Incidental Mutation 'R4981:Megf6'
| ID |
384811 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Megf6
|
| Ensembl Gene |
ENSMUSG00000057751 |
| Gene Name |
multiple EGF-like-domains 6 |
| Synonyms |
2600001P17Rik, Egfl3 |
| MMRRC Submission |
042576-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4981 (G1)
|
| Quality Score |
222 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
154255187-154360170 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 154351907 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 1169
(F1169L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000030897
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030897]
[ENSMUST00000152159]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000030897
AA Change: F1169L
PolyPhen 2
Score 0.954 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000030897
Gene: ENSMUSG00000057751
AA Change: F1169L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
EGF_CA
|
122 |
162 |
1.54e-6 |
SMART |
|
EGF_CA
|
163 |
203 |
2.08e-12 |
SMART |
|
EGF
|
207 |
245 |
5.4e-2 |
SMART |
|
EGF
|
249 |
286 |
2.39e-3 |
SMART |
|
EGF_CA
|
287 |
327 |
4.96e-10 |
SMART |
|
EGF
|
336 |
373 |
1.64e-1 |
SMART |
|
EGF
|
377 |
413 |
1.99e1 |
SMART |
|
EGF_CA
|
414 |
454 |
7.4e-9 |
SMART |
|
EGF
|
521 |
554 |
4.26e0 |
SMART |
|
EGF_Lam
|
570 |
609 |
1.19e-3 |
SMART |
|
EGF_like
|
613 |
652 |
5.29e-1 |
SMART |
|
EGF
|
642 |
685 |
2.2e1 |
SMART |
|
EGF_Lam
|
656 |
697 |
1.04e-3 |
SMART |
|
EGF
|
687 |
730 |
1.59e1 |
SMART |
|
EGF_like
|
701 |
742 |
2.27e0 |
SMART |
|
EGF_Lam
|
746 |
784 |
1.33e-1 |
SMART |
|
EGF
|
783 |
816 |
2.85e-1 |
SMART |
|
EGF_Lam
|
832 |
871 |
3.88e-3 |
SMART |
|
EGF_Lam
|
875 |
915 |
3.25e-5 |
SMART |
|
EGF
|
914 |
946 |
4.7e-2 |
SMART |
|
EGF_like
|
962 |
1001 |
1.69e-1 |
SMART |
|
EGF
|
1000 |
1032 |
7.02e-1 |
SMART |
|
EGF_Lam
|
1048 |
1087 |
3.1e-2 |
SMART |
|
EGF
|
1077 |
1118 |
7.53e-1 |
SMART |
|
EGF_like
|
1091 |
1130 |
5.59e-1 |
SMART |
|
EGF
|
1129 |
1161 |
5.04e-2 |
SMART |
|
EGF_Lam
|
1177 |
1216 |
2.94e-3 |
SMART |
|
EGF
|
1206 |
1248 |
1.87e1 |
SMART |
|
EGF_Lam
|
1220 |
1260 |
3.1e-2 |
SMART |
|
EGF
|
1259 |
1291 |
1.73e0 |
SMART |
|
EGF
|
1302 |
1334 |
6.55e-1 |
SMART |
|
EGF
|
1345 |
1377 |
4.39e-2 |
SMART |
|
EGF_Lam
|
1393 |
1432 |
7.64e-2 |
SMART |
|
EGF_Lam
|
1436 |
1475 |
2.64e-5 |
SMART |
|
EGF_like
|
1465 |
1506 |
4.2e1 |
SMART |
|
EGF_Lam
|
1479 |
1518 |
1.19e-3 |
SMART |
|
EGF
|
1517 |
1549 |
1.84e1 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127088
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000128700
AA Change: F80L
|
| SMART Domains |
Protein: ENSMUSP00000117277
Gene: ENSMUSG00000057751
AA Change: F80L
| Domain | Start | End | E-Value | Type |
|---|
|
EGF_Lam
|
3 |
42 |
3.1e-2 |
SMART |
|
EGF
|
32 |
73 |
7.53e-1 |
SMART |
|
EGF_like
|
46 |
85 |
8.92e-1 |
SMART |
|
EGF
|
84 |
116 |
7.13e-2 |
SMART |
|
EGF
|
127 |
159 |
1.73e0 |
SMART |
|
EGF
|
170 |
202 |
6.55e-1 |
SMART |
|
EGF
|
213 |
245 |
4.39e-2 |
SMART |
|
EGF_Lam
|
261 |
300 |
7.64e-2 |
SMART |
|
EGF
|
299 |
331 |
1.51e0 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138945
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142110
