Incidental Mutation 'R5074:Cyp2a22'
ID 386826
Institutional Source Beutler Lab
Gene Symbol Cyp2a22
Ensembl Gene ENSMUSG00000091867
Gene Name cytochrome P450, family 2, subfamily a, polypeptide 22
Synonyms EG233005
MMRRC Submission 042663-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R5074 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 26631056-26638809 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 26631906 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 450 (F450Y)
Ref Sequence ENSEMBL: ENSMUSP00000128030 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170227]
AlphaFold B2RXZ2
Predicted Effect probably benign
Transcript: ENSMUST00000170227
AA Change: F450Y

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000128030
Gene: ENSMUSG00000091867
AA Change: F450Y

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
Pfam:p450 33 489 7.4e-148 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206638
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206957
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 115 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik A T 3: 124,210,482 (GRCm39) H143Q probably benign Het
Abca3 C T 17: 24,593,274 (GRCm39) R224C probably damaging Het
Adcy8 A T 15: 64,659,207 (GRCm39) W528R probably damaging Het
Agbl1 A G 7: 76,071,665 (GRCm39) E329G probably damaging Het
Agbl5 G A 5: 31,060,403 (GRCm39) R141Q probably damaging Het
Ampd2 A T 3: 107,986,549 (GRCm39) M245K probably damaging Het
Apob G A 12: 8,055,219 (GRCm39) probably null Het
Apool C T X: 111,259,540 (GRCm39) Q60* probably null Het
Aqp1 A T 6: 55,322,520 (GRCm39) I172F probably damaging Het
Atp7a A G X: 105,153,374 (GRCm39) D1092G probably benign Het
Ccdc83 A T 7: 89,899,737 (GRCm39) F45Y probably damaging Het
Cct8l1 G A 5: 25,721,881 (GRCm39) V199I probably benign Het
Cdc23 C A 18: 34,784,742 (GRCm39) V7L unknown Het
Cdc25a T A 9: 109,713,208 (GRCm39) C227S possibly damaging Het
Ces1a A G 8: 93,759,303 (GRCm39) S278P possibly damaging Het
Cfap65 A T 1: 74,962,137 (GRCm39) S695T probably benign Het
Col13a1 A G 10: 61,709,797 (GRCm39) silent Het
Ctps1 A T 4: 120,411,170 (GRCm39) L282Q probably damaging Het
Cyp2d10 C T 15: 82,287,954 (GRCm39) R383H probably benign Het
Dennd3 G A 15: 73,419,144 (GRCm39) R645H probably damaging Het
Dnaaf5 G T 5: 139,159,962 (GRCm39) R620L probably damaging Het
Dnah11 A T 12: 118,046,188 (GRCm39) L1750* probably null Het
Dnah9 A G 11: 65,740,866 (GRCm39) F4107L probably damaging Het
Dnaja3 A T 16: 4,514,289 (GRCm39) T274S probably damaging Het
Dot1l A G 10: 80,620,480 (GRCm39) D514G possibly damaging Het
Dst A C 1: 34,334,344 (GRCm39) K4857N probably damaging Het
Dysf A T 6: 84,114,254 (GRCm39) K1226M probably damaging Het
Enpep T A 3: 129,097,404 (GRCm39) Q409L probably damaging Het
