Incidental Mutation 'R4970:Lrp1'
ID 384399
Institutional Source Beutler Lab
Gene Symbol Lrp1
Ensembl Gene ENSMUSG00000040249
Gene Name low density lipoprotein receptor-related protein 1
Synonyms b2b1554Clo, CD91, A2mr
MMRRC Submission 042565-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4970 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 127374030-127457017 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 127375389 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Arginine at position 4435 (L4435R)
Ref Sequence ENSEMBL: ENSMUSP00000044004 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049149] [ENSMUST00000095266]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000049149
AA Change: L4435R

PolyPhen 2 Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000044004
Gene: ENSMUSG00000040249
AA Change: L4435R

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
LDLa 27 67 1.03e-15 SMART
LDLa 72 111 1.04e-11 SMART
EGF 115 150 8.78e-2 SMART
EGF_CA 151 190 4.49e-8 SMART
low complexity region 222 232 N/A INTRINSIC
LY 273 315 7.07e-6 SMART
LY 316 359 2.31e-10 SMART
LY 360 402 8.3e-12 SMART
EGF 478 521 9.93e-1 SMART
LY 552 594 8.84e-7 SMART
LY 595 638 6.54e-10 SMART
LY 641 690 2.5e-15 SMART
LY 691 734 1.06e-9 SMART
EGF 807 844 1.38e1 SMART
LDLa 854 893 3.39e-16 SMART
LDLa 895 934 1.73e-13 SMART
LDLa 936 974 4.47e-16 SMART
LDLa 976 1014 2.53e-15 SMART
LDLa 1015 1054 2.95e-16 SMART
LDLa 1062 1100 3.24e-13 SMART
LDLa 1104 1143 2.97e-12 SMART
LDLa 1145 1185 1.24e-9 SMART
EGF 1185 1223 4.97e-1 SMART
EGF 1227 1263 6.02e0 SMART
LY 1290 1332 3.76e-1 SMART
LY 1337 1379 8.56e-14 SMART
LY 1380 1424 8.43e-13 SMART
LY 1425 1469 3.05e-10 SMART
LY 1471 1513 3.88e-3 SMART
EGF 1540 1580 1.85e0 SMART
LY 1606 1650 2.83e-5 SMART
LY 1651 1695 2.01e-10 SMART
LY 1698 1735 1.87e-5 SMART
LY 1736 1777 3.54e-6 SMART
LY 1778 1820 4.17e1 SMART
EGF 1850 1888 1.24e-1 SMART
LY 1915 1957 3.2e-4 SMART
LY 1958 2000 2.33e-15 SMART
LY 2001 2044 7.45e-14 SMART
LY 2045 2087 3.87e-12 SMART
LY 2089 2131 1.37e0 SMART
EGF 2159 2196 1.66e1 SMART
LY 2276 2318 5.57e-4 SMART
LY 2324 2369 3.3e-6 SMART
LY 2370 2412 3.93e-13 SMART
LY 2413 2454 3.62e-3 SMART
EGF_like 2482 2519 3.16e1 SMART
LDLa 2524 2564 3.31e-10 SMART
LDLa 2566 2603 7.21e-11 SMART
LDLa 2605 2642 1.09e-10 SMART
LDLa 2660 2691 6.05e-4 SMART
LDLa 2696 2733 2.49e-14 SMART
LDLa 2734 2772 4.65e-14 SMART
LDLa 2774 2815 3.92e-12 SMART
LDLa 2818 2856 1.51e-13 SMART
LDLa 2858 2900 1.93e-11 SMART
LDLa 2904 2942 1.73e-13 SMART
EGF_CA 2941 2982 6.16e-6 SMART
EGF_CA 2983 3023 2.66e-10 SMART
LY 3050 3094 6.64e-11 SMART
LY 3095 3137 7.17e-16 SMART
LY 3138 3181 4.28e-14 SMART
LY 3182 3224 8.11e-15 SMART
LY 3225 3265 1.44e-6 SMART
EGF 3294 3332 1.02e-2 SMART
LDLa 3334 3372 2.25e-12 SMART
LDLa 3374 3411 9.81e-13 SMART
LDLa 3413 3451 9.81e-13 SMART
LDLa 3453 3492 5.67e-18 SMART
LDLa 3494 3534 7.15e-15 SMART
LDLa 3536 3573 1.79e-15 SMART
EGF_like 3575 3611 4.83e1 SMART
LDLa 3575 3612 1.92e-15 SMART
LDLa 3613 3650 1.18e-15 SMART
LDLa 3654 3693 7.55e-14 SMART
LDLa 3695 3734 1.14e-8 SMART
LDLa 3741 3779 6.28e-11 SMART
EGF 3785 3824 1.06e1 SMART
EGF 3828 3862 1.51e0 SMART
LY 3893 3935 9.43e0 SMART
LY 3951 3993 1.23e-14 SMART
LY 3994 4037 2.98e-13 SMART
LY 4038 4080 4.28e-14 SMART
EGF 4151 4184 3.76e-1 SMART
low complexity region 4185 4198 N/A INTRINSIC
EGF 4200 4233 3.82e-2 SMART
EGF 4236 4269 4.03e-1 SMART
EGF 4272 4305 5.2e-4 SMART
EGF 4308 4341 1.22e0 SMART
