Incidental Mutation 'R5060:Abcc9'
ID 386559
Institutional Source Beutler Lab
Gene Symbol Abcc9
Ensembl Gene ENSMUSG00000030249
Gene Name ATP-binding cassette, sub-family C member 9
Synonyms SUR2A, Sur2, SUR2B
MMRRC Submission 042650-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R5060 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 142533588-142648041 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to G at 142571836 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000144779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073173] [ENSMUST00000087527] [ENSMUST00000100827] [ENSMUST00000111771] [ENSMUST00000205202]
AlphaFold P70170
Predicted Effect probably benign
Transcript: ENSMUST00000073173
SMART Domains Protein: ENSMUSP00000072914
Gene: ENSMUSG00000030249

DomainStartEndE-ValueType
transmembrane domain 28 50 N/A INTRINSIC
transmembrane domain 71 93 N/A INTRINSIC
transmembrane domain 103 125 N/A INTRINSIC
transmembrane domain 137 159 N/A INTRINSIC
transmembrane domain 169 188 N/A INTRINSIC
low complexity region 265 276 N/A INTRINSIC
Pfam:ABC_membrane 297 583 7.7e-33 PFAM
AAA 659 867 3.11e-13 SMART
coiled coil region 881 935 N/A INTRINSIC
Pfam:ABC_membrane 956 1228 6.6e-35 PFAM
AAA 1300 1502 9.94e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000087527
SMART Domains Protein: ENSMUSP00000084805
Gene: ENSMUSG00000030249

DomainStartEndE-ValueType
transmembrane domain 28 50 N/A INTRINSIC
transmembrane domain 71 93 N/A INTRINSIC
transmembrane domain 103 125 N/A INTRINSIC
transmembrane domain 137 159 N/A INTRINSIC
transmembrane domain 169 188 N/A INTRINSIC
low complexity region 265 276 N/A INTRINSIC
Pfam:ABC_membrane 297 583 8e-33 PFAM
AAA 694 902 3.11e-13 SMART
coiled coil region 916 970 N/A INTRINSIC
Pfam:ABC_membrane 991 1263 6.8e-35 PFAM
AAA 1335 1537 9.94e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000100827
SMART Domains Protein: ENSMUSP00000098390
Gene: ENSMUSG00000030249

DomainStartEndE-ValueType
transmembrane domain 28 50 N/A INTRINSIC
transmembrane domain 71 93 N/A INTRINSIC
transmembrane domain 103 125 N/A INTRINSIC
transmembrane domain 137 159 N/A INTRINSIC
transmembrane domain 169 188 N/A INTRINSIC
low complexity region 265 276 N/A INTRINSIC
Pfam:ABC_membrane 297 583 7.1e-35 PFAM
AAA 694 902 3.11e-13 SMART
coiled coil region 916 970 N/A INTRINSIC
Pfam:ABC_membrane 991 1263 5.2e-38 PFAM
AAA 1335 1520 5.13e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000111771
SMART Domains Protein: ENSMUSP00000107401
Gene: ENSMUSG00000030249

DomainStartEndE-ValueType
transmembrane domain 28 50 N/A INTRINSIC
transmembrane domain 71 93 N/A INTRINSIC
transmembrane domain 103 125 N/A INTRINSIC
transmembrane domain 137 159 N/A INTRINSIC
transmembrane domain 169 188 N/A INTRINSIC
low complexity region 265 276 N/A INTRINSIC
Pfam:ABC_membrane 297 583 1.4e-32 PFAM
AAA 694 889 3.77e-12 SMART
coiled coil region 903 957 N/A INTRINSIC
Pfam:ABC_membrane 978 1250 1.2e-34 PFAM
AAA 1322 1524 9.94e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194811
Predicted Effect probably benign
Transcript: ENSMUST00000205202
SMART Domains Protein: ENSMUSP00000144779
