Incidental Mutation 'R4981:Epha5'
| ID |
384815 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Epha5
|
| Ensembl Gene |
ENSMUSG00000029245 |
| Gene Name |
Eph receptor A5 |
| Synonyms |
Rek7, Cek7, Els1, Ehk1, Hek7, bsk |
| MMRRC Submission |
042576-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4981 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
84202620-84565241 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 84298342 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 406
(T406S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109025
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053733]
[ENSMUST00000113398]
[ENSMUST00000113399]
[ENSMUST00000113401]
[ENSMUST00000113403]
[ENSMUST00000113406]
|
| AlphaFold |
Q60629 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000053733
AA Change: T354S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000060646
Gene: ENSMUSG00000029245
AA Change: T354S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
307 |
387 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
413 |
511 |
2.1e-22 |
PFAM |
|
TyrKc
|
514 |
771 |
9.33e-138 |
SMART |
|
SAM
|
801 |
868 |
6.65e-23 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113398
AA Change: T406S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000109025
Gene: ENSMUSG00000029245
AA Change: T406S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
359 |
439 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
465 |
563 |
8.4e-23 |
PFAM |
|
TyrKc
|
566 |
823 |
9.33e-138 |
SMART |
|
Pfam:SAM_1
|
854 |
894 |
7.2e-11 |
PFAM |
|
Pfam:SAM_2
|
856 |
894 |
1.6e-9 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113399
AA Change: T518S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000109026
Gene: ENSMUSG00000029245
AA Change: T518S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
360 |
450 |
1.53e-6 |
SMART |
|
FN3
|
471 |
551 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
577 |
675 |
3.4e-22 |
PFAM |
|
TyrKc
|
678 |
935 |
9.33e-138 |
SMART |
|
Pfam:SAM_1
|
966 |
1006 |
2.9e-10 |
PFAM |
|
Pfam:SAM_2
|
968 |
1006 |
5.9e-9 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113401
AA Change: T354S
PolyPhen 2
Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000109028
Gene: ENSMUSG00000029245
AA Change: T354S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
307 |
387 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
411 |
488 |
3.1e-30 |
PFAM |
|
TyrKc
|
491 |
748 |
9.33e-138 |
SMART |
|
Pfam:SAM_1
|
779 |
819 |
1.7e-10 |
PFAM |
|
Pfam:SAM_2
|
781 |
819 |
3.5e-9 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113403
AA Change: T518S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000109030
Gene: ENSMUSG00000029245
AA Change: T518S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
360 |
450 |
1.53e-6 |
SMART |
|
FN3
|
471 |
551 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
577 |
675 |
1.2e-25 |
PFAM |
|
TyrKc
|
678 |
935 |
9.33e-138 |
SMART |
|
SAM
|
965 |
1032 |
6.65e-23 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113406
AA Change: T518S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000109033
Gene: ENSMUSG00000029245
AA Change: T518S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
360 |
450 |
1.53e-6 |
SMART |
|
FN3
|
471 |
551 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
575 |
652 |
1.9e-30 |
PFAM |
|
TyrKc
|
655 |
912 |
9.33e-138 |
SMART |
|
SAM
|
942 |
1009 |
6.65e-23 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000154804
|
| Meta Mutation Damage Score |
0.1591 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 96.0%