EGF_like 4344 4376 4.11e1 SMART
EGF 4377 4410 5.12e-3 SMART
transmembrane domain 4423 4445 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000095266
SMART Domains Protein: ENSMUSP00000092900
Gene: ENSMUSG00000040258

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:Neurexophilin 70 166 3e-32 PFAM
Pfam:Neurexophilin 217 304 1e-37 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135188
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140269
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145947
Meta Mutation Damage Score 0.3617 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.6%
Validation Efficiency 99% (114/115)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit lethality during late organogenesis. [provided by MGI curators]
Allele List at MGI

All alleles(42) : Targeted(9) Gene trapped(33)

Other mutations in this stock
Total: 101 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700128F08Rik A G 9: 8,222,066 (GRCm39) noncoding transcript Het
Aars1 A G 8: 111,770,311 (GRCm39) M370V probably benign Het
Abca2 A G 2: 25,328,383 (GRCm39) K846R probably damaging Het
Acad9 A T 3: 36,139,674 (GRCm39) I425F probably damaging Het
Adhfe1 C A 1: 9,628,463 (GRCm39) D278E possibly damaging Het
Afg3l1 G A 8: 124,225,392 (GRCm39) V532I probably benign Het
Anks6 C T 4: 47,030,795 (GRCm39) G601S probably damaging Het
Ano7 G A 1: 93,325,085 (GRCm39) V546M possibly damaging Het
Aox1 G A 1: 58,349,254 (GRCm39) probably null Het
Asah1 G T 8: 41,813,314 (GRCm39) S33* probably null Het
Astn1 C T 1: 158,484,763 (GRCm39) S15F possibly damaging Het
Bag4 A T 8: 26,261,272 (GRCm39) Y156* probably null Het
Bmpr1b T C 3: 141,550,948 (GRCm39) E381G probably damaging Het
Btnl7-ps A G 17: 34,756,092 (GRCm39) noncoding transcript Het
Caap1 A T 4: 94,409,297 (GRCm39) probably null Het
Card10 C T 15: 78,686,580 (GRCm39) probably null Het
Ccp110 T C 7: 118,321,614 (GRCm39) V423A possibly damaging Het
Cdc123 A G 2: 5,809,748 (GRCm39) L221P possibly damaging Het
Cdh19 A G 1: 110,882,354 (GRCm39) V46A possibly damaging Het
Cfap57 A G 4: 118,477,568 (GRCm39) F12S probably damaging Het
Clvs1 A G 4: 9,350,857 (GRCm39) probably benign Het
Dgkh A T 14: 78,856,077 (GRCm39) V199E probably damaging Het
Dhx32 T A 7: 133,340,384 (GRCm39) probably benign Het
Dpf3 G T 12: 83,417,385 (GRCm39) S29* probably null Het
Efcab7 C A 4: 99,719,780 (GRCm39) S87R probably damaging Het
Fam81a G A 9: 70,000,872 (GRCm39) Q291* probably null Het
Fbxo41 G T 6: 85,454,906 (GRCm39) N667K probably damaging Het
Flacc1 T C 1: 58,698,441 (GRCm39) T326A probably benign Het
Gm10313 A T 8: 46,708,462 (GRCm39) noncoding transcript Het
Gm28051 G A 12: 102,686,430 (GRCm39) Q77* probably null Het
Gm5535 T A 2: 144,016,569 (GRCm39) noncoding transcript Het
Gtf2ird1 A T 5: 134,431,038 (GRCm39) D339E probably damaging Het
Gvin3 A T 7: 106,199,864 (GRCm39) noncoding transcript Het
Igfbp7 A G 5: 77,555,608 (GRCm39) M85T possibly damaging Het
Il20ra A G 10: 19,634,691 (GRCm39) T311A possibly damaging Het
Il24 T C 1: 130,811,179 (GRCm39) probably null Het
Itch T C 2: 155,027,513 (GRCm39) F379L possibly damaging Het
Itgad T A 7: 127,789,015 (GRCm39) V488D possibly damaging Het
Itpr2 A T 6: 146,135,489 (GRCm39) M1814K possibly damaging Het
Kirrel3 A G 9: 34,855,735 (GRCm39) E92G possibly damaging Het
Lpin2 T C 17: 71,538,329 (GRCm39) V325A probably damaging Het
Lrba C T 3: 86,132,678 (GRCm39) T28M probably benign Het