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000152159
AA Change: F932L
PolyPhen 2
Score 0.917 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000121641
Gene: ENSMUSG00000057751
AA Change: F932L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
EGF_CA
|
55 |
95 |
2.08e-12 |
SMART |
|
EGF
|
99 |
137 |
5.4e-2 |
SMART |
|
EGF
|
141 |
178 |
2.39e-3 |
SMART |
|
EGF_CA
|
179 |
219 |
4.96e-10 |
SMART |
|
EGF
|
228 |
265 |
1.64e-1 |
SMART |
|
EGF
|
269 |
305 |
1.99e1 |
SMART |
|
EGF_CA
|
306 |
346 |
7.4e-9 |
SMART |
|
EGF
|
413 |
446 |
4.26e0 |
SMART |
|
EGF_Lam
|
462 |
501 |
1.19e-3 |
SMART |
|
EGF_like
|
505 |
544 |
5.29e-1 |
SMART |
|
EGF
|
534 |
577 |
2.2e1 |
SMART |
|
EGF_Lam
|
548 |
589 |
1.04e-3 |
SMART |
|
EGF
|
579 |
622 |
1.59e1 |
SMART |
|
EGF_like
|
593 |
634 |
2.27e0 |
SMART |
|
EGF_Lam
|
638 |
676 |
1.33e-1 |
SMART |
|
EGF
|
675 |
708 |
2.85e-1 |
SMART |
|
EGF_Lam
|
724 |
763 |
3.88e-3 |
SMART |
|
EGF_Lam
|
767 |
807 |
3.25e-5 |
SMART |
|
EGF
|
806 |
838 |
4.7e-2 |
SMART |
|
EGF_Lam
|
854 |
893 |
2.56e-3 |
SMART |
|
EGF
|
892 |
924 |
2.02e-1 |
SMART |
|
EGF
|
935 |
967 |
7.13e-2 |
SMART |
|
EGF
|
978 |
1010 |
1.73e0 |
SMART |
|
EGF
|
1021 |
1053 |
6.55e-1 |
SMART |
|
EGF
|
1064 |
1096 |
4.39e-2 |
SMART |
|
EGF
|
1107 |
1139 |
4.97e-1 |
SMART |
|
EGF
|
1159 |
1191 |
1.84e1 |
SMART |
|
| Meta Mutation Damage Score |
0.1460 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 96.0%
- 20x: 91.3%
|
| Validation Efficiency |
100% (105/105) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700097O09Rik |
A |
T |
12: 55,095,772 (GRCm39) |
|
probably null |
Het |
| Aatf |
T |
C |
11: 84,402,323 (GRCm39) |
D121G |
probably benign |
Het |
| Amer2 |
T |
A |
14: 60,617,176 (GRCm39) |
L331H |
probably damaging |
Het |
| Ang4 |
T |
G |
14: 52,001,829 (GRCm39) |
K40Q |
probably benign |
Het |
| Aspm |
A |
C |
1: 139,398,498 (GRCm39) |
|
probably null |
Het |
| Cacna1c |
A |
T |
6: 118,728,432 (GRCm39) |
D337E |
probably benign |
Het |
| Ccdc124 |
T |
C |
8: 71,321,429 (GRCm39) |
E134G |
probably benign |
Het |
| Ccdc7a |
G |
T |
8: 129,711,464 (GRCm39) |
A312E |
probably benign |
Het |
| Cd209g |
A |
G |
8: 4,186,845 (GRCm39) |
D130G |
probably damaging |
Het |
| Cd320 |
T |
C |
17: 34,066,549 (GRCm39) |
S96P |
probably benign |
Het |
| Cenatac |
A |
T |
9: 44,329,245 (GRCm39) |
F14Y |
probably damaging |
Het |
| Clu |
C |
G |
14: 66,210,815 (GRCm39) |
Q134E |
probably damaging |
Het |
| Cnksr3 |
T |
A |
10: 7,110,777 (GRCm39) |
H28L |
probably benign |
Het |
| Cntnap1 |
T |
C |
11: 101,067,159 (GRCm39) |
|
probably null |
Het |
| Col22a1 |
C |
T |
15: 71,732,915 (GRCm39) |
C546Y |
unknown |
Het |
| Col6a3 |
C |
T |
1: 90,706,565 (GRCm39) |
V2183I |
unknown |
Het |
| Cop1 |
A |
G |
1: 159,152,638 (GRCm39) |
|
probably benign |
Het |
| Cpne8 |
T |
C |
15: 90,563,438 (GRCm39) |
I24V |
probably benign |
Het |
| Cspp1 |
T |
A |
1: 10,196,688 (GRCm39) |
N900K |
probably damaging |
Het |
| Dennd5b |
G |
A |
6: 148,911,270 (GRCm39) |
L978F |
possibly damaging |
Het |
| Depdc1a |
G |
T |
3: 159,229,550 (GRCm39) |
M627I |
probably benign |
Het |
| Dnah3 |
A |
T |
7: 119,555,424 (GRCm39) |
N2721K |
probably benign |
Het |
| Dnase1l1 |
C |
T |