Fign A T 2: 63,810,037 (GRCm39) L411* probably null Het
Flt1 C A 5: 147,620,749 (GRCm39) A132S probably benign Het
Fryl G A 5: 73,232,110 (GRCm39) P1550L probably damaging Het
Gas2l3 CACTCGTCATACT CACT 10: 89,266,820 (GRCm39) probably benign Het
H2ab3 T C X: 119,222,543 (GRCm39) T84A probably damaging Het
Hal A T 10: 93,349,904 (GRCm39) I555F probably damaging Het
Hibadh C T 6: 52,597,079 (GRCm39) V122M possibly damaging Het
Hsd3b3 T C 3: 98,649,340 (GRCm39) T328A possibly damaging Het
Ifi44 T C 3: 151,455,269 (GRCm39) probably benign Het
Ifi47 A G 11: 48,986,361 (GRCm39) T43A probably benign Het
Inf2 A T 12: 112,578,473 (GRCm39) probably null Het
Itga10 C T 3: 96,559,527 (GRCm39) Q475* probably null Het
Itga6 T A 2: 71,656,779 (GRCm39) D344E probably benign Het
Kcnmb4 T C 10: 116,309,102 (GRCm39) T109A probably benign Het
Kif19a G A 11: 114,658,053 (GRCm39) M37I probably benign Het
Kiss1r C A 10: 79,754,596 (GRCm39) S30* probably null Het
Lrrc66 G A 5: 73,765,354 (GRCm39) P563L probably damaging Het
Mamdc2 T C 19: 23,356,160 (GRCm39) D96G probably benign Het
Map3k12 A T 15: 102,410,267 (GRCm39) probably null Het
Mc3r A T 2: 172,091,533 (GRCm39) I252F possibly damaging Het
Metrn C T 17: 26,015,613 (GRCm39) G34D probably damaging Het
Mipep A G 14: 61,046,462 (GRCm39) E328G probably benign Het
Mrtfa A G 15: 80,906,627 (GRCm39) V91A probably damaging Het
Muc5b A T 7: 141,412,999 (GRCm39) T1982S unknown Het
Myh8 A T 11: 67,196,742 (GRCm39) T1792S possibly damaging Het
Myo1a T C 10: 127,543,288 (GRCm39) probably null Het
Myo5a T A 9: 75,081,438 (GRCm39) S1008T probably benign Het
Ncald A T 15: 37,397,478 (GRCm39) H67Q probably damaging Het
Nudt5 T A 2: 5,869,198 (GRCm39) H141Q probably benign Het
Numbl G A 7: 26,980,415 (GRCm39) D466N probably damaging Het
Nup210 T A 6: 91,032,309 (GRCm39) I20F probably benign Het
Odad1 T A 7: 45,578,514 (GRCm39) M29K probably benign Het
Or10ak12 A C 4: 118,666,057 (GRCm39) W319G possibly damaging Het
Or10p21 T C 10: 128,847,213 (GRCm39) Y20H possibly damaging Het
Or14c46 A G 7: 85,918,799 (GRCm39) I66T probably damaging Het
Or51l14 A T 7: 103,100,617 (GRCm39) E24D probably benign Het
Or52e8b A T 7: 104,673,260 (GRCm39) M309K probably benign Het
Or52n2c A C 7: 104,574,700 (GRCm39) N90K probably benign Het
Or7h8 A T 9: 20,123,878 (GRCm39) I78F possibly damaging Het
Or8h10 A T 2: 86,808,666 (GRCm39) V158D possibly damaging Het
Papolg G A 11: 23,817,331 (GRCm39) T153I possibly damaging Het
Pappa A G 4: 65,123,365 (GRCm39) H900R probably benign Het
Pcdh17 T C 14: 84,770,782 (GRCm39) S1087P probably benign Het
Phf11a T G 14: 59,521,849 (GRCm39) L107F possibly damaging Het
Phlpp2 A T 8: 110,652,461 (GRCm39) I602F probably damaging Het
Pik3c2g T A 6: 139,665,873 (GRCm39) C65S probably null Het