Lrch3 T C 16: 32,818,883 (GRCm39) Y661H probably damaging Het
Lrfn5 C A 12: 61,886,461 (GRCm39) S83Y probably damaging Het
Lrrn1 A G 6: 107,546,305 (GRCm39) D701G probably benign Het
Map4k3 A T 17: 80,961,332 (GRCm39) Y125N probably benign Het
Mau2 A T 8: 70,480,353 (GRCm39) H273Q possibly damaging Het
Med16 A C 10: 79,742,871 (GRCm39) probably null Het
Mmp17 A G 5: 129,679,229 (GRCm39) H376R possibly damaging Het
Nlrp12 G A 7: 3,289,613 (GRCm39) H300Y possibly damaging Het
Nlrp3 A T 11: 59,439,554 (GRCm39) Y377F probably damaging Het
Notch2 T C 3: 98,008,952 (GRCm39) probably null Het
Nudcd1 A T 15: 44,240,039 (GRCm39) C500* probably null Het
Or52z14 T C 7: 103,253,197 (GRCm39) I112T probably damaging Het
Or5d37 A G 2: 87,923,353 (GRCm39) V309A probably damaging Het
Or6b6 T A 7: 106,570,778 (GRCm39) M258L probably benign Het
Or8g23 A T 9: 38,971,827 (GRCm39) M45K probably benign Het
Or8h9 A T 2: 86,789,698 (GRCm39) Y35N probably damaging Het
Pcdhb20 T A 18: 37,639,824 (GRCm39) N783K probably benign Het
Pclo T A 5: 14,727,896 (GRCm39) probably benign Het
Pdyn T A 2: 129,530,021 (GRCm39) D216V probably damaging Het
Phldb3 A T 7: 24,324,110 (GRCm39) I495F possibly damaging Het
Pmpca A T 2: 26,285,178 (GRCm39) I468F probably damaging Het
Pmpcb G A 5: 21,961,441 (GRCm39) R399H probably damaging Het
Polrmt G T 10: 79,572,421 (GRCm39) H1145N probably damaging Het
Proser1 A G 3: 53,371,727 (GRCm39) D11G probably damaging Het
Ptprc A G 1: 138,022,037 (GRCm39) S544P probably damaging Het
Ptprn2 G A 12: 117,240,215 (GRCm39) E991K probably damaging Het
Pwp2 A C 10: 78,009,527 (GRCm39) L797R possibly damaging Het
Rbm20 G A 19: 53,840,100 (GRCm39) A1030T probably damaging Het
Rdh7 T C 10: 127,721,691 (GRCm39) Y195C probably benign Het
Rev3l T A 10: 39,699,326 (GRCm39) D1274E probably benign Het
Scfd2 G T 5: 74,366,982 (GRCm39) H639Q probably benign Het
Sell T A 1: 163,892,887 (GRCm39) H34Q possibly damaging Het
Senp8 A C 9: 59,644,504 (GRCm39) D204E probably benign Het
Setd2 A G 9: 110,377,226 (GRCm39) D347G probably benign Het
Sh2b1 T A 7: 126,067,975 (GRCm39) R560W probably damaging Het
Slc36a3 T A 11: 55,039,399 (GRCm39) K76N probably damaging Het
Slc6a9 A T 4: 117,713,205 (GRCm39) Y60F probably damaging Het
Slfn10-ps C T 11: 82,921,207 (GRCm39) noncoding transcript Het
Spata31d1d G A 13: 59,875,334 (GRCm39) H734Y probably benign Het
Spmip10 G T 18: 56,725,494 (GRCm39) M46I possibly damaging Het
Spsb1 T A 4: 149,991,612 (GRCm39) probably benign Het
Sptbn5 T A 2: 119,882,258 (GRCm39) noncoding transcript Het
Sugp2 G A 8: 70,712,462 (GRCm39) V1026I possibly damaging Het
Syt14 T A 1: 192,613,285 (GRCm39) probably benign Het
Sytl1 G A 4: 132,982,893 (GRCm39) Q373* probably null Het
Trim38 T A 13: 23,975,312 (GRCm39) L417Q probably damaging Het
Ttll1 T C 15: 83,380,597 (GRCm39) H256R probably damaging Het
Ttyh2 A T 11: 114,587,583 (GRCm39) T195S probably benign Het
Unc119b A G 5: 115,263,553 (GRCm39) L217P probably damaging Het
Usp6nl A G 2: 6,425,714 (GRCm39) K152E probably benign Het
Vcam1 T C 3: 115,910,941 (GRCm39) R486G probably benign Het
Vmn1r225 G A 17: 20,722,831 (GRCm39) G91S possibly damaging Het
Vmn2r1 A C 3: 63,997,544 (GRCm39) Q400P possibly damaging Het
Vmn2r87 A T 10: 130,314,422 (GRCm39) L388Q probably damaging Het
Wnk1 A T 6: 119,942,696 (GRCm39) probably benign Het
Zfp239 A G 6: 117,847,478 (GRCm39) probably benign Het
Zfp688 T C 7: 127,018,327 (GRCm39) Y266C probably damaging Het