X: 73,320,644 (GRCm39) |
|
probably null |
Homo |
| Dsg1b |
A |
G |
18: 20,541,925 (GRCm39) |
T811A |
possibly damaging |
Het |
| Emilin1 |
C |
G |
5: 31,076,695 (GRCm39) |
Q847E |
probably benign |
Het |
| Epha3 |
A |
T |
16: 63,472,775 (GRCm39) |
V370D |
probably benign |
Het |
| Epha5 |
T |
A |
5: 84,298,342 (GRCm39) |
T406S |
probably damaging |
Het |
| Ephb1 |
A |
T |
9: 101,918,159 (GRCm39) |
I450N |
probably benign |
Het |
| Ephb2 |
A |
G |
4: 136,423,321 (GRCm39) |
M319T |
probably benign |
Het |
| Eps15l1 |
A |
G |
8: 73,132,833 (GRCm39) |
|
probably null |
Het |
| Fbxo9 |
G |
A |
9: 77,993,168 (GRCm39) |
|
probably benign |
Het |
| Fgd5 |
T |
C |
6: 91,966,281 (GRCm39) |
I838T |
probably damaging |
Het |
| Fnbp4 |
T |
C |
2: 90,596,174 (GRCm39) |
F582L |
probably damaging |
Het |
| Frs3 |
T |
C |
17: 48,000,187 (GRCm39) |
|
probably null |
Het |
| Fscb |
C |
T |
12: 64,520,393 (GRCm39) |
V358I |
possibly damaging |
Het |
| Fus |
G |
T |
7: 127,566,727 (GRCm39) |
|
probably benign |
Het |
| Fyb1 |
CCTCTCTCTCTCTCTCTCTCT |
CCTCTCTCTCTCTCTCTCT |
15: 6,676,092 (GRCm39) |
|
probably benign |
Het |
| Glra3 |
A |
T |
8: 56,444,270 (GRCm39) |
I77F |
possibly damaging |
Het |
| Gm4454 |
C |
T |
7: 38,269,860 (GRCm39) |
|
noncoding transcript |
Het |
| Gng3 |
G |
A |
19: 8,815,625 (GRCm39) |
A37V |
possibly damaging |
Het |
| Grin3b |
T |
A |
10: 79,812,191 (GRCm39) |
|
probably benign |
Het |
| Herpud1 |
A |
G |
8: 95,118,422 (GRCm39) |
Y41C |
probably damaging |
Het |
| Igkv4-92 |
G |
C |
6: 68,732,028 (GRCm39) |
S115R |
possibly damaging |
Het |
| Ikbip |
T |
A |
10: 90,931,848 (GRCm39) |
I164N |
probably benign |
Het |
| Kank1 |
A |
G |
19: 25,388,759 (GRCm39) |
T783A |
probably benign |
Het |
| Kcnq3 |
A |
T |
15: 65,903,254 (GRCm39) |
V152E |
possibly damaging |
Het |
| Kif23 |
C |
T |
9: 61,839,153 (GRCm39) |
R314H |
probably damaging |
Het |
| Klc4 |
T |
C |
17: 46,955,287 (GRCm39) |
H49R |
probably benign |
Het |
| Klhl20 |
A |
T |
1: 160,930,575 (GRCm39) |
I309N |
possibly damaging |
Het |
| Lgals4 |
A |
G |
7: 28,540,701 (GRCm39) |
Y268C |
probably damaging |
Het |
| Lingo4 |
A |
G |
3: 94,306,761 (GRCm39) |
Q13R |
probably benign |
Het |
| Lmtk2 |
C |
A |
5: 144,113,265 (GRCm39) |
F1328L |
probably damaging |
Het |
| Mapk14 |
A |
G |
17: 28,960,765 (GRCm39) |
R179G |
probably damaging |
Het |
| Mbd3l1 |
A |
T |
9: 18,396,201 (GRCm39) |
T109S |
probably benign |
Het |
| Mrgpra1 |
A |
T |
7: 46,984,959 (GRCm39) |
V240D |
probably damaging |
Het |
| Muc6 |
G |
A |
7: 141,218,313 (GRCm39) |
S2120F |
possibly damaging |
Het |
| Myh1 |
T |
C |
11: 67,115,300 (GRCm39) |
|
probably benign |
Het |
| Nav3 |
T |
C |
10: 109,716,553 (GRCm39) |
I172V |
probably benign |
Het |
| Nemp1 |
T |
A |
10: 127,529,399 (GRCm39) |
L178Q |
probably damaging |
Het |
| Numa1 |
T |
C |
7: 101,641,881 (GRCm39) |
S110P |
probably damaging |
Het |
| Or4a75 |
A |
G |
2: 89,447,769 (GRCm39) |
Y256H |
probably damaging |
Het |
| Or4c117 |
T |
C |
2: 88,955,845 (GRCm39) |
T77A |
probably benign |
Het |
| Or51k1 |
A |
G |
7: 103,661,312 (GRCm39) |
I199T |
probably damaging |
Het |
| Or5ak25 |
A |
G |
2: 85,268,813 (GRCm39) |
S230P |
probably damaging |
Het |