Pilra A G 5: 137,833,674 (GRCm39) F131L probably damaging Het
Pomt2 A C 12: 87,180,234 (GRCm39) C256G probably damaging Het
Ppl A T 16: 4,906,742 (GRCm39) S1184R probably benign Het
Prkaa1 G T 15: 5,206,392 (GRCm39) R416L possibly damaging Het
Prkdc C A 16: 15,589,912 (GRCm39) R2592S probably damaging Het
Prmt2 C T 10: 76,058,390 (GRCm39) V140I probably damaging Het
Prodh A T 16: 17,895,653 (GRCm39) probably null Het
Psg29 T A 7: 16,945,763 (GRCm39) D444E probably damaging Het
Ptgs1 A T 2: 36,141,272 (GRCm39) N573I probably damaging Het
Rbm38 C T 2: 172,863,875 (GRCm39) P15S probably benign Het
Riox2 T C 16: 59,312,236 (GRCm39) S458P possibly damaging Het
Rnase4 T C 14: 51,342,702 (GRCm39) V142A possibly damaging Het
Rnf138 A G 18: 21,159,204 (GRCm39) N244S probably benign Het
Rnf40 T C 7: 127,196,458 (GRCm39) L802P probably damaging Het
Sfxn4 C T 19: 60,839,450 (GRCm39) V203M probably damaging Het
Skor2 G T 18: 76,946,649 (GRCm39) E124* probably null Het
Slc4a2 G A 5: 24,643,760 (GRCm39) S855N probably benign Het
Slc8a2 T C 7: 15,884,508 (GRCm39) L626P possibly damaging Het
Slco4c1 G A 1: 96,768,953 (GRCm39) P303L probably damaging Het
Slirp A G 12: 87,490,784 (GRCm39) T29A probably damaging Het
Snrpd3 G T 10: 75,355,227 (GRCm39) C20F possibly damaging Het
Spag17 T A 3: 99,987,434 (GRCm39) Y1575N possibly damaging Het
St8sia4 G A 1: 95,594,910 (GRCm39) A26V probably benign Het
Stab2 A T 10: 86,699,422 (GRCm39) I481N probably benign Het
Tenm2 T A 11: 35,959,208 (GRCm39) T1114S probably damaging Het
Tgm1 A G 14: 55,947,392 (GRCm39) V323A probably damaging Het
Tmco4 A G 4: 138,785,433 (GRCm39) H501R probably damaging Het
Tob1 A T 11: 94,104,567 (GRCm39) R34S possibly damaging Het
Trhr2 C T 8: 123,084,110 (GRCm39) V297I probably benign Het
Trim30d A C 7: 104,137,165 (GRCm39) V13G probably damaging Het
Trpm3 T C 19: 22,862,713 (GRCm39) V485A possibly damaging Het
Trrap T C 5: 144,787,989 (GRCm39) I3518T probably damaging Het
Ttc27 T C 17: 75,054,750 (GRCm39) L352P probably damaging Het
Ush1g A G 11: 115,209,123 (GRCm39) L357P possibly damaging Het
Usp24 A G 4: 106,277,644 (GRCm39) H2258R probably benign Het
Vcam1 A G 3: 115,918,037 (GRCm39) V308A probably damaging Het
Vdr A G 15: 97,755,459 (GRCm39) S355P probably benign Het
Vldlr T C 19: 27,215,677 (GRCm39) S184P probably damaging Het
Xpo4 C A 14: 57,822,098 (GRCm39) A1073S probably benign Het
Zfand2b A G 1: 75,147,634 (GRCm39) D224G probably benign Het
Zfp263 A G 16: 3,564,704 (GRCm39) R240G possibly damaging Het
Other mutations in Cyp2a22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00156:Cyp2a22 APN 7 26,637,163 (GRCm39) missense probably benign 0.09
IGL01111:Cyp2a22 APN 7 26,635,883 (GRCm39) missense probably damaging 1.00
