Incidental Mutation 'R5017:Or8g20'
ID 385624
Institutional Source Beutler Lab
Gene Symbol Or8g20
Ensembl Gene ENSMUSG00000062649
Gene Name olfactory receptor family 8 subfamily G member 20
Synonyms GA_x6K02T2PVTD-33181773-33180838, Olfr44, IB3, MOR171-5
MMRRC Submission 042608-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R5017 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 39395500-39405284 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 39396051 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 166 (M166K)
Ref Sequence ENSEMBL: ENSMUSP00000076935 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077757] [ENSMUST00000215065] [ENSMUST00000216316]
AlphaFold Q9EQB8
Predicted Effect possibly damaging
Transcript: ENSMUST00000077757
AA Change: M166K

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000076935
Gene: ENSMUSG00000062649
AA Change: M166K

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 4.1e-50 PFAM
Pfam:7tm_1 44 293 1.7e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215065
AA Change: M163K

PolyPhen 2 Score 0.879 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216316
AA Change: M163K

PolyPhen 2 Score 0.879 (Sensitivity: 0.82; Specificity: 0.94)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.1%
  • 3x: 97.0%
  • 10x: 94.3%
  • 20x: 87.9%
Validation Efficiency 96% (46/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamdec1 T C 14: 68,810,694 (GRCm39) D154G probably benign Het
Agbl5 G A 5: 31,060,403 (GRCm39) R141Q probably damaging Het
Arhgef3 G T 14: 26,987,487 (GRCm39) R20L possibly damaging Het
Birc2 A T 9: 7,818,886 (GRCm39) C568* probably null Het
Bltp3a T A 17: 28,113,713 (GRCm39) L1295* probably null Het
Cep44 A G 8: 56,997,242 (GRCm39) S99P possibly damaging Het
Clstn2 A G 9: 97,365,139 (GRCm39) W456R probably damaging Het
Cog5 T A 12: 31,970,604 (GRCm39) S783T probably benign Het
Endod1 G A 9: 14,268,187 (GRCm39) R433* probably null Het
Fchsd1 C T 18: 38,092,926 (GRCm39) probably benign Het
Gdpd4 C A 7: 97,653,482 (GRCm39) Y498* probably null Het
Gm10722 T C 9: 3,000,937 (GRCm39) C6R probably benign Het
Hapln2 A G 3: 87,931,308 (GRCm39) V69A probably damaging Het
Ifit3 A C 19: 34,564,592 (GRCm39) N46T possibly damaging Het
Kcnh8 T C 17: 53,200,958 (GRCm39) L464S probably damaging Het
Lrrc9 C A 12: 72,553,099 (GRCm39) R1334S possibly damaging Het
Macf1 A G 4: 123,345,906 (GRCm39) F2631L probably damaging Het
Mafa T C 15: 75,619,338 (GRCm39) H145R probably benign Het
Muc6 T C 7: 141,226,795 (GRCm39) T1411A probably benign Het
Nos3 A G 5: 24,571,717 (GRCm39) probably benign Het
Nwd2 T A 5: 63,807,484 (GRCm39) probably benign Het
Or10g6 A T 9: 39,933,672 (GRCm39) probably benign Het
Or8a1b A T 9: 37,622,821 (GRCm39) Y251* probably null Het
Pde11a A T 2: 75,966,711 (GRCm39) D579E probably benign Het
Phkb A T 8: 86,776,438 (GRCm39) H954L probably benign Het
Phldb3 C T 7: 24,319,521 (GRCm39) T353M probably damaging Het