Zfp850 A T 7: 27,689,658 (GRCm39) C183* probably null Het
Zscan29 T C 2: 120,999,676 (GRCm39) probably null Het
Other mutations in Lrp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00793:Lrp1 APN 10 127,378,074 (GRCm39) missense possibly damaging 0.89
IGL01065:Lrp1 APN 10 127,410,907 (GRCm39) missense probably benign 0.10
IGL01121:Lrp1 APN 10 127,419,722 (GRCm39) nonsense probably null
IGL01360:Lrp1 APN 10 127,381,689 (GRCm39) missense possibly damaging 0.93
IGL01402:Lrp1 APN 10 127,430,901 (GRCm39) missense probably damaging 1.00
IGL01404:Lrp1 APN 10 127,430,901 (GRCm39) missense probably damaging 1.00
IGL01411:Lrp1 APN 10 127,417,634 (GRCm39) nonsense probably null
IGL01469:Lrp1 APN 10 127,420,283 (GRCm39) missense probably damaging 1.00
IGL01552:Lrp1 APN 10 127,424,379 (GRCm39) nonsense probably null
IGL01682:Lrp1 APN 10 127,410,847 (GRCm39) missense probably benign 0.00
IGL01760:Lrp1 APN 10 127,409,370 (GRCm39) missense probably benign 0.00
IGL01918:Lrp1 APN 10 127,390,458 (GRCm39) missense probably damaging 0.99
IGL01989:Lrp1 APN 10 127,413,998 (GRCm39) missense probably damaging 1.00
IGL02105:Lrp1 APN 10 127,380,448 (GRCm39) missense probably damaging 1.00
IGL02158:Lrp1 APN 10 127,390,140 (GRCm39) missense probably benign 0.02
IGL02164:Lrp1 APN 10 127,399,536 (GRCm39) missense probably benign 0.39
IGL02337:Lrp1 APN 10 127,412,756 (GRCm39) missense possibly damaging 0.87
IGL02425:Lrp1 APN 10 127,407,756 (GRCm39) critical splice donor site probably null
IGL02493:Lrp1 APN 10 127,417,647 (GRCm39) missense probably damaging 0.99
IGL02563:Lrp1 APN 10 127,387,555 (GRCm39) missense probably damaging 1.00
IGL02590:Lrp1 APN 10 127,388,660 (GRCm39) missense probably damaging 1.00
IGL02624:Lrp1 APN 10 127,408,291 (GRCm39) missense probably damaging 0.98
IGL02625:Lrp1 APN 10 127,410,355 (GRCm39) missense probably damaging 1.00
IGL02825:Lrp1 APN 10 127,378,474 (GRCm39) missense probably damaging 1.00
IGL02880:Lrp1 APN 10 127,376,091 (GRCm39) missense probably benign 0.12
IGL02900:Lrp1 APN 10 127,412,516 (GRCm39) splice site probably benign
IGL02956:Lrp1 APN 10 127,380,428 (GRCm39) missense probably benign 0.00
IGL02974:Lrp1 APN 10 127,390,885 (GRCm39) missense probably damaging 0.99
IGL02983:Lrp1 APN 10 127,386,068 (GRCm39) missense probably damaging 1.00
IGL03002:Lrp1 APN 10 127,425,505 (GRCm39) missense probably damaging 1.00
IGL03091:Lrp1 APN 10 127,394,993 (GRCm39) missense probably benign 0.30
IGL03109:Lrp1 APN 10 127,402,514 (GRCm39) missense probably benign
IGL03194:Lrp1 APN 10 127,404,554 (GRCm39) missense probably damaging 1.00
IGL03232:Lrp1 APN 10 127,375,245 (GRCm39) missense probably damaging 1.00
calculus UTSW 10 127,393,937 (GRCm39) splice site probably null
Delimiter UTSW 10 127,382,731 (GRCm39) missense probably damaging 1.00
extremis UTSW 10 127,392,857 (GRCm39) missense probably benign 0.00
Jockey UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
peripheral UTSW 10 127,446,250 (GRCm39) missense probably damaging 1.00
tangential UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
P0015:Lrp1 UTSW 10 127,402,532 (GRCm39) missense probably damaging 0.99
PIT4519001:Lrp1 UTSW 10 127,443,843 (GRCm39) missense possibly damaging 0.91
PIT4520001:Lrp1 UTSW 10 127,443,843 (GRCm39) missense possibly damaging 0.91
R0004:Lrp1 UTSW 10 127,377,694 (GRCm39) splice site probably null
R0034:Lrp1 UTSW 10 127,381,520 (GRCm39) missense probably benign 0.42
