Incidental Mutation 'R5059:Zfp988'
ID 386507
Institutional Source Beutler Lab
Gene Symbol Zfp988
Ensembl Gene ENSMUSG00000078498
Gene Name zinc finger protein 988
Synonyms Gm13151
MMRRC Submission 042649-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.161) question?
Stock # R5059 (G1)
Quality Score 110
Status Not validated
Chromosome 4
Chromosomal Location 147390131-147418191 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 147416372 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 269 (K269*)
Ref Sequence ENSEMBL: ENSMUSP00000120413 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000148762] [ENSMUST00000166764]
AlphaFold F6VKC7
Predicted Effect probably null
Transcript: ENSMUST00000148762
AA Change: K269*
SMART Domains Protein: ENSMUSP00000120413
Gene: ENSMUSG00000078498
AA Change: K269*

DomainStartEndE-ValueType
KRAB 13 76 4.74e-16 SMART
ZnF_C2H2 240 262 2.61e-4 SMART
ZnF_C2H2 268 290 1.3e-4 SMART
ZnF_C2H2 296 318 9.73e-4 SMART
ZnF_C2H2 324 346 7.78e-3 SMART
ZnF_C2H2 352 374 1.3e-4 SMART
ZnF_C2H2 380 402 8.34e-3 SMART
ZnF_C2H2 408 430 2.79e-4 SMART
ZnF_C2H2 436 458 3.74e-5 SMART
ZnF_C2H2 464 486 1.3e-4 SMART
ZnF_C2H2 492 514 1.5e-4 SMART
ZnF_C2H2 520 542 2.43e-4 SMART
ZnF_C2H2 548 570 9.73e-4 SMART
ZnF_C2H2 576 598 1.56e-2 SMART
ZnF_C2H2 604 626 2.53e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000166764
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181084
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181486
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181752
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.9%
Validation Efficiency 98% (52/53)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26b T A 8: 43,973,637 (GRCm39) N455I probably damaging Het
Alg12 A G 15: 88,695,659 (GRCm39) F279S probably damaging Het
Angpt4 A G 2: 151,776,360 (GRCm39) D296G probably damaging Het
Ank1 T A 8: 23,586,204 (GRCm39) S437T probably damaging Het
Apol7a G A 15: 77,274,012 (GRCm39) probably benign Het
Arhgef38 T A 3: 132,843,175 (GRCm39) Y465F probably damaging Het
Atp8a2 T G 14: 59,928,986 (GRCm39) T1023P probably benign Het
Cdh20 C A 1: 109,993,430 (GRCm39) A295E probably damaging Het
Cela3b T C 4: 137,152,181 (GRCm39) E92G probably benign Het
Cntnap5a T C 1: 116,356,224 (GRCm39) S752P probably benign Het
Dlx2 T C 2: 71,376,585 (GRCm39) H51R probably damaging Het
Dnm2 T C 9: 21,415,874 (GRCm39) I736T probably damaging Het
Dst A G 1: 34,202,427 (GRCm39) T252A possibly damaging Het
Fbxo40 T C 16: 36,790,658 (GRCm39) R151G possibly damaging Het
Gapdhs C T 7: 30,431,410 (GRCm39) A357T probably benign Het
Gon4l T A 3: 88,807,319 (GRCm39) M1671K probably benign Het
Gpi1 T C 7: 33,907,113 (GRCm39) Y327C probably damaging Het
Gucy2g T C 19: 55,214,503 (GRCm39) R542G probably benign Het
Hectd3 A G 4: 116,854,361 (GRCm39) K308E possibly damaging Het
Hip1 A G 5: 135,478,675 (GRCm39) F178S probably damaging Het
Hydin A G 8: 111,232,401 (GRCm39) D1640G probably damaging Het
Il18r1 G A 1: 40,520,227 (GRCm39) probably null Het
