Incidental Mutation 'R0374:Vmn2r87'
| ID |
38529 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r87
|
| Ensembl Gene |
ENSMUSG00000091511 |
| Gene Name |
vomeronasal 2, receptor 87 |
| Synonyms |
EG625131 |
| MMRRC Submission |
038580-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.067)
|
| Stock # |
R0374 (G1)
|
| Quality Score |
117 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
130307690-130333248 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 130307848 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Cysteine
at position 797
(S797C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129215
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164227]
|
| AlphaFold |
E9PZX4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164227
AA Change: S797C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129215
Gene: ENSMUSG00000091511
AA Change: S797C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
422 |
1.8e-27 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
1.8e-19 |
PFAM |
|
Pfam:7tm_3
|
595 |
829 |
8.8e-55 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000218030
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.0%
- 20x: 94.9%
|
| Validation Efficiency |
99% (69/70) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ano9 |
A |
G |
7: 140,687,727 (GRCm39) |
I267T |
probably damaging |
Het |
| Anxa6 |
T |
A |
11: 54,896,654 (GRCm39) |
N168I |
probably benign |
Het |
| Apbb1ip |
A |
G |
2: 22,709,717 (GRCm39) |
|
probably benign |
Het |
| Aqr |
G |
A |
2: 113,961,092 (GRCm39) |
H723Y |
probably damaging |
Het |
| Bbx |
C |
T |
16: 50,100,755 (GRCm39) |
E47K |
probably benign |
Het |
| Car13 |
A |
G |
3: 14,721,357 (GRCm39) |
|
probably benign |
Het |
| Casp9 |
T |
A |
4: 141,534,484 (GRCm39) |
I298N |
possibly damaging |
Het |
| Ccdc66 |
T |
C |
14: 27,220,430 (GRCm39) |
E261G |
probably damaging |
Het |
| Cep192 |
T |
A |
18: 67,951,954 (GRCm39) |
Y376* |
probably null |
Het |
| Cped1 |
T |
A |
6: 22,222,545 (GRCm39) |
|
probably benign |
Het |
| Ctbp2 |
A |
T |
7: 132,601,073 (GRCm39) |
S563R |
possibly damaging |
Het |
| Ctdp1 |
A |
G |
18: 80,490,637 (GRCm39) |
|
probably null |
Het |
| Dgka |
G |
C |
10: 128,556,952 (GRCm39) |
|
probably benign |
Het |
| Drd2 |
A |
G |
9: 49,311,084 (GRCm39) |
T112A |
probably benign |
Het |
| Dusp1 |
A |
G |
17: 26,727,143 (GRCm39) |
V52A |
probably damaging |
Het |
| Eea1 |
T |
A |
10: 95,875,634 (GRCm39) |
|
probably benign |
Het |
| Etfrf1 |
T |
C |
6: 145,161,288 (GRCm39) |
V86A |
probably benign |
Het |
| Fbn1 |
A |
T |
2: 125,163,596 (GRCm39) |
C2087S |
possibly damaging |
Het |
| Fosb |
T |
G |
7: 19,041,075 (GRCm39) |
R139S |
probably damaging |
Het |
| Foxm1 |
C |
T |
6: 128,349,566 (GRCm39) |
R362W |
probably damaging |
Het |
| Frem2 |
A |
G |
3: 53,561,381 (GRCm39) |
V1042A |
probably damaging |
Het |
| Gbe1 |
A |
G |
16: 70,280,802 (GRCm39) |
H401R |
probably benign |
Het |
| Gm10549 |
C |
T |
18: 33,597,235 (GRCm39) |
|
probably benign |
Het |
| Golga7b |
A |
T |
19: 42,251,758 (GRCm39) |
|
probably benign |
Het |
| H2-DMb1 |
T |
C |
17: 34,378,399 (GRCm39) |
V235A |
probably benign |
Het |
| Hr |
A |
G |
14: 70,793,916 (GRCm39) |
T59A |
probably benign |
Het |
| Itpr2 |
C |
A |
6: 146,260,890 (GRCm39) |
A588S |
probably benign |
Het |
| Kmt2c |
G |
A |
5: 25,514,706 (GRCm39) |
P3046S |
probably damaging |
Het |
| Lamc1 |
G |
A |
1: 153,126,811 (GRCm39) |
|
probably benign |
Het |
| Lrp2 |
A |
G |
2: 69,260,651 (GRCm39) |
Y4527H |
probably damaging |
Het |
| Map3k2 |
G |
A |
18: 32,345,226 (GRCm39) |
|
probably null |
Het |
| Mroh2a |
C |
A |
1: 88,170,142 (GRCm39) |
A685D |
possibly damaging |
Het |
| Nfs1 |
C |
G |
2: 155,974,580 (GRCm39) |
G212R |
probably damaging |
Het |
| Nol8 |
C |
T |
13: 49,815,923 (GRCm39) |
A677V |
possibly damaging |
Het |
| Nrap |
T |
A |
19: 56,340,054 (GRCm39) |
Y740F |
probably damaging |
Het |
| Nup205 |
T |
A |
6: 35,185,772 (GRCm39) |
M859K |
probably damaging |
Het |
| Nxf1 |
T |
C |
19: 8,745,103 (GRCm39) |
F451S |
possibly damaging |
Het |
| Or5an1c |
A |
T |
19: 12,218,505 (GRCm39) |
N173K |
probably damaging |
Het |
| Or6c6c |
G |
A |
10: 129,541,516 (GRCm39) |
M256I |
probably benign |
Het |
| Pcdhac2 |
T |
C |
18: 37,278,720 (GRCm39) |
Y567H |
