Incidental Mutation 'R4981:Cnksr3'
ID 384847
Institutional Source Beutler Lab
Gene Symbol Cnksr3
Ensembl Gene ENSMUSG00000015202
Gene Name Cnksr family member 3
Synonyms Magi1
MMRRC Submission 042576-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R4981 (G1)
Quality Score 215
Status Validated
Chromosome 10
Chromosomal Location 7069063-7162237 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 7110777 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 28 (H28L)
Ref Sequence ENSEMBL: ENSMUSP00000015346 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000015346]
AlphaFold Q8BMA3
Predicted Effect probably benign
Transcript: ENSMUST00000015346
AA Change: H28L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000015346
Gene: ENSMUSG00000015202
AA Change: H28L

DomainStartEndE-ValueType
SAM 4 72 7.25e-15 SMART
Pfam:CRIC_ras_sig 80 172 3.3e-39 PFAM
PDZ 221 293 4.65e-10 SMART
low complexity region 311 329 N/A INTRINSIC
Pfam:DUF1170 332 545 3.6e-104 PFAM
Meta Mutation Damage Score 0.0836 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.3%
Validation Efficiency 100% (105/105)
Allele List at MGI
Other mutations in this stock
Total: 93 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700097O09Rik A T 12: 55,095,772 (GRCm39) probably null Het
Aatf T C 11: 84,402,323 (GRCm39) D121G probably benign Het
Amer2 T A 14: 60,617,176 (GRCm39) L331H probably damaging Het
Ang4 T G 14: 52,001,829 (GRCm39) K40Q probably benign Het
Aspm A C 1: 139,398,498 (GRCm39) probably null Het
Cacna1c A T 6: 118,728,432 (GRCm39) D337E probably benign Het
Ccdc124 T C 8: 71,321,429 (GRCm39) E134G probably benign Het
Ccdc7a G T 8: 129,711,464 (GRCm39) A312E probably benign Het
Cd209g A G 8: 4,186,845 (GRCm39) D130G probably damaging Het
Cd320 T C 17: 34,066,549 (GRCm39) S96P probably benign Het
Cenatac A T 9: 44,329,245 (GRCm39) F14Y probably damaging Het
Clu C G 14: 66,210,815 (GRCm39) Q134E probably damaging Het
Cntnap1 T C 11: 101,067,159 (GRCm39) probably null Het
Col22a1 C T 15: 71,732,915 (GRCm39) C546Y unknown Het
Col6a3 C T 1: 90,706,565 (GRCm39) V2183I unknown Het
Cop1 A G 1: 159,152,638 (GRCm39) probably benign Het
Cpne8 T C 15: 90,563,438 (GRCm39) I24V probably benign Het
Cspp1 T A 1: 10,196,688 (GRCm39) N900K probably damaging Het
Dennd5b G A 6: 148,911,270 (GRCm39) L978F possibly damaging Het
Depdc1a G T 3: 159,229,550 (GRCm39) M627I probably benign Het
Dnah3 A T 7: 119,555,424 (GRCm39) N2721K probably benign Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Homo
Dsg1b A G 18: 20,541,925 (GRCm39) T811A possibly damaging Het
Emilin1 C G 5: 31,076,695 (GRCm39) Q847E probably benign Het
Epha3 A T 16: 63,472,775 (GRCm39) V370D probably benign Het
Epha5 T A 5: 84,298,342 (GRCm39) T406S probably damaging Het
Ephb1 A T 9: 101,918,159 (GRCm39) I450N probably benign Het
Ephb2 A G 4: 136,423,321 (GRCm39) M319T probably benign Het
Eps15l1 A G 8: 73,132,833 (GRCm39) probably null Het
Fbxo9 G A 9: 77,993,168 (GRCm39) probably benign Het
Fgd5 T C 6: 91,966,281 (GRCm39) I838T probably damaging Het
Fnbp4 T C 2: 90,596,174 (GRCm39) F582L probably damaging Het
Frs3 T C 17: 48,000,187 (GRCm39) probably null Het
Fscb C T 12: 64,520,393 (GRCm39) V358I possibly damaging Het
Fus G T 7: 127,566,727 (GRCm39) probably benign Het