Kdm3b T C 18: 34,910,250 (GRCm39) S23P possibly damaging Het
Lactb T C 9: 66,882,426 (GRCm39) E83G probably benign Het
Larp4 A T 15: 99,903,171 (GRCm39) D414V probably damaging Het
Map2k5 T C 9: 63,164,296 (GRCm39) H336R probably benign Het
Mast4 T C 13: 102,887,071 (GRCm39) E1006G probably damaging Het
Mbd5 T C 2: 49,146,467 (GRCm39) S226P probably damaging Het
Micall1 A T 15: 79,007,034 (GRCm39) probably benign Het
Mtpap T A 18: 4,375,827 (GRCm39) probably benign Het
Or52ae7 A T 7: 103,119,488 (GRCm39) K81* probably null Het
Or5p58 A G 7: 107,694,522 (GRCm39) L85P probably damaging Het
Pnrc1 G A 4: 33,246,072 (GRCm39) Q296* probably null Het
Poc1a G T 9: 106,227,012 (GRCm39) probably benign Het
Pramel28 A G 4: 143,691,565 (GRCm39) V386A probably damaging Het
Prkcsh T A 9: 21,924,046 (GRCm39) L439Q probably damaging Het
Prkdc T C 16: 15,655,882 (GRCm39) L3970P probably damaging Het
Ptcd1 G A 5: 145,089,034 (GRCm39) P542L probably benign Het
Rps6ka5 G A 12: 100,520,634 (GRCm39) T631I probably damaging Het
Rxfp1 T C 3: 79,570,619 (GRCm39) N271S probably benign Het
Taf6 A G 5: 138,177,709 (GRCm39) M541T probably benign Het
Tek T A 4: 94,692,551 (GRCm39) C169S probably benign Het
Tgfbr3l T A 8: 4,299,343 (GRCm39) probably null Het
Trpv3 A G 11: 73,186,149 (GRCm39) N647D probably benign Het
Ube3c A G 5: 29,836,293 (GRCm39) K638R probably null Het
Vmn1r191 G A 13: 22,363,163 (GRCm39) A197V probably damaging Het
Vmn2r6 T C 3: 64,445,044 (GRCm39) T894A possibly damaging Het
Vstm4 T G 14: 32,585,687 (GRCm39) Y85D probably damaging Het
Wnt7a A G 6: 91,371,482 (GRCm39) I160T probably benign Het
Zc3h7a TAGAGAG TAGAGAGAG 16: 10,978,985 (GRCm39) probably null Het
Other mutations in Zfp988
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02282:Zfp988 APN 4 147,416,125 (GRCm39) nonsense probably null
R1672:Zfp988 UTSW 4 147,415,739 (GRCm39) missense probably benign
R1834:Zfp988 UTSW 4 147,417,344 (GRCm39) missense probably damaging 0.97
R2324:Zfp988 UTSW 4 147,417,242 (GRCm39) missense probably benign
R2380:Zfp988 UTSW 4 147,417,242 (GRCm39) missense probably benign
R3795:Zfp988 UTSW 4 147,416,040 (GRCm39) missense possibly damaging 0.51
R3945:Zfp988 UTSW 4 147,417,242 (GRCm39) missense probably benign
R4024:Zfp988 UTSW 4 147,417,242 (GRCm39) missense probably benign
R5012:Zfp988 UTSW 4 147,416,060 (GRCm39) missense probably benign
R6008:Zfp988 UTSW 4 147,416,259 (GRCm39) missense probably benign 0.16
R6245:Zfp988 UTSW 4 147,416,470 (GRCm39) nonsense probably null
R6549:Zfp988 UTSW 4 147,416,310 (GRCm39) missense probably benign 0.03
R7658:Zfp988 UTSW 4 147,416,751 (GRCm39) missense probably damaging 1.00
R8309:Zfp988 UTSW 4 147,416,765 (GRCm39) missense probably damaging 0.99
R8439:Zfp988 UTSW 4 147,416,808 (GRCm39) missense probably benign 0.01
R9159:Zfp988 UTSW 4 147,416,450 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- CCAGGAACACTAAAGAAGTTTGC -3'
(R):5'- GCATTTGTCACATTCACTGCATTTG -3'

Sequencing Primer
(F):5'- GTCTCAATCAAGGAATTAACATGCAG -3'
(R):5'- GTCACATTCACTGCATTTGTAAGG -3'
Posted On 2016-06-06