Incidental Mutation 'R4989:2700049A03Rik'
| ID |
386063 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
2700049A03Rik
|
| Ensembl Gene |
ENSMUSG00000034601 |
| Gene Name |
RIKEN cDNA 2700049A03 gene |
| Synonyms |
talpid3, Ta3 |
| MMRRC Submission |
042583-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4989 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
71183622-71290077 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to T
at 71211320 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Stop codon
at position 685
(E685*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000118956
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045907]
[ENSMUST00000149564]
|
| AlphaFold |
E9PV87 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000045907
AA Change: E685*
|
| SMART Domains |
Protein: ENSMUSP00000044701
Gene: ENSMUSG00000034601
AA Change: E685*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TALPID3
|
116 |
1351 |
N/A |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000149564
AA Change: E685*
|
| SMART Domains |
Protein: ENSMUSP00000118956
Gene: ENSMUSG00000034601
AA Change: E685*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TALPID3
|
116 |
1349 |
N/A |
PFAM |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.4%
|
| Validation Efficiency |
100% (115/115) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a conserved centrosomal protein that functions in ciliogenesis and responds to hedgehog signaling. Mutations in this gene causes Joubert syndrome 23. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Aug 2016]
PHENOTYPE: Mice homozygous for a null allele die during organogenesis, lack cilia, and show randomized L-R patterning, face and neural tube defects, pericardial edema and hemorrhages. Mouse embryonic fibroblasts homozygous for a different null allele lack cilia and asymmetrical centriolar localization. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(12) : Targeted, other(2) Gene trapped(10) |
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acot6 |
A |
G |
12: 84,155,789 (GRCm39) |
K246E |
probably benign |
Het |
| Actl11 |
T |
A |
9: 107,808,615 (GRCm39) |
H979Q |
probably damaging |
Het |
| Adal |
T |
A |
2: 120,986,030 (GRCm39) |
|
probably benign |
Het |
| Add2 |
G |
A |
6: 86,087,840 (GRCm39) |
V596I |
probably benign |
Het |
| Adrb3 |
A |
C |
8: 27,717,798 (GRCm39) |
M217R |
probably damaging |
Het |
| Ank1 |
T |
C |
8: 23,631,134 (GRCm39) |
|
probably benign |
Het |
| Ank2 |
A |
T |
3: 126,757,094 (GRCm39) |
N1054K |
possibly damaging |
Het |
| Ankib1 |
T |
C |
5: 3,763,217 (GRCm39) |
Y504C |
probably damaging |
Het |
| Ankrd29 |
T |
C |
18: 12,395,242 (GRCm39) |
K217R |
probably damaging |
Het |
| Ankrd45 |
T |
C |
1: 160,982,876 (GRCm39) |
V129A |
probably damaging |
Het |
| Aox4 |
A |
T |
1: 58,275,835 (GRCm39) |
D389V |
probably benign |
Het |
| Aph1a |
G |
T |
3: 95,802,843 (GRCm39) |
G148W |
probably damaging |
Het |
| Arhgef26 |
G |
A |
3: 62,247,806 (GRCm39) |
D297N |
possibly damaging |
Het |
| Atxn7l3b |
C |
A |
10: 112,764,649 (GRCm39) |
|
probably benign |
Het |
| Auh |
A |
G |
13: 52,995,065 (GRCm39) |
S167P |
probably damaging |
Het |
| Bach1 |
A |
T |
16: 87,515,888 (GRCm39) |
K143I |
possibly damaging |
Het |
| Bbx |
T |
A |
16: 50,045,101 (GRCm39) |
T487S |
probably damaging |
Het |
| Bche |
T |
G |
3: 73,609,177 (GRCm39) |
D83A |
probably benign |
Het |
| Bri3bp |
G |
T |
5: 125,518,760 (GRCm39) |
|
probably benign |
Het |
| Cd3d |
A |
T |
9: 44,896,296 (GRCm39) |
E28D |
probably damaging |
Het |
| Cdc42bpa |
A |
G |
1: 179,965,366 (GRCm39) |
T1028A |
probably damaging |
Het |
| Ceacam23 |
A |
G |
7: 17,639,143 (GRCm39) |
|
probably null |
Het |
| Celsr2 |
T |
C |
3: 108,319,945 (GRCm39) |
I956V |
possibly damaging |
Het |
| Cep95 |
A |
T |
11: 106,707,480 (GRCm39) |
|
probably null |
Het |
| Cic |
G |
T |
7: 24,986,535 (GRCm39) |
G1289C |
probably damaging |
Het |
| Cndp1 |
A |
G |
18: 84,650,025 (GRCm39) |
Y223H |
probably damaging |
Het |
| Cops8 |
A |
G |
1: 90,538,724 (GRCm39) |
D51G |
probably damaging |
Het |
| Csgalnact1 |
T |
C |
8: 68,913,623 (GRCm39) |
E194G |
probably benign |
Het |
| Ctsm |
A |
G |
13: 61,686,776 (GRCm39) |
Y39H |
probably damaging |
Het |
| Dhrs2 |
T |
C |
14: 55,474,722 (GRCm39) |
V119A |
probably damaging |
Het |
| Drosha |
T |
A |
15: 12,935,093 (GRCm39) |
M1336K |
probably benign |
Het |
| Dsp |
G |
A |
13: 38,381,678 (GRCm39) |
D2808N |
possibly damaging |
Het |
| Ehmt1 |
G |
T |
2: 24,767,509 (GRCm39) |
P135T |
probably damaging |
Het |
| Epas1 |
A |
G |
17: 87,116,882 (GRCm39) |
