Incidental Mutation 'R5059:Apol7a'
ID 386531
Institutional Source Beutler Lab
Gene Symbol Apol7a
Ensembl Gene ENSMUSG00000010601
Gene Name apolipoprotein L 7a
Synonyms 9130022K13Rik, Apol3
MMRRC Submission 042649-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5059 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 77272419-77283310 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to A at 77274012 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000135369 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000010745] [ENSMUST00000175789] [ENSMUST00000175919] [ENSMUST00000176074]
AlphaFold B2RT54
Predicted Effect unknown
Transcript: ENSMUST00000010745
AA Change: T150M
SMART Domains Protein: ENSMUSP00000010745
Gene: ENSMUSG00000010601
AA Change: T150M

DomainStartEndE-ValueType
Pfam:ApoL 20 82 2.4e-13 PFAM
low complexity region 84 95 N/A INTRINSIC
Pfam:ApoL 123 416 1.8e-122 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000175789
Predicted Effect unknown
Transcript: ENSMUST00000175919
AA Change: T150M
SMART Domains Protein: ENSMUSP00000135864
Gene: ENSMUSG00000010601
AA Change: T150M

DomainStartEndE-ValueType
Pfam:ApoL 20 416 3.1e-138 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000176074
AA Change: T150M
SMART Domains Protein: ENSMUSP00000134864
Gene: ENSMUSG00000010601
AA Change: T150M

