Incidental Mutation 'R0423:Zmym4'
ID |
38574 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zmym4
|
Ensembl Gene |
ENSMUSG00000042446 |
Gene Name |
zinc finger, MYM-type 4 |
Synonyms |
Zfp262, 6330503C17Rik |
MMRRC Submission |
038625-MU
|
Accession Numbers |
|
Essential gene? |
Possibly essential
(E-score: 0.586)
|
Stock # |
R0423 (G1)
|
Quality Score |
171 |
Status
|
Validated
|
Chromosome |
4 |
Chromosomal Location |
126755732-126861928 bp(-) (GRCm39) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
A to G
at 126776112 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106108]
|
AlphaFold |
A2A791 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000106108
|
SMART Domains |
Protein: ENSMUSP00000101714 Gene: ENSMUSG00000042446
Domain | Start | End | E-Value | Type |
TRASH
|
341 |
377 |
6.53e-4 |
SMART |
TRASH
|
389 |
429 |
7.22e-6 |
SMART |
TRASH
|
441 |
479 |
1.77e0 |
SMART |
TRASH
|
486 |
525 |
4.95e-4 |
SMART |
TRASH
|
531 |
569 |
1.05e-2 |
SMART |
TRASH
|
579 |
615 |
2.82e1 |
SMART |
low complexity region
|
640 |
649 |
N/A |
INTRINSIC |
TRASH
|
687 |
723 |
8.49e-3 |
SMART |
TRASH
|
729 |
764 |
1.14e-3 |
SMART |
TRASH
|
772 |
810 |
4.48e-2 |
SMART |
TRASH
|
816 |
851 |
2.06e-1 |
SMART |
low complexity region
|
974 |
993 |
N/A |
INTRINSIC |
low complexity region
|
1002 |
1021 |
N/A |
INTRINSIC |
Pfam:DUF3504
|
1357 |
1527 |
1.7e-68 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000135003
|
SMART Domains |
Protein: ENSMUSP00000120813 Gene: ENSMUSG00000042446
Domain | Start | End | E-Value | Type |
TRASH
|
90 |
126 |
6.53e-4 |
SMART |
TRASH
|
138 |
178 |
7.22e-6 |
SMART |
TRASH
|
190 |
228 |
1.77e0 |
SMART |
TRASH
|
235 |
274 |
3.05e-4 |
SMART |
low complexity region
|
300 |
309 |
N/A |
INTRINSIC |
TRASH
|
347 |
383 |
8.49e-3 |
SMART |
TRASH
|
389 |
424 |
1.14e-3 |
SMART |
TRASH
|
432 |
470 |
4.48e-2 |
SMART |
TRASH
|
476 |
511 |
2.06e-1 |
SMART |
low complexity region
|
634 |
653 |
N/A |
INTRINSIC |
low complexity region
|
662 |
681 |
N/A |
INTRINSIC |
Pfam:DUF3504
|
1017 |
1187 |
1.5e-68 |
PFAM |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.1%
- 10x: 95.9%
- 20x: 91.9%
|
Validation Efficiency |
99% (84/85) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 71 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930432E11Rik |
A |
T |
7: 29,261,825 (GRCm39) |
|
noncoding transcript |
Het |
A630001G21Rik |
A |
G |
1: 85,654,187 (GRCm39) |
I50T |
probably benign |
Het |
Abhd12 |
T |
C |
2: 150,680,312 (GRCm39) |
T264A |
possibly damaging |
Het |
Acsm3 |
T |
C |
7: 119,376,382 (GRCm39) |
Y370H |
probably damaging |
Het |
Ank2 |
G |
T |
3: 126,723,509 (GRCm39) |
Y3789* |
probably null |
Het |
Anxa4 |
C |
T |
