Incidental Mutation 'R0423:Zmym4'
ID 38574
Institutional Source Beutler Lab
Gene Symbol Zmym4
Ensembl Gene ENSMUSG00000042446
Gene Name zinc finger, MYM-type 4
Synonyms Zfp262, 6330503C17Rik
MMRRC Submission 038625-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.586) question?
Stock # R0423 (G1)
Quality Score 171
Status Validated
Chromosome 4
Chromosomal Location 126755732-126861928 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 126776112 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000106108]
AlphaFold A2A791
Predicted Effect probably benign
Transcript: ENSMUST00000106108
SMART Domains Protein: ENSMUSP00000101714
Gene: ENSMUSG00000042446

DomainStartEndE-ValueType
TRASH 341 377 6.53e-4 SMART
TRASH 389 429 7.22e-6 SMART
TRASH 441 479 1.77e0 SMART
TRASH 486 525 4.95e-4 SMART
TRASH 531 569 1.05e-2 SMART
TRASH 579 615 2.82e1 SMART
low complexity region 640 649 N/A INTRINSIC
TRASH 687 723 8.49e-3 SMART
TRASH 729 764 1.14e-3 SMART
TRASH 772 810 4.48e-2 SMART
TRASH 816 851 2.06e-1 SMART
low complexity region 974 993 N/A INTRINSIC
low complexity region 1002 1021 N/A INTRINSIC
Pfam:DUF3504 1357 1527 1.7e-68 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000135003
SMART Domains Protein: ENSMUSP00000120813
Gene: ENSMUSG00000042446

DomainStartEndE-ValueType
TRASH 90 126 6.53e-4 SMART
TRASH 138 178 7.22e-6 SMART
TRASH 190 228 1.77e0 SMART
TRASH 235 274 3.05e-4 SMART
low complexity region 300 309 N/A INTRINSIC
TRASH 347 383 8.49e-3 SMART
TRASH 389 424 1.14e-3 SMART
TRASH 432 470 4.48e-2 SMART
TRASH 476 511 2.06e-1 SMART
low complexity region 634 653 N/A INTRINSIC
low complexity region 662 681 N/A INTRINSIC
Pfam:DUF3504 1017 1187 1.5e-68 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.1%
  • 10x: 95.9%
  • 20x: 91.9%
Validation Efficiency 99% (84/85)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432E11Rik A T 7: 29,261,825 (GRCm39) noncoding transcript Het
A630001G21Rik A G 1: 85,654,187 (GRCm39) I50T probably benign Het
Abhd12 T C 2: 150,680,312 (GRCm39) T264A possibly damaging Het
Acsm3 T C 7: 119,376,382 (GRCm39) Y370H probably damaging Het
Ank2 G T 3: 126,723,509 (GRCm39) Y3789* probably null Het
Anxa4 C T 6: 86,737,719 (GRCm39) A1T probably damaging Het
Apba1 T A 19: 23,922,362 (GRCm39) V810D probably damaging Het
Bank1 A G 3: 135,989,778 (GRCm39) I104T possibly damaging Het
Birc6 T C 17: 75,003,292 (GRCm39) Y4721H probably damaging Het
Bmpr2 A G 1: 59,907,669 (GRCm39) T921A probably benign Het
Ccdc102a A C 8: 95,632,554 (GRCm39) probably benign Het
Ccdc141 C A 2: 76,869,794 (GRCm39) D904Y probably damaging Het
Ccdc96 A G 5: 36,642,591 (GRCm39) K199R probably benign Het
Cdh10 G A 15: 18,986,965 (GRCm39) V399I probably benign Het
Cenpk A G 13: 104,370,733 (GRCm39) T85A probably benign Het