DomainStartEndE-ValueType
Pfam:ApoL 20 416 3.1e-138 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176779
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177135
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.9%
Validation Efficiency 98% (52/53)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26b T A 8: 43,973,637 (GRCm39) N455I probably damaging Het
Alg12 A G 15: 88,695,659 (GRCm39) F279S probably damaging Het
Angpt4 A G 2: 151,776,360 (GRCm39) D296G probably damaging Het
Ank1 T A 8: 23,586,204 (GRCm39) S437T probably damaging Het
Arhgef38 T A 3: 132,843,175 (GRCm39) Y465F probably damaging Het
Atp8a2 T G 14: 59,928,986 (GRCm39) T1023P probably benign Het
Cdh20 C A 1: 109,993,430 (GRCm39) A295E probably damaging Het
Cela3b T C 4: 137,152,181 (GRCm39) E92G probably benign Het
Cntnap5a T C 1: 116,356,224 (GRCm39) S752P probably benign Het
Dlx2 T C 2: 71,376,585 (GRCm39) H51R probably damaging Het
Dnm2 T C 9: 21,415,874 (GRCm39) I736T probably damaging Het
Dst A G 1: 34,202,427 (GRCm39) T252A possibly damaging Het
Fbxo40 T C 16: 36,790,658 (GRCm39) R151G possibly damaging Het
Gapdhs C T 7: 30,431,410 (GRCm39) A357T probably benign Het
Gon4l T A 3: 88,807,319 (GRCm39) M1671K probably benign Het
Gpi1 T C 7: 33,907,113 (GRCm39) Y327C probably damaging Het
Gucy2g T C 19: 55,214,503 (GRCm39) R542G probably benign Het
Hectd3 A G 4: 116,854,361 (GRCm39) K308E possibly damaging Het
Hip1 A G 5: 135,478,675 (GRCm39) F178S probably damaging Het
Hydin A G 8: 111,232,401 (GRCm39) D1640G probably damaging Het
Il18r1 G A 1: 40,520,227 (GRCm39) probably null Het
Kdm3b T C 18: 34,910,250 (GRCm39) S23P possibly damaging Het
Lactb T C 9: 66,882,426 (GRCm39) E83G probably benign Het
Larp4 A T 15: 99,903,171 (GRCm39) D414V probably damaging Het
Map2k5 T C 9: 63,164,296 (GRCm39) H336R probably benign Het
Mast4 T C 13: 102,887,071 (GRCm39) E1006G probably damaging Het
Mbd5 T C 2: 49,146,467 (GRCm39) S226P probably damaging Het
Micall1 A T 15: 79,007,034 (GRCm39) probably benign Het
Mtpap T A 18: 4,375,827 (GRCm39) probably benign Het
Or52ae7 A T 7: 103,119,488 (GRCm39) K81* probably null Het
Or5p58 A G 7: 107,694,522 (GRCm39) L85P probably damaging Het
Pnrc1 G A 4: 33,246,072 (GRCm39) Q296* probably null Het
Poc1a G T 9: 106,227,012 (GRCm39) probably benign Het
Pramel28 A G 4: 143,691,565 (GRCm39) V386A probably damaging Het
Prkcsh T A 9: 21,924,046 (GRCm39) L439Q probably damaging Het
Prkdc T C 16: 15,655,882 (GRCm39) L3970P probably damaging Het
Ptcd1 G A 5: 145,089,034 (GRCm39) P542L probably benign Het
Rps6ka5 G A 12: 100,520,634 (GRCm39) T631I probably damaging Het
Rxfp1 T C 3: 79,570,619 (GRCm39) N271S probably benign Het
Taf6 A G 5: 138,177,709 (GRCm39) M541T probably benign Het
Tek T A 4: 94,692,551 (GRCm39) C169S probably benign Het
Tgfbr3l T A 8: 4,299,343 (GRCm39) probably null Het
Trpv3 A G 11: 73,186,149 (GRCm39) N647D probably benign Het
Ube3c A G 5: 29,836,293 (GRCm39) K638R probably null Het
Vmn1r191 G A 13: 22,363,163 (GRCm39) A197V probably damaging Het
Vmn2r6 T C 3: 64,445,044 (GRCm39) T894A possibly damaging Het
Vstm4 T G 14: 32,585,687 (GRCm39) Y85D probably damaging Het
Wnt7a A G 6: 91,371,482 (GRCm39) I160T probably benign Het
Zc3h7a TAGAGAG TAGAGAGAG 16: 10,978,985 (GRCm39) probably null Het
Zfp988 A T 4: 147,416,372 (GRCm39) K269* probably null Het
Other mutations in Apol7a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01015:Apol7a APN 15 77,274,055 (GRCm39) unclassified probably benign
IGL01408:Apol7a APN 15 77,273,530 (GRCm39) missense probably damaging 1.00
IGL01702:Apol7a APN 15 77,273,886 (GRCm39) splice site probably null
IGL02215:Apol7a APN 15 77,277,690 (GRCm39) missense possibly damaging 0.81
IGL02931:Apol7a APN 15 77,277,650 (GRCm39) nonsense probably null
R0610:Apol7a UTSW 15 77,273,454 (GRCm39) missense probably benign 0.06
R0652:Apol7a UTSW 15 77,274,055 (GRCm39) unclassified probably benign
R1616:Apol7a UTSW 15 77,273,806 (GRCm39) missense probably damaging 1.00
R1756:Apol7a UTSW 15 77,277,671 (GRCm39) missense possibly damaging 0.93
R3034:Apol7a UTSW 15 77,273,923 (GRCm39) missense probably benign 0.03
R4566:Apol7a UTSW 15 77,273,951 (GRCm39) nonsense probably null
R6807:Apol7a UTSW 15 77,277,520 (GRCm39) splice site probably null
R6995:Apol7a UTSW 15 77,274,176 (GRCm39) unclassified probably benign
R7824:Apol7a UTSW 15 77,273,275 (GRCm39) missense probably damaging 1.00
R8364:Apol7a UTSW 15 77,273,820 (GRCm39) missense possibly damaging 0.51
R8375:Apol7a UTSW 15 77,273,547 (GRCm39) missense probably damaging 1.00
R9396:Apol7a UTSW 15 77,273,925 (GRCm39) missense possibly damaging 0.76
R9471:Apol7a UTSW 15 77,273,680 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- ACCAAGGATGATCAGGACTCC -3'
(R):5'- AGATTCCTTGAGTGAAGATCTTGG -3'

Sequencing Primer
(F):5'- GGATGATCAGGACTCCAGACAC -3'
(R):5'- AAGATCTTGGTGAGAGTGTAGC -3'
Posted On 2016-06-06