IGL01388:Cyp2a22 APN 7 26,637,217 (GRCm39) missense probably benign 0.02
IGL01449:Cyp2a22 APN 7 26,632,978 (GRCm39) missense probably benign 0.01
IGL01642:Cyp2a22 APN 7 26,638,184 (GRCm39) missense possibly damaging 0.81
IGL02253:Cyp2a22 APN 7 26,637,662 (GRCm39) splice site probably benign
IGL02327:Cyp2a22 APN 7 26,634,206 (GRCm39) missense probably damaging 0.99
IGL02673:Cyp2a22 APN 7 26,637,525 (GRCm39) missense probably benign 0.00
IGL02813:Cyp2a22 APN 7 26,635,859 (GRCm39) missense probably benign 0.19
IGL02896:Cyp2a22 APN 7 26,635,886 (GRCm39) missense probably damaging 0.98
IGL03193:Cyp2a22 APN 7 26,635,846 (GRCm39) missense probably benign 0.00
IGL03350:Cyp2a22 APN 7 26,634,279 (GRCm39) missense possibly damaging 0.88
R1648:Cyp2a22 UTSW 7 26,631,793 (GRCm39) missense probably damaging 0.98
R1679:Cyp2a22 UTSW 7 26,635,736 (GRCm39) nonsense probably null
R1733:Cyp2a22 UTSW 7 26,634,187 (GRCm39) missense possibly damaging 0.78
R2001:Cyp2a22 UTSW 7 26,634,197 (GRCm39) missense probably damaging 1.00
R2858:Cyp2a22 UTSW 7 26,633,687 (GRCm39) missense probably damaging 0.99
R3054:Cyp2a22 UTSW 7 26,638,254 (GRCm39) missense probably damaging 1.00
R4528:Cyp2a22 UTSW 7 26,634,194 (GRCm39) missense possibly damaging 0.95
R4623:Cyp2a22 UTSW 7 26,632,916 (GRCm39) missense probably damaging 1.00
R4669:Cyp2a22 UTSW 7 26,637,280 (GRCm39) missense possibly damaging 0.88
R4690:Cyp2a22 UTSW 7 26,638,634 (GRCm39) nonsense probably null
R4840:Cyp2a22 UTSW 7 26,631,949 (GRCm39) missense probably benign 0.13
R4915:Cyp2a22 UTSW 7 26,637,195 (GRCm39) missense probably benign 0.33
R5071:Cyp2a22 UTSW 7 26,631,906 (GRCm39) missense probably benign 0.01
R5072:Cyp2a22 UTSW 7 26,631,906 (GRCm39) missense probably benign 0.01
R5147:Cyp2a22 UTSW 7 26,635,750 (GRCm39) missense probably damaging 1.00
R5363:Cyp2a22 UTSW 7 26,635,858 (GRCm39) missense probably damaging 0.99
R5705:Cyp2a22 UTSW 7 26,638,640 (GRCm39) missense probably benign 0.05
R6014:Cyp2a22 UTSW 7 26,638,605 (GRCm39) splice site probably null
R6042:Cyp2a22 UTSW 7 26,633,664 (GRCm39) missense probably damaging 1.00
R6253:Cyp2a22 UTSW 7 26,633,657 (GRCm39) missense probably benign 0.18
R6757:Cyp2a22 UTSW 7 26,638,629 (GRCm39) missense probably benign 0.00
R6994:Cyp2a22 UTSW 7 26,638,606 (GRCm39) critical splice donor site probably null
R7581:Cyp2a22 UTSW 7 26,637,573 (GRCm39) missense possibly damaging 0.87
R8212:Cyp2a22 UTSW 7 26,637,205 (GRCm39) missense possibly damaging 0.89
R9225:Cyp2a22 UTSW 7 26,637,202 (GRCm39) missense possibly damaging 0.81
R9749:Cyp2a22 UTSW 7 26,638,715 (GRCm39) missense probably null 0.41
Predicted Primers PCR Primer
(F):5'- GCACGTGGTCCCTTCTTAAC -3'
(R):5'- GGAGCCTTTCCTAATGATCCC -3'

Sequencing Primer
(F):5'- TGGCACCACTTCAGGCTC -3'
(R):5'- TAATGATCCCTCACACTCCACTGTAG -3'
Posted On 2016-06-06