Gene: ENSMUSG00000030249

DomainStartEndE-ValueType
transmembrane domain 28 50 N/A INTRINSIC
transmembrane domain 71 93 N/A INTRINSIC
transmembrane domain 103 125 N/A INTRINSIC
transmembrane domain 137 159 N/A INTRINSIC
transmembrane domain 169 188 N/A INTRINSIC
low complexity region 265 276 N/A INTRINSIC
Pfam:ABC_membrane 297 583 6.9e-35 PFAM
AAA 659 867 3.11e-13 SMART
coiled coil region 881 935 N/A INTRINSIC
Pfam:ABC_membrane 956 1228 5e-38 PFAM
AAA 1300 1502 9.94e-12 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 92.9%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]
PHENOTYPE: Mice homozygous for a null allele display lower serum glucose, enhanced insulin action, growth retardation, hypertension and spontaneous death due to episodic coronary artery vasospasm. Homozygous exon 5 deletion leads to cardiac mitochondrial defects, cardiomyopathy, and early postnatal death. [provided by MGI curators]
Allele List at MGI

All alleles(4) : Targeted(4)

Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530064D06Rik A T 17: 48,474,107 (GRCm39) L17Q probably damaging Het
Abca6 A G 11: 110,110,430 (GRCm39) V573A possibly damaging Het
Actg1 A G 11: 120,237,839 (GRCm39) S234P probably benign Het
Acvr2a A G 2: 48,780,311 (GRCm39) D177G probably damaging Het
Adamts12 T C 15: 11,300,054 (GRCm39) C914R probably damaging Het
Adprhl1 A G 8: 13,298,621 (GRCm39) I103T possibly damaging Het
Als2cl C T 9: 110,713,205 (GRCm39) L32F probably damaging Het
Ank2 T C 3: 126,739,570 (GRCm39) probably benign Het
Ankrd52 T A 10: 128,225,710 (GRCm39) S959R possibly damaging Het
Bnc2 C A 4: 84,449,872 (GRCm39) A122S probably benign Het
Cert1 A T 13: 96,739,663 (GRCm39) K226N probably benign Het
Cfap54 C T 10: 92,875,013 (GRCm39) V443M probably damaging Het
Cilk1 C T 9: 78,060,978 (GRCm39) T208I probably benign Het
Clca4b T A 3: 144,617,267 (GRCm39) R794S probably damaging Het
Cyp2c65 T C 19: 39,049,514 (GRCm39) L14P unknown Het
Ggt5 T C 10: 75,440,608 (GRCm39) M243T probably benign Het
Gmds A G 13: 32,124,482 (GRCm39) I292T probably benign Het
Gpcpd1 A T 2: 132,386,355 (GRCm39) V341E probably damaging Het
Grm3 A G 5: 9,620,167 (GRCm39) F359S probably damaging Het
Hcn1 A T 13: 118,010,441 (GRCm39) K340* probably null Het
Heatr9 T C 11: 83,403,258 (GRCm39) E427G probably benign Het
Kif26b G A 1: 178,358,195 (GRCm39) G102D unknown Het
Mark3 T C 12: 111,584,760 (GRCm39) F119L probably damaging Het
Melk T C 4: 44,350,959 (GRCm39) V500A probably benign Het
Mrpl41 A G 2: 24,864,295 (GRCm39) F126L probably damaging Het
Or10c1 C A 17: 37,522,307 (GRCm39) A146S probably benign Het
Or6c3b C T 10: 129,527,699 (GRCm39) M70I probably benign Het
Pax7 A T 4: 139,506,928 (GRCm39) S372T probably benign Het
Pax7 A T 4: 139,556,906 (GRCm39) I118N probably damaging Het
Plcl1 G T 1: 55,735,671 (GRCm39) M337I possibly damaging Het
Poc1a G T 9: 106,227,012 (GRCm39) probably benign Het
Rabgef1 A G 5: 130,240,844 (GRCm39) Y321C probably damaging Het
Rhobtb3 A C 13: 76,061,389 (GRCm39) L252R probably benign Het
Rlf A G 4: 121,004,063 (GRCm39) V1639A probably benign Het
Tff1 A G 17: 31,381,682 (GRCm39) V65A probably damaging Het
