Incidental Mutation 'R4986:Or5w8'
ID 385864
Institutional Source Beutler Lab
Gene Symbol Or5w8
Ensembl Gene ENSMUSG00000047039
Gene Name olfactory receptor family 5 subfamily W member 8
Synonyms MOR177-9, Olfr1151, GA_x6K02T2Q125-49358694-49359620
MMRRC Submission 042580-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.158) question?
Stock # R4986 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87687521-87688447 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87687858 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 113 (L113Q)
Ref Sequence ENSEMBL: ENSMUSP00000151107 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061081] [ENSMUST00000217376]
AlphaFold Q8VFQ8
Predicted Effect probably damaging
Transcript: ENSMUST00000061081
AA Change: L113Q

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000055394
Gene: ENSMUSG00000047039
AA Change: L113Q

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.6e-45 PFAM
Pfam:7tm_1 41 290 1.7e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217376
AA Change: L113Q

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
Meta Mutation Damage Score 0.2132 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.5%
  • 20x: 89.2%
Validation Efficiency 95% (41/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 A T 6: 142,573,317 (GRCm39) C1005S probably benign Het
Armh4 A T 14: 49,989,111 (GRCm39) D619E probably damaging Het
Ccdc34 T C 2: 109,848,214 (GRCm39) M1T probably null Het
Ceacam5 T A 7: 17,491,758 (GRCm39) N709K possibly damaging Het
Ces2f G A 8: 105,678,657 (GRCm39) S298N probably benign Het
Defa30 T A 8: 21,625,432 (GRCm39) Y65* probably null Het
Dock3 A C 9: 106,809,182 (GRCm39) C1314G probably damaging Het
Emc2 A G 15: 43,375,180 (GRCm39) M226V probably benign Het
Fat3 T C 9: 15,909,636 (GRCm39) Y2122C probably damaging Het
Gad1 A G 2: 70,431,037 (GRCm39) D560G probably benign Het
Gm9944 T C 4: 144,179,760 (GRCm39) probably benign Het
Gpr137c A T 14: 45,483,743 (GRCm39) probably null Het
Igf2bp2 C T 16: 21,889,056 (GRCm39) probably null Het
Igsf10 T C 3: 59,236,027 (GRCm39) T1385A probably benign Het
Itpr2 T A 6: 146,141,840 (GRCm39) N1734I probably damaging Het
Kbtbd6 A G 14: 79,690,049 (GRCm39) H248R probably damaging Het
Macf1 C T 4: 123,284,914 (GRCm39) R5650Q probably damaging Het
Mdh1 A G 11: 21,508,545 (GRCm39) F266L possibly damaging Het
Mecom G T 3: 30,034,848 (GRCm39) P466Q probably damaging Het
Muc20 A G 16: 32,598,009 (GRCm39) probably benign Het
Or4x11 A T 2: 89,867,772 (GRCm39) N170Y probably damaging Het
Osmr A G 15: 6,846,061 (GRCm39) probably null Het
Rrs1 G A 1: 9,615,992 (GRCm39) E82K probably damaging Het
Sacs T A 14: 61,450,492 (GRCm39) Y4179* probably null Het
Septin11 T C 5: 93,309,100 (GRCm39) V203A probably damaging Het
Skint9 T A 4: 112,248,910 (GRCm39) T173S probably benign Het
Slain1 A T 14: 103,925,541 (GRCm39) R296S probably damaging Het
Slc36a3 T A 11: 55,037,592 (GRCm39) *93C probably null Het
Sp110 G A 1: 85,519,481 (GRCm39) P116S probably benign Het
Srl T C 16: 4,314,646 (GRCm39) Y332C probably benign Het
Ubtf G A 11: 102,205,000 (GRCm39) H95Y probably benign Het
Ugt1a1 CAGAGAGAGAGAGA CAGAGAGAGAGA 1: 88,139,706 (GRCm39) probably benign Het
Wdfy3 C T 5: 102,090,985 (GRCm39) D532N probably benign Het
Ybx1 C T 4: 119,139,627 (GRCm39) V123I probably damaging Het
Zfp944 A T 17: 22,558,211 (GRCm39) H345Q probably damaging Het
Zfp993 T A 4: 146,742,014 (GRCm39) F113I probably benign Het
Other mutations in Or5w8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01755:Or5w8 APN 2 87,687,854 (GRCm39) missense possibly damaging 0.60
IGL02314:Or5w8 APN 2 87,688,400 (GRCm39) missense probably damaging 1.00
R0127:Or5w8 UTSW 2 87,687,827 (GRCm39) missense probably benign
R0233:Or5w8 UTSW 2 87,688,096 (GRCm39) missense probably benign 0.19
R0233:Or5w8 UTSW 2 87,688,096 (GRCm39) missense probably benign 0.19
R0398:Or5w8 UTSW 2 87,688,401 (GRCm39) missense probably damaging 1.00
R1079:Or5w8 UTSW 2 87,687,699 (GRCm39) missense probably damaging 1.00
R1598:Or5w8 UTSW 2 87,688,095 (GRCm39) missense probably benign 0.01
R1965:Or5w8 UTSW 2 87,687,759 (GRCm39) missense probably benign 0.44
R3409:Or5w8 UTSW 2 87,688,005 (GRCm39) nonsense probably null
R4824:Or5w8 UTSW 2 87,687,621 (GRCm39) missense probably benign 0.24
R4962:Or5w8 UTSW 2 87,687,632 (GRCm39) missense probably benign 0.02
R5324:Or5w8 UTSW 2 87,688,040 (GRCm39) missense probably damaging 1.00
R5934:Or5w8 UTSW 2 87,687,585 (GRCm39) missense probably benign
R6335:Or5w8 UTSW 2 87,687,811 (GRCm39) nonsense probably null
R6389:Or5w8 UTSW 2 87,688,367 (GRCm39) missense probably damaging 1.00
R6958:Or5w8 UTSW 2 87,688,295 (GRCm39) missense probably damaging 1.00
R7329:Or5w8 UTSW 2 87,687,585 (GRCm39) missense probably benign
R8228:Or5w8 UTSW 2 87,688,284 (GRCm39) missense probably benign 0.12
R8506:Or5w8 UTSW 2 87,688,181 (GRCm39) missense probably damaging 1.00
R8726:Or5w8 UTSW 2 87,688,161 (GRCm39) missense probably benign 0.14
R8845:Or5w8 UTSW 2 87,687,545 (GRCm39) missense probably benign 0.00
R9548:Or5w8 UTSW 2 87,688,040 (GRCm39) missense probably damaging 1.00
Z1177:Or5w8 UTSW 2 87,687,768 (GRCm39) missense probably benign 0.13
Predicted Primers PCR Primer
(F):5'- AAAAGTGGCCCTGTTCACC -3'
(R):5'- TGGTTGATCTCATTAGAACCACAG -3'

Sequencing Primer
(F):5'- TCTTCTTGCGAATCTTGGAATTATC -3'
(R):5'- TGATCTCATTAGAACCACAGAAACAC -3'
Posted On 2016-05-10