| Or8k30 |
T |
C |
2: 86,339,171 (GRCm39) |
Y123H |
probably damaging |
Het |
| Or9q1 |
A |
T |
19: 13,805,458 (GRCm39) |
F101I |
probably damaging |
Het |
| Pard3b |
T |
G |
1: 62,383,219 (GRCm39) |
M771R |
probably damaging |
Het |
| Phkg2 |
A |
G |
7: 127,181,551 (GRCm39) |
I245V |
probably damaging |
Het |
| Pik3cg |
A |
T |
12: 32,254,103 (GRCm39) |
M628K |
possibly damaging |
Het |
| Poln |
A |
G |
5: 34,264,429 (GRCm39) |
|
probably null |
Het |
| Ppip5k1 |
A |
T |
2: 121,142,871 (GRCm39) |
S1172T |
probably damaging |
Het |
| Prdm5 |
A |
T |
6: 65,847,446 (GRCm39) |
H363L |
probably damaging |
Het |
| Prkdc |
A |
G |
16: 15,496,173 (GRCm39) |
Y788C |
probably damaging |
Het |
| Prrc2c |
T |
A |
1: 162,520,116 (GRCm39) |
R2076S |
probably damaging |
Het |
| Sh2d2a |
A |
G |
3: 87,756,728 (GRCm39) |
Y191C |
probably damaging |
Het |
| Slc20a1 |
T |
C |
2: 129,041,919 (GRCm39) |
I94T |
probably damaging |
Het |
| Sptbn2 |
T |
C |
19: 4,801,686 (GRCm39) |
V2366A |
probably benign |
Het |
| Stab2 |
T |
A |
10: 86,796,087 (GRCm39) |
M387L |
probably benign |
Het |
| Syne2 |
T |
G |
12: 75,987,993 (GRCm39) |
M1718R |
probably damaging |
Het |
| Synm |
G |
T |
7: 67,384,235 (GRCm39) |
F700L |
probably benign |
Het |
| Tmco4 |
T |
C |
4: 138,718,012 (GRCm39) |
F51L |
possibly damaging |
Het |
| Tmem104 |
C |
A |
11: 115,095,962 (GRCm39) |
P168T |
probably damaging |
Het |
| Tril |
G |
T |
6: 53,795,905 (GRCm39) |
T439K |
probably benign |
Het |
| Trim2 |
A |
G |
3: 84,085,042 (GRCm39) |
L559P |
probably damaging |
Het |
| Trim3 |
A |
G |
7: 105,268,335 (GRCm39) |
V149A |
probably damaging |
Het |
| Triml2 |
A |
G |
8: 43,640,717 (GRCm39) |
N191S |
probably benign |
Het |
| Usp4 |
A |
G |
9: 108,258,617 (GRCm39) |
D16G |
probably benign |
Het |
| Vmn2r58 |
G |
A |
7: 41,486,885 (GRCm39) |
T670I |
probably damaging |
Het |
| Vmn2r97 |
G |
T |
17: 19,160,436 (GRCm39) |
G524* |
probably null |
Het |
| Xpo5 |
C |
A |
17: 46,531,743 (GRCm39) |
F426L |
probably damaging |
Het |
| Zfp800 |
A |
G |
6: 28,247,190 (GRCm39) |
L84S |
probably damaging |
Het |
| Zranb2 |
T |
G |
3: 157,252,378 (GRCm39) |
|
probably benign |
Het |
| Zswim4 |
C |
T |
8: 84,953,296 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Megf6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01122:Megf6
|
APN |
4 |
154,338,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01410:Megf6
|
APN |
4 |
154,337,020 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01512:Megf6
|
APN |
4 |
154,347,040 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL01824:Megf6
|
APN |
4 |
154,336,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02172:Megf6
|
APN |
4 |
154,355,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02727:Megf6
|
APN |
4 |
154,337,606 (GRCm39) |
splice site |
probably null |
|
|
IGL02966:Megf6
|
APN |
4 |
154,338,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Didactic
|
UTSW |
4 |
154,339,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0118:Megf6
|
UTSW |
4 |
154,339,098 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0220:Megf6
|
UTSW |
4 |
154,342,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0347:Megf6
|
UTSW |
4 |