Trpm4 G T 7: 44,971,258 (GRCm39) D222E probably damaging Het
Ttn A T 2: 76,643,741 (GRCm39) D13162E probably damaging Het
Unc5d A T 8: 29,209,723 (GRCm39) S466T probably benign Het
Vmn1r73 A G 7: 11,490,683 (GRCm39) Y167C probably damaging Het
Vwde C T 6: 13,208,323 (GRCm39) probably null Het
Xpr1 T C 1: 155,204,430 (GRCm39) probably null Het
Zbtb40 A G 4: 136,728,604 (GRCm39) V413A possibly damaging Het
Other mutations in Abcc9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Abcc9 APN 6 142,578,916 (GRCm39) splice site probably benign
IGL00670:Abcc9 APN 6 142,633,007 (GRCm39) missense probably damaging 1.00
IGL00675:Abcc9 APN 6 142,610,347 (GRCm39) missense probably damaging 1.00
IGL00741:Abcc9 APN 6 142,632,956 (GRCm39) missense probably benign
IGL01371:Abcc9 APN 6 142,602,340 (GRCm39) missense probably benign 0.04
IGL01686:Abcc9 APN 6 142,548,801 (GRCm39) missense possibly damaging 0.71
IGL01724:Abcc9 APN 6 142,610,259 (GRCm39) missense probably benign 0.00
IGL01807:Abcc9 APN 6 142,551,640 (GRCm39) missense probably damaging 1.00
IGL01941:Abcc9 APN 6 142,551,630 (GRCm39) missense probably damaging 1.00
IGL01946:Abcc9 APN 6 142,571,763 (GRCm39) missense probably benign 0.16
IGL02210:Abcc9 APN 6 142,633,097 (GRCm39) missense probably damaging 1.00
IGL02498:Abcc9 APN 6 142,617,265 (GRCm39) critical splice donor site probably null
IGL02535:Abcc9 APN 6 142,574,152 (GRCm39) missense probably benign 0.00
IGL02552:Abcc9 APN 6 142,551,645 (GRCm39) missense possibly damaging 0.94
IGL02812:Abcc9 APN 6 142,643,516 (GRCm39) missense possibly damaging 0.77
IGL02954:Abcc9 APN 6 142,592,007 (GRCm39) missense probably damaging 0.97
IGL03035:Abcc9 APN 6 142,573,319 (GRCm39) missense probably damaging 1.00
IGL03040:Abcc9 APN 6 142,598,323 (GRCm39) nonsense probably null
IGL03100:Abcc9 APN 6 142,640,270 (GRCm39) missense probably damaging 1.00
IGL03157:Abcc9 APN 6 142,551,649 (GRCm39) splice site probably benign
R0054:Abcc9 UTSW 6 142,547,500 (GRCm39) critical splice donor site probably null
R0054:Abcc9 UTSW 6 142,547,500 (GRCm39) critical splice donor site probably null
R0084:Abcc9 UTSW 6 142,604,277 (GRCm39) missense probably damaging 0.97
R0211:Abcc9 UTSW 6 142,634,710 (GRCm39) missense probably benign 0.01
R0349:Abcc9 UTSW 6 142,610,351 (GRCm39) missense probably benign 0.00
R0387:Abcc9 UTSW 6 142,585,230 (GRCm39) nonsense probably null
R0393:Abcc9 UTSW 6 142,591,604 (GRCm39) splice site probably benign
R0528:Abcc9 UTSW 6 142,638,606 (GRCm39) missense probably damaging 1.00
R0588:Abcc9 UTSW 6 142,548,787 (GRCm39) nonsense probably null
R0646:Abcc9 UTSW 6 142,627,830 (GRCm39) missense probably benign 0.05
R0691:Abcc9 UTSW 6 142,584,979 (GRCm39) missense possibly damaging 0.94
R0881:Abcc9 UTSW 6 142,592,029 (GRCm39) missense probably damaging 1.00
R1264:Abcc9 UTSW 6 142,592,103 (GRCm39) splice site probably benign
R1340:Abcc9 UTSW 6 142,628,581 (GRCm39) splice site probably benign
R1413:Abcc9 UTSW 6 142,573,245 (GRCm39) missense possibly damaging 0.65
R1413:Abcc9 UTSW 6 142,536,222 (GRCm39) missense probably damaging 1.00
