Incidental Mutation 'R4972:Fcrl5'
ID 384501
Institutional Source Beutler Lab
Gene Symbol Fcrl5
Ensembl Gene ENSMUSG00000048031
Gene Name Fc receptor-like 5
Synonyms Fcrh3, BXMAS1-like protein 2, mBXMH2
MMRRC Submission 042567-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R4972 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 87343084-87407985 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87361957 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 407 (M407V)
Ref Sequence ENSEMBL: ENSMUSP00000141311 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049926] [ENSMUST00000166297] [ENSMUST00000178261] [ENSMUST00000193229] [ENSMUST00000194102]
AlphaFold Q68SN8
Predicted Effect probably benign
Transcript: ENSMUST00000049926
AA Change: M495V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000050151
Gene: ENSMUSG00000048031
AA Change: M495V

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000166297
AA Change: M407V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000131176
Gene: ENSMUSG00000048031
AA Change: M407V

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IGc2 40 100 6.16e-4 SMART
IG_like 125 208 4.41e1 SMART
IGc2 228 292 3.97e-7 SMART
IG_like 322 385 2.94e-1 SMART
transmembrane domain 407 429 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000178261
AA Change: M495V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000136046
Gene: ENSMUSG00000048031
AA Change: M495V

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193229
AA Change: M407V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000141311
Gene: ENSMUSG00000048031
AA Change: M407V

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IGc2 40 100 6.16e-4 SMART
IG_like 125 208 4.41e1 SMART
IGc2 228 292 3.97e-7 SMART
IG_like 322 385 2.94e-1 SMART
transmembrane domain 407 429 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000194102
AA Change: M495V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000142210
Gene: ENSMUSG00000048031
AA Change: M495V