N184S |
probably damaging |
Het |
| Erich3 |
C |
T |
3: 154,454,025 (GRCm39) |
T597I |
possibly damaging |
Het |
| F10 |
T |
C |
8: 13,105,698 (GRCm39) |
V421A |
probably damaging |
Het |
| Fabp3 |
C |
T |
4: 130,206,180 (GRCm39) |
T57I |
probably benign |
Het |
| Fam227b |
G |
A |
2: 125,958,043 (GRCm39) |
P241S |
probably damaging |
Het |
| Fcgrt |
C |
T |
7: 44,751,372 (GRCm39) |
G192D |
probably benign |
Het |
| Fras1 |
A |
G |
5: 96,798,541 (GRCm39) |
E1184G |
possibly damaging |
Het |
| Garre1 |
A |
C |
7: 33,945,225 (GRCm39) |
Y552D |
probably damaging |
Het |
| Grn |
C |
A |
11: 102,321,380 (GRCm39) |
|
probably benign |
Het |
| Gvin-ps5 |
A |
T |
7: 105,928,664 (GRCm39) |
|
noncoding transcript |
Het |
| Hadh |
A |
T |
3: 131,029,197 (GRCm39) |
L274* |
probably null |
Het |
| Hus1 |
T |
C |
11: 8,956,027 (GRCm39) |
S169G |
probably damaging |
Het |
| Hydin |
A |
T |
8: 111,290,554 (GRCm39) |
I3338F |
possibly damaging |
Het |
| Ighv11-1 |
T |
G |
12: 113,945,768 (GRCm39) |
E28D |
probably benign |
Het |
| Kctd9 |
C |
T |
14: 67,966,805 (GRCm39) |
T106I |
probably damaging |
Het |
| Krit1 |
A |
T |
5: 3,872,238 (GRCm39) |
N421I |
probably damaging |
Het |
| Lamb1 |
A |
G |
12: 31,376,677 (GRCm39) |
D1619G |
probably damaging |
Het |
| Lpar6 |
G |
A |
14: 73,476,147 (GRCm39) |
C36Y |
probably damaging |
Het |
| Lrrc37a |
G |
C |
11: 103,347,565 (GRCm39) |
F3043L |
unknown |
Het |
| Lrrc46 |
A |
T |
11: 96,931,765 (GRCm39) |
V19D |
probably damaging |
Het |
| Mapkap1 |
G |
T |
2: 34,471,303 (GRCm39) |
S197I |
probably damaging |
Het |
| Mrps35 |
A |
C |
6: 146,961,645 (GRCm39) |
K173N |
possibly damaging |
Het |
| Mtf2 |
A |
G |
5: 108,220,894 (GRCm39) |
|
probably benign |
Het |
| Ncf1 |
A |
C |
5: 134,252,267 (GRCm39) |
D261E |
probably damaging |
Het |
| Notch1 |
C |
T |
2: 26,371,193 (GRCm39) |
E298K |
probably damaging |
Het |
| Nrxn1 |
A |
T |
17: 90,928,274 (GRCm39) |
|
probably benign |
Het |
| Or13a18 |
C |
A |
7: 140,190,304 (GRCm39) |
A75E |
possibly damaging |
Het |
| Or4x13 |
T |
A |
2: 90,231,107 (GRCm39) |
M34K |
probably benign |
Het |
| Or52a33 |
A |
G |
7: 103,289,308 (GRCm39) |
F13S |
probably damaging |
Het |
| Or5k3 |
T |
C |
16: 58,969,981 (GRCm39) |
L256P |
probably damaging |
Het |
| Or5v1 |
G |
T |
17: 37,810,017 (GRCm39) |
L158F |
probably benign |
Het |
| Otud4 |
G |
A |
8: 80,382,318 (GRCm39) |
V176I |
probably damaging |
Het |
| Pakap |
T |
A |
4: 57,856,552 (GRCm39) |
V668E |
probably benign |
Het |
| Papolg |
T |
C |
11: 23,823,919 (GRCm39) |
|
probably null |
Het |
| Pgk2 |
A |
G |
17: 40,518,402 (GRCm39) |
V342A |
probably damaging |
Het |
| Phf2 |
G |
A |
13: 48,961,320 (GRCm39) |
A790V |
unknown |
Het |
| Prkdc |
T |
C |
16: 15,491,861 (GRCm39) |
I602T |
possibly damaging |
Het |
| Prl3d3 |
T |
C |
13: 27,343,072 (GRCm39) |
I86T |
possibly damaging |
Het |
| Prss8 |
G |
T |
7: 127,525,635 (GRCm39) |
Q295K |
probably benign |
Het |
| Ptpre |
C |
T |
7: 135,270,861 (GRCm39) |
H346Y |
probably benign |
Het |
| Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
| Pwwp3a |
T |
C |
10: 80,068,702 (GRCm39) |
L282P |
probably benign |
Het |
| Qrfpr |
A |
G |
3: 36,276,285 (GRCm39) |
V35A |
probably damaging |
Het |
| Rpf1 |
A |
G |
3: 146,212,293 (GRCm39) |
L349S |
probably damaging |
Het |
| Rpl41 |
G |
T |
10: 128,384,652 (GRCm39) |
|
probably null |
Het |
| Rprd2 |
G |
C |
3: 95,672,632 (GRCm39) |
R924G |
probably benign |
Het |
| Serpini1 |
T |
A |
3: 75,521,795 (GRCm39) |
N95K |
probably benign |
Het |
| Sfxn1 |
A |
T |
13: 54,242,933 (GRCm39) |
T64S |
probably benign |
Het |
| Siae |
T |
G |
9: 37,557,816 (GRCm39) |
I541S |
possibly damaging |
Het |
| Slc25a4 |
T |
A |
8: 46,660,509 (GRCm39) |
K296N |
probably benign |
Het |
| Slc37a1 |
A |
G |
17: 31,541,120 (GRCm39) |
N204S |
probably damaging |
Het |
| Slc9c1 |
A |
G |
16: 45,413,800 (GRCm39) |
N976S |
probably benign |
Het |
| Smarcal1 |
T |
C |
1: 72,672,019 (GRCm39) |
S847P |
possibly damaging |
Het |
| Smg1 |
A |
T |
7: 117,757,323 (GRCm39) |
|
probably benign |
Het |
| Smg1 |
C |
T |
7: 117,807,274 (GRCm39) |
A168T |
probably benign |
Het |
| Sptlc1 |
A |
G |
13: 53,505,692 (GRCm39) |
I242T |
probably damaging |
Het |
| St8sia2 |
T |
C |
7: 73,616,709 (GRCm39) |
I89V |
possibly damaging |
Het |
| Supt20 |
A |
T |
3: 54,602,555 (GRCm39) |
|
probably benign |
Het |
| Tep1 |
T |
C |
14: 51,076,457 (GRCm39) |
D1659G |
probably benign |
Het |
| Tex10 |
C |
A |
4: 48,458,525 (GRCm39) |
|
probably benign |
Het |
| Thbs3 |
CAGAAG |
CAG |
3: 89,130,409 (GRCm39) |
|
probably benign |
Het |
| Tmbim6 |