R1535:Abcc9 UTSW 6 142,610,361 (GRCm39) missense probably damaging 1.00
R1595:Abcc9 UTSW 6 142,578,821 (GRCm39) missense probably benign 0.02
R1670:Abcc9 UTSW 6 142,540,448 (GRCm39) missense possibly damaging 0.89
R1769:Abcc9 UTSW 6 142,573,194 (GRCm39) splice site probably benign
R1888:Abcc9 UTSW 6 142,625,040 (GRCm39) missense probably benign
R1888:Abcc9 UTSW 6 142,625,040 (GRCm39) missense probably benign
R1918:Abcc9 UTSW 6 142,643,408 (GRCm39) missense probably damaging 1.00
R1925:Abcc9 UTSW 6 142,617,333 (GRCm39) missense probably damaging 0.98
R2019:Abcc9 UTSW 6 142,621,160 (GRCm39) missense probably damaging 1.00
R2698:Abcc9 UTSW 6 142,578,862 (GRCm39) missense possibly damaging 0.93
R2860:Abcc9 UTSW 6 142,571,736 (GRCm39) missense probably benign 0.01
R2861:Abcc9 UTSW 6 142,571,736 (GRCm39) missense probably benign 0.01
R2980:Abcc9 UTSW 6 142,633,034 (GRCm39) missense probably benign 0.00
R3115:Abcc9 UTSW 6 142,634,755 (GRCm39) missense probably benign 0.08
R3617:Abcc9 UTSW 6 142,625,015 (GRCm39) missense probably damaging 0.97
R3880:Abcc9 UTSW 6 142,584,959 (GRCm39) missense probably damaging 1.00
R4063:Abcc9 UTSW 6 142,551,645 (GRCm39) missense possibly damaging 0.94
R4065:Abcc9 UTSW 6 142,591,616 (GRCm39) missense probably damaging 1.00
R4290:Abcc9 UTSW 6 142,539,738 (GRCm39) missense probably benign 0.08
R4538:Abcc9 UTSW 6 142,560,138 (GRCm39) critical splice donor site probably null
R4615:Abcc9 UTSW 6 142,634,833 (GRCm39) missense possibly damaging 0.93
R4659:Abcc9 UTSW 6 142,618,321 (GRCm39) splice site probably null
R4774:Abcc9 UTSW 6 142,585,043 (GRCm39) missense probably damaging 1.00
R4788:Abcc9 UTSW 6 142,566,456 (GRCm39) nonsense probably null
R4832:Abcc9 UTSW 6 142,617,282 (GRCm39) missense probably damaging 1.00
R4844:Abcc9 UTSW 6 142,634,824 (GRCm39) missense probably benign 0.09
R4903:Abcc9 UTSW 6 142,546,691 (GRCm39) missense probably damaging 1.00
R4921:Abcc9 UTSW 6 142,536,162 (GRCm39) missense probably benign
R4960:Abcc9 UTSW 6 142,566,509 (GRCm39) splice site probably null
R4983:Abcc9 UTSW 6 142,627,867 (GRCm39) missense probably benign 0.44
R4986:Abcc9 UTSW 6 142,573,317 (GRCm39) missense probably benign 0.00
R5120:Abcc9 UTSW 6 142,602,344 (GRCm39) missense probably benign 0.00
R5198:Abcc9 UTSW 6 142,571,726 (GRCm39) missense probably benign 0.00
R5301:Abcc9 UTSW 6 142,536,207 (GRCm39) missense probably benign 0.41
R5328:Abcc9 UTSW 6 142,627,785 (GRCm39) missense probably benign 0.25
R5568:Abcc9 UTSW 6 142,634,742 (GRCm39) missense possibly damaging 0.62
R5654:Abcc9 UTSW 6 142,571,371 (GRCm39) intron probably benign
R5694:Abcc9 UTSW 6 142,546,673 (GRCm39) missense probably damaging 1.00
R5734:Abcc9 UTSW 6 142,571,457 (GRCm39) intron probably benign
R5774:Abcc9 UTSW 6 142,574,285 (GRCm39) missense probably damaging 0.98
R5802:Abcc9 UTSW 6 142,602,402 (GRCm39) critical splice acceptor site probably null
R5890:Abcc9 UTSW 6 142,550,554 (GRCm39) critical splice donor site probably null
R5946:Abcc9 UTSW 6 142,571,678 (GRCm39) missense probably damaging 1.00
R5971:Abcc9 UTSW 6 142,585,301 (GRCm39) missense probably damaging 1.00
R6078:Abcc9 UTSW 6 142,585,301 (GRCm39) missense probably damaging 1.00