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.2%
Validation Efficiency 93% (82/88)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A T 14: 32,383,361 (GRCm39) I868N possibly damaging Het
A730013G03Rik C G 1: 192,516,081 (GRCm39) noncoding transcript Het
Actl11 A G 9: 107,807,155 (GRCm39) T493A probably benign Het
Actn1 T C 12: 80,219,813 (GRCm39) D686G probably benign Het
Adamts1 G A 16: 85,592,833 (GRCm39) T525I probably damaging Het
Adcy10 T A 1: 165,384,431 (GRCm39) L1064H probably damaging Het
AI661453 A T 17: 47,777,324 (GRCm39) probably benign Het
Apba1 T A 19: 23,889,900 (GRCm39) S433T probably benign Het
Arid4b T A 13: 14,334,857 (GRCm39) N355K probably benign Het
Bsn A T 9: 107,992,377 (GRCm39) M1125K probably damaging Het
C2cd5 A T 6: 142,958,950 (GRCm39) M1003K probably damaging Het
Ccdc18 A G 5: 108,339,869 (GRCm39) M805V probably benign Het
Cep89 T G 7: 35,131,977 (GRCm39) L637R probably damaging Het
Col24a1 A T 3: 145,215,439 (GRCm39) I1444F probably benign Het
Commd4 A T 9: 57,062,732 (GRCm39) S175T probably benign Het
Coq7 A G 7: 118,109,340 (GRCm39) V236A unknown Het
Dctn2 C T 10: 127,112,572 (GRCm39) R176C probably damaging Het
Ddx31 T C 2: 28,750,782 (GRCm39) F389L probably damaging Het
Dgkz C T 2: 91,776,047 (GRCm39) R72H probably benign Het
Dpysl4 A G 7: 138,670,206 (GRCm39) D24G probably damaging Het
Dydc1 A G 14: 40,804,295 (GRCm39) T106A probably benign Het
F13b A G 1: 139,438,661 (GRCm39) Y355C probably damaging Het
Fzd5 C A 1: 64,775,171 (GRCm39) V197L probably benign Het
Galnt16 G T 12: 80,619,103 (GRCm39) E70* probably null Het
Gpr171 A T 3: 59,005,386 (GRCm39) F130I probably damaging Het
Grin3a T C 4: 49,770,484 (GRCm39) N763D probably damaging Het
Gsta2 A T 9: 78,244,961 (GRCm39) M51K probably damaging Het
Gvin-ps3 T C 7: 105,682,521 (GRCm39) noncoding transcript Het
Hacd3 A T 9: 64,897,718 (GRCm39) I298N probably damaging Het
Il18r1 C T 1: 40,530,224 (GRCm39) P317L probably benign Het
Iscu T A 5: 113,915,037 (GRCm39) probably benign Het
Kif6 A G 17: 50,014,647 (GRCm39) D250G probably damaging Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lcn6 T A 2: 25,570,079 (GRCm39) C82S probably damaging Het
Mob4 C G 1: 55,190,161 (GRCm39) L135V possibly damaging Het
Mpzl3 T A 9: 44,973,554 (GRCm39) probably benign Het
Mvp T C 7: 126,588,970 (GRCm39) D599G probably damaging Het
Myo1a T C 10: 127,552,178 (GRCm39) Y766H probably benign Het
Myo5b A G 18: 74,760,264 (GRCm39) H260R probably damaging Het
Nbea C T 3: 55,992,667 (GRCm39) R313H probably damaging Het
Necab1 T A 4: 14,978,216 (GRCm39) D211V probably damaging Het
Nefl G T 14: 68,324,212 (GRCm39) probably benign Het
Nfx1 T A 4: 40,976,375 (GRCm39) D16E probably benign Het
Nlrp9a G T 7: 26,269,964 (GRCm39) C797F probably damaging Het
Or4k36 T A 2: 111,146,163 (GRCm39) V113E probably damaging Het
Or5p5 A G 7: 107,413,953 (GRCm39) Q56R probably benign Het
Pde6b A G 5: 108,573,130 (GRCm39) D500G probably benign Het
Pgs1 T C 11: 117,896,719 (GRCm39) probably null Het
Polr3b T A 10: 84,473,988 (GRCm39) I189N probably damaging Het
Ppwd1 A T 13: 104,356,616 (GRCm39) S300T probably benign Het
Prl2c2 A C 13: 13,176,755 (GRCm39) N55K possibly damaging Het
Prpf19 C T 19: 10,876,709 (GRCm39) probably benign Het
Prph2 G T 17: 47,221,733 (GRCm39) L37F possibly damaging Het
Ptprg G T 14: 12,226,427 (GRCm38) R565L possibly damaging Het
Rab8a C T 8: 72,925,119 (GRCm39) T74M probably damaging Het
Rexo1 A T 10: 80,385,527 (GRCm39) F510L probably damaging Het
Rexo2 G T 9: 48,390,689 (GRCm39) T51K probably damaging Het
Sh3d21 T C 4: 126,046,209 (GRCm39) K147R possibly damaging Het
Skint6 A G 4: 112,692,265 (GRCm39) I1062T probably benign Het
Spag16 C T 1: 70,764,087 (GRCm39) R636W probably damaging Het
Spata16 T C 3: 26,894,872 (GRCm39) I307T possibly damaging Het
Speer4f2 T G 5: 17,579,423 (GRCm39) I74S probably benign Het
Svep1 T A 4: 58,087,778 (GRCm39) Y1767F possibly damaging Het
Swt1 T C 1: 151,299,293 (GRCm39) S7G probably benign Het