Fyb1 CCTCTCTCTCTCTCTCTCTCT CCTCTCTCTCTCTCTCTCT 15: 6,676,092 (GRCm39) probably benign Het
Glra3 A T 8: 56,444,270 (GRCm39) I77F possibly damaging Het
Gm4454 C T 7: 38,269,860 (GRCm39) noncoding transcript Het
Gng3 G A 19: 8,815,625 (GRCm39) A37V possibly damaging Het
Grin3b T A 10: 79,812,191 (GRCm39) probably benign Het
Herpud1 A G 8: 95,118,422 (GRCm39) Y41C probably damaging Het
Igkv4-92 G C 6: 68,732,028 (GRCm39) S115R possibly damaging Het
Ikbip T A 10: 90,931,848 (GRCm39) I164N probably benign Het
Kank1 A G 19: 25,388,759 (GRCm39) T783A probably benign Het
Kcnq3 A T 15: 65,903,254 (GRCm39) V152E possibly damaging Het
Kif23 C T 9: 61,839,153 (GRCm39) R314H probably damaging Het
Klc4 T C 17: 46,955,287 (GRCm39) H49R probably benign Het
Klhl20 A T 1: 160,930,575 (GRCm39) I309N possibly damaging Het
Lgals4 A G 7: 28,540,701 (GRCm39) Y268C probably damaging Het
Lingo4 A G 3: 94,306,761 (GRCm39) Q13R probably benign Het
Lmtk2 C A 5: 144,113,265 (GRCm39) F1328L probably damaging Het
Mapk14 A G 17: 28,960,765 (GRCm39) R179G probably damaging Het
Mbd3l1 A T 9: 18,396,201 (GRCm39) T109S probably benign Het
Megf6 T C 4: 154,351,907 (GRCm39) F1169L possibly damaging Het
Mrgpra1 A T 7: 46,984,959 (GRCm39) V240D probably damaging Het
Muc6 G A 7: 141,218,313 (GRCm39) S2120F possibly damaging Het
Myh1 T C 11: 67,115,300 (GRCm39) probably benign Het
Nav3 T C 10: 109,716,553 (GRCm39) I172V probably benign Het
Nemp1 T A 10: 127,529,399 (GRCm39) L178Q probably damaging Het
Numa1 T C 7: 101,641,881 (GRCm39) S110P probably damaging Het
Or4a75 A G 2: 89,447,769 (GRCm39) Y256H probably damaging Het
Or4c117 T C 2: 88,955,845 (GRCm39) T77A probably benign Het
Or51k1 A G 7: 103,661,312 (GRCm39) I199T probably damaging Het
Or5ak25 A G 2: 85,268,813 (GRCm39) S230P probably damaging Het
Or8k30 T C 2: 86,339,171 (GRCm39) Y123H probably damaging Het
Or9q1 A T 19: 13,805,458 (GRCm39) F101I probably damaging Het
Pard3b T G 1: 62,383,219 (GRCm39) M771R probably damaging Het
Phkg2 A G 7: 127,181,551 (GRCm39) I245V probably damaging Het
Pik3cg A T 12: 32,254,103 (GRCm39) M628K possibly damaging Het
Poln A G 5: 34,264,429 (GRCm39) probably null Het
Ppip5k1 A T 2: 121,142,871 (GRCm39) S1172T probably damaging Het
Prdm5 A T 6: 65,847,446 (GRCm39) H363L probably damaging Het
Prkdc A G 16: 15,496,173 (GRCm39) Y788C probably damaging Het
Prrc2c T A 1: 162,520,116 (GRCm39) R2076S probably damaging Het
Sh2d2a A G 3: 87,756,728 (GRCm39) Y191C probably damaging Het
Slc20a1 T C 2: 129,041,919 (GRCm39) I94T probably damaging Het
Sptbn2 T C 19: 4,801,686 (GRCm39) V2366A probably benign Het
Stab2 T A 10: 86,796,087 (GRCm39) M387L probably benign Het
Syne2 T G 12: 75,987,993 (GRCm39) M1718R probably damaging Het
Synm G T 7: 67,384,235 (GRCm39) F700L probably benign Het
Tmco4 T C 4: 138,718,012 (GRCm39) F51L possibly damaging Het
Tmem104 C A 11: 115,095,962 (GRCm39) P168T probably damaging Het
Tril G T 6: 53,795,905 (GRCm39) T439K probably benign Het
Trim2 A G 3: 84,085,042 (GRCm39) L559P probably damaging Het
Trim3 A G 7: 105,268,335 (GRCm39) V149A probably damaging Het
Triml2 A G 8: 43,640,717 (GRCm39) N191S probably benign Het
Usp4 A G 9: 108,258,617 (GRCm39) D16G probably benign Het
Vmn2r58 G A 7: 41,486,885 (GRCm39) T670I probably damaging Het