154,339,092 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0383:Megf6
|
UTSW |
4 |
154,349,783 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0417:Megf6
|
UTSW |
4 |
154,352,424 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0526:Megf6
|
UTSW |
4 |
154,343,398 (GRCm39) |
missense |
probably benign |
|
|
R0528:Megf6
|
UTSW |
4 |
154,343,630 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0928:Megf6
|
UTSW |
4 |
154,261,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1311:Megf6
|
UTSW |
4 |
154,348,239 (GRCm39) |
splice site |
probably null |
|
|
R1458:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1470:Megf6
|
UTSW |
4 |
154,336,876 (GRCm39) |
splice site |
probably benign |
|
|
R1476:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1479:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1624:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1626:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1638:Megf6
|
UTSW |
4 |
154,346,967 (GRCm39) |
splice site |
probably benign |
|
|
R1777:Megf6
|
UTSW |
4 |
154,355,147 (GRCm39) |
nonsense |
probably null |
|
|
R1831:Megf6
|
UTSW |
4 |
154,355,134 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1944:Megf6
|
UTSW |
4 |
154,340,523 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1984:Megf6
|
UTSW |
4 |
154,352,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2109:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2448:Megf6
|
UTSW |
4 |
154,351,102 (GRCm39) |
splice site |
probably null |
|
|
R2880:Megf6
|
UTSW |
4 |
154,337,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4032:Megf6
|
UTSW |
4 |
154,261,550 (GRCm39) |
nonsense |
probably null |
|
|
R4058:Megf6
|
UTSW |
4 |
154,326,989 (GRCm39) |
splice site |
probably benign |
|
|
R4672:Megf6
|
UTSW |
4 |
154,333,909 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4688:Megf6
|
UTSW |
4 |
154,338,271 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4752:Megf6
|
UTSW |
4 |
154,336,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4863:Megf6
|
UTSW |
4 |
154,338,738 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4909:Megf6
|
UTSW |
4 |
154,349,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4942:Megf6
|
UTSW |
4 |
154,338,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4990:Megf6
|
UTSW |
4 |
154,351,683 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5001:Megf6
|
UTSW |
4 |
154,352,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5189:Megf6
|
UTSW |
4 |
154,336,980 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5210:Megf6
|
UTSW |
4 |
154,354,273 (GRCm39) |
intron |
probably benign |
|
|
R5220:Megf6
|
UTSW |
4 |
154,338,295 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5250:Megf6
|
UTSW |
4 |
154,340,467 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5697:Megf6
|
UTSW |
4 |
154,342,686 (GRCm39) |
missense |
probably null |
0.15 |
|
R5808:Megf6
|
UTSW |
4 |
154,352,119 (GRCm39) |
missense |
probably benign |
|
|
R5916:Megf6
|
UTSW |
4 |
154,333,882 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6054:Megf6
|
UTSW |
4 |
154,347,636 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6075:Megf6
|
UTSW |
4 |
154,347,056 (GRCm39) |