6: 86,737,719 (GRCm39) |
A1T |
probably damaging |
Het |
Apba1 |
T |
A |
19: 23,922,362 (GRCm39) |
V810D |
probably damaging |
Het |
Bank1 |
A |
G |
3: 135,989,778 (GRCm39) |
I104T |
possibly damaging |
Het |
Birc6 |
T |
C |
17: 75,003,292 (GRCm39) |
Y4721H |
probably damaging |
Het |
Bmpr2 |
A |
G |
1: 59,907,669 (GRCm39) |
T921A |
probably benign |
Het |
Ccdc102a |
A |
C |
8: 95,632,554 (GRCm39) |
|
probably benign |
Het |
Ccdc141 |
C |
A |
2: 76,869,794 (GRCm39) |
D904Y |
probably damaging |
Het |
Ccdc96 |
A |
G |
5: 36,642,591 (GRCm39) |
K199R |
probably benign |
Het |
Cdh10 |
G |
A |
15: 18,986,965 (GRCm39) |
V399I |
probably benign |
Het |
Cenpk |
A |
G |
13: 104,370,733 (GRCm39) |
T85A |
probably benign |
Het |
Col6a2 |
A |
C |
10: 76,450,751 (GRCm39) |
V60G |
possibly damaging |
Het |
Cops7b |
A |
G |
1: 86,526,753 (GRCm39) |
D119G |
probably benign |
Het |
Cstf2t |
A |
G |
19: 31,061,676 (GRCm39) |
E404G |
possibly damaging |
Het |
Ctnna2 |
A |
T |
6: 77,630,052 (GRCm39) |
V134E |
probably damaging |
Het |
Cwh43 |
A |
C |
5: 73,574,085 (GRCm39) |
M250L |
probably benign |
Het |
Daam2 |
T |
A |
17: 49,776,449 (GRCm39) |
K813* |
probably null |
Het |
Dhcr24 |
G |
A |
4: 106,443,733 (GRCm39) |
|
probably benign |
Het |
Dnah8 |
G |
T |
17: 30,920,955 (GRCm39) |
R1182L |
probably benign |
Het |
Doc2a |
C |
T |
7: 126,447,830 (GRCm39) |
P25S |
probably damaging |
Het |
Dst |
A |
G |
1: 34,317,116 (GRCm39) |
S6823G |
possibly damaging |
Het |
Espl1 |
T |
A |
15: 102,212,421 (GRCm39) |
L509* |
probably null |
Het |
Fbxw19 |
C |
T |
9: 109,315,134 (GRCm39) |
V143I |
probably benign |
Het |
Fbxw5 |
A |
G |
2: 25,394,538 (GRCm39) |
T171A |
possibly damaging |
Het |
Gfra2 |
C |
T |
14: 71,133,521 (GRCm39) |
T117M |
probably damaging |
Het |
Gm454 |
T |
A |
5: 138,202,403 (GRCm39) |
|
noncoding transcript |
Het |
Ilrun |
A |
C |
17: 28,005,207 (GRCm39) |
Y117D |
probably damaging |
Het |
Kcnq4 |
A |
G |
4: 120,574,705 (GRCm39) |
S120P |
probably damaging |
Het |
Krt84 |
A |
T |
15: 101,437,155 (GRCm39) |
L336Q |
probably damaging |
Het |
Lilra6 |
T |
A |
7: 3,917,774 (GRCm39) |
|
probably benign |
Het |
Mbnl2 |
G |
A |
14: 120,562,736 (GRCm39) |
R29H |
probably damaging |
Het |
Mcm3ap |
G |
A |
10: 76,338,539 (GRCm39) |
G1389D |
probably benign |
Het |
Mettl13 |
A |
T |
1: 162,371,954 (GRCm39) |
I305N |
probably damaging |
Het |
Muc6 |
A |
G |
7: 141,238,548 (GRCm39) |
S30P |
probably benign |
Het |
Myh7 |
T |
A |
14: 55,216,646 (GRCm39) |
Q1237L |
probably benign |
Het |
Myo9a |
T |
G |
9: 59,802,619 (GRCm39) |
D2035E |
probably damaging |
Het |
Nat10 |
A |
G |
2: 103,578,572 (GRCm39) |
S211P |
probably damaging |
Het |
Ntm |
T |
C |
9: 29,090,395 (GRCm39) |