Col6a2 A C 10: 76,450,751 (GRCm39) V60G possibly damaging Het
Cops7b A G 1: 86,526,753 (GRCm39) D119G probably benign Het
Cstf2t A G 19: 31,061,676 (GRCm39) E404G possibly damaging Het
Ctnna2 A T 6: 77,630,052 (GRCm39) V134E probably damaging Het
Cwh43 A C 5: 73,574,085 (GRCm39) M250L probably benign Het
Daam2 T A 17: 49,776,449 (GRCm39) K813* probably null Het
Dhcr24 G A 4: 106,443,733 (GRCm39) probably benign Het
Dnah8 G T 17: 30,920,955 (GRCm39) R1182L probably benign Het
Doc2a C T 7: 126,447,830 (GRCm39) P25S probably damaging Het
Dst A G 1: 34,317,116 (GRCm39) S6823G possibly damaging Het
Espl1 T A 15: 102,212,421 (GRCm39) L509* probably null Het
Fbxw19 C T 9: 109,315,134 (GRCm39) V143I probably benign Het
Fbxw5 A G 2: 25,394,538 (GRCm39) T171A possibly damaging Het
Gfra2 C T 14: 71,133,521 (GRCm39) T117M probably damaging Het
Gm454 T A 5: 138,202,403 (GRCm39) noncoding transcript Het
Ilrun A C 17: 28,005,207 (GRCm39) Y117D probably damaging Het
Kcnq4 A G 4: 120,574,705 (GRCm39) S120P probably damaging Het
Krt84 A T 15: 101,437,155 (GRCm39) L336Q probably damaging Het
Lilra6 T A 7: 3,917,774 (GRCm39) probably benign Het
Mbnl2 G A 14: 120,562,736 (GRCm39) R29H probably damaging Het
Mcm3ap G A 10: 76,338,539 (GRCm39) G1389D probably benign Het
Mettl13 A T 1: 162,371,954 (GRCm39) I305N probably damaging Het
Muc6 A G 7: 141,238,548 (GRCm39) S30P probably benign Het
Myh7 T A 14: 55,216,646 (GRCm39) Q1237L probably benign Het
Myo9a T G 9: 59,802,619 (GRCm39) D2035E probably damaging Het
Nat10 A G 2: 103,578,572 (GRCm39) S211P probably damaging Het
Ntm T C 9: 29,090,395 (GRCm39) Y108C probably damaging Het
Or14c39 T C 7: 86,344,434 (GRCm39) Y257H possibly damaging Het
Or7g25 A T 9: 19,160,248 (GRCm39) L149* probably null Het
Pcdhb16 A G 18: 37,613,422 (GRCm39) D794G probably benign Het
Phlpp1 A G 1: 106,267,345 (GRCm39) T753A probably benign Het
Pierce1 T C 2: 28,356,036 (GRCm39) probably benign Het
Pnldc1 T C 17: 13,108,963 (GRCm39) Q511R possibly damaging Het
Ppip5k2 A G 1: 97,689,152 (GRCm39) S38P possibly damaging Het
Pygb A G 2: 150,665,904 (GRCm39) K593E probably benign Het
Rangap1 A T 15: 81,589,664 (GRCm39) F564I probably damaging Het
Rictor A T 15: 6,803,381 (GRCm39) I498F possibly damaging Het
Rnase12 A T 14: 51,294,613 (GRCm39) V22D probably benign Het
Rpl7l1 T A 17: 47,091,324 (GRCm39) M93L probably benign Het
Smg1 T C 7: 117,776,103 (GRCm39) R1396G possibly damaging Het
Snx19 C A 9: 30,347,133 (GRCm39) T692N probably damaging Het
Spag6 A G 2: 18,715,404 (GRCm39) D61G probably benign Het
Spen T A 4: 141,206,647 (GRCm39) N660I unknown Het
Sptan1 T G 2: 29,918,684 (GRCm39) C2246G probably null Het
Svopl A G 6: 38,013,642 (GRCm39) probably benign Het
Taf2 A T 15: 54,928,078 (GRCm39) N108K probably benign Het