probably damaging |
Het |
| Phlpp2 |
C |
T |
8: 110,634,145 (GRCm39) |
R242W |
probably damaging |
Het |
| Pi4ka |
A |
G |
16: 17,100,796 (GRCm39) |
|
probably benign |
Het |
| Pmpcb |
A |
G |
5: 21,953,829 (GRCm39) |
D359G |
probably damaging |
Het |
| Poll |
T |
G |
19: 45,546,309 (GRCm39) |
S244R |
probably benign |
Het |
| Prkd3 |
T |
C |
17: 79,264,644 (GRCm39) |
D657G |
probably null |
Het |
| Prune2 |
G |
A |
19: 17,098,274 (GRCm39) |
M1259I |
probably benign |
Het |
| Ptpra |
T |
A |
2: 130,379,541 (GRCm39) |
M329K |
probably damaging |
Het |
| Rbm10 |
GGGAGGAGGAGGAGGAGGAGGATGAGGAGGAGGAGGAGGAG |
GGGAGGAGGAGGAGGAGGATGAGGAGGAGGAGGAGGAG |
X: 20,503,798 (GRCm39) |
|
probably benign |
Het |
| Rbm15 |
G |
T |
3: 107,237,880 (GRCm39) |
D839E |
probably damaging |
Het |
| Sap30bp |
T |
A |
11: 115,855,103 (GRCm39) |
I271N |
probably damaging |
Het |
| Scart2 |
T |
A |
7: 139,828,874 (GRCm39) |
C178S |
probably damaging |
Het |
| Scn3a |
A |
T |
2: 65,338,918 (GRCm39) |
V587E |
probably damaging |
Het |
| Setdb1 |
A |
T |
3: 95,232,164 (GRCm39) |
|
probably benign |
Het |
| Sgk3 |
T |
A |
1: 9,949,306 (GRCm39) |
|
probably null |
Het |
| Shox2 |
A |
T |
3: 66,881,184 (GRCm39) |
H265Q |
probably damaging |
Het |
| Slc9a2 |
T |
C |
1: 40,783,017 (GRCm39) |
F427S |
possibly damaging |
Het |
| Smarca5 |
T |
A |
8: 81,463,360 (GRCm39) |
Q69H |
probably benign |
Het |
| Specc1l |
T |
A |
10: 75,084,293 (GRCm39) |
F672Y |
probably damaging |
Het |
| Ssh2 |
T |
A |
11: 77,298,969 (GRCm39) |
S105R |
probably damaging |
Het |
| Syne2 |
C |
T |
12: 75,968,000 (GRCm39) |
R917* |
probably null |
Het |
| Tbc1d2 |
G |
A |
4: 46,649,913 (GRCm39) |
T41M |
possibly damaging |
Het |
| Tbx18 |
T |
A |
9: 87,606,408 (GRCm39) |
I246F |
probably damaging |
Het |
| Tcf4 |
T |
A |
18: 69,814,883 (GRCm39) |
|
probably benign |
Het |
| Tmed2 |
C |
A |
5: 124,679,502 (GRCm39) |
|
probably null |
Het |
| Tmem243 |
A |
T |
5: 9,151,361 (GRCm39) |
D15V |
possibly damaging |
Het |
| Vps13c |
T |
A |
9: 67,793,528 (GRCm39) |
|
probably benign |
Het |
| Wls |
T |
A |
3: 159,603,074 (GRCm39) |
C162* |
probably null |
Het |
| Zbtb7c |
C |
T |
18: 76,270,464 (GRCm39) |
T184I |
probably benign |
Het |
| Zc3h13 |
A |
G |
14: 75,546,405 (GRCm39) |
K169E |
probably damaging |
Het |
|
| Other mutations in Vmn2r87 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01090:Vmn2r87
|
APN |
10 |
130,333,247 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
IGL01295:Vmn2r87
|
APN |
10 |
130,307,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01411:Vmn2r87
|
APN |
10 |
130,308,429 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01680:Vmn2r87
|
APN |
10 |
130,315,586 (GRCm39) |
nonsense |
probably null |
|
|
IGL01822:Vmn2r87
|
APN |
10 |
130,307,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Vmn2r87
|
APN |
10 |
130,314,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01965:Vmn2r87
|
APN |
10 |
130,314,924 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02562:Vmn2r87
|
APN |
10 |
130,314,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02665:Vmn2r87
|
APN |
10 |
130,333,049 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03202:Vmn2r87
|
APN |
10 |
130,333,091 (GRCm39) |
missense |
probably benign |
|
|
FR4304:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4340:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4342:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4589:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
LCD18:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0344:Vmn2r87
|
UTSW |
10 |
130,315,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0384:Vmn2r87
|
UTSW |
10 |
130,307,712 (GRCm39) |
missense |
probably benign |
|
|
R1144:Vmn2r87
|
UTSW |
10 |
130,312,098 (GRCm39) |
splice site |
probably benign |
|
|
R1172:Vmn2r87
|
UTSW |
10 |
130,313,453 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1860:Vmn2r87
|
UTSW |
10 |
130,315,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1866:Vmn2r87
|
UTSW |
10 |
130,308,441 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1897:Vmn2r87
|
UTSW |
10 |
130,307,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2360:Vmn2r87
|
UTSW |
10 |
130,315,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2909:Vmn2r87
|
UTSW |
10 |