Pigu A T 2: 155,141,128 (GRCm39) probably null Het
Pla2r1 A G 2: 60,353,104 (GRCm39) probably null Het
Polr1c G T 17: 46,558,635 (GRCm39) probably benign Het
Setbp1 C A 18: 78,899,809 (GRCm39) G1286V possibly damaging Het
Siglecg T A 7: 43,060,810 (GRCm39) probably benign Het
Slc25a46 A T 18: 31,738,836 (GRCm39) H118Q probably damaging Het
Spata31h1 A T 10: 82,132,510 (GRCm39) F167I unknown Het
Sycp1 A T 3: 102,803,303 (GRCm39) probably null Het
Tmem132c A G 5: 127,640,414 (GRCm39) T862A probably benign Het
Tmem256 T C 11: 69,729,818 (GRCm39) probably benign Het
Tpr A T 1: 150,274,388 (GRCm39) E98D probably benign Het
Trdn A G 10: 33,344,155 (GRCm39) D623G probably benign Het
Trip11 T C 12: 101,812,879 (GRCm39) N1485S probably benign Het
Trpm1 T C 7: 63,894,580 (GRCm39) probably benign Het
Vmn1r227 T C 17: 20,956,340 (GRCm39) noncoding transcript Het
Xpo6 G A 7: 125,703,919 (GRCm39) A21V probably benign Het
Zfp276 A G 8: 123,991,716 (GRCm39) probably benign Het
Other mutations in Or8g20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Or8g20 APN 9 39,395,944 (GRCm39) missense probably benign 0.02
IGL02239:Or8g20 APN 9 39,395,857 (GRCm39) missense probably damaging 1.00
IGL02305:Or8g20 APN 9 39,396,333 (GRCm39) missense probably damaging 0.97
IGL02353:Or8g20 APN 9 39,396,444 (GRCm39) missense probably benign
IGL02360:Or8g20 APN 9 39,396,444 (GRCm39) missense probably benign
R0212:Or8g20 UTSW 9 39,396,384 (GRCm39) missense probably damaging 1.00
R0600:Or8g20 UTSW 9 39,396,284 (GRCm39) missense probably benign 0.34
R1329:Or8g20 UTSW 9 39,395,740 (GRCm39) missense probably damaging 0.97
R1348:Or8g20 UTSW 9 39,396,532 (GRCm39) missense probably benign
R1594:Or8g20 UTSW 9 39,396,042 (GRCm39) missense probably benign 0.03
R5141:Or8g20 UTSW 9 39,395,827 (GRCm39) missense probably damaging 1.00
R5244:Or8g20 UTSW 9 39,395,808 (GRCm39) missense probably damaging 1.00
R5524:Or8g20 UTSW 9 39,396,283 (GRCm39) missense probably damaging 0.97
R5630:Or8g20 UTSW 9 39,396,247 (GRCm39) missense probably benign 0.00
R5860:Or8g20 UTSW 9 39,395,767 (GRCm39) missense probably benign 0.07
R6444:Or8g20 UTSW 9 39,395,614 (GRCm39) missense probably benign 0.04
R6649:Or8g20 UTSW 9 39,396,048 (GRCm39) missense probably benign 0.02
R6653:Or8g20 UTSW 9 39,396,048 (GRCm39) missense probably benign 0.02
R7115:Or8g20 UTSW 9 39,395,944 (GRCm39) missense probably benign 0.02
R7595:Or8g20 UTSW 9 39,395,611 (GRCm39) missense probably benign 0.05
R7791:Or8g20 UTSW 9 39,396,177 (GRCm39) missense probably damaging 1.00
R8054:Or8g20 UTSW 9 39,396,033 (GRCm39) missense probably damaging 1.00
R9176:Or8g20 UTSW 9 39,396,247 (GRCm39) missense probably benign 0.00
R9640:Or8g20 UTSW 9 39,396,396 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTACTGAAGGCTTTAGACCTGCC -3'
(R):5'- TTGCAATTGCGGAGTGTTAC -3'

Sequencing Primer
(F):5'- TTAGACCTGCCTTCAGTGGAGC -3'
(R):5'- CAATTGCGGAGTGTTACATTTTAGC -3'
Posted On 2016-05-10