Incidental Mutation 'R4994:Arhgap21'
| ID |
385068 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgap21
|
| Ensembl Gene |
ENSMUSG00000036591 |
| Gene Name |
Rho GTPase activating protein 21 |
| Synonyms |
ARHGAP10, 5530401C11Rik |
| MMRRC Submission |
042588-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.442)
|
| Stock # |
R4994 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
20852730-20973692 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 20854701 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 1554
(T1554S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133851
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000114594]
[ENSMUST00000141298]
[ENSMUST00000154230]
[ENSMUST00000173194]
[ENSMUST00000174584]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000114594
AA Change: T1558S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000110241
Gene: ENSMUSG00000036591
AA Change: T1558S
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
58 |
159 |
1.03e-16 |
SMART |
|
low complexity region
|
351 |
362 |
N/A |
INTRINSIC |
|
low complexity region
|
445 |
459 |
N/A |
INTRINSIC |
|
low complexity region
|
625 |
635 |
N/A |
INTRINSIC |
|
low complexity region
|
911 |
925 |
N/A |
INTRINSIC |
|
PH
|
930 |
1040 |
2.09e-16 |
SMART |
|
RhoGAP
|
1157 |
1334 |
3.26e-62 |
SMART |
|
low complexity region
|
1381 |
1399 |
N/A |
INTRINSIC |
|
low complexity region
|
1448 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1533 |
1565 |
N/A |
INTRINSIC |
|
low complexity region
|
1573 |
1593 |
N/A |
INTRINSIC |
|
low complexity region
|
1891 |
1900 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127512
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131542
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136241
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141298
AA Change: T1564S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000120357
Gene: ENSMUSG00000036591
AA Change: T1564S
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
357 |
368 |
N/A |
INTRINSIC |
|
low complexity region
|
451 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
931 |
N/A |
INTRINSIC |
|
PH
|
936 |
1046 |
2.09e-16 |
SMART |
|
RhoGAP
|
1163 |
1340 |
3.26e-62 |
SMART |
|
low complexity region
|
1387 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1472 |
N/A |
INTRINSIC |
|
low complexity region
|
1539 |
1571 |
N/A |
INTRINSIC |
|
low complexity region
|
1579 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1897 |
1906 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143491
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000154230
AA Change: T1564S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000122497
Gene: ENSMUSG00000036591
AA Change: T1564S
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
357 |
368 |
N/A |
INTRINSIC |
|
low complexity region
|
451 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
931 |
N/A |
INTRINSIC |
|
PH
|
936 |
1046 |
2.09e-16 |
SMART |
|
RhoGAP
|
1163 |
1340 |
3.26e-62 |
SMART |
|
low complexity region
|
1387 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1472 |
N/A |
INTRINSIC |
|
low complexity region
|
1539 |
1571 |
N/A |
INTRINSIC |
|
low complexity region
|
1579 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1897 |
1906 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173194
AA Change: T1554S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000133851
Gene: ENSMUSG00000036591
AA Change: T1554S
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
347 |
358 |
N/A |
INTRINSIC |
|
low complexity region
|
441 |
455 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
631 |
N/A |
INTRINSIC |
|
low complexity region
|
907 |
921 |
N/A |
INTRINSIC |
|
PH
|
926 |
1036 |
2.09e-16 |
SMART |
|
RhoGAP
|
1153 |
1330 |
3.26e-62 |
SMART |
|
low complexity region
|
1377 |
1395 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1529 |