- 20x: 91.3%
|
| Validation Efficiency |
100% (105/105) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]
PHENOTYPE: Homozygous mutant mice are overtly normal but show abnormal retinal axon mapping. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700097O09Rik |
A |
T |
12: 55,095,772 (GRCm39) |
|
probably null |
Het |
| Aatf |
T |
C |
11: 84,402,323 (GRCm39) |
D121G |
probably benign |
Het |
| Amer2 |
T |
A |
14: 60,617,176 (GRCm39) |
L331H |
probably damaging |
Het |
| Ang4 |
T |
G |
14: 52,001,829 (GRCm39) |
K40Q |
probably benign |
Het |
| Aspm |
A |
C |
1: 139,398,498 (GRCm39) |
|
probably null |
Het |
| Cacna1c |
A |
T |
6: 118,728,432 (GRCm39) |
D337E |
probably benign |
Het |
| Ccdc124 |
T |
C |
8: 71,321,429 (GRCm39) |
E134G |
probably benign |
Het |
| Ccdc7a |
G |
T |
8: 129,711,464 (GRCm39) |
A312E |
probably benign |
Het |
| Cd209g |
A |
G |
8: 4,186,845 (GRCm39) |
D130G |
probably damaging |
Het |
| Cd320 |
T |
C |
17: 34,066,549 (GRCm39) |
S96P |
probably benign |
Het |
| Cenatac |
A |
T |
9: 44,329,245 (GRCm39) |
F14Y |
probably damaging |
Het |
| Clu |
C |
G |
14: 66,210,815 (GRCm39) |
Q134E |
probably damaging |
Het |
| Cnksr3 |
T |
A |
10: 7,110,777 (GRCm39) |
H28L |
probably benign |
Het |
| Cntnap1 |
T |
C |
11: 101,067,159 (GRCm39) |
|
probably null |
Het |
| Col22a1 |
C |
T |
15: 71,732,915 (GRCm39) |
C546Y |
unknown |
Het |
| Col6a3 |
C |
T |
1: 90,706,565 (GRCm39) |
V2183I |
unknown |
Het |
| Cop1 |
A |
G |
1: 159,152,638 (GRCm39) |
|
probably benign |
Het |
| Cpne8 |
T |
C |
15: 90,563,438 (GRCm39) |
I24V |
probably benign |
Het |
| Cspp1 |
T |
A |
1: 10,196,688 (GRCm39) |
N900K |
probably damaging |
Het |
| Dennd5b |
G |
A |
6: 148,911,270 (GRCm39) |
L978F |
possibly damaging |
Het |
| Depdc1a |
G |
T |
3: 159,229,550 (GRCm39) |
M627I |
probably benign |
Het |
| Dnah3 |
A |
T |
7: 119,555,424 (GRCm39) |
N2721K |
probably benign |
Het |
| Dnase1l1 |
C |
T |
X: 73,320,644 (GRCm39) |
|
probably null |
Homo |
| Dsg1b |
A |
G |
18: 20,541,925 (GRCm39) |
T811A |
possibly damaging |
Het |
| Emilin1 |
C |
G |
5: 31,076,695 (GRCm39) |
Q847E |
probably benign |
Het |
| Epha3 |
A |
T |
16: 63,472,775 (GRCm39) |
V370D |
probably benign |
Het |
| Ephb1 |
A |
T |
9: 101,918,159 (GRCm39) |
I450N |
probably benign |
Het |
| Ephb2 |
A |
G |
4: 136,423,321 (GRCm39) |
M319T |
probably benign |
Het |
| Eps15l1 |
A |
G |
8: 73,132,833 (GRCm39) |
|
probably null |
Het |
| Fbxo9 |
G |
A |
9: 77,993,168 (GRCm39) |
|
probably benign |
Het |
| Fgd5 |
T |
C |
6: 91,966,281 (GRCm39) |
I838T |
probably damaging |
Het |
| Fnbp4 |
T |
C |
2: 90,596,174 (GRCm39) |
F582L |
probably damaging |
Het |
| Frs3 |
T |
C |
17: 48,000,187 (GRCm39) |
|
probably null |
Het |
| Fscb |
C |
T |
12: 64,520,393 (GRCm39) |
V358I |
possibly damaging |
Het |
| Fus |
G |
T |
7: 127,566,727 (GRCm39) |
|
probably benign |
Het |
| Fyb1 |
CCTCTCTCTCTCTCTCTCTCT |
CCTCTCTCTCTCTCTCTCT |
15: 6,676,092 (GRCm39) |
|
probably benign |
Het |
| Glra3 |
A |
T |
8: 56,444,270 (GRCm39) |
I77F |
possibly damaging |
Het |
| Gm4454 |
C |
T |
7: 38,269,860 (GRCm39) |
|
noncoding transcript |
Het |
| Gng3 |
G |
A |
19: 8,815,625 (GRCm39) |
A37V |
possibly damaging |
Het |
| Grin3b |
T |
A |
10: 79,812,191 (GRCm39) |
|
probably benign |
Het |
| Herpud1 |
A |
G |
8: 95,118,422 (GRCm39) |
Y41C |
probably damaging |
Het |
| Igkv4-92 |
G |
C |
6: 68,732,028 (GRCm39) |
S115R |
possibly damaging |
Het |
| Ikbip |
T |
A |
10: 90,931,848 (GRCm39) |
I164N |
probably benign |
Het |
| Kank1 |
A |
G |
19: 25,388,759 (GRCm39) |
T783A |
probably benign |
Het |
| Kcnq3 |
A |