130,314,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3874:Vmn2r87
|
UTSW |
10 |
130,315,856 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4113:Vmn2r87
|
UTSW |
10 |
130,315,691 (GRCm39) |
missense |
probably benign |
|
|
R4190:Vmn2r87
|
UTSW |
10 |
130,308,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4197:Vmn2r87
|
UTSW |
10 |
130,315,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4201:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4202:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4368:Vmn2r87
|
UTSW |
10 |
130,315,676 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4485:Vmn2r87
|
UTSW |
10 |
130,315,678 (GRCm39) |
nonsense |
probably null |
|
|
R4537:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4590:Vmn2r87
|
UTSW |
10 |
130,315,014 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4752:Vmn2r87
|
UTSW |
10 |
130,314,336 (GRCm39) |
nonsense |
probably null |
|
|
R4873:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4875:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4923:Vmn2r87
|
UTSW |
10 |
130,314,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4970:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Vmn2r87
|
UTSW |
10 |
130,308,298 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5112:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5187:Vmn2r87
|
UTSW |
10 |
130,333,208 (GRCm39) |
missense |
probably null |
0.99 |
|
R5618:Vmn2r87
|
UTSW |
10 |
130,315,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Vmn2r87
|
UTSW |
10 |
130,308,226 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6220:Vmn2r87
|
UTSW |
10 |
130,315,807 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6287:Vmn2r87
|
UTSW |
10 |
130,314,291 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6383:Vmn2r87
|
UTSW |
10 |
130,314,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6576:Vmn2r87
|
UTSW |
10 |
130,314,654 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6742:Vmn2r87
|
UTSW |
10 |
130,308,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7086:Vmn2r87
|
UTSW |
10 |
130,333,178 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7162:Vmn2r87
|
UTSW |
10 |
130,313,416 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7419:Vmn2r87
|
UTSW |
10 |
130,307,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7425:Vmn2r87
|
UTSW |
10 |
130,314,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7443:Vmn2r87
|
UTSW |
10 |
130,308,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7571:Vmn2r87
|
UTSW |
10 |
130,314,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7663:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7716:Vmn2r87
|
UTSW |
10 |
130,308,018 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7793:Vmn2r87
|
UTSW |
10 |
130,313,413 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7806:Vmn2r87
|
UTSW |
10 |
130,315,679 (GRCm39) |
missense |
probably benign |
|
|
R7841:Vmn2r87
|
UTSW |
10 |
130,333,095 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8326:Vmn2r87
|
UTSW |
10 |
130,308,180 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8411:Vmn2r87
|
UTSW |
10 |
130,308,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8445:Vmn2r87
|
UTSW |
10 |
130,313,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8540:Vmn2r87
|
UTSW |
10 |
130,314,762 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8892:Vmn2r87
|
UTSW |
10 |
130,308,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9093:Vmn2r87
|
UTSW |
10 |
130,308,165 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9623:Vmn2r87
|
UTSW |
10 |
130,315,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9667:Vmn2r87
|
UTSW |
10 |
130,314,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,312,064 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,308,138 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r87
|
UTSW |
10 |
130,308,183 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Vmn2r87
|
UTSW |
10 |
130,307,713 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCCTCAACAATATGCAATGCTGTAAC -3'
(R):5'- GGGATGATGACAGGGGCACCTAA -3'
Sequencing Primer
(F):5'- ccacaggtgaaaatgatggtag -3'
(R):5'- GCAACAAAGGCTCTGTCATTG -3'
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| Posted On |
2013-05-23 |
Incidental Mutation