R0091:Lrp1 UTSW 10 127,376,848 (GRCm39) missense probably damaging 1.00
R0098:Lrp1 UTSW 10 127,388,607 (GRCm39) missense probably benign
R0098:Lrp1 UTSW 10 127,388,607 (GRCm39) missense probably benign
R0143:Lrp1 UTSW 10 127,429,811 (GRCm39) missense probably damaging 1.00
R0372:Lrp1 UTSW 10 127,428,005 (GRCm39) missense probably damaging 1.00
R0379:Lrp1 UTSW 10 127,430,838 (GRCm39) missense probably damaging 1.00
R0445:Lrp1 UTSW 10 127,426,505 (GRCm39) nonsense probably null
R0529:Lrp1 UTSW 10 127,377,463 (GRCm39) splice site probably null
R0551:Lrp1 UTSW 10 127,407,827 (GRCm39) missense probably benign
R0570:Lrp1 UTSW 10 127,390,878 (GRCm39) nonsense probably null
R0600:Lrp1 UTSW 10 127,403,252 (GRCm39) missense probably benign 0.00
R0626:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R0647:Lrp1 UTSW 10 127,407,346 (GRCm39) missense probably damaging 1.00
R0680:Lrp1 UTSW 10 127,425,530 (GRCm39) missense probably damaging 1.00
R0792:Lrp1 UTSW 10 127,411,155 (GRCm39) missense probably benign 0.04
R0792:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R0848:Lrp1 UTSW 10 127,389,231 (GRCm39) splice site probably null
R0866:Lrp1 UTSW 10 127,375,147 (GRCm39) missense probably damaging 1.00
R0918:Lrp1 UTSW 10 127,429,834 (GRCm39) missense probably damaging 1.00
R1076:Lrp1 UTSW 10 127,399,666 (GRCm39) splice site probably benign
R1107:Lrp1 UTSW 10 127,393,304 (GRCm39) missense probably damaging 1.00
R1346:Lrp1 UTSW 10 127,441,735 (GRCm39) missense probably damaging 1.00
R1403:Lrp1 UTSW 10 127,417,760 (GRCm39) critical splice acceptor site probably null
R1403:Lrp1 UTSW 10 127,417,760 (GRCm39) critical splice acceptor site probably null
R1496:Lrp1 UTSW 10 127,374,880 (GRCm39) missense probably damaging 1.00
R1522:Lrp1 UTSW 10 127,411,155 (GRCm39) missense probably benign 0.04
R1522:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R1525:Lrp1 UTSW 10 127,375,398 (GRCm39) missense probably damaging 1.00
R1539:Lrp1 UTSW 10 127,420,250 (GRCm39) splice site probably null
R1589:Lrp1 UTSW 10 127,441,475 (GRCm39) missense probably benign 0.00
R1591:Lrp1 UTSW 10 127,441,475 (GRCm39) missense probably benign 0.00
R1663:Lrp1 UTSW 10 127,392,790 (GRCm39) missense probably damaging 1.00
R1682:Lrp1 UTSW 10 127,410,201 (GRCm39) missense probably damaging 1.00
R1717:Lrp1 UTSW 10 127,399,534 (GRCm39) missense probably damaging 1.00
R1717:Lrp1 UTSW 10 127,392,138 (GRCm39) missense possibly damaging 0.59
R1758:Lrp1 UTSW 10 127,424,453 (GRCm39) missense possibly damaging 0.76
R1826:Lrp1 UTSW 10 127,389,576 (GRCm39) missense probably damaging 1.00
R1842:Lrp1 UTSW 10 127,409,337 (GRCm39) missense possibly damaging 0.93
R1844:Lrp1 UTSW 10 127,431,152 (GRCm39) critical splice donor site probably null
R1845:Lrp1 UTSW 10 127,414,542 (GRCm39) missense probably damaging 1.00
R1896:Lrp1 UTSW 10 127,395,867 (GRCm39) missense possibly damaging 0.64
R1952:Lrp1 UTSW 10 127,403,300 (GRCm39) missense probably damaging 1.00
R2009:Lrp1 UTSW 10 127,380,385 (GRCm39) missense probably damaging 1.00
R2015:Lrp1 UTSW 10 127,376,563 (GRCm39) missense probably benign 0.00
R2116:Lrp1 UTSW 10 127,412,362 (GRCm39) nonsense probably null
R2161:Lrp1 UTSW 10 127,391,607 (GRCm39) missense probably damaging 1.00
R2199:Lrp1 UTSW 10 127,382,709 (GRCm39) missense probably damaging 1.00
R2213:Lrp1 UTSW 10 127,376,571 (GRCm39) missense probably damaging 1.00
R2300:Lrp1 UTSW 10 127,392,784 (GRCm39) nonsense probably null