T |
15: 65,903,254 (GRCm39) |
V152E |
possibly damaging |
Het |
| Kif23 |
C |
T |
9: 61,839,153 (GRCm39) |
R314H |
probably damaging |
Het |
| Klc4 |
T |
C |
17: 46,955,287 (GRCm39) |
H49R |
probably benign |
Het |
| Klhl20 |
A |
T |
1: 160,930,575 (GRCm39) |
I309N |
possibly damaging |
Het |
| Lgals4 |
A |
G |
7: 28,540,701 (GRCm39) |
Y268C |
probably damaging |
Het |
| Lingo4 |
A |
G |
3: 94,306,761 (GRCm39) |
Q13R |
probably benign |
Het |
| Lmtk2 |
C |
A |
5: 144,113,265 (GRCm39) |
F1328L |
probably damaging |
Het |
| Mapk14 |
A |
G |
17: 28,960,765 (GRCm39) |
R179G |
probably damaging |
Het |
| Mbd3l1 |
A |
T |
9: 18,396,201 (GRCm39) |
T109S |
probably benign |
Het |
| Megf6 |
T |
C |
4: 154,351,907 (GRCm39) |
F1169L |
possibly damaging |
Het |
| Mrgpra1 |
A |
T |
7: 46,984,959 (GRCm39) |
V240D |
probably damaging |
Het |
| Muc6 |
G |
A |
7: 141,218,313 (GRCm39) |
S2120F |
possibly damaging |
Het |
| Myh1 |
T |
C |
11: 67,115,300 (GRCm39) |
|
probably benign |
Het |
| Nav3 |
T |
C |
10: 109,716,553 (GRCm39) |
I172V |
probably benign |
Het |
| Nemp1 |
T |
A |
10: 127,529,399 (GRCm39) |
L178Q |
probably damaging |
Het |
| Numa1 |
T |
C |
7: 101,641,881 (GRCm39) |
S110P |
probably damaging |
Het |
| Or4a75 |
A |
G |
2: 89,447,769 (GRCm39) |
Y256H |
probably damaging |
Het |
| Or4c117 |
T |
C |
2: 88,955,845 (GRCm39) |
T77A |
probably benign |
Het |
| Or51k1 |
A |
G |
7: 103,661,312 (GRCm39) |
I199T |
probably damaging |
Het |
| Or5ak25 |
A |
G |
2: 85,268,813 (GRCm39) |
S230P |
probably damaging |
Het |
| Or8k30 |
T |
C |
2: 86,339,171 (GRCm39) |
Y123H |
probably damaging |
Het |
| Or9q1 |
A |
T |
19: 13,805,458 (GRCm39) |
F101I |
probably damaging |
Het |
| Pard3b |
T |
G |
1: 62,383,219 (GRCm39) |
M771R |
probably damaging |
Het |
| Phkg2 |
A |
G |
7: 127,181,551 (GRCm39) |
I245V |
probably damaging |
Het |
| Pik3cg |
A |
T |
12: 32,254,103 (GRCm39) |
M628K |
possibly damaging |
Het |
| Poln |
A |
G |
5: 34,264,429 (GRCm39) |
|
probably null |
Het |
| Ppip5k1 |
A |
T |
2: 121,142,871 (GRCm39) |
S1172T |
probably damaging |
Het |
| Prdm5 |
A |
T |
6: 65,847,446 (GRCm39) |
H363L |
probably damaging |
Het |
| Prkdc |
A |
G |
16: 15,496,173 (GRCm39) |
Y788C |
probably damaging |
Het |
| Prrc2c |
T |
A |
1: 162,520,116 (GRCm39) |
R2076S |
probably damaging |
Het |
| Sh2d2a |
A |
G |
3: 87,756,728 (GRCm39) |
Y191C |
probably damaging |
Het |
| Slc20a1 |
T |
C |
2: 129,041,919 (GRCm39) |
I94T |
probably damaging |
Het |
| Sptbn2 |
T |
C |
19: 4,801,686 (GRCm39) |
V2366A |
probably benign |
Het |
| Stab2 |
T |
A |
10: 86,796,087 (GRCm39) |
M387L |
probably benign |
Het |
| Syne2 |
T |
G |
12: 75,987,993 (GRCm39) |
M1718R |
probably damaging |
Het |
| Synm |
G |
T |
7: 67,384,235 (GRCm39) |
F700L |
probably benign |
Het |
| Tmco4 |
T |
C |
4: 138,718,012 (GRCm39) |
F51L |
possibly damaging |
Het |
| Tmem104 |
C |
A |
11: 115,095,962 (GRCm39) |
P168T |
probably damaging |
Het |
| Tril |
G |
T |
6: 53,795,905 (GRCm39) |
T439K |
probably benign |
Het |
| Trim2 |
A |
G |
3: 84,085,042 (GRCm39) |
L559P |
probably damaging |
Het |
| Trim3 |
A |
G |
7: 105,268,335 (GRCm39) |
V149A |
probably damaging |
Het |
| Triml2 |
A |
G |
8: 43,640,717 (GRCm39) |
N191S |
probably benign |
Het |
| Usp4 |
A |
G |
9: 108,258,617 (GRCm39) |
D16G |
probably benign |
Het |
| Vmn2r58 |
G |
A |
7: 41,486,885 (GRCm39) |
T670I |
probably damaging |
Het |
| Vmn2r97 |
G |
T |
17: 19,160,436 (GRCm39) |
G524* |
probably null |
Het |
| Xpo5 |
C |
A |
17: 46,531,743 (GRCm39) |
F426L |
probably damaging |
Het |
| Zfp800 |
A |
G |
6: 28,247,190 (GRCm39) |
L84S |