Thbs4 T C 13: 92,893,079 (GRCm39) D703G probably damaging Het
Tle6 G T 10: 81,434,457 (GRCm39) N47K possibly damaging Het
Usp48 G T 4: 137,343,722 (GRCm39) V452L probably benign Het
Ust A T 10: 8,173,912 (GRCm39) S198T probably damaging Het
Wnk2 T A 13: 49,248,894 (GRCm39) M386L possibly damaging Het
Ywhaq T C 12: 21,441,382 (GRCm39) probably benign Het
Zfp11 C T 5: 129,735,302 (GRCm39) G53E possibly damaging Het
Zfp316 A G 5: 143,238,993 (GRCm39) S1009P probably damaging Het
Zfp963 A G 8: 70,197,156 (GRCm39) Y29H probably damaging Het
Zranb3 A G 1: 128,019,607 (GRCm39) I45T probably damaging Het
Other mutations in Zmym4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00537:Zmym4 APN 4 126,783,851 (GRCm39) missense probably benign
IGL00845:Zmym4 APN 4 126,794,406 (GRCm39) missense probably benign 0.28
IGL01122:Zmym4 APN 4 126,758,045 (GRCm39) missense probably damaging 1.00
IGL01374:Zmym4 APN 4 126,762,750 (GRCm39) missense probably damaging 1.00
IGL01564:Zmym4 APN 4 126,805,073 (GRCm39) missense possibly damaging 0.84
IGL02014:Zmym4 APN 4 126,794,462 (GRCm39) missense possibly damaging 0.67
IGL02187:Zmym4 APN 4 126,764,066 (GRCm39) missense probably damaging 0.97
IGL02887:Zmym4 APN 4 126,842,268 (GRCm39) missense probably damaging 0.96
IGL03371:Zmym4 APN 4 126,808,881 (GRCm39) missense possibly damaging 0.90
IGL03400:Zmym4 APN 4 126,816,920 (GRCm39) missense probably benign 0.12
arriba UTSW 4 126,809,415 (GRCm39) missense probably damaging 0.97
foreclosed UTSW 4 126,789,099 (GRCm39) missense probably damaging 1.00
Foreshortened UTSW 4 126,804,729 (GRCm39) missense possibly damaging 0.75
levantese UTSW 4 126,757,961 (GRCm39) missense probably damaging 0.99
terminated UTSW 4 126,819,588 (GRCm39) missense probably benign 0.02
BB004:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
BB014:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
R0149:Zmym4 UTSW 4 126,804,938 (GRCm39) missense probably benign 0.00
R0361:Zmym4 UTSW 4 126,804,938 (GRCm39) missense probably benign 0.00
R0532:Zmym4 UTSW 4 126,792,194 (GRCm39) nonsense probably null
R0745:Zmym4 UTSW 4 126,796,496 (GRCm39) splice site probably benign
R1183:Zmym4 UTSW 4 126,819,632 (GRCm39) missense probably damaging 0.99
R1401:Zmym4 UTSW 4 126,804,962 (GRCm39) missense probably benign 0.00
R1446:Zmym4 UTSW 4 126,776,275 (GRCm39) missense probably damaging 1.00
R1491:Zmym4 UTSW 4 126,776,105 (GRCm39) critical splice acceptor site probably null
R1566:Zmym4 UTSW 4 126,804,940 (GRCm39) missense possibly damaging 0.94
R1962:Zmym4 UTSW 4 126,796,463 (GRCm39) missense possibly damaging 0.47
R2398:Zmym4 UTSW 4 126,816,929 (GRCm39) missense probably damaging 1.00
R2930:Zmym4 UTSW 4 126,819,316 (GRCm39) missense probably benign 0.00
R3891:Zmym4 UTSW 4 126,798,269 (GRCm39) missense probably benign 0.04