R2324:Lrp1 UTSW 10 127,402,455 (GRCm39) missense possibly damaging 0.92
R2849:Lrp1 UTSW 10 127,378,165 (GRCm39) missense probably damaging 1.00
R2926:Lrp1 UTSW 10 127,423,982 (GRCm39) missense probably damaging 0.98
R2993:Lrp1 UTSW 10 127,446,250 (GRCm39) missense probably damaging 1.00
R3522:Lrp1 UTSW 10 127,389,424 (GRCm39) missense probably damaging 1.00
R3702:Lrp1 UTSW 10 127,430,972 (GRCm39) missense probably damaging 1.00
R3789:Lrp1 UTSW 10 127,407,838 (GRCm39) missense possibly damaging 0.94
R3898:Lrp1 UTSW 10 127,427,969 (GRCm39) nonsense probably null
R3941:Lrp1 UTSW 10 127,389,265 (GRCm39) missense probably damaging 1.00
R3958:Lrp1 UTSW 10 127,407,827 (GRCm39) missense probably benign
R4369:Lrp1 UTSW 10 127,386,155 (GRCm39) missense possibly damaging 0.87
R4510:Lrp1 UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
R4511:Lrp1 UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
R4576:Lrp1 UTSW 10 127,376,057 (GRCm39) small deletion probably benign
R4583:Lrp1 UTSW 10 127,377,241 (GRCm39) missense probably benign 0.00
R4662:Lrp1 UTSW 10 127,388,054 (GRCm39) nonsense probably null
R4721:Lrp1 UTSW 10 127,390,928 (GRCm39) missense possibly damaging 0.58
R4728:Lrp1 UTSW 10 127,399,606 (GRCm39) missense probably damaging 1.00
R4745:Lrp1 UTSW 10 127,385,813 (GRCm39) missense probably benign 0.20
R4785:Lrp1 UTSW 10 127,394,002 (GRCm39) missense probably benign 0.12
R4841:Lrp1 UTSW 10 127,419,805 (GRCm39) missense probably damaging 1.00
R4842:Lrp1 UTSW 10 127,419,805 (GRCm39) missense probably damaging 1.00
R4855:Lrp1 UTSW 10 127,446,311 (GRCm39) missense probably benign 0.03
R4860:Lrp1 UTSW 10 127,389,693 (GRCm39) missense probably damaging 1.00
R4860:Lrp1 UTSW 10 127,389,693 (GRCm39) missense probably damaging 1.00
R4891:Lrp1 UTSW 10 127,377,621 (GRCm39) missense probably damaging 1.00
R4925:Lrp1 UTSW 10 127,410,944 (GRCm39) nonsense probably null
R4999:Lrp1 UTSW 10 127,389,648 (GRCm39) missense probably damaging 1.00
R5044:Lrp1 UTSW 10 127,403,364 (GRCm39) missense probably damaging 1.00
R5127:Lrp1 UTSW 10 127,375,503 (GRCm39) intron probably benign
R5188:Lrp1 UTSW 10 127,443,821 (GRCm39) missense probably damaging 1.00
R5218:Lrp1 UTSW 10 127,384,488 (GRCm39) missense probably damaging 1.00
R5225:Lrp1 UTSW 10 127,391,965 (GRCm39) missense probably benign 0.04
R5291:Lrp1 UTSW 10 127,429,747 (GRCm39) missense probably damaging 1.00
R5386:Lrp1 UTSW 10 127,427,983 (GRCm39) missense probably damaging 1.00
R5395:Lrp1 UTSW 10 127,431,166 (GRCm39) missense probably damaging 1.00
R5413:Lrp1 UTSW 10 127,423,936 (GRCm39) critical splice donor site probably null
R5430:Lrp1 UTSW 10 127,376,930 (GRCm39) missense probably damaging 0.99
R5499:Lrp1 UTSW 10 127,408,813 (GRCm39) missense possibly damaging 0.58
R5526:Lrp1 UTSW 10 127,391,593 (GRCm39) missense probably benign 0.37
R5580:Lrp1 UTSW 10 127,424,389 (GRCm39) missense probably benign
R5583:Lrp1 UTSW 10 127,424,332 (GRCm39) missense probably benign 0.08
R5599:Lrp1 UTSW 10 127,429,738 (GRCm39) missense probably damaging 1.00
R5639:Lrp1 UTSW 10 127,429,708 (GRCm39) missense probably damaging 0.99
R5677:Lrp1 UTSW 10 127,410,298 (GRCm39) missense probably damaging 1.00
R5730:Lrp1 UTSW 10 127,419,703 (GRCm39) missense probably benign 0.00
R5742:Lrp1 UTSW 10 127,384,216 (GRCm39) missense probably damaging 0.98
R5764:Lrp1 UTSW 10 127,431,187 (GRCm39) missense probably benign 0.41
R5864:Lrp1 UTSW 10 127,403,374 (GRCm39) missense possibly damaging 0.58