probably damaging |
Het |
| Zranb2 |
T |
G |
3: 157,252,378 (GRCm39) |
|
probably benign |
Het |
| Zswim4 |
C |
T |
8: 84,953,296 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Epha5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00808:Epha5
|
APN |
5 |
84,254,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01084:Epha5
|
APN |
5 |
84,218,946 (GRCm39) |
nonsense |
probably null |
|
|
IGL01462:Epha5
|
APN |
5 |
84,219,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Epha5
|
APN |
5 |
84,534,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01998:Epha5
|
APN |
5 |
84,232,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02744:Epha5
|
APN |
5 |
84,255,848 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL03076:Epha5
|
APN |
5 |
84,479,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03123:Epha5
|
APN |
5 |
84,479,085 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03381:Epha5
|
APN |
5 |
84,479,191 (GRCm39) |
missense |
probably damaging |
0.98 |
|
BB001:Epha5
|
UTSW |
5 |
84,232,705 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
BB011:Epha5
|
UTSW |
5 |
84,232,705 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
PIT4544001:Epha5
|
UTSW |
5 |
84,479,471 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0004:Epha5
|
UTSW |
5 |
84,479,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0490:Epha5
|
UTSW |
5 |
84,255,833 (GRCm39) |
splice site |
probably benign |
|
|
R0545:Epha5
|
UTSW |
5 |
84,215,217 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0835:Epha5
|
UTSW |
5 |
84,534,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1074:Epha5
|
UTSW |
5 |
84,298,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1074:Epha5
|
UTSW |
5 |
84,298,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1075:Epha5
|
UTSW |
5 |
84,298,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1075:Epha5
|
UTSW |
5 |
84,298,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1102:Epha5
|
UTSW |
5 |
84,381,434 (GRCm39) |
splice site |
probably benign |
|
|
R1184:Epha5
|
UTSW |
5 |
84,219,134 (GRCm39) |
splice site |
probably null |
|
|
R1255:Epha5
|
UTSW |
5 |
84,298,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1255:Epha5
|
UTSW |
5 |
84,298,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1327:Epha5
|
UTSW |
5 |
84,254,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1437:Epha5
|
UTSW |
5 |
84,381,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1804:Epha5
|
UTSW |
5 |
84,479,674 (GRCm39) |
missense |
probably benign |
0.21 |
|
R1967:Epha5
|
UTSW |
5 |
84,564,288 (GRCm39) |
missense |
probably benign |
0.23 |
|
R2187:Epha5
|
UTSW |
5 |
84,234,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2282:Epha5
|
UTSW |
5 |
84,298,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2899:Epha5
|
UTSW |
5 |
84,381,667 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3746:Epha5
|
UTSW |
5 |
84,206,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4454:Epha5
|
UTSW |
5 |
84,304,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Epha5
|
UTSW |
5 |
84,298,278 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4809:Epha5
|
UTSW |
5 |
84,253,750 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4810:Epha5
|
UTSW |
5 |
84,253,750 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4825:Epha5
|
UTSW |
5 |
84,381,699 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4833:Epha5
|
UTSW |
5 |
84,253,750 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4961:Epha5
|
UTSW |
5 |
84,381,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4976:Epha5
|
UTSW |
5 |