Y108C |
probably damaging |
Het |
Or14c39 |
T |
C |
7: 86,344,434 (GRCm39) |
Y257H |
possibly damaging |
Het |
Or7g25 |
A |
T |
9: 19,160,248 (GRCm39) |
L149* |
probably null |
Het |
Pcdhb16 |
A |
G |
18: 37,613,422 (GRCm39) |
D794G |
probably benign |
Het |
Phlpp1 |
A |
G |
1: 106,267,345 (GRCm39) |
T753A |
probably benign |
Het |
Pierce1 |
T |
C |
2: 28,356,036 (GRCm39) |
|
probably benign |
Het |
Pnldc1 |
T |
C |
17: 13,108,963 (GRCm39) |
Q511R |
possibly damaging |
Het |
Ppip5k2 |
A |
G |
1: 97,689,152 (GRCm39) |
S38P |
possibly damaging |
Het |
Pygb |
A |
G |
2: 150,665,904 (GRCm39) |
K593E |
probably benign |
Het |
Rangap1 |
A |
T |
15: 81,589,664 (GRCm39) |
F564I |
probably damaging |
Het |
Rictor |
A |
T |
15: 6,803,381 (GRCm39) |
I498F |
possibly damaging |
Het |
Rnase12 |
A |
T |
14: 51,294,613 (GRCm39) |
V22D |
probably benign |
Het |
Rpl7l1 |
T |
A |
17: 47,091,324 (GRCm39) |
M93L |
probably benign |
Het |
Smg1 |
T |
C |
7: 117,776,103 (GRCm39) |
R1396G |
possibly damaging |
Het |
Snx19 |
C |
A |
9: 30,347,133 (GRCm39) |
T692N |
probably damaging |
Het |
Spag6 |
A |
G |
2: 18,715,404 (GRCm39) |
D61G |
probably benign |
Het |
Spen |
T |
A |
4: 141,206,647 (GRCm39) |
N660I |
unknown |
Het |
Sptan1 |
T |
G |
2: 29,918,684 (GRCm39) |
C2246G |
probably null |
Het |
Svopl |
A |
G |
6: 38,013,642 (GRCm39) |
|
probably benign |
Het |
Taf2 |
A |
T |
15: 54,928,078 (GRCm39) |
N108K |
probably benign |
Het |
Thbs4 |
T |
C |
13: 92,893,079 (GRCm39) |
D703G |
probably damaging |
Het |
Tle6 |
G |
T |
10: 81,434,457 (GRCm39) |
N47K |
possibly damaging |
Het |
Usp48 |
G |
T |
4: 137,343,722 (GRCm39) |
V452L |
probably benign |
Het |
Ust |
A |
T |
10: 8,173,912 (GRCm39) |
S198T |
probably damaging |
Het |
Wnk2 |
T |
A |
13: 49,248,894 (GRCm39) |
M386L |
possibly damaging |
Het |
Ywhaq |
T |
C |
12: 21,441,382 (GRCm39) |
|
probably benign |
Het |
Zfp11 |
C |
T |
5: 129,735,302 (GRCm39) |
G53E |
possibly damaging |
Het |
Zfp316 |
A |
G |
5: 143,238,993 (GRCm39) |
S1009P |
probably damaging |
Het |
Zfp963 |
A |
G |
8: 70,197,156 (GRCm39) |
Y29H |
probably damaging |
Het |
Zranb3 |
A |
G |
1: 128,019,607 (GRCm39) |
I45T |
probably damaging |
Het |
|
Other mutations in Zmym4 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00537:Zmym4
|
APN |
4 |
126,783,851 (GRCm39) |
missense |
probably benign |
|
IGL00845:Zmym4
|
APN |
4 |
126,794,406 (GRCm39) |
missense |
probably benign |
0.28 |
IGL01122:Zmym4
|
APN |
4 |
126,758,045 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01374:Zmym4
|
APN |
4 |
126,762,750 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01564:Zmym4
|
APN |
4 |
126,805,073 (GRCm39) |
missense |
possibly damaging |
0.84 |