R5937:Lrp1 UTSW 10 127,419,745 (GRCm39) missense possibly damaging 0.93
R5947:Lrp1 UTSW 10 127,425,423 (GRCm39) critical splice donor site probably null
R5976:Lrp1 UTSW 10 127,419,770 (GRCm39) missense probably damaging 1.00
R6021:Lrp1 UTSW 10 127,413,883 (GRCm39) missense probably damaging 1.00
R6026:Lrp1 UTSW 10 127,409,272 (GRCm39) missense probably damaging 1.00
R6045:Lrp1 UTSW 10 127,402,469 (GRCm39) missense probably damaging 0.98
R6057:Lrp1 UTSW 10 127,403,359 (GRCm39) missense probably damaging 1.00
R6084:Lrp1 UTSW 10 127,396,422 (GRCm39) missense probably benign 0.09
R6131:Lrp1 UTSW 10 127,396,026 (GRCm39) missense probably benign
R6235:Lrp1 UTSW 10 127,424,046 (GRCm39) missense probably damaging 1.00
R6280:Lrp1 UTSW 10 127,425,453 (GRCm39) missense probably benign 0.04
R6307:Lrp1 UTSW 10 127,427,944 (GRCm39) missense probably damaging 1.00
R6532:Lrp1 UTSW 10 127,385,276 (GRCm39) missense probably damaging 1.00
R6532:Lrp1 UTSW 10 127,377,551 (GRCm39) missense probably damaging 1.00
R6536:Lrp1 UTSW 10 127,393,937 (GRCm39) splice site probably null
R6605:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6607:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6631:Lrp1 UTSW 10 127,410,201 (GRCm39) missense probably damaging 1.00
R6676:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6678:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6809:Lrp1 UTSW 10 127,390,925 (GRCm39) missense probably benign 0.04
R6884:Lrp1 UTSW 10 127,394,986 (GRCm39) missense probably benign 0.00
R6925:Lrp1 UTSW 10 127,392,857 (GRCm39) missense probably benign 0.00
R6987:Lrp1 UTSW 10 127,410,874 (GRCm39) missense probably damaging 1.00
R7016:Lrp1 UTSW 10 127,395,836 (GRCm39) critical splice donor site probably null
R7030:Lrp1 UTSW 10 127,388,745 (GRCm39) missense probably damaging 0.97
R7053:Lrp1 UTSW 10 127,376,963 (GRCm39) missense probably damaging 1.00
R7076:Lrp1 UTSW 10 127,386,052 (GRCm39) critical splice donor site probably null
R7136:Lrp1 UTSW 10 127,394,491 (GRCm39) missense probably damaging 1.00
R7180:Lrp1 UTSW 10 127,392,834 (GRCm39) missense probably damaging 1.00
R7199:Lrp1 UTSW 10 127,409,325 (GRCm39) missense probably damaging 0.99
R7219:Lrp1 UTSW 10 127,393,097 (GRCm39) missense probably benign 0.40
R7233:Lrp1 UTSW 10 127,430,930 (GRCm39) missense probably damaging 1.00
R7251:Lrp1 UTSW 10 127,408,423 (GRCm39) missense probably damaging 1.00
R7264:Lrp1 UTSW 10 127,427,962 (GRCm39) missense probably damaging 1.00
R7302:Lrp1 UTSW 10 127,374,856 (GRCm39) missense probably benign 0.01
R7313:Lrp1 UTSW 10 127,389,337 (GRCm39) missense probably damaging 1.00
R7322:Lrp1 UTSW 10 127,381,433 (GRCm39) missense probably benign 0.24
R7354:Lrp1 UTSW 10 127,407,277 (GRCm39) missense probably damaging 1.00
R7375:Lrp1 UTSW 10 127,375,217 (GRCm39) missense probably damaging 1.00
R7388:Lrp1 UTSW 10 127,419,766 (GRCm39) nonsense probably null
R7404:Lrp1 UTSW 10 127,418,577 (GRCm39) missense
R7405:Lrp1 UTSW 10 127,417,620 (GRCm39) missense possibly damaging 0.93
R7477:Lrp1 UTSW 10 127,404,789 (GRCm39) missense probably damaging 1.00
R7555:Lrp1 UTSW 10 127,382,731 (GRCm39) missense probably damaging 1.00
R7600:Lrp1 UTSW 10 127,391,575 (GRCm39) missense probably benign
R7678:Lrp1 UTSW 10 127,409,922 (GRCm39) missense probably damaging 1.00
R7679:Lrp1 UTSW 10 127,424,297 (GRCm39) nonsense probably null
R7951:Lrp1 UTSW 10 127,374,933 (GRCm39) nonsense probably null