1561 |
N/A |
INTRINSIC |
|
low complexity region
|
1569 |
1589 |
N/A |
INTRINSIC |
|
low complexity region
|
1887 |
1896 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000174825
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174584
|
| SMART Domains |
Protein: ENSMUSP00000133347
Gene: ENSMUSG00000036591
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
186 |
197 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
294 |
N/A |
INTRINSIC |
|
low complexity region
|
460 |
470 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
760 |
N/A |
INTRINSIC |
|
PH
|
765 |
875 |
2.09e-16 |
SMART |
|
RhoGAP
|
992 |
1169 |
3.26e-62 |
SMART |
|
| Meta Mutation Damage Score |
0.0687 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
100% (79/79) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700030K09Rik |
A |
G |
8: 73,208,962 (GRCm39) |
E364G |
probably benign |
Het |
| 4930505A04Rik |
C |
T |
11: 30,376,349 (GRCm39) |
V173M |
probably damaging |
Het |
| Abcb4 |
A |
G |
5: 8,978,524 (GRCm39) |
T557A |
probably damaging |
Het |
| Acadm |
C |
T |
3: 153,635,221 (GRCm39) |
E298K |
probably damaging |
Het |
| Adrb3 |
T |
C |
8: 27,717,855 (GRCm39) |
|
probably null |
Het |
| Aldh1b1 |
A |
G |
4: 45,803,128 (GRCm39) |
Y222C |
possibly damaging |
Het |
| Ankrd6 |
A |
G |
4: 32,860,387 (GRCm39) |
Y19H |
probably damaging |
Het |
| BC043934 |
T |
C |
9: 96,319,173 (GRCm39) |
|
noncoding transcript |
Het |
| Birc6 |
A |
G |
17: 74,901,319 (GRCm39) |
|
probably benign |
Het |
| Blm |
A |
C |
7: 80,108,573 (GRCm39) |
F1357C |
probably benign |
Het |
| Cd209a |
T |
C |
8: 3,797,713 (GRCm39) |
|
probably null |
Het |
| Cdk7 |
G |
A |
13: 100,854,103 (GRCm39) |
H129Y |
probably damaging |
Het |
| Clec14a |
G |
T |
12: 58,315,070 (GRCm39) |
P184Q |
probably damaging |
Het |
| Cma1 |
T |
A |
14: 56,179,128 (GRCm39) |
I243F |
probably damaging |
Het |
| Cntnap3 |
G |
T |
13: 64,909,798 (GRCm39) |
T769K |
possibly damaging |
Het |
| Col5a1 |
A |
C |
2: 27,922,751 (GRCm39) |
K273T |
possibly damaging |
Het |
| Csnk1e |
A |
G |
15: 79,309,129 (GRCm39) |
Y266H |
probably damaging |
Het |
| Cyb5d1 |
A |
G |
11: 69,284,597 (GRCm39) |
L185S |
probably damaging |
Het |
| Dennd5b |
T |
C |
6: 148,942,998 (GRCm39) |
|
probably null |
Het |
| Dipk2a |
C |
A |
9: 94,419,486 (GRCm39) |
R148L |
probably benign |
Het |
| Drp2 |
G |
A |
X: 133,342,065 (GRCm39) |
R567H |
probably damaging |
Homo |
| Dzank1 |
T |
G |
2: 144,364,486 (GRCm39) |
D37A |
probably damaging |
Het |
| Echdc2 |
A |
G |
4: 108,022,825 (GRCm39) |
I34V |
probably benign |
Het |
| Esm1 |
A |
T |
13: 113,349,965 (GRCm39) |
R128S |
probably benign |
Het |
| Fbh1 |
T |
A |
2: 11,769,041 (GRCm39) |
I251F |
probably damaging |
Het |
| Fbrsl1 |
A |
G |
5: 110,595,817 (GRCm39) |
S73P |
probably damaging |
Het |
| Fbxo6 |
A |
T |
4: 148,233,948 (GRCm39) |
S49R |
probably damaging |
Het |
| Gm17093 |
A |
T |
14: 44,756,779 (GRCm39) |
Q82L |
probably damaging |
Het |
| Hmcn2 |
T |
C |
2: 31,348,067 (GRCm39) |
|
probably null |
Het |
| Hspa4l |
C |
A |
3: 40,700,081 (GRCm39) |
|
probably benign |
Het |
| Il3ra |
G |
A |
14: 14,351,080 (GRCm38) |
A201T |
probably benign |
Het |
| Irx5 |
T |
A |
8: 93,087,409 (GRCm39) |
V447E |
probably damaging |
Het |
| Kif14 |
G |
T |
1: 136,410,697 (GRCm39) |
L668F |
probably damaging |
Het |
| Lag3 |
T |
A |
6: 124,881,416 (GRCm39) |
R519W |
unknown |
Het |
| Lgr4 |
A |
G |
2: 109,842,283 (GRCm39) |
N756S |
probably damaging |
Het |
| Lingo4 |
A |
G |
3: 94,309,848 (GRCm39) |
H262R |
probably benign |
Het |
| Lingo4 |
T |
A |
3: 94,310,308 (GRCm39) |
H415Q |
probably benign |
Het |
| Lkaaear1 |
C |
A |
2: 181,339,376 (GRCm39) |
G25* |
probably null |
Het |
| Maco1 |
A |
G |
4: 134,555,610 (GRCm39) |
Y288H |
probably damaging |
Het |
| Marf1 |
T |
C |
16: 13,932,095 (GRCm39) |
K1641E |
probably benign |
Het |
| Mtfmt |
T |
C |