IGL02014:Zmym4
|
APN |
4 |
126,794,462 (GRCm39) |
missense |
possibly damaging |
0.67 |
IGL02187:Zmym4
|
APN |
4 |
126,764,066 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL02887:Zmym4
|
APN |
4 |
126,842,268 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL03371:Zmym4
|
APN |
4 |
126,808,881 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL03400:Zmym4
|
APN |
4 |
126,816,920 (GRCm39) |
missense |
probably benign |
0.12 |
arriba
|
UTSW |
4 |
126,809,415 (GRCm39) |
missense |
probably damaging |
0.97 |
foreclosed
|
UTSW |
4 |
126,789,099 (GRCm39) |
missense |
probably damaging |
1.00 |
Foreshortened
|
UTSW |
4 |
126,804,729 (GRCm39) |
missense |
possibly damaging |
0.75 |
levantese
|
UTSW |
4 |
126,757,961 (GRCm39) |
missense |
probably damaging |
0.99 |
terminated
|
UTSW |
4 |
126,819,588 (GRCm39) |
missense |
probably benign |
0.02 |
BB004:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
BB014:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
R0149:Zmym4
|
UTSW |
4 |
126,804,938 (GRCm39) |
missense |
probably benign |
0.00 |
R0361:Zmym4
|
UTSW |
4 |
126,804,938 (GRCm39) |
missense |
probably benign |
0.00 |
R0532:Zmym4
|
UTSW |
4 |
126,792,194 (GRCm39) |
nonsense |
probably null |
|
R0745:Zmym4
|
UTSW |
4 |
126,796,496 (GRCm39) |
splice site |
probably benign |
|
R1183:Zmym4
|
UTSW |
4 |
126,819,632 (GRCm39) |
missense |
probably damaging |
0.99 |
R1401:Zmym4
|
UTSW |
4 |
126,804,962 (GRCm39) |
missense |
probably benign |
0.00 |
R1446:Zmym4
|
UTSW |
4 |
126,776,275 (GRCm39) |
missense |
probably damaging |
1.00 |
R1491:Zmym4
|
UTSW |
4 |
126,776,105 (GRCm39) |
critical splice acceptor site |
probably null |
|
R1566:Zmym4
|
UTSW |
4 |
126,804,940 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1962:Zmym4
|
UTSW |
4 |
126,796,463 (GRCm39) |
missense |
possibly damaging |
0.47 |
R2398:Zmym4
|
UTSW |
4 |
126,816,929 (GRCm39) |
missense |
probably damaging |
1.00 |
R2930:Zmym4
|
UTSW |
4 |
126,819,316 (GRCm39) |
missense |
probably benign |
0.00 |
R3891:Zmym4
|
UTSW |
4 |
126,798,269 (GRCm39) |
missense |
probably benign |
0.04 |
R3892:Zmym4
|
UTSW |
4 |
126,798,269 (GRCm39) |
missense |
probably benign |
0.04 |
R4659:Zmym4
|
UTSW |
4 |
126,842,221 (GRCm39) |
splice site |
probably null |
|
R4702:Zmym4
|
UTSW |
4 |
126,816,958 (GRCm39) |
missense |
probably benign |
0.01 |
R5160:Zmym4
|
UTSW |
4 |
126,763,977 (GRCm39) |
missense |
probably damaging |
0.97 |
R5614:Zmym4
|
UTSW |
4 |
126,804,729 (GRCm39) |
missense |
possibly damaging |
0.75 |
R5773:Zmym4
|
UTSW |
4 |
126,799,163 (GRCm39) |
missense |
possibly damaging |
0.52 |
R6450:Zmym4
|
UTSW |
4 |
126,789,099 (GRCm39) |
missense |
probably damaging |
1.00 |
R6741:Zmym4