C |
A |
15: 99,299,950 (GRCm39) |
S22* |
probably null |
Het |
| Tmc2 |
A |
T |
2: 130,043,961 (GRCm39) |
K65M |
possibly damaging |
Het |
| Tmod1 |
A |
G |
4: 46,090,872 (GRCm39) |
S142G |
probably damaging |
Het |
| Tns2 |
C |
T |
15: 102,017,369 (GRCm39) |
R281C |
probably damaging |
Het |
| Trmt6 |
T |
C |
2: 132,650,191 (GRCm39) |
R349G |
possibly damaging |
Het |
| Ttn |
T |
A |
2: 76,537,586 (GRCm39) |
T26454S |
possibly damaging |
Het |
| Ttn |
C |
T |
2: 76,605,122 (GRCm39) |
V16555I |
probably benign |
Het |
| Tut4 |
T |
A |
4: 108,384,042 (GRCm39) |
|
probably benign |
Het |
| Ubr3 |
T |
C |
2: 69,850,790 (GRCm39) |
|
probably benign |
Het |
| Vmn1r17 |
A |
C |
6: 57,337,460 (GRCm39) |
F253V |
possibly damaging |
Het |
| Vmn1r201 |
G |
T |
13: 22,659,622 (GRCm39) |
A279S |
possibly damaging |
Het |
| Vmn2r17 |
A |
T |
5: 109,575,739 (GRCm39) |
R203S |
probably benign |
Het |
| Vwa5a |
A |
G |
9: 38,633,926 (GRCm39) |
E43G |
probably benign |
Het |
| Wdr86 |
C |
T |
5: 24,917,843 (GRCm39) |
|
probably null |
Het |
| Wdsub1 |
A |
T |
2: 59,700,758 (GRCm39) |
|
probably benign |
Het |
| Zcchc7 |
T |
C |
4: 44,931,039 (GRCm39) |
L76P |
probably damaging |
Het |
| Zfp108 |
G |
T |
7: 23,960,163 (GRCm39) |
K251N |
probably benign |
Het |
| Zfp263 |
T |
C |
16: 3,566,992 (GRCm39) |
C148R |
probably damaging |
Het |
| Zfp687 |
A |
C |
3: 94,917,697 (GRCm39) |
F692V |
probably damaging |
Het |
|
| Other mutations in 2700049A03Rik |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00339:2700049A03Rik
|
APN |
12 |
71,213,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01107:2700049A03Rik
|
APN |
12 |
71,241,242 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01404:2700049A03Rik
|
APN |
12 |
71,211,152 (GRCm39) |
splice site |
probably null |
|
|
IGL01835:2700049A03Rik
|
APN |
12 |
71,213,957 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01835:2700049A03Rik
|
APN |
12 |
71,213,955 (GRCm39) |
nonsense |
probably null |
|
|
IGL02122:2700049A03Rik
|
APN |
12 |
71,217,299 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02140:2700049A03Rik
|
APN |
12 |
71,195,034 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02385:2700049A03Rik
|
APN |
12 |
71,201,630 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03181:2700049A03Rik
|
APN |
12 |
71,240,147 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL03253:2700049A03Rik
|
APN |
12 |
71,187,657 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL03278:2700049A03Rik
|
APN |
12 |
71,205,599 (GRCm39) |
splice site |
probably benign |
|
|
G4846:2700049A03Rik
|
UTSW |
12 |
71,184,683 (GRCm39) |
missense |
probably benign |
|
|
PIT1430001:2700049A03Rik
|
UTSW |
12 |
71,207,160 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
PIT4519001:2700049A03Rik
|
UTSW |
12 |
71,217,440 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0108:2700049A03Rik
|
UTSW |
12 |
71,224,692 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0165:2700049A03Rik
|
UTSW |
12 |
71,213,924 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R0211:2700049A03Rik
|
UTSW |
12 |
71,262,870 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0211:2700049A03Rik
|
UTSW |
12 |
71,262,870 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0220:2700049A03Rik
|
UTSW |
12 |
71,195,194 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0352:2700049A03Rik
|
UTSW |
12 |
71,184,804 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0468:2700049A03Rik
|
UTSW |
12 |
71,240,084 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0508:2700049A03Rik
|
UTSW |
12 |
71,211,162 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0673:2700049A03Rik
|
UTSW |
12 |
71,224,642 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0840:2700049A03Rik
|
UTSW |
12 |
71,205,657 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0893:2700049A03Rik
|
UTSW |
12 |
71,266,082 (GRCm39) |
splice site |
probably benign |
|
|
R1244:2700049A03Rik
|
UTSW |
12 |
71,262,918 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1432:2700049A03Rik
|
UTSW |
12 |
71,217,361 (GRCm39) |
splice site |
probably null |
|
|
R1599:2700049A03Rik
|
UTSW |
12 |
71,197,033 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1732:2700049A03Rik
|
UTSW |
12 |
71,265,995 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1820:2700049A03Rik
|
UTSW |
12 |
71,197,018 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1939:2700049A03Rik
|
UTSW |
12 |
71,207,186 (GRCm39) |
splice site |
probably null |
|
|
R1998:2700049A03Rik
|
UTSW |
12 |
71,235,393 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2337:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2337:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R2340:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2340:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R2382:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2382:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R2384:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2384:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R2445:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2445:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R2449:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2449:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R2512:2700049A03Rik
|
UTSW |
12 |
71,219,945 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R2872:2700049A03Rik
|
UTSW |
12 |
71,201,530 (GRCm39) |
splice site |
probably benign |
|
|
R3236:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3236:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R3237:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3237:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R3734:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3734:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R3808:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R3808:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3809:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R3809:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3944:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R3944:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3959:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R3959:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3960:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R3960:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4593:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4593:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4595:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4595:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4596:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4596:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4600:2700049A03Rik
|
UTSW |
12 |
71,195,037 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4649:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4649:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4651:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4651:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4652:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4652:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4714:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4714:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4735:2700049A03Rik
|
UTSW |
12 |
71,262,897 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4810:2700049A03Rik
|
UTSW |
12 |
71,236,216 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4852:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4852:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4854:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4854:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4855:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4855:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4884:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4884:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4893:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4893:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4905:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4905:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4915:2700049A03Rik
|
UTSW |
12 |
71,236,420 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4919:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4919:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4959:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R4959:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4989:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5011:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R5011:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5012:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R5012:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5118:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R5118:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5146:2700049A03Rik
|
UTSW |
12 |
71,289,799 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5163:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R5163:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5188:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R5188:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5189:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R5189:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5189:2700049A03Rik
|
UTSW |
12 |
71,240,123 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5190:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R5190:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5290:2700049A03Rik
|
UTSW |
12 |
71,235,565 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5344:2700049A03Rik
|
UTSW |
12 |
71,289,801 (GRCm39) |
missense |
probably benign |
|
|
R5502:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5502:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R5503:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5503:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R5619:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5619:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R5667:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5667:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R5669:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5669:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R5671:2700049A03Rik
|
UTSW |
12 |
71,211,320 (GRCm39) |
nonsense |
probably null |
|
|
R5671:2700049A03Rik
|
UTSW |
12 |
71,211,321 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5725:2700049A03Rik
|
UTSW |
12 |
71,240,093 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5956:2700049A03Rik
|
UTSW |
12 |
71,203,893 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6051:2700049A03Rik
|
UTSW |
12 |
71,231,304 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6148:2700049A03Rik
|
UTSW |
12 |
71,234,200 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6158:2700049A03Rik
|
UTSW |
12 |
71,217,410 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6916:2700049A03Rik
|
UTSW |
12 |
71,211,318 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7129:2700049A03Rik
|
UTSW |
12 |
71,263,004 (GRCm39) |
splice site |
probably null |
|
|
R7168:2700049A03Rik
|
UTSW |
12 |
71,262,831 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7193:2700049A03Rik
|
UTSW |
12 |
71,265,963 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7200:2700049A03Rik
|
UTSW |
12 |
71,187,680 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7359:2700049A03Rik
|
UTSW |
12 |
71,236,348 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R7488:2700049A03Rik
|
UTSW |
12 |
71,197,179 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7755:2700049A03Rik
|
UTSW |
12 |
71,236,187 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7757:2700049A03Rik
|
UTSW |
12 |
71,236,187 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7922:2700049A03Rik
|
UTSW |
12 |
71,211,180 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7966:2700049A03Rik
|
UTSW |
12 |
71,219,903 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8082:2700049A03Rik
|
UTSW |
12 |
71,188,895 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8311:2700049A03Rik
|
UTSW |
12 |
71,184,815 (GRCm39) |
unclassified |
probably benign |
|
|
R8408:2700049A03Rik
|
UTSW |
12 |
71,236,356 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8852:2700049A03Rik
|
UTSW |
12 |
71,231,197 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8860:2700049A03Rik
|
UTSW |
12 |
71,231,197 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9039:2700049A03Rik
|
UTSW |
12 |
71,213,849 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9281:2700049A03Rik
|
UTSW |
12 |
71,205,687 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9308:2700049A03Rik
|
UTSW |
12 |
71,231,233 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9385:2700049A03Rik
|
UTSW |
12 |
71,207,966 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R9412:2700049A03Rik
|
UTSW |
12 |
71,235,457 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9643:2700049A03Rik
|
UTSW |
12 |
71,211,189 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9676:2700049A03Rik
|
UTSW |
12 |
71,207,905 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9776:2700049A03Rik
|
UTSW |
12 |
71,235,448 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9789:2700049A03Rik
|
UTSW |
12 |
71,231,357 (GRCm39) |
missense |
probably benign |
|
|
Z1177:2700049A03Rik
|
UTSW |
12 |
71,211,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGACCTTTTATGTTTCCTAGGTGG -3'
(R):5'- ACTGTTCCCTGGCAGATAAC -3'
Sequencing Primer
(F):5'- AACATGTTTTGCATTGGTAGGGCC -3'
(R):5'- TAACGGTACTGAAGCTCTGC -3'
|
| Posted On |
2016-05-10 |
Incidental Mutation