9: 65,351,133 (GRCm39) |
|
probably benign |
Het |
| Mtif3 |
G |
A |
5: 146,893,598 (GRCm39) |
T203M |
probably benign |
Het |
| Mycbp2 |
A |
G |
14: 103,407,430 (GRCm39) |
I2740T |
probably benign |
Het |
| Nrdc |
A |
G |
4: 108,903,809 (GRCm39) |
T720A |
probably benign |
Het |
| Or2d2 |
T |
C |
7: 106,728,271 (GRCm39) |
T110A |
probably benign |
Het |
| Peak1 |
T |
A |
9: 56,148,560 (GRCm39) |
D32V |
possibly damaging |
Het |
| Pigr |
G |
A |
1: 130,769,554 (GRCm39) |
D122N |
probably benign |
Het |
| Plekhg3 |
A |
G |
12: 76,612,311 (GRCm39) |
R391G |
possibly damaging |
Het |
| Ppfia3 |
T |
C |
7: 44,990,542 (GRCm39) |
D919G |
probably damaging |
Het |
| Pramel23 |
T |
A |
4: 143,424,939 (GRCm39) |
Q168L |
possibly damaging |
Het |
| Rnase2b |
T |
A |
14: 51,400,208 (GRCm39) |
D96E |
possibly damaging |
Het |
| Rsf1 |
CGGCGGC |
CGGCGGCCGCGGCGGC |
7: 97,229,130 (GRCm39) |
|
probably benign |
Het |
| Rsf1 |
G |
GACGGCGGCT |
7: 97,229,116 (GRCm39) |
|
probably benign |
Het |
| Serpina3f |
A |
G |
12: 104,186,615 (GRCm39) |
T394A |
probably benign |
Het |
| Six3 |
A |
G |
17: 85,928,720 (GRCm39) |
N18S |
possibly damaging |
Het |
| Slc12a5 |
T |
A |
2: 164,825,285 (GRCm39) |
|
probably null |
Het |
| Slc35f6 |
A |
G |
5: 30,805,427 (GRCm39) |
N21S |
probably damaging |
Het |
| Slc39a6 |
A |
T |
18: 24,729,351 (GRCm39) |
I454N |
probably damaging |
Het |
| Slc40a1 |
T |
A |
1: 45,948,824 (GRCm39) |
E485D |
probably damaging |
Het |
| Sort1 |
G |
A |
3: 108,235,385 (GRCm39) |
C255Y |
probably damaging |
Het |
| Stab2 |
T |
A |
10: 86,785,771 (GRCm39) |
T624S |
probably benign |
Het |
| Stk33 |
T |
A |
7: 108,939,605 (GRCm39) |
I99L |
probably benign |
Het |
| Taf4b |
T |
A |
18: 15,031,100 (GRCm39) |
I828N |
probably damaging |
Het |
| Terf2 |
T |
C |
8: 107,803,110 (GRCm39) |
|
probably benign |
Het |
| Timd4 |
C |
T |
11: 46,706,344 (GRCm39) |
R49C |
probably damaging |
Het |
| Tpte |
T |
C |
8: 22,808,362 (GRCm39) |
S166P |
probably benign |
Het |
| Trabd2b |
T |
C |
4: 114,264,052 (GRCm39) |
L13P |
probably benign |
Het |
| Trappc11 |
A |
T |
8: 47,975,476 (GRCm39) |
Y247* |
probably null |
Het |
| Trnt1 |
C |
T |
6: 106,755,853 (GRCm39) |
Q303* |
probably null |
Het |
| Tspyl5 |
T |
A |
15: 33,687,201 (GRCm39) |
Q248L |
possibly damaging |
Het |
| Ubxn7 |
A |
T |
16: 32,200,322 (GRCm39) |
K337N |
probably damaging |
Het |
| Unc13a |
T |
A |
8: 72,095,816 (GRCm39) |
I1234F |
probably benign |
Het |
| Vmn1r127 |
A |
T |
7: 21,052,943 (GRCm39) |
F282I |
probably damaging |
Het |
| Wdhd1 |
A |
T |
14: 47,506,111 (GRCm39) |
|
probably null |
Het |
| Zfp605 |
A |
G |
5: 110,275,352 (GRCm39) |
K157E |
probably damaging |
Het |
| Zhx2 |
T |
A |
15: 57,684,755 (GRCm39) |
D41E |
probably benign |
Het |
|
| Other mutations in Arhgap21 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01382:Arhgap21
|
APN |
2 |
20,860,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01472:Arhgap21
|
APN |
2 |
20,854,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01634:Arhgap21
|
APN |
2 |
20,919,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01766:Arhgap21
|
APN |
2 |
20,854,448 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02097:Arhgap21
|
APN |
2 |
20,884,813 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02197:Arhgap21
|
APN |
2 |
20,885,117 (GRCm39) |
missense |
probably benign |
|
|
IGL02264:Arhgap21
|
APN |
2 |
20,864,850 (GRCm39) |
splice site |
probably null |
|
|
IGL02346:Arhgap21
|
APN |
2 |
20,884,762 (GRCm39) |
splice site |
probably benign |
|
|
IGL02418:Arhgap21
|
APN |
2 |
20,885,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02605:Arhgap21
|
APN |
2 |
20,860,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02701:Arhgap21
|
APN |
2 |
20,896,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03019:Arhgap21
|
APN |
2 |
20,865,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03085:Arhgap21