R6392:Abcc9 UTSW 6 142,627,825 (GRCm39) missense probably damaging 1.00
R6400:Abcc9 UTSW 6 142,638,435 (GRCm39) makesense probably null
R6478:Abcc9 UTSW 6 142,625,034 (GRCm39) missense probably damaging 1.00
R6481:Abcc9 UTSW 6 142,550,621 (GRCm39) missense probably damaging 0.99
R6564:Abcc9 UTSW 6 142,548,834 (GRCm39) missense probably damaging 1.00
R6700:Abcc9 UTSW 6 142,633,013 (GRCm39) missense possibly damaging 0.94
R6902:Abcc9 UTSW 6 142,624,953 (GRCm39) missense probably damaging 1.00
R6946:Abcc9 UTSW 6 142,624,953 (GRCm39) missense probably damaging 1.00
R6989:Abcc9 UTSW 6 142,634,707 (GRCm39) missense probably damaging 0.97
R7052:Abcc9 UTSW 6 142,604,261 (GRCm39) missense probably benign 0.00
R7062:Abcc9 UTSW 6 142,544,872 (GRCm39) missense probably damaging 1.00
R7121:Abcc9 UTSW 6 142,634,853 (GRCm39) nonsense probably null
R7284:Abcc9 UTSW 6 142,628,643 (GRCm39) missense probably damaging 1.00
R7296:Abcc9 UTSW 6 142,617,319 (GRCm39) missense probably damaging 1.00
R7353:Abcc9 UTSW 6 142,546,731 (GRCm39) missense probably damaging 1.00
R7359:Abcc9 UTSW 6 142,617,408 (GRCm39) missense probably damaging 1.00
R7815:Abcc9 UTSW 6 142,598,331 (GRCm39) missense probably damaging 1.00
R7894:Abcc9 UTSW 6 142,539,733 (GRCm39) makesense probably null
R8095:Abcc9 UTSW 6 142,590,048 (GRCm39) missense probably benign 0.22
R8099:Abcc9 UTSW 6 142,621,257 (GRCm39) missense probably damaging 1.00
R8245:Abcc9 UTSW 6 142,539,870 (GRCm39) critical splice acceptor site probably null
R8355:Abcc9 UTSW 6 142,638,478 (GRCm39) missense probably benign 0.00
R8356:Abcc9 UTSW 6 142,536,096 (GRCm39) missense probably benign 0.06
R8365:Abcc9 UTSW 6 142,544,798 (GRCm39) missense probably benign 0.03
R8846:Abcc9 UTSW 6 142,551,610 (GRCm39) missense possibly damaging 0.56
R8886:Abcc9 UTSW 6 142,546,420 (GRCm39) intron probably benign
R8939:Abcc9 UTSW 6 142,624,977 (GRCm39) missense probably damaging 0.99
R9049:Abcc9 UTSW 6 142,628,658 (GRCm39) missense probably damaging 0.99
R9113:Abcc9 UTSW 6 142,591,656 (GRCm39) missense probably damaging 1.00
R9368:Abcc9 UTSW 6 142,640,251 (GRCm39) missense probably damaging 1.00
R9401:Abcc9 UTSW 6 142,543,836 (GRCm39) missense possibly damaging 0.90
R9407:Abcc9 UTSW 6 142,574,229 (GRCm39) missense possibly damaging 0.88
R9597:Abcc9 UTSW 6 142,578,813 (GRCm39) missense possibly damaging 0.81
R9600:Abcc9 UTSW 6 142,536,102 (GRCm39) missense possibly damaging 0.54
R9687:Abcc9 UTSW 6 142,578,889 (GRCm39) missense probably benign 0.00
R9698:Abcc9 UTSW 6 142,571,757 (GRCm39) missense probably benign
R9761:Abcc9 UTSW 6 142,544,854 (GRCm39) missense possibly damaging 0.78
U15987:Abcc9 UTSW 6 142,585,301 (GRCm39) missense probably damaging 1.00
Z1177:Abcc9 UTSW 6 142,591,664 (GRCm39) missense probably null 0.96
Z1177:Abcc9 UTSW 6 142,571,708 (GRCm39) missense probably benign 0.07
Z1177:Abcc9 UTSW 6 142,540,484 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTACTTAGAGGCAACCCGGAAG -3'
(R):5'- CATCGTAAAGCAAACAAACTTCTGG -3'

Sequencing Primer
(F):5'- CTTAGAGGCAACCCGGAAGTATTTC -3'
(R):5'- TATCTATAGTATCCGAGACAAGCAGG -3'
Posted On 2016-06-06