nonsense |
probably null |
|
|
R6515:Megf6
|
UTSW |
4 |
154,343,376 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6599:Megf6
|
UTSW |
4 |
154,342,544 (GRCm39) |
splice site |
probably null |
|
|
R6811:Megf6
|
UTSW |
4 |
154,336,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6925:Megf6
|
UTSW |
4 |
154,339,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Megf6
|
UTSW |
4 |
154,338,602 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7117:Megf6
|
UTSW |
4 |
154,343,379 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7163:Megf6
|
UTSW |
4 |
154,351,898 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7345:Megf6
|
UTSW |
4 |
154,351,772 (GRCm39) |
missense |
probably benign |
|
|
R7580:Megf6
|
UTSW |
4 |
154,355,201 (GRCm39) |
nonsense |
probably null |
|
|
R7649:Megf6
|
UTSW |
4 |
154,349,542 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7702:Megf6
|
UTSW |
4 |
154,354,927 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8010:Megf6
|
UTSW |
4 |
154,354,964 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8175:Megf6
|
UTSW |
4 |
154,353,076 (GRCm39) |
nonsense |
probably null |
|
|
R8231:Megf6
|
UTSW |
4 |
154,336,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8436:Megf6
|
UTSW |
4 |
154,349,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8460:Megf6
|
UTSW |
4 |
154,350,634 (GRCm39) |
nonsense |
probably null |
|
|
R8738:Megf6
|
UTSW |
4 |
154,352,436 (GRCm39) |
missense |
probably benign |
|
|
R8854:Megf6
|
UTSW |
4 |
154,352,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Megf6
|
UTSW |
4 |
154,326,860 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9098:Megf6
|
UTSW |
4 |
154,354,160 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9147:Megf6
|
UTSW |
4 |
154,339,130 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9148:Megf6
|
UTSW |
4 |
154,339,130 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9161:Megf6
|
UTSW |
4 |
154,352,172 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9355:Megf6
|
UTSW |
4 |
154,338,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9386:Megf6
|
UTSW |
4 |
154,340,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9404:Megf6
|
UTSW |
4 |
154,348,225 (GRCm39) |
missense |
|
|
|
R9469:Megf6
|
UTSW |
4 |
154,335,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9472:Megf6
|
UTSW |
4 |
154,333,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9777:Megf6
|
UTSW |
4 |
154,343,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Megf6
|
UTSW |
4 |
154,322,283 (GRCm39) |
missense |
probably benign |
0.12 |
|
Z1177:Megf6
|
UTSW |
4 |
154,354,198 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Megf6
|
UTSW |
4 |
154,352,204 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Megf6
|
UTSW |
4 |
154,352,139 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Megf6
|
UTSW |
4 |
154,352,138 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
Z1177:Megf6
|
UTSW |
4 |
154,335,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGGAGCTATAATTCCCAACCTTC -3'
(R):5'- TGGCCTAACCCTCAGGAATC -3'
Sequencing Primer
(F):5'- ACCTGTCACCATGTCACGG -3'
(R):5'- AGGAATCCCCCAGTTGTCC -3'
|
| Posted On |
2016-05-10 |
Incidental Mutation