|
APN |
2 |
20,919,532 (GRCm39) |
missense |
probably benign |
|
|
IGL03265:Arhgap21
|
APN |
2 |
20,854,439 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03379:Arhgap21
|
APN |
2 |
20,885,500 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0304:Arhgap21
|
UTSW |
2 |
20,864,612 (GRCm39) |
splice site |
probably benign |
|
|
R0363:Arhgap21
|
UTSW |
2 |
20,885,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0498:Arhgap21
|
UTSW |
2 |
20,867,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0539:Arhgap21
|
UTSW |
2 |
20,919,610 (GRCm39) |
nonsense |
probably null |
|
|
R0633:Arhgap21
|
UTSW |
2 |
20,860,198 (GRCm39) |
nonsense |
probably null |
|
|
R0905:Arhgap21
|
UTSW |
2 |
20,854,745 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1550:Arhgap21
|
UTSW |
2 |
20,886,576 (GRCm39) |
nonsense |
probably null |
|
|
R1570:Arhgap21
|
UTSW |
2 |
20,885,651 (GRCm39) |
missense |
probably benign |
|
|
R1686:Arhgap21
|
UTSW |
2 |
20,886,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1746:Arhgap21
|
UTSW |
2 |
20,865,910 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1864:Arhgap21
|
UTSW |
2 |
20,866,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1865:Arhgap21
|
UTSW |
2 |
20,866,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2209:Arhgap21
|
UTSW |
2 |
20,854,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2211:Arhgap21
|
UTSW |
2 |
20,886,451 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2276:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2277:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2279:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2336:Arhgap21
|
UTSW |
2 |
20,884,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2516:Arhgap21
|
UTSW |
2 |
20,859,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3722:Arhgap21
|
UTSW |
2 |
20,855,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3877:Arhgap21
|
UTSW |
2 |
20,864,717 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4017:Arhgap21
|
UTSW |
2 |
20,896,915 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4232:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4233:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4234:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4235:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4236:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4434:Arhgap21
|
UTSW |
2 |
20,972,146 (GRCm39) |
missense |
probably benign |
|
|
R4686:Arhgap21
|
UTSW |
2 |
20,868,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4817:Arhgap21
|
UTSW |
2 |
20,854,967 (GRCm39) |
missense |
probably benign |
|
|
R4834:Arhgap21
|
UTSW |
2 |
20,870,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4845:Arhgap21
|
UTSW |
2 |
20,885,998 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4889:Arhgap21
|
UTSW |
2 |
20,885,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4904:Arhgap21
|
UTSW |
2 |
20,854,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4911:Arhgap21
|
UTSW |
2 |
20,863,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5067:Arhgap21
|
UTSW |
2 |
20,884,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5086:Arhgap21
|
UTSW |
2 |
20,853,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5281:Arhgap21
|
UTSW |
2 |
20,854,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5364:Arhgap21
|
UTSW |
2 |
20,854,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5420:Arhgap21
|
UTSW |
2 |
20,885,897 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5476:Arhgap21
|
UTSW |
2 |
20,885,497 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5831:Arhgap21
|
UTSW |
2 |
20,868,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5949:Arhgap21
|
UTSW |
2 |
20,853,852 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5994:Arhgap21
|
UTSW |
2 |
20,886,187 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6014:Arhgap21
|
UTSW |
2 |