R7964:Lrp1 UTSW 10 127,410,913 (GRCm39) missense possibly damaging 0.94
R8006:Lrp1 UTSW 10 127,425,488 (GRCm39) missense probably damaging 1.00
R8021:Lrp1 UTSW 10 127,384,215 (GRCm39) missense possibly damaging 0.92
R8098:Lrp1 UTSW 10 127,410,324 (GRCm39) missense possibly damaging 0.78
R8112:Lrp1 UTSW 10 127,441,715 (GRCm39) missense probably damaging 1.00
R8210:Lrp1 UTSW 10 127,412,354 (GRCm39) missense probably damaging 1.00
R8249:Lrp1 UTSW 10 127,441,412 (GRCm39) missense probably benign
R8291:Lrp1 UTSW 10 127,425,572 (GRCm39) missense probably damaging 1.00
R8332:Lrp1 UTSW 10 127,407,805 (GRCm39) missense probably damaging 1.00
R8435:Lrp1 UTSW 10 127,392,199 (GRCm39) missense probably damaging 0.97
R8467:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8468:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8474:Lrp1 UTSW 10 127,375,572 (GRCm39) missense probably damaging 1.00
R8481:Lrp1 UTSW 10 127,404,779 (GRCm39) missense probably damaging 1.00
R8483:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8485:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8488:Lrp1 UTSW 10 127,396,356 (GRCm39) missense probably damaging 1.00
R8715:Lrp1 UTSW 10 127,396,490 (GRCm39) missense possibly damaging 0.77
R8790:Lrp1 UTSW 10 127,374,946 (GRCm39) missense probably damaging 1.00
R8854:Lrp1 UTSW 10 127,378,968 (GRCm39) missense probably damaging 1.00
R8926:Lrp1 UTSW 10 127,381,671 (GRCm39) missense probably benign
R8949:Lrp1 UTSW 10 127,425,405 (GRCm39) intron probably benign
R8971:Lrp1 UTSW 10 127,391,896 (GRCm39) missense possibly damaging 0.94
R9103:Lrp1 UTSW 10 127,430,979 (GRCm39) nonsense probably null
R9108:Lrp1 UTSW 10 127,390,206 (GRCm39) missense probably damaging 0.99
R9130:Lrp1 UTSW 10 127,382,281 (GRCm39) missense probably benign 0.18
R9157:Lrp1 UTSW 10 127,410,209 (GRCm39) missense probably damaging 1.00
R9162:Lrp1 UTSW 10 127,441,368 (GRCm39) missense probably benign 0.32
R9205:Lrp1 UTSW 10 127,430,850 (GRCm39) nonsense probably null
R9228:Lrp1 UTSW 10 127,382,807 (GRCm39) missense probably damaging 0.98
R9231:Lrp1 UTSW 10 127,382,268 (GRCm39) missense probably benign 0.06
R9287:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R9381:Lrp1 UTSW 10 127,441,337 (GRCm39) missense probably benign 0.17
R9412:Lrp1 UTSW 10 127,409,287 (GRCm39) missense probably damaging 1.00
R9434:Lrp1 UTSW 10 127,381,689 (GRCm39) missense possibly damaging 0.93
R9463:Lrp1 UTSW 10 127,429,334 (GRCm39) nonsense probably null
R9526:Lrp1 UTSW 10 127,431,229 (GRCm39) missense probably damaging 0.96
R9548:Lrp1 UTSW 10 127,388,733 (GRCm39) missense probably damaging 0.99
R9599:Lrp1 UTSW 10 127,410,246 (GRCm39) missense probably damaging 1.00
R9649:Lrp1 UTSW 10 127,409,368 (GRCm39) missense probably benign 0.14
R9687:Lrp1 UTSW 10 127,402,562 (GRCm39) missense probably damaging 1.00
R9707:Lrp1 UTSW 10 127,408,414 (GRCm39) missense probably benign 0.08
R9770:Lrp1 UTSW 10 127,420,268 (GRCm39) missense probably damaging 1.00
V3553:Lrp1 UTSW 10 127,407,311 (GRCm39) missense probably damaging 1.00
Y5406:Lrp1 UTSW 10 127,390,152 (GRCm39) missense probably damaging 1.00
Z1088:Lrp1 UTSW 10 127,420,248 (GRCm39) missense probably damaging 1.00
Z1176:Lrp1 UTSW 10 127,390,831 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATCAGCATCCAGTAGGCCC -3'
(R):5'- TTAGTCAGCAACAGCCTGG -3'

Sequencing Primer
(F):5'- AGGTAGGGTTTCCAATTTCCAC -3'
(R):5'- CCTGGGCGTAAGTGGTG -3'
Posted On 2016-04-27