84,232,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5149:Epha5
|
UTSW |
5 |
84,298,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5422:Epha5
|
UTSW |
5 |
84,479,349 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5575:Epha5
|
UTSW |
5 |
84,564,361 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5664:Epha5
|
UTSW |
5 |
84,479,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5801:Epha5
|
UTSW |
5 |
84,479,085 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5821:Epha5
|
UTSW |
5 |
84,232,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5924:Epha5
|
UTSW |
5 |
84,381,533 (GRCm39) |
nonsense |
probably null |
|
|
R5951:Epha5
|
UTSW |
5 |
84,479,051 (GRCm39) |
intron |
probably benign |
|
|
R5956:Epha5
|
UTSW |
5 |
84,298,228 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6127:Epha5
|
UTSW |
5 |
84,218,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6189:Epha5
|
UTSW |
5 |
84,385,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6240:Epha5
|
UTSW |
5 |
84,265,438 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6343:Epha5
|
UTSW |
5 |
84,254,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6463:Epha5
|
UTSW |
5 |
84,254,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6517:Epha5
|
UTSW |
5 |
84,304,360 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6622:Epha5
|
UTSW |
5 |
84,385,387 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6667:Epha5
|
UTSW |
5 |
84,219,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6741:Epha5
|
UTSW |
5 |
84,254,557 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6757:Epha5
|
UTSW |
5 |
84,253,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6762:Epha5
|
UTSW |
5 |
84,479,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6819:Epha5
|
UTSW |
5 |
84,254,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7019:Epha5
|
UTSW |
5 |
84,564,321 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7031:Epha5
|
UTSW |
5 |
84,290,159 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7213:Epha5
|
UTSW |
5 |
84,381,782 (GRCm39) |
splice site |
probably null |
|
|
R7728:Epha5
|
UTSW |
5 |
84,215,267 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7924:Epha5
|
UTSW |
5 |
84,232,705 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7953:Epha5
|
UTSW |
5 |
84,381,513 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8043:Epha5
|
UTSW |
5 |
84,381,513 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8468:Epha5
|
UTSW |
5 |
84,290,275 (GRCm39) |
splice site |
probably null |
|
|
R8558:Epha5
|
UTSW |
5 |
84,206,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8796:Epha5
|
UTSW |
5 |
84,255,850 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9035:Epha5
|
UTSW |
5 |
84,255,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9060:Epha5
|
UTSW |
5 |
84,218,977 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9244:Epha5
|
UTSW |
5 |
84,265,441 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9347:Epha5
|
UTSW |
5 |
84,479,731 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9355:Epha5
|
UTSW |
5 |
84,253,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9434:Epha5
|
UTSW |
5 |
84,479,227 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
Z1088:Epha5
|
UTSW |
5 |
84,385,381 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Epha5
|
UTSW |
5 |
84,218,979 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGCCTATCGATCCATGGAC -3'
(R):5'- GCTTCAGGGGTAAGAGTCAG -3'
Sequencing Primer
(F):5'- CTCTTCTGGTAACCATTACAGAGAC -3'
(R):5'- GGTAAGAGTCAGAGCTTTGGC -3'
|
| Posted On |
2016-05-10 |
Incidental Mutation