Incidental Mutation 'R5016:Gpr19'
ID 385575
Institutional Source Beutler Lab
Gene Symbol Gpr19
Ensembl Gene ENSMUSG00000032641
Gene Name G protein-coupled receptor 19
Synonyms
MMRRC Submission 042607-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5016 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 134846055-134875157 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 134846880 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 231 (K231*)
Ref Sequence ENSEMBL: ENSMUSP00000149995 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046255] [ENSMUST00000066107] [ENSMUST00000111932] [ENSMUST00000116515] [ENSMUST00000165392] [ENSMUST00000203409] [ENSMUST00000203762] [ENSMUST00000204880] [ENSMUST00000215088]
AlphaFold Q61121
Predicted Effect probably null
Transcript: ENSMUST00000046255
AA Change: K182*
SMART Domains Protein: ENSMUSP00000047630
Gene: ENSMUSG00000032641
AA Change: K182*

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 76 345 1.7e-12 PFAM
Pfam:7tm_1 82 330 1.8e-50 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000066107
AA Change: K268*
SMART Domains Protein: ENSMUSP00000066287
Gene: ENSMUSG00000032641
AA Change: K268*

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 76 345 1.7e-12 PFAM
Pfam:7tm_1 82 330 5.3e-45 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000111932
AA Change: K176*
SMART Domains Protein: ENSMUSP00000107563
Gene: ENSMUSG00000032641
AA Change: K176*

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 70 339 2.6e-12 PFAM
Pfam:7tm_1 76 324 3.5e-50 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000116515
AA Change: K176*
SMART Domains Protein: ENSMUSP00000112214
Gene: ENSMUSG00000032641
AA Change: K176*

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 70 339 2.6e-12 PFAM
Pfam:7tm_1 76 324 3.5e-50 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000165392
AA Change: K176*
SMART Domains Protein: ENSMUSP00000127876
Gene: ENSMUSG00000032641
AA Change: K176*

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 70 339 2.6e-12 PFAM
Pfam:7tm_1 76 324 3.5e-50 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000203409
SMART Domains Protein: ENSMUSP00000145128
Gene: ENSMUSG00000032641

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 70 132 9e-5 PFAM
Pfam:7tm_1 76 135 2.6e-16 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000203762
Predicted Effect probably null
Transcript: ENSMUST00000204880
SMART Domains Protein: ENSMUSP00000144918
Gene: ENSMUSG00000032641

