Mutagenetix > Incidental Mutation

Incidental Mutation 'R4472:Or8g37'

386340

Institutional Source

Beutler Lab

Gene Symbol

Or8g37

Ensembl Gene

ENSMUSG00000095774

Gene Name

olfactory receptor family 8 subfamily G member 37

Synonyms

Olfr970, GA_x6K02T2PVTD-33517322-33518257, MOR171-16

MMRRC Submission

041729-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.318) question?

Stock #

R4472 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

39730937-39731872 bp(+) (GRCm39)

Type of Mutation

makesense

DNA Base Change (assembly)

T to A at 39731870 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Arginine at position 312 (*312R)

Ref Sequence

ENSEMBL: ENSMUSP00000150325 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071132] [ENSMUST00000213975] [ENSMUST00000215922]

AlphaFold

Q8VFN3

Predicted Effect

probably null
Transcript: ENSMUST00000071132
AA Change: *312R

SMART Domains

Protein: ENSMUSP00000071132
Gene: ENSMUSG00000095774
AA Change: *312R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	5.2e-53	PFAM
Pfam:7tm_1	41	290	1.6e-22	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000213975
AA Change: *312R

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215265

Predicted Effect

probably null
Transcript: ENSMUST00000215922
AA Change: *312R

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.1%

Validation Efficiency

97% (66/68)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001J11Rik	A	T	9: 39,961,994 (GRCm39)		noncoding transcript	Het
Accsl	T	A	2: 93,694,336 (GRCm39)		probably null	Het
Accsl	G	T	2: 93,694,337 (GRCm39)		probably null	Het
Adcy1	G	A	11: 7,080,369 (GRCm39)	V371M	probably damaging	Het
Adgrb2	C	T	4: 129,902,146 (GRCm39)	A509V	probably benign	Het
Adgrg6	T	A	10: 14,312,525 (GRCm39)	Q754L	probably damaging	Het
Agap2	T	C	10: 126,927,082 (GRCm39)	I1008T	probably damaging	Het
Aph1c	T	G	9: 66,735,051 (GRCm39)	H150P	probably damaging	Het
Atcay	T	C	10: 81,048,361 (GRCm39)	R242G	possibly damaging	Het
Atg2a	G	A	19: 6,308,985 (GRCm39)	V1724M	probably damaging	Het
Bbs12	T	C	3: 37,373,369 (GRCm39)	V54A	possibly damaging	Het
Card14	A	G	11: 119,224,784 (GRCm39)	M604V	possibly damaging	Het
Cd28	A	T	1: 60,802,393 (GRCm39)	H104L	probably benign	Het
Cntn5	A	T	9: 10,048,776 (GRCm39)	D262E	probably damaging	Het
Col6a3	A	G	1: 90,749,736 (GRCm39)	V366A	probably benign	Het
Csnk1d	G	A	11: 120,855,800 (GRCm39)		probably benign	Het
Dcaf11	T	A	14: 55,803,063 (GRCm39)		probably benign	Het
Dpy19l4	G	A	4: 11,304,053 (GRCm39)	T119M	possibly damaging	Het
Eif3f	T	C	7: 108,540,153 (GRCm39)	V316A	possibly damaging	Het
Fbrsl1	G	A	5: 110,526,932 (GRCm39)		probably benign	Het
Fbxo10	C	T	4: 45,043,693 (GRCm39)	R710H	probably damaging	Het
Fbxw9	G	A	8: 85,786,829 (GRCm39)	D25N	probably damaging	Het
Gm14295	C	T	2: 176,501,386 (GRCm39)	T292I	possibly damaging	Het
Gm4884	C	G	7: 40,692,687 (GRCm39)	Q219E	probably benign	Het
Gpr150	A	G	13: 76,204,273 (GRCm39)	V224A	probably benign	Het
Hps1	A	T	19: 42,750,935 (GRCm39)	I355N	probably damaging	Het
Lmbr1l	A	G	15: 98,804,178 (GRCm39)	S374P	probably benign	Het
Macf1	A	T	4: 123,289,782 (GRCm39)	N5458K	probably damaging	Het
Man1b1	C	G	2: 25,222,867 (GRCm39)		probably benign	Het
Morc3	A	G	16: 93,671,645 (GRCm39)		probably null	Het
Mrgpra4	T	C	7: 47,631,539 (GRCm39)	T21A	probably benign	Het
Myo1a	G	T	10: 127,546,327 (GRCm39)	V277L	probably benign	Het
Nkain4	C	G	2: 180,596,415 (GRCm39)	M1I	probably null	Het
Nktr	T	C	9: 121,577,962 (GRCm39)		probably benign	Het
Nrxn3	T	C	12: 90,171,515 (GRCm39)	S276P	probably damaging	Het
Oas2	A	T	5: 120,879,220 (GRCm39)	D373E	possibly damaging	Het
Oser1	T	A	2: 163,257,500 (GRCm39)	E11V	probably null	Het
Oser1	C	T	2: 163,257,501 (GRCm39)	E11K	probably damaging	Het
Pacsin3	A	G	2: 91,093,288 (GRCm39)		probably null	Het
Pcdh20	T	C	14: 88,706,434 (GRCm39)	S289G	probably benign	Het
Phlpp1	A	G	1: 106,314,176 (GRCm39)	D1183G	probably damaging	Het
Pign	T	C	1: 105,575,945 (GRCm39)	K232E	probably benign	Het
Polk	A	G	13: 96,630,413 (GRCm39)	S383P	probably damaging	Het
Prom2	C	A	2: 127,382,111 (GRCm39)	R101L	probably benign	Het
Rest	T	C	5: 77,429,027 (GRCm39)	V482A	probably benign	Het
Rexo1	A	T	10: 80,378,492 (GRCm39)	S476T	probably damaging	Het
Rnf31	T	A	14: 55,840,777 (GRCm39)	Y1015N	probably damaging	Het
Spata3	T	C	1: 85,954,152 (GRCm39)	Y305H	probably benign	Het
Sv2a	G	A	3: 96,099,810 (GRCm39)	V587M	probably benign	Het
Synj1	A	G	16: 90,766,069 (GRCm39)		probably null	Het
Syt17	A	G	7: 118,036,040 (GRCm39)		probably null	Het
Taf2	T	C	15: 54,922,276 (GRCm39)	D337G	possibly damaging	Het
Tcaf1	A	C	6: 42,656,248 (GRCm39)	S243A	probably benign	Het
Tmem9	A	G	1: 135,955,234 (GRCm39)	T123A	probably benign	Het
Trav4-4-dv10	T	C	14: 53,921,187 (GRCm39)		probably benign	Het
Trbv15	G	A	6: 41,118,493 (GRCm39)	R83Q	probably damaging	Het
Trim27	A	G	13: 21,374,056 (GRCm39)	I268V	probably benign	Het
Tubgcp6	T	A	15: 88,987,857 (GRCm39)	S1031C	probably damaging	Het
Vmn1r89	C	A	7: 12,953,799 (GRCm39)	H110Q	probably benign	Het
Vmn2r30	T	C	7: 7,320,091 (GRCm39)	N545S	probably damaging	Het
Wls	G	A	3: 159,603,020 (GRCm39)	M144I	probably benign	Het
Yme1l1	T	C	2: 23,076,344 (GRCm39)		probably null	Het
Zeb2	A	T	2: 44,913,023 (GRCm39)	L56Q	probably damaging	Het