R3892:Zmym4 UTSW 4 126,798,269 (GRCm39) missense probably benign 0.04
R4659:Zmym4 UTSW 4 126,842,221 (GRCm39) splice site probably null
R4702:Zmym4 UTSW 4 126,816,958 (GRCm39) missense probably benign 0.01
R5160:Zmym4 UTSW 4 126,763,977 (GRCm39) missense probably damaging 0.97
R5614:Zmym4 UTSW 4 126,804,729 (GRCm39) missense possibly damaging 0.75
R5773:Zmym4 UTSW 4 126,799,163 (GRCm39) missense possibly damaging 0.52
R6450:Zmym4 UTSW 4 126,789,099 (GRCm39) missense probably damaging 1.00
R6741:Zmym4 UTSW 4 126,808,878 (GRCm39) missense possibly damaging 0.80
R7023:Zmym4 UTSW 4 126,762,593 (GRCm39) missense probably damaging 1.00
R7315:Zmym4 UTSW 4 126,776,385 (GRCm39) missense probably benign 0.09
R7468:Zmym4 UTSW 4 126,776,029 (GRCm39) missense probably benign 0.40
R7546:Zmym4 UTSW 4 126,757,961 (GRCm39) missense probably damaging 0.99
R7609:Zmym4 UTSW 4 126,819,588 (GRCm39) missense probably benign 0.02
R7764:Zmym4 UTSW 4 126,819,409 (GRCm39) missense probably benign 0.06
R7897:Zmym4 UTSW 4 126,783,332 (GRCm39) missense possibly damaging 0.76
R7918:Zmym4 UTSW 4 126,804,797 (GRCm39) critical splice acceptor site probably null
R7927:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
R8129:Zmym4 UTSW 4 126,808,956 (GRCm39) missense possibly damaging 0.87
R8240:Zmym4 UTSW 4 126,798,188 (GRCm39) critical splice donor site probably null
R8248:Zmym4 UTSW 4 126,799,162 (GRCm39) missense possibly damaging 0.56
R8261:Zmym4 UTSW 4 126,798,360 (GRCm39) missense probably damaging 1.00
R8313:Zmym4 UTSW 4 126,804,762 (GRCm39) missense probably benign 0.19
R8353:Zmym4 UTSW 4 126,800,905 (GRCm39) missense possibly damaging 0.46
R8747:Zmym4 UTSW 4 126,787,198 (GRCm39) missense probably damaging 1.00
R8787:Zmym4 UTSW 4 126,816,953 (GRCm39) missense probably benign 0.41
R8795:Zmym4 UTSW 4 126,799,819 (GRCm39) missense probably benign 0.35
R8948:Zmym4 UTSW 4 126,758,060 (GRCm39) missense probably damaging 1.00
R9218:Zmym4 UTSW 4 126,809,415 (GRCm39) missense probably damaging 0.97
R9233:Zmym4 UTSW 4 126,776,310 (GRCm39) missense probably damaging 0.99
R9286:Zmym4 UTSW 4 126,783,812 (GRCm39) missense probably damaging 1.00
R9468:Zmym4 UTSW 4 126,800,993 (GRCm39) missense probably benign 0.01
R9542:Zmym4 UTSW 4 126,799,164 (GRCm39) missense probably benign 0.00
R9756:Zmym4 UTSW 4 126,771,502 (GRCm39) missense probably damaging 1.00
R9776:Zmym4 UTSW 4 126,804,942 (GRCm39) missense possibly damaging 0.51
U24488:Zmym4 UTSW 4 126,819,453 (GRCm39) missense possibly damaging 0.69
Z1177:Zmym4 UTSW 4 126,801,005 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTTTGCAGTGCCAAGACTAGCAAAC -3'
(R):5'- GAACCCAGAAGTCTTATTCAAGGAGCC -3'

Sequencing Primer
(F):5'- agcactgattgctctgcc -3'
(R):5'- TGCTCAGTGTCTGGAATGAC -3'
Posted On 2013-05-23