DomainStartEndE-ValueType
transmembrane domain 59 76 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000215088
AA Change: K231*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.2%
  • 10x: 95.1%
  • 20x: 91.0%
Validation Efficiency 97% (56/58)
MGI Phenotype PHENOTYPE: Homozygous mutation of this gene results in increased anxiety-like behavior. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp C T 16: 56,491,631 (GRCm39) P768S probably damaging Het
Adprhl1 A G 8: 13,274,889 (GRCm39) L623P possibly damaging Het
Anapc1 A T 2: 128,449,095 (GRCm39) probably benign Het
Ankzf1 C A 1: 75,172,622 (GRCm39) probably benign Het
Ash1l A G 3: 88,889,630 (GRCm39) D503G probably damaging Het
Atp7b T C 8: 22,505,885 (GRCm39) probably null Het
Bach1 T A 16: 87,516,206 (GRCm39) V249D possibly damaging Het
Ccdc158 A G 5: 92,805,751 (GRCm39) S335P probably benign Het
Chd9 T A 8: 91,733,254 (GRCm39) C1374* probably null Het
Col16a1 C T 4: 129,972,988 (GRCm39) T643M probably benign Het
Cygb A G 11: 116,540,840 (GRCm39) F49L probably benign Het
Dnah17 G C 11: 117,971,592 (GRCm39) T2147S probably damaging Het
Drd3 C A 16: 43,582,609 (GRCm39) A34E possibly damaging Het
Ephb6 G A 6: 41,595,041 (GRCm39) R685Q probably benign Het
Ezh1 G A 11: 101,090,063 (GRCm39) probably benign Het
Gpr61 A G 3: 108,057,983 (GRCm39) V226A possibly damaging Het
Gprc5c G T 11: 114,755,093 (GRCm39) V257L possibly damaging Het
Hnrnpul2 A G 19: 8,800,189 (GRCm39) K185R possibly damaging Het
Igsf9 A C 1: 172,318,279 (GRCm39) T140P probably damaging Het
Ksr2 A G 5: 117,638,857 (GRCm39) D87G probably benign Het
Llgl2 A G 11: 115,744,250 (GRCm39) E843G probably damaging Het
Ltbp4 GT G 7: 27,027,110 (GRCm39) probably null Het
Luc7l2 A G 6: 38,562,036 (GRCm39) I20V possibly damaging Het
Mcm6 G A 1: 128,271,164 (GRCm39) T485M probably damaging Het
Miox A G 15: 89,219,767 (GRCm39) D85G probably null Het
Nudt18 T C 14: 70,816,903 (GRCm39) F169S probably benign Het
Nxpe4 A G 9: 48,304,185 (GRCm39) N91D probably benign Het
Or13c7 T C 4: 43,854,596 (GRCm39) S96P probably benign Het
Or6c215 A G 10: 129,637,662 (GRCm39) V244A probably benign Het
Or8k39 T G 2: 86,563,090 (GRCm39) I289L probably benign Het
Pdss2 G T 10: 43,098,001 (GRCm39) A82S probably damaging Het
Ptprs T C 17: 56,726,070 (GRCm39) D998G probably damaging Het
Rasd2 C A 8: 75,948,603 (GRCm39) N176K probably damaging Het
Serpinb3a A G 1: 106,974,060 (GRCm39) F284L probably damaging Het
Skint6 T A 4: 113,028,730 (GRCm39) probably null Het
Slc12a6 C T 2: 112,186,972 (GRCm39) probably benign Het
Slc22a19 G A 19: 7,651,737 (GRCm39) T490M probably benign Het
Sp2 A T 11: 96,846,658 (GRCm39) C562S probably damaging Het
Specc1 A G 11: 62,009,783 (GRCm39) E433G possibly damaging Het
Sspo C T 6: 48,429,214 (GRCm39) Q451* probably null Het
St6galnac1 A T 11: 116,656,706 (GRCm39) S478T probably damaging Het
Steap4 C T 5: 8,026,699 (GRCm39) R221* probably null Het
Ugt1a5 C G 1: 88,093,963 (GRCm39) R64G probably benign Het
Vmn1r202 A T 13: 22,686,375 (GRCm39) F14Y probably damaging Het
Vmn2r79 T C 7: 86,686,548 (GRCm39) V643A probably benign Het
Vmn2r91 C A 17: 18,330,322 (GRCm39) Y535* probably null Het
Wdr3 A T 3: 100,048,936 (GRCm39) probably benign Het
Wdr95 T C 5: 149,468,266 (GRCm39) M41T probably benign Het
Other mutations in Gpr19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01310:Gpr19 APN 6 134,846,705 (GRCm39) missense probably damaging 0.99
IGL01373:Gpr19 APN 6 134,847,284 (GRCm39) missense possibly damaging 0.81
IGL01988:Gpr19 APN 6 134,846,247 (GRCm39) missense probably damaging 1.00
R1530:Gpr19 UTSW 6 134,846,961 (GRCm39) missense probably damaging 0.97
R1548:Gpr19 UTSW 6 134,847,047 (GRCm39) missense possibly damaging 0.92
R1699:Gpr19 UTSW 6 134,847,192 (GRCm39) missense possibly damaging 0.93
R2131:Gpr19 UTSW 6 134,847,405 (GRCm39) start codon destroyed probably null 0.99
R6605:Gpr19 UTSW 6 134,847,398 (GRCm39) missense probably benign 0.02
R7080:Gpr19 UTSW 6 134,847,419 (GRCm39) missense probably damaging 0.99
R7746:Gpr19 UTSW 6 134,846,355 (GRCm39) missense probably damaging 1.00
R8014:Gpr19 UTSW 6 134,846,436 (GRCm39) missense probably damaging 1.00
R9176:Gpr19 UTSW 6 134,846,718 (GRCm39) missense probably damaging 0.99
R9408:Gpr19 UTSW 6 134,864,704 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- GGGACAATGTTCATCGTCCTTC -3'
(R):5'- TTGTCGTGCTGCAGTTCACC -3'

Sequencing Primer
(F):5'- CCTTCTGGTAAAACAGGATTATGAGG -3'
(R):5'- TGCAGTTCACCACCGGGAG -3'
Posted On 2016-05-10