Other mutations in Or8g37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01388:Or8g37	APN	9	39,731,298 (GRCm39)	missense	probably damaging	1.00
IGL02674:Or8g37	APN	9	39,730,934 (GRCm39)	splice site	probably null
R0659:Or8g37	UTSW	9	39,731,112 (GRCm39)	missense	possibly damaging	0.78
R0686:Or8g37	UTSW	9	39,730,964 (GRCm39)	missense	probably damaging	0.98
R1952:Or8g37	UTSW	9	39,731,363 (GRCm39)	missense	probably benign	0.09
R2068:Or8g37	UTSW	9	39,731,846 (GRCm39)	missense	probably benign	0.00
R4798:Or8g37	UTSW	9	39,731,193 (GRCm39)	missense	probably benign	0.13
R5035:Or8g37	UTSW	9	39,731,390 (GRCm39)	missense	possibly damaging	0.82
R5339:Or8g37	UTSW	9	39,731,229 (GRCm39)	missense	probably damaging	0.97
R6751:Or8g37	UTSW	9	39,731,193 (GRCm39)	missense	probably benign	0.13
R7211:Or8g37	UTSW	9	39,731,154 (GRCm39)	missense	possibly damaging	0.76
R7471:Or8g37	UTSW	9	39,731,423 (GRCm39)	missense	probably benign	0.00
R7609:Or8g37	UTSW	9	39,731,583 (GRCm39)	missense	probably benign
R7638:Or8g37	UTSW	9	39,731,189 (GRCm39)	missense	probably damaging	1.00
R7890:Or8g37	UTSW	9	39,731,310 (GRCm39)	missense	probably damaging	0.99
R7918:Or8g37	UTSW	9	39,731,406 (GRCm39)	missense	probably damaging	0.98
R8548:Or8g37	UTSW	9	39,731,537 (GRCm39)	missense	probably benign	0.00
R8817:Or8g37	UTSW	9	39,730,939 (GRCm39)	start codon destroyed	probably null	0.40
R8868:Or8g37	UTSW	9	39,731,252 (GRCm39)	missense	probably benign
R9689:Or8g37	UTSW	9	39,731,801 (GRCm39)	missense	possibly damaging	0.95
Z1176:Or8g37	UTSW	9	39,731,651 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCTTGCATTCATGTACTTGCAG -3'
(R):5'- AAACTGACTAGTGTGATGCATGC -3'

Sequencing Primer
(F):5'- GTACTTGCAGCCATCATCAGTCAG -3'
(R):5'- AAGCAGATGGTTCTCTATATCCC -3'

Posted On

2016-05-17