|
UTSW |
4 |
126,808,878 (GRCm39) |
missense |
possibly damaging |
0.80 |
R7023:Zmym4
|
UTSW |
4 |
126,762,593 (GRCm39) |
missense |
probably damaging |
1.00 |
R7315:Zmym4
|
UTSW |
4 |
126,776,385 (GRCm39) |
missense |
probably benign |
0.09 |
R7468:Zmym4
|
UTSW |
4 |
126,776,029 (GRCm39) |
missense |
probably benign |
0.40 |
R7546:Zmym4
|
UTSW |
4 |
126,757,961 (GRCm39) |
missense |
probably damaging |
0.99 |
R7609:Zmym4
|
UTSW |
4 |
126,819,588 (GRCm39) |
missense |
probably benign |
0.02 |
R7764:Zmym4
|
UTSW |
4 |
126,819,409 (GRCm39) |
missense |
probably benign |
0.06 |
R7897:Zmym4
|
UTSW |
4 |
126,783,332 (GRCm39) |
missense |
possibly damaging |
0.76 |
R7918:Zmym4
|
UTSW |
4 |
126,804,797 (GRCm39) |
critical splice acceptor site |
probably null |
|
R7927:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
R8129:Zmym4
|
UTSW |
4 |
126,808,956 (GRCm39) |
missense |
possibly damaging |
0.87 |
R8240:Zmym4
|
UTSW |
4 |
126,798,188 (GRCm39) |
critical splice donor site |
probably null |
|
R8248:Zmym4
|
UTSW |
4 |
126,799,162 (GRCm39) |
missense |
possibly damaging |
0.56 |
R8261:Zmym4
|
UTSW |
4 |
126,798,360 (GRCm39) |
missense |
probably damaging |
1.00 |
R8313:Zmym4
|
UTSW |
4 |
126,804,762 (GRCm39) |
missense |
probably benign |
0.19 |
R8353:Zmym4
|
UTSW |
4 |
126,800,905 (GRCm39) |
missense |
possibly damaging |
0.46 |
R8747:Zmym4
|
UTSW |
4 |
126,787,198 (GRCm39) |
missense |
probably damaging |
1.00 |
R8787:Zmym4
|
UTSW |
4 |
126,816,953 (GRCm39) |
missense |
probably benign |
0.41 |
R8795:Zmym4
|
UTSW |
4 |
126,799,819 (GRCm39) |
missense |
probably benign |
0.35 |
R8948:Zmym4
|
UTSW |
4 |
126,758,060 (GRCm39) |
missense |
probably damaging |
1.00 |
R9218:Zmym4
|
UTSW |
4 |
126,809,415 (GRCm39) |
missense |
probably damaging |
0.97 |
R9233:Zmym4
|
UTSW |
4 |
126,776,310 (GRCm39) |
missense |
probably damaging |
0.99 |
R9286:Zmym4
|
UTSW |
4 |
126,783,812 (GRCm39) |
missense |
probably damaging |
1.00 |
R9468:Zmym4
|
UTSW |
4 |
126,800,993 (GRCm39) |
missense |
probably benign |
0.01 |
R9542:Zmym4
|
UTSW |
4 |
126,799,164 (GRCm39) |
missense |
probably benign |
0.00 |
R9756:Zmym4
|
UTSW |
4 |
126,771,502 (GRCm39) |
missense |
probably damaging |
1.00 |
R9776:Zmym4
|
UTSW |
4 |
126,804,942 (GRCm39) |
missense |
possibly damaging |
0.51 |
U24488:Zmym4
|
UTSW |
4 |
126,819,453 (GRCm39) |
missense |
possibly damaging |
0.69 |
Z1177:Zmym4
|
UTSW |
4 |
126,801,005 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- CTTTGCAGTGCCAAGACTAGCAAAC -3'
(R):5'- GAACCCAGAAGTCTTATTCAAGGAGCC -3'
Sequencing Primer
(F):5'- agcactgattgctctgcc -3'
(R):5'- TGCTCAGTGTCTGGAATGAC -3'
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Posted On |
2013-05-23 |