Vmn2r97 G T 17: 19,160,436 (GRCm39) G524* probably null Het
Xpo5 C A 17: 46,531,743 (GRCm39) F426L probably damaging Het
Zfp800 A G 6: 28,247,190 (GRCm39) L84S probably damaging Het
Zranb2 T G 3: 157,252,378 (GRCm39) probably benign Het
Zswim4 C T 8: 84,953,296 (GRCm39) probably null Het
Other mutations in Cnksr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01303:Cnksr3 APN 10 7,104,281 (GRCm39) critical splice donor site probably null
IGL01583:Cnksr3 APN 10 7,070,512 (GRCm39) missense probably benign
IGL02374:Cnksr3 APN 10 7,070,335 (GRCm39) missense probably damaging 1.00
IGL02541:Cnksr3 APN 10 7,085,073 (GRCm39) missense probably damaging 1.00
IGL02551:Cnksr3 APN 10 7,102,912 (GRCm39) missense probably damaging 1.00
IGL02975:Cnksr3 APN 10 7,088,354 (GRCm39) critical splice donor site probably null
R0652:Cnksr3 UTSW 10 7,070,463 (GRCm39) missense probably damaging 1.00
R1451:Cnksr3 UTSW 10 7,076,830 (GRCm39) missense probably null 0.93
R1453:Cnksr3 UTSW 10 7,079,132 (GRCm39) missense probably benign 0.00
R1847:Cnksr3 UTSW 10 7,104,324 (GRCm39) missense probably benign 0.01
R1852:Cnksr3 UTSW 10 7,070,539 (GRCm39) missense probably benign 0.06
R3002:Cnksr3 UTSW 10 7,102,856 (GRCm39) splice site probably benign
R4621:Cnksr3 UTSW 10 7,076,182 (GRCm39) missense possibly damaging 0.85
R4835:Cnksr3 UTSW 10 7,110,757 (GRCm39) missense possibly damaging 0.76
R4941:Cnksr3 UTSW 10 7,102,925 (GRCm39) missense probably benign 0.07
R5000:Cnksr3 UTSW 10 7,076,746 (GRCm39) nonsense probably null
R5001:Cnksr3 UTSW 10 7,076,746 (GRCm39) nonsense probably null
R5267:Cnksr3 UTSW 10 7,076,633 (GRCm39) critical splice donor site probably null
R5322:Cnksr3 UTSW 10 7,085,078 (GRCm39) missense probably damaging 1.00
R5623:Cnksr3 UTSW 10 7,070,548 (GRCm39) missense probably damaging 1.00
R5853:Cnksr3 UTSW 10 7,092,977 (GRCm39) missense probably benign 0.09
R5930:Cnksr3 UTSW 10 7,092,993 (GRCm39) missense probably benign
R6459:Cnksr3 UTSW 10 7,076,820 (GRCm39) missense probably benign 0.00
R6893:Cnksr3 UTSW 10 7,085,129 (GRCm39) splice site probably null
R6941:Cnksr3 UTSW 10 7,076,758 (GRCm39) missense probably damaging 1.00
R6949:Cnksr3 UTSW 10 7,110,757 (GRCm39) missense probably benign 0.02
R7075:Cnksr3 UTSW 10 7,102,931 (GRCm39) missense probably benign 0.33
R7487:Cnksr3 UTSW 10 7,085,097 (GRCm39) missense probably benign 0.01
R8165:Cnksr3 UTSW 10 7,104,467 (GRCm39) missense probably damaging 0.99
R8181:Cnksr3 UTSW 10 7,070,475 (GRCm39) missense possibly damaging 0.94
R8472:Cnksr3 UTSW 10 7,084,532 (GRCm39) missense probably damaging 0.98
R8885:Cnksr3 UTSW 10 7,090,201 (GRCm39) unclassified probably benign
R8887:Cnksr3 UTSW 10 7,104,467 (GRCm39) missense probably damaging 0.99
R8930:Cnksr3 UTSW 10 7,110,780 (GRCm39) missense probably damaging 1.00
R8932:Cnksr3 UTSW 10 7,110,780 (GRCm39) missense probably damaging 1.00
R9195:Cnksr3 UTSW 10 7,088,379 (GRCm39) missense probably damaging 1.00
R9617:Cnksr3 UTSW 10 7,079,021 (GRCm39) critical splice donor site probably null
Z1176:Cnksr3 UTSW 10 7,084,544 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTCTGATGGTCCGCTGATAC -3'
(R):5'- TGCTGCACTGGATCCATTTG -3'

Sequencing Primer
(F):5'- TTCCATCCTCCTAAGAACGTGAGG -3'
(R):5'- TGAGAGTTTGCAGTGCCCAC -3'
Posted On 2016-05-10