Tex9 A G 9: 72,385,620 (GRCm39) probably null Het
Thsd7b C A 1: 130,116,309 (GRCm39) P1354H probably damaging Het
Ticrr A G 7: 79,319,416 (GRCm39) D467G probably damaging Het
Tmco5b A C 2: 113,127,338 (GRCm39) D303A probably damaging Het
Trpm7 A G 2: 126,665,978 (GRCm39) V876A probably damaging Het
Ttc21a G A 9: 119,774,027 (GRCm39) E245K probably benign Het
Vezt C T 10: 93,836,212 (GRCm39) probably null Het
Zscan20 G A 4: 128,486,152 (GRCm39) P183S probably benign Het
Other mutations in Fcrl5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01743:Fcrl5 APN 3 87,351,598 (GRCm39) missense probably damaging 0.96
IGL01868:Fcrl5 APN 3 87,351,014 (GRCm39) missense possibly damaging 0.58
IGL01939:Fcrl5 APN 3 87,353,606 (GRCm39) missense probably damaging 0.99
IGL02817:Fcrl5 APN 3 87,343,220 (GRCm39) missense probably benign 0.35
IGL03106:Fcrl5 APN 3 87,343,190 (GRCm39) splice site probably null
R0381:Fcrl5 UTSW 3 87,353,767 (GRCm39) missense probably damaging 1.00
R0523:Fcrl5 UTSW 3 87,365,099 (GRCm39) missense possibly damaging 0.72
R0646:Fcrl5 UTSW 3 87,349,320 (GRCm39) missense probably benign 0.00
R1231:Fcrl5 UTSW 3 87,349,486 (GRCm39) missense probably benign 0.13
R1353:Fcrl5 UTSW 3 87,355,669 (GRCm39) missense probably damaging 1.00
R1711:Fcrl5 UTSW 3 87,364,721 (GRCm39) missense possibly damaging 0.61
R1714:Fcrl5 UTSW 3 87,353,713 (GRCm39) missense probably damaging 1.00
R1719:Fcrl5 UTSW 3 87,364,704 (GRCm39) missense probably damaging 0.98
R2084:Fcrl5 UTSW 3 87,351,537 (GRCm39) missense probably benign 0.24
R2358:Fcrl5 UTSW 3 87,353,726 (GRCm39) missense probably damaging 0.99
R2884:Fcrl5 UTSW 3 87,364,698 (GRCm39) missense probably damaging 1.00
R2885:Fcrl5 UTSW 3 87,364,698 (GRCm39) missense probably damaging 1.00
R3085:Fcrl5 UTSW 3 87,353,771 (GRCm39) missense probably damaging 1.00
R3153:Fcrl5 UTSW 3 87,350,987 (GRCm39) missense probably benign 0.09
R4288:Fcrl5 UTSW 3 87,349,531 (GRCm39) missense probably benign 0.09
R4289:Fcrl5 UTSW 3 87,349,531 (GRCm39) missense probably benign 0.09
R4614:Fcrl5 UTSW 3 87,355,733 (GRCm39) missense probably damaging 1.00
R4719:Fcrl5 UTSW 3 87,351,496 (GRCm39) missense probably damaging 1.00
R4788:Fcrl5 UTSW 3 87,364,495 (GRCm39) missense probably damaging 1.00
R4920:Fcrl5 UTSW 3 87,351,480 (GRCm39) missense probably damaging 1.00
R5373:Fcrl5 UTSW 3 87,353,698 (GRCm39) missense probably benign 0.01
R5374:Fcrl5 UTSW 3 87,353,698 (GRCm39) missense probably benign 0.01
R5963:Fcrl5 UTSW 3 87,351,480 (GRCm39) missense probably damaging 1.00
R5975:Fcrl5 UTSW 3 87,349,410 (GRCm39) missense probably benign 0.00
R6022:Fcrl5 UTSW 3 87,363,070 (GRCm39) missense probably benign 0.42
R6267:Fcrl5 UTSW 3 87,355,631 (GRCm39) missense probably damaging 1.00
R6372:Fcrl5 UTSW 3 87,351,501 (GRCm39) nonsense probably null
R6393:Fcrl5 UTSW 3 87,355,634 (GRCm39) missense probably damaging 1.00
R7088:Fcrl5 UTSW 3 87,365,141 (GRCm39) makesense probably null
R7175:Fcrl5 UTSW 3 87,353,645 (GRCm39) missense probably benign 0.37
R7210:Fcrl5 UTSW 3 87,353,719 (GRCm39) missense possibly damaging 0.85
R7217:Fcrl5 UTSW 3 87,351,081 (GRCm39) missense probably damaging 1.00
R7243:Fcrl5 UTSW 3 87,349,552 (GRCm39) missense probably benign
R7776:Fcrl5 UTSW 3 87,351,502 (GRCm39) missense possibly damaging 0.84
R7813:Fcrl5 UTSW 3 87,350,930 (GRCm39) missense probably benign 0.09
R8357:Fcrl5 UTSW 3 87,351,567 (GRCm39) missense probably damaging 0.99
R8457:Fcrl5 UTSW 3 87,351,567 (GRCm39) missense probably damaging 0.99
R9257:Fcrl5 UTSW 3 87,343,195 (GRCm39) missense probably benign 0.11
R9276:Fcrl5 UTSW 3 87,343,138 (GRCm39) start gained probably benign
R9748:Fcrl5 UTSW 3 87,364,469 (GRCm39) missense possibly damaging 0.93
X0054:Fcrl5 UTSW 3 87,353,606 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTAAGGCTTGGTACTCCTGGTC -3'
(R):5'- AACAGGACTTCTGAGGGACC -3'

Sequencing Primer
(F):5'- GGTACTCCTGGTCACAAAGGTTC -3'
(R):5'- ACTTCTGAGGGACCCAGAG -3'
Posted On 2016-04-27