20,886,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6739:Arhgap21
|
UTSW |
2 |
20,885,543 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6817:Arhgap21
|
UTSW |
2 |
20,885,107 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6821:Arhgap21
|
UTSW |
2 |
20,853,659 (GRCm39) |
missense |
probably benign |
|
|
R6844:Arhgap21
|
UTSW |
2 |
20,886,116 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6870:Arhgap21
|
UTSW |
2 |
20,885,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6891:Arhgap21
|
UTSW |
2 |
20,855,142 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7011:Arhgap21
|
UTSW |
2 |
20,853,689 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7144:Arhgap21
|
UTSW |
2 |
20,870,198 (GRCm39) |
missense |
probably benign |
|
|
R7237:Arhgap21
|
UTSW |
2 |
20,854,783 (GRCm39) |
nonsense |
probably null |
|
|
R7261:Arhgap21
|
UTSW |
2 |
20,885,177 (GRCm39) |
missense |
probably benign |
|
|
R7558:Arhgap21
|
UTSW |
2 |
20,860,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7566:Arhgap21
|
UTSW |
2 |
20,917,102 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7738:Arhgap21
|
UTSW |
2 |
20,855,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7738:Arhgap21
|
UTSW |
2 |
20,854,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7820:Arhgap21
|
UTSW |
2 |
20,867,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7822:Arhgap21
|
UTSW |
2 |
20,885,524 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7965:Arhgap21
|
UTSW |
2 |
20,854,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7986:Arhgap21
|
UTSW |
2 |
20,867,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8028:Arhgap21
|
UTSW |
2 |
20,885,216 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8209:Arhgap21
|
UTSW |
2 |
20,876,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8226:Arhgap21
|
UTSW |
2 |
20,876,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8251:Arhgap21
|
UTSW |
2 |
20,854,221 (GRCm39) |
missense |
probably benign |
|
|
R8486:Arhgap21
|
UTSW |
2 |
20,865,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8487:Arhgap21
|
UTSW |
2 |
20,886,116 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8508:Arhgap21
|
UTSW |
2 |
20,858,991 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8835:Arhgap21
|
UTSW |
2 |
20,972,144 (GRCm39) |
nonsense |
probably null |
|
|
R9140:Arhgap21
|
UTSW |
2 |
20,886,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9190:Arhgap21
|
UTSW |
2 |
20,858,983 (GRCm39) |
missense |
probably null |
0.04 |
|
R9204:Arhgap21
|
UTSW |
2 |
20,885,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9227:Arhgap21
|
UTSW |
2 |
20,860,469 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9230:Arhgap21
|
UTSW |
2 |
20,860,469 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9308:Arhgap21
|
UTSW |
2 |
20,854,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9374:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9449:Arhgap21
|
UTSW |
2 |
20,885,464 (GRCm39) |
missense |
probably benign |
|
|
R9454:Arhgap21
|
UTSW |
2 |
20,870,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9499:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9544:Arhgap21
|
UTSW |
2 |
20,858,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9552:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9567:Arhgap21
|
UTSW |
2 |
20,896,953 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9588:Arhgap21
|
UTSW |
2 |
20,858,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9749:Arhgap21
|
UTSW |
2 |
20,854,026 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1191:Arhgap21
|
UTSW |
2 |
20,886,283 (GRCm39) |
missense |
probably benign |
0.30 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAACTCACTCTCACTGTCGG -3'
(R):5'- GATACCGTGGGAAGAACCATC -3'
Sequencing Primer
(F):5'- ACTGTCGGTCTCCACTGG -3'
(R):5'- GGAAGAACCATCCCCACCAC -3'
|
| Posted On |
2016-05-10 |
Incidental Mutation