |
155,279,881 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3618:Ncoa6
|
UTSW |
2 |
155,249,709 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3747:Ncoa6
|
UTSW |
2 |
155,253,561 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3778:Ncoa6
|
UTSW |
2 |
155,263,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3784:Ncoa6
|
UTSW |
2 |
155,249,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3802:Ncoa6
|
UTSW |
2 |
155,247,484 (GRCm39) |
missense |
probably benign |
|
|
R3820:Ncoa6
|
UTSW |
2 |
155,248,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3821:Ncoa6
|
UTSW |
2 |
155,248,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3822:Ncoa6
|
UTSW |
2 |
155,248,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3870:Ncoa6
|
UTSW |
2 |
155,257,477 (GRCm39) |
splice site |
probably null |
|
|
R4037:Ncoa6
|
UTSW |
2 |
155,249,290 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4488:Ncoa6
|
UTSW |
2 |
155,249,396 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4719:Ncoa6
|
UTSW |
2 |
155,233,081 (GRCm39) |
unclassified |
probably benign |
|
|
R4732:Ncoa6
|
UTSW |
2 |
155,263,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4733:Ncoa6
|
UTSW |
2 |
155,263,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4829:Ncoa6
|
UTSW |
2 |
155,257,147 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4835:Ncoa6
|
UTSW |
2 |
155,249,053 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4883:Ncoa6
|
UTSW |
2 |
155,248,687 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5021:Ncoa6
|
UTSW |
2 |
155,248,869 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5234:Ncoa6
|
UTSW |
2 |
155,279,933 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5356:Ncoa6
|
UTSW |
2 |
155,263,112 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5358:Ncoa6
|
UTSW |
2 |
155,248,907 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5375:Ncoa6
|
UTSW |
2 |
155,275,915 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5412:Ncoa6
|
UTSW |
2 |
155,249,701 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5579:Ncoa6
|
UTSW |
2 |
155,248,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5618:Ncoa6
|
UTSW |
2 |
155,279,817 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5641:Ncoa6
|
UTSW |
2 |
155,263,756 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5757:Ncoa6
|
UTSW |
2 |
155,253,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5761:Ncoa6
|
UTSW |
2 |
155,250,061 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5778:Ncoa6
|
UTSW |
2 |
155,248,688 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5852:Ncoa6
|
UTSW |
2 |
155,247,419 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5940:Ncoa6
|
UTSW |
2 |
155,257,785 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6155:Ncoa6
|
UTSW |
2 |
155,249,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6374:Ncoa6
|
UTSW |
2 |
155,263,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6389:Ncoa6
|
UTSW |
2 |
155,237,736 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6669:Ncoa6
|
UTSW |
2 |
155,241,613 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7097:Ncoa6
|
UTSW |
2 |
155,279,983 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7385:Ncoa6
|
UTSW |
2 |
155,249,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7963:Ncoa6
|
UTSW |
2 |
155,247,916 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8356:Ncoa6
|
UTSW |
2 |
155,248,172 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R8698:Ncoa6
|
UTSW |
2 |
155,257,041 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8859:Ncoa6
|
UTSW |
2 |
155,248,388 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R8870:Ncoa6
|
UTSW |
2 |
155,263,078 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9041:Ncoa6
|
UTSW |
2 |
155,257,450 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9062:Ncoa6
|
UTSW |
2 |
155,263,348 (GRCm39) |
missense |
probably benign |
0.42 |
|
R9088:Ncoa6
|
UTSW |
2 |
155,249,726 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9225:Ncoa6
|
UTSW |
2 |
155,249,441 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9445:Ncoa6
|
UTSW |
2 |
155,250,063 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9497:Ncoa6
|
UTSW |
2 |
155,248,238 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9514:Ncoa6
|
UTSW |
2 |
155,248,133 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9656:Ncoa6
|
UTSW |
2 |
155,274,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9720:Ncoa6
|
UTSW |
2 |
155,250,304 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9732:Ncoa6
|
UTSW |
2 |
155,244,636 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF033:Ncoa6
|
UTSW |
2 |
155,263,651 (GRCm39) |
small deletion |
probably benign |
|
|
RF040:Ncoa6
|
UTSW |
2 |
155,263,651 (GRCm39) |
small deletion |
probably benign |
|
|
RF048:Ncoa6
|
UTSW |
2 |
155,263,632 (GRCm39) |
small deletion |
probably benign |
|
|
X0017:Ncoa6
|
UTSW |
2 |
155,248,460 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Ncoa6
|
UTSW |
2 |
155,263,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Ncoa6
|
UTSW |
2 |
155,263,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ncoa6
|
UTSW |
2 |
155,248,062 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGGCTGCTGAAATCCCTG -3'
(R):5'- AGGGATCTCTGGGCACAATG -3'
Sequencing Primer
(F):5'- CTGCTGAAATCCCTGGGAAAGTG -3'
(R):5'- GGATCTCTGGGCACAATGACTAC -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation