Mutagenetix > Incidental Mutation

Incidental Mutation 'R4992:Polq'

386303

Institutional Source

Beutler Lab

Gene Symbol

Polq

Ensembl Gene

ENSMUSG00000034206

Gene Name

polymerase (DNA directed), theta

Synonyms

A430110D14Rik

MMRRC Submission

042586-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.492) question?

Stock #

R4992 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

36832148-36915779 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 36881524 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 1229 (N1229K)

Ref Sequence

ENSEMBL: ENSMUSP00000059757 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054034] [ENSMUST00000071452] [ENSMUST00000182946] [ENSMUST00000183112]

AlphaFold

Q8CGS6

Predicted Effect

possibly damaging
Transcript: ENSMUST00000054034
AA Change: N1229K

PolyPhen 2 Score 0.587 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000059757
Gene: ENSMUSG00000034206
AA Change: N1229K

Domain	Start	End	E-Value	Type
low complexity region	2	29	N/A	INTRINSIC
low complexity region	38	55	N/A	INTRINSIC
DEXDc	87	298	4.09e-18	SMART
HELICc	398	484	4.02e-17	SMART
Blast:DEXDc	485	550	2e-25	BLAST
low complexity region	609	626	N/A	INTRINSIC
PDB:2ZJA\|A	712	826	5e-9	PDB
low complexity region	845	852	N/A	INTRINSIC
low complexity region	898	911	N/A	INTRINSIC
low complexity region	1126	1149	N/A	INTRINSIC
low complexity region	1813	1822	N/A	INTRINSIC
POLAc	2265	2504	3.3e-101	SMART
low complexity region	2521	2531	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000071452
AA Change: N950K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000071396
Gene: ENSMUSG00000034206
AA Change: N950K

Domain	Start	End	E-Value	Type
low complexity region	2	29	N/A	INTRINSIC
low complexity region	38	55	N/A	INTRINSIC
Pfam:DEAD	92	216	5.9e-12	PFAM
low complexity region	330	347	N/A	INTRINSIC
PDB:2ZJA\|A	433	547	5e-9	PDB
low complexity region	566	573	N/A	INTRINSIC
low complexity region	619	632	N/A	INTRINSIC
low complexity region	847	870	N/A	INTRINSIC
low complexity region	1534	1543	N/A	INTRINSIC
POLAc	1986	2225	3.3e-101	SMART
low complexity region	2242	2252	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182622

Predicted Effect

probably benign
Transcript: ENSMUST00000182946

SMART Domains

Protein: ENSMUSP00000138685
Gene: ENSMUSG00000034206

Domain	Start	End	E-Value	Type
low complexity region	2	29	N/A	INTRINSIC
low complexity region	38	55	N/A	INTRINSIC
Pfam:DEAD	92	164	1.3e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000183112

SMART Domains

Protein: ENSMUSP00000138648
Gene: ENSMUSG00000034206

Domain	Start	End	E-Value	Type
low complexity region	2	29	N/A	INTRINSIC
low complexity region	38	55	N/A	INTRINSIC
Pfam:DEAD	92	164	1.3e-9	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 93.7%

Validation Efficiency

98% (84/86)

MGI Phenotype

PHENOTYPE: Animals carrying a homozygous mutation at this locus display elevated levels of chromosomal damage. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 81 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930407I10Rik	G	A	15: 81,948,203 (GRCm39)	R700Q	possibly damaging	Het
4930444P10Rik	T	A	1: 16,151,101 (GRCm39)	E27V	probably damaging	Het
Acsm4	T	A	7: 119,310,640 (GRCm39)	I509N	probably benign	Het
Asb18	T	C	1: 89,880,585 (GRCm39)	M143V	probably benign	Het
Birc6	A	G	17: 74,996,251 (GRCm39)	D4475G	probably benign	Het
Bsn	A	T	9: 107,992,747 (GRCm39)	S1002T	probably damaging	Het
Bub3	T	C	7: 131,162,535 (GRCm39)	S33P	probably damaging	Het
Ccna1	T	A	3: 54,957,311 (GRCm39)	R35S	probably damaging	Het
Cdc23	T	A	18: 34,779,972 (GRCm39)	M119L	probably benign	Het
Ces1a	A	G	8: 93,771,650 (GRCm39)	V49A	probably benign	Het
Chi3l1	A	T	1: 134,116,364 (GRCm39)	E282D	probably benign	Het
Crocc	G	A	4: 140,773,977 (GRCm39)	A220V	probably damaging	Het
Cstf1	A	G	2: 172,219,720 (GRCm39)	Y277C	probably damaging	Het
D930020B18Rik	C	G	10: 121,490,666 (GRCm39)	P89A	probably damaging	Het
D930020B18Rik	C	T	10: 121,490,667 (GRCm39)	P89L	probably damaging	Het
Dennd5a	A	G	7: 109,493,919 (GRCm39)	S1262P	probably damaging	Het
Dnajb5	G	A	4: 42,953,386 (GRCm39)		probably null	Het
E330034G19Rik	A	G	14: 24,357,064 (GRCm39)	K200R	unknown	Het
Ect2l	A	G	10: 18,048,477 (GRCm39)	F156S	probably benign	Het
Egf	T	C	3: 129,505,179 (GRCm39)		probably null	Het
Elmo1	T	C	13: 20,526,689 (GRCm39)	F413S	probably damaging	Het
Elmo3	T	A	8: 106,036,133 (GRCm39)	Y607*	probably null	Het
Eno3	A	G	11: 70,549,473 (GRCm39)	D98G	probably damaging	Het
Ephb2	A	G	4: 136,388,150 (GRCm39)	V651A	probably damaging	Het
Fbp1	C	T	13: 63,012,888 (GRCm39)	V102I	probably benign	Het
Gcn1	T	C	5: 115,737,225 (GRCm39)	V1321A	probably benign	Het
Gimd1	A	T	3: 132,340,718 (GRCm39)	Y78F	probably benign	Het
Glmn	T	G	5: 107,705,167 (GRCm39)	D483A	probably damaging	Het
Gsr	C	T	8: 34,183,941 (GRCm39)	T401I	probably damaging	Het
Htr3b	G	A	9: 48,870,518 (GRCm39)	H62Y	possibly damaging	Het
Ifna6	T	C	4: 88,745,777 (GRCm39)	V42A	probably benign	Het
Igkv4-80	A	C	6: 68,993,649 (GRCm39)	S81A	probably benign	Het
Inpp4b	A	T	8: 82,759,837 (GRCm39)	R627S	probably damaging	Het
Kif13a	C	T	13: 46,930,639 (GRCm39)	V142M	probably damaging	Het
Lims1	A	C	10: 58,246,063 (GRCm39)		probably benign	Het
Ltn1	T	C	16: 87,202,475 (GRCm39)	T1059A	possibly damaging	Het
Lyst	T	C	13: 13,835,748 (GRCm39)	L1810P	probably damaging	Het
Mboat1	T	G	13: 30,386,343 (GRCm39)	I119R	possibly damaging	Het
Mgat3	T	A	15: 80,096,743 (GRCm39)	D523E	probably benign	Het
Mphosph9	T	C	5: 124,442,253 (GRCm39)	E395G	probably damaging	Het
Mtcl1	G	T	17: 66,649,834 (GRCm39)	P1877Q	probably damaging	Het
Myo6	T	C	9: 80,190,792 (GRCm39)	V781A	possibly damaging	Het
Ncoa3	T	A	2: 165,911,859 (GRCm39)	M1395K	probably benign	Het
Nhlrc2	T	A	19: 56,558,966 (GRCm39)	D150E	probably benign	Het
Nlrp9a	T	C	7: 26,256,811 (GRCm39)	V54A	probably benign	Het
Or1e32	G	A	11: 73,705,146 (GRCm39)	T254I	probably damaging	Het
Or3a1d	A	G	11: 74,238,023 (GRCm39)	I129T	probably damaging	Het
Parp14	A	T	16: 35,661,512 (GRCm39)	C1479S	probably benign	Het
Pdcd1lg2	T	C	19: 29,423,484 (GRCm39)	V176A	probably damaging	Het
Pibf1	T	A	14: 99,388,103 (GRCm39)	N416K	probably damaging	Het
Pip4p1	A	G	14: 51,166,690 (GRCm39)	V179A	probably damaging	Het
Polb	A	T	8: 23,135,087 (GRCm39)	V115E	probably damaging	Het
Ppp1r21	A	T	17: 88,876,508 (GRCm39)	D440V	probably benign	Het
Ppp2ca	T	A	11: 52,004,033 (GRCm39)	H63Q	possibly damaging	Het
Prl7a1	C	T	13: 27,819,669 (GRCm39)		probably null	Het
Rgs1	C	A	1: 144,122,060 (GRCm39)	K77N	probably damaging	Het
Rnf112	T	A	11: 61,343,537 (GRCm39)	I100F	possibly damaging	Het
Rnf139	G	T	15: 58,770,325 (GRCm39)	E117*	probably null	Het
Robo1	G	A	16: 72,776,756 (GRCm39)	V743I	probably damaging	Het
Scarf1	T	C	11: 75,416,841 (GRCm39)	V761A	probably benign	Het
Scarf1	T	C	11: 75,413,056 (GRCm39)	L434P	probably damaging	Het
Sgsm1	A	T	5: 113,430,486 (GRCm39)	S300T	possibly damaging	Het
Slc26a7	T	G	4: 14,565,508 (GRCm39)	T192P	probably damaging	Het
Smarcc2	A	G	10: 128,310,579 (GRCm39)	K403E	probably damaging	Het
Snai3	G	A	8: 123,183,071 (GRCm39)	T158M	possibly damaging	Het
Spata31d1a	T	C	13: 59,850,965 (GRCm39)	N388D	probably benign	Het
Sptlc3	G	A	2: 139,437,923 (GRCm39)	V406I	probably benign	Het
Tgds	A	C	14: 118,355,175 (GRCm39)	Y197D	probably damaging	Het
Tll1	G	T	8: 64,546,978 (GRCm39)	R323S	probably damaging	Het
Trim14	A	G	4: 46,507,110 (GRCm39)	Y369H	probably damaging	Het
Ube2nl	C	T	7: 61,199,112 (GRCm39)		noncoding transcript	Het
Ube3a	T	A	7: 58,934,568 (GRCm39)	D560E	possibly damaging	Het
Vmn2r10	A	G	5: 109,145,592 (GRCm39)	V505A	possibly damaging	Het
Vmn2r114	T	G	17: 23,510,765 (GRCm39)	I572L	probably benign	Het
Vmn2r26	A	T	6: 124,003,070 (GRCm39)	Q160L	probably benign	Het
Vmn2r75	A	C	7: 85,815,375 (GRCm39)		probably null	Het
Vps8	A	G	16: 21,280,158 (GRCm39)	K336E	possibly damaging	Het
Zfp324	T	C	7: 12,703,300 (GRCm39)	S32P	probably benign	Het
Zfp366	T	C	13: 99,366,003 (GRCm39)	I388T	possibly damaging	Het
Zfp68	A	T	5: 138,605,599 (GRCm39)	N203K	possibly damaging	Het
Zhx2	A	T	15: 57,686,983 (GRCm39)	N784I	probably damaging	Het

Other mutations in Polq

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00336:Polq	APN	16	36,885,609 (GRCm39)	splice site	probably benign
IGL00539:Polq	APN	16	36,880,931 (GRCm39)	missense	probably damaging	0.98
IGL00960:Polq	APN	16	36,880,874 (GRCm39)	missense	probably damaging	0.96
IGL01100:Polq	APN	16	36,881,474 (GRCm39)	missense	probably benign
IGL01112:Polq	APN	16	36,837,671 (GRCm39)	missense	probably damaging	1.00
IGL01138:Polq	APN	16	36,866,231 (GRCm39)	missense	possibly damaging	0.94
IGL01432:Polq	APN	16	36,892,184 (GRCm39)	splice site	probably benign
IGL01522:Polq	APN	16	36,848,265 (GRCm39)	missense	probably damaging	1.00
IGL01565:Polq	APN	16	36,833,475 (GRCm39)	missense	probably benign	0.00
IGL01592:Polq	APN	16	36,855,212 (GRCm39)	missense	probably benign	0.01
IGL01690:Polq	APN	16	36,883,200 (GRCm39)	missense	probably damaging	0.97
IGL01943:Polq	APN	16	36,881,805 (GRCm39)	missense	possibly damaging	0.47
IGL02531:Polq	APN	16	36,882,736 (GRCm39)	missense	possibly damaging	0.75
IGL02553:Polq	APN	16	36,862,130 (GRCm39)	missense	probably damaging	1.00
IGL02623:Polq	APN	16	36,880,737 (GRCm39)	missense	probably benign	0.04
IGL02692:Polq	APN	16	36,880,989 (GRCm39)	missense	probably damaging	1.00
IGL02717:Polq	APN	16	36,843,102 (GRCm39)	missense	probably damaging	1.00
IGL02937:Polq	APN	16	36,833,471 (GRCm39)	missense	probably benign	0.14
IGL02959:Polq	APN	16	36,906,928 (GRCm39)	missense	probably damaging	1.00
IGL03086:Polq	APN	16	36,911,411 (GRCm39)	missense	probably benign	0.02
IGL03141:Polq	APN	16	36,837,720 (GRCm39)	splice site	probably benign
IGL03302:Polq	APN	16	36,892,134 (GRCm39)	missense	probably damaging	1.00
IGL03393:Polq	APN	16	36,865,156 (GRCm39)	missense	probably damaging	1.00
R0013_Polq_667	UTSW	16	36,882,201 (GRCm39)	missense	possibly damaging	0.56
R4238_Polq_233	UTSW	16	36,833,543 (GRCm39)	missense	probably damaging	1.00
R4280_polq_867	UTSW	16	36,902,419 (GRCm39)	missense	probably damaging	1.00
G1Funyon:Polq	UTSW	16	36,882,181 (GRCm39)	missense	probably damaging	1.00
PIT4403001:Polq	UTSW	16	36,880,949 (GRCm39)	missense	probably benign	0.00
R0013:Polq	UTSW	16	36,882,201 (GRCm39)	missense	possibly damaging	0.56
R0082:Polq	UTSW	16	36,837,619 (GRCm39)	missense	probably benign	0.01
R0212:Polq	UTSW	16	36,887,216 (GRCm39)	missense	probably damaging	0.99
R0387:Polq	UTSW	16	36,909,679 (GRCm39)	missense	probably damaging	1.00
R0387:Polq	UTSW	16	36,849,792 (GRCm39)	missense	probably damaging	1.00
R0427:Polq	UTSW	16	36,882,355 (GRCm39)	nonsense	probably null
R0454:Polq	UTSW	16	36,855,252 (GRCm39)	missense	probably damaging	0.98
R0513:Polq	UTSW	16	36,914,864 (GRCm39)	missense	probably damaging	1.00
R0622:Polq	UTSW	16	36,881,355 (GRCm39)	missense	probably benign	0.02
R0848:Polq	UTSW	16	36,882,492 (GRCm39)	missense	probably benign	0.08
R1142:Polq	UTSW	16	36,833,579 (GRCm39)	missense	probably damaging	0.98
R1218:Polq	UTSW	16	36,849,808 (GRCm39)	missense	possibly damaging	0.93
R1331:Polq	UTSW	16	36,862,109 (GRCm39)	missense	probably damaging	1.00
R1398:Polq	UTSW	16	36,882,857 (GRCm39)	missense	possibly damaging	0.87
R1424:Polq	UTSW	16	36,906,890 (GRCm39)	missense	probably damaging	1.00
R1644:Polq	UTSW	16	36,880,626 (GRCm39)	missense	probably damaging	0.96
R1777:Polq	UTSW	16	36,880,586 (GRCm39)	missense	possibly damaging	0.94
R1820:Polq	UTSW	16	36,849,780 (GRCm39)	missense	possibly damaging	0.48
R1854:Polq	UTSW	16	36,882,471 (GRCm39)	missense	probably benign	0.01
R1880:Polq	UTSW	16	36,906,954 (GRCm39)	missense	possibly damaging	0.90
R1932:Polq	UTSW	16	36,882,666 (GRCm39)	missense	possibly damaging	0.92
R2008:Polq	UTSW	16	36,882,844 (GRCm39)	missense	probably damaging	0.96
R2014:Polq	UTSW	16	36,898,728 (GRCm39)	missense	probably damaging	1.00
R2026:Polq	UTSW	16	36,883,107 (GRCm39)	missense	possibly damaging	0.93
R2178:Polq	UTSW	16	36,883,191 (GRCm39)	missense	probably damaging	1.00
R2259:Polq	UTSW	16	36,882,459 (GRCm39)	missense	probably benign	0.03
R2266:Polq	UTSW	16	36,882,515 (GRCm39)	missense	possibly damaging	0.59
R2305:Polq	UTSW	16	36,882,699 (GRCm39)	missense	probably damaging	0.99
R2370:Polq	UTSW	16	36,894,301 (GRCm39)	missense	probably damaging	1.00
R2504:Polq	UTSW	16	36,832,304 (GRCm39)	missense	unknown
R2517:Polq	UTSW	16	36,909,687 (GRCm39)	missense	probably damaging	1.00
R2697:Polq	UTSW	16	36,862,515 (GRCm39)	missense	probably damaging	1.00
R2858:Polq	UTSW	16	36,883,115 (GRCm39)	missense	possibly damaging	0.88
R3436:Polq	UTSW	16	36,882,699 (GRCm39)	missense	probably damaging	0.99
R3437:Polq	UTSW	16	36,882,699 (GRCm39)	missense	probably damaging	0.99
R3699:Polq	UTSW	16	36,862,518 (GRCm39)	missense	probably damaging	1.00
R3838:Polq	UTSW	16	36,898,711 (GRCm39)	missense	probably damaging	1.00
R3875:Polq	UTSW	16	36,894,389 (GRCm39)	missense	probably damaging	0.99
R4050:Polq	UTSW	16	36,913,182 (GRCm39)	critical splice acceptor site	probably null
R4172:Polq	UTSW	16	36,881,120 (GRCm39)	missense	probably benign	0.02
R4238:Polq	UTSW	16	36,833,543 (GRCm39)	missense	probably damaging	1.00
R4240:Polq	UTSW	16	36,833,543 (GRCm39)	missense	probably damaging	1.00
R4280:Polq	UTSW	16	36,902,419 (GRCm39)	missense	probably damaging	1.00
R4296:Polq	UTSW	16	36,881,663 (GRCm39)	missense	possibly damaging	0.94
R4360:Polq	UTSW	16	36,880,701 (GRCm39)	missense	probably benign	0.00
R4373:Polq	UTSW	16	36,833,543 (GRCm39)	missense	probably damaging	1.00
R4375:Polq	UTSW	16	36,833,543 (GRCm39)	missense	probably damaging	1.00
R4376:Polq	UTSW	16	36,833,543 (GRCm39)	missense	probably damaging	1.00
R4509:Polq	UTSW	16	36,868,925 (GRCm39)	missense	probably damaging	1.00
R4510:Polq	UTSW	16	36,868,925 (GRCm39)	missense	probably damaging	1.00
R4511:Polq	UTSW	16	36,868,925 (GRCm39)	missense	probably damaging	1.00
R4543:Polq	UTSW	16	36,881,147 (GRCm39)	missense	probably benign	0.43
R4633:Polq	UTSW	16	36,868,904 (GRCm39)	missense	probably damaging	1.00
R4739:Polq	UTSW	16	36,862,109 (GRCm39)	missense	probably damaging	1.00
R4834:Polq	UTSW	16	36,848,176 (GRCm39)	missense	probably damaging	1.00
R4841:Polq	UTSW	16	36,869,145 (GRCm39)	critical splice donor site	probably null
R4842:Polq	UTSW	16	36,869,145 (GRCm39)	critical splice donor site	probably null
R4937:Polq	UTSW	16	36,848,274 (GRCm39)	missense	probably benign	0.01
R4955:Polq	UTSW	16	36,881,444 (GRCm39)	missense	probably benign	0.32
R5008:Polq	UTSW	16	36,882,749 (GRCm39)	missense	probably benign
R5221:Polq	UTSW	16	36,862,540 (GRCm39)	missense	probably damaging	0.98
R5254:Polq	UTSW	16	36,909,681 (GRCm39)	missense	probably damaging	1.00
R5292:Polq	UTSW	16	36,881,745 (GRCm39)	missense	probably damaging	1.00
R5375:Polq	UTSW	16	36,903,146 (GRCm39)	missense	probably damaging	1.00
R5480:Polq	UTSW	16	36,833,652 (GRCm39)	splice site	probably benign
R5552:Polq	UTSW	16	36,914,872 (GRCm39)	missense	possibly damaging	0.93
R5591:Polq	UTSW	16	36,832,247 (GRCm39)	utr 5 prime	probably benign
R5653:Polq	UTSW	16	36,860,896 (GRCm39)	missense	probably damaging	1.00
R5708:Polq	UTSW	16	36,881,380 (GRCm39)	missense	probably damaging	0.98
R5754:Polq	UTSW	16	36,837,625 (GRCm39)	missense	probably benign
R5757:Polq	UTSW	16	36,907,043 (GRCm39)	missense	probably benign	0.01
R5764:Polq	UTSW	16	36,837,706 (GRCm39)	missense	probably damaging	0.97
R6019:Polq	UTSW	16	36,882,126 (GRCm39)	missense	probably damaging	1.00
R6170:Polq	UTSW	16	36,866,174 (GRCm39)	missense	possibly damaging	0.82
R6177:Polq	UTSW	16	36,892,071 (GRCm39)	missense	probably damaging	0.98
R6307:Polq	UTSW	16	36,837,718 (GRCm39)	critical splice donor site	probably null
R6499:Polq	UTSW	16	36,881,189 (GRCm39)	missense	probably benign	0.03
R6520:Polq	UTSW	16	36,880,739 (GRCm39)	missense	possibly damaging	0.88
R6598:Polq	UTSW	16	36,881,993 (GRCm39)	missense	probably benign	0.39
R6694:Polq	UTSW	16	36,835,535 (GRCm39)	missense	probably null	0.99
R6788:Polq	UTSW	16	36,897,510 (GRCm39)	missense	probably damaging	1.00
R7104:Polq	UTSW	16	36,909,715 (GRCm39)	nonsense	probably null
R7159:Polq	UTSW	16	36,883,215 (GRCm39)	missense	possibly damaging	0.87
R7222:Polq	UTSW	16	36,906,995 (GRCm39)	nonsense	probably null
R7340:Polq	UTSW	16	36,881,288 (GRCm39)	missense	probably benign	0.00
R7361:Polq	UTSW	16	36,880,790 (GRCm39)	missense	probably benign	0.00
R7384:Polq	UTSW	16	36,849,780 (GRCm39)	missense	probably damaging	1.00
R7509:Polq	UTSW	16	36,880,706 (GRCm39)	missense	probably benign	0.00
R7509:Polq	UTSW	16	36,880,705 (GRCm39)	missense	probably benign
R7575:Polq	UTSW	16	36,911,496 (GRCm39)	missense	probably benign	0.00
R7785:Polq	UTSW	16	36,848,239 (GRCm39)	missense	probably damaging	1.00
R7787:Polq	UTSW	16	36,837,671 (GRCm39)	missense	probably damaging	1.00
R7891:Polq	UTSW	16	36,848,244 (GRCm39)	missense	probably damaging	1.00
R7898:Polq	UTSW	16	36,865,245 (GRCm39)	missense	probably damaging	0.98
R7917:Polq	UTSW	16	36,885,650 (GRCm39)	missense	probably benign	0.08
R7940:Polq	UTSW	16	36,881,004 (GRCm39)	missense	probably benign	0.27
R8028:Polq	UTSW	16	36,881,678 (GRCm39)	missense	possibly damaging	0.82
R8114:Polq	UTSW	16	36,862,577 (GRCm39)	missense	possibly damaging	0.94
R8144:Polq	UTSW	16	36,849,846 (GRCm39)	missense	probably benign	0.01
R8288:Polq	UTSW	16	36,848,272 (GRCm39)	missense	probably damaging	1.00
R8301:Polq	UTSW	16	36,882,181 (GRCm39)	missense	probably damaging	1.00
R8341:Polq	UTSW	16	36,892,133 (GRCm39)	missense	possibly damaging	0.96
R8348:Polq	UTSW	16	36,837,559 (GRCm39)	critical splice acceptor site	probably null
R8448:Polq	UTSW	16	36,837,559 (GRCm39)	critical splice acceptor site	probably null
R8815:Polq	UTSW	16	36,853,893 (GRCm39)	missense	probably damaging	1.00
R8843:Polq	UTSW	16	36,832,280 (GRCm39)	missense	unknown
R8878:Polq	UTSW	16	36,860,869 (GRCm39)	missense	probably benign	0.02
R9016:Polq	UTSW	16	36,843,159 (GRCm39)	missense	probably damaging	1.00
R9189:Polq	UTSW	16	36,865,265 (GRCm39)	missense	probably damaging	1.00
R9209:Polq	UTSW	16	36,869,011 (GRCm39)	missense	possibly damaging	0.94
R9352:Polq	UTSW	16	36,862,252 (GRCm39)	missense	probably damaging	0.98
R9398:Polq	UTSW	16	36,881,394 (GRCm39)	missense	probably benign	0.02
R9403:Polq	UTSW	16	36,882,215 (GRCm39)	missense	probably benign	0.00
R9489:Polq	UTSW	16	36,843,173 (GRCm39)	missense	probably benign	0.00
R9605:Polq	UTSW	16	36,843,173 (GRCm39)	missense	probably benign	0.00
R9664:Polq	UTSW	16	36,848,176 (GRCm39)	missense	probably damaging	0.98
R9801:Polq	UTSW	16	36,913,190 (GRCm39)	missense	probably damaging	1.00
X0060:Polq	UTSW	16	36,837,599 (GRCm39)	nonsense	probably null
Z1176:Polq	UTSW	16	36,862,619 (GRCm39)	critical splice donor site	probably null

Predicted Primers

PCR Primer
(F):5'- TGCTGCTGCTAGAGACAGAAG -3'
(R):5'- GGCTGGGTTAGAAGCATGAC -3'

Sequencing Primer
(F):5'- CAGAAGAGGACTGGCTGCTC -3'
(R):5'- GGTTAGAAGCATGACTATGTTCAG -3'

Posted On

2016-05-10