Incidental Mutation 'R5081:Cd101'
ID 387114
Institutional Source Beutler Lab
Gene Symbol Cd101
Ensembl Gene ENSMUSG00000086564
Gene Name CD101 antigen
Synonyms LOC381460, Igsf2
MMRRC Submission 042670-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5081 (G1)
Quality Score 181
Status Validated
Chromosome 3
Chromosomal Location 100900845-100936872 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 100911021 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 879 (Y879F)
Ref Sequence ENSEMBL: ENSMUSP00000126027 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000147399] [ENSMUST00000167086]
AlphaFold A8E0Y8
Predicted Effect possibly damaging
Transcript: ENSMUST00000147399
AA Change: Y883F

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000116643
Gene: ENSMUSG00000086564
AA Change: Y883F

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
IG 28 143 4.96e-8 SMART
IG 153 266 4.74e-5 SMART
IG_like 274 379 2.19e-1 SMART
IG 289 395 3.25e-3 SMART
IG 417 533 4.85e-11 SMART
IG 545 659 1.52e-3 SMART
IG 680 805 3.16e-1 SMART
IG_like 827 927 2.95e-1 SMART
IG 856 955 1.04e-1 SMART
transmembrane domain 971 993 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000167086
AA Change: Y879F

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000126027
Gene: ENSMUSG00000086564
AA Change: Y879F

DomainStartEndE-ValueType
IG 24 139 4.96e-8 SMART
IG 149 262 4.74e-5 SMART
IG_like 270 375 2.19e-1 SMART
IG 285 391 3.25e-3 SMART
IG 413 529 4.85e-11 SMART
IG 541 655 1.52e-3 SMART
IG 676 801 3.16e-1 SMART
IG_like 823 923 2.95e-1 SMART
IG 852 951 1.04e-1 SMART
transmembrane domain 967 989 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.2%
Validation Efficiency 93% (65/70)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced Gr-1+ cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agbl5 G A 5: 31,060,403 (GRCm39) R141Q probably damaging Het
AI593442 TGAGGAGGAGGAGGAGGA TGAGGAGGAGGAGGA 9: 52,589,114 (GRCm39) probably benign Het
Aig1 A G 10: 13,677,644 (GRCm39) I116T probably benign Het
Alox12 A T 11: 70,146,140 (GRCm39) probably null Het
Ap3s1 T A 18: 46,887,497 (GRCm39) D43E probably benign Het
Arhgap35 A G 7: 16,299,059 (GRCm39) M2T possibly damaging Het
Asah2 T A 19: 31,991,708 (GRCm39) E451V probably benign Het
Ash1l T G 3: 88,892,024 (GRCm39) I1301S probably damaging Het
Ass1 G A 2: 31,378,665 (GRCm39) probably null Het
Ccpg1 A G 9: 72,906,360 (GRCm39) T39A possibly damaging Het
Cdc23 C A 18: 34,784,742 (GRCm39) V7L unknown Het
Cdh23 T C 10: 60,272,586 (GRCm39) T530A possibly damaging Het
Cep68 G T 11: 20,188,477 (GRCm39) Q643K probably damaging Het
Ces1c A G 8: 93,854,197 (GRCm39) S113P probably damaging Het
Cnga4 T C 7: 105,056,232 (GRCm39) I278T probably benign Het
Col1a1 A G 11: 94,842,402 (GRCm39) D1440G unknown Het
Cspp1 A G 1: 10,117,691 (GRCm39) I48V possibly damaging Het
Ctsj T A 13: 61,151,664 (GRCm39) S85C possibly damaging Het
Cyp39a1 C A 17: 44,057,488 (GRCm39) D442E probably damaging Het
Dock3 A T 9: 106,868,292 (GRCm39) F664Y probably damaging Het
Gpcpd1 A T 2: 132,389,622 (GRCm39) H244Q probably benign Het
Gtf3a T A 5: 146,888,092 (GRCm39) V131E probably benign Het
Gtpbp3 A T 8: 71,943,026 (GRCm39) R147W probably damaging Het
H2-Oa A T 17: 34,313,344 (GRCm39) I132F probably damaging Het
Hsd17b8 G A 17: 34,246,552 (GRCm39) probably benign Het
Idi1 T A 13: 8,937,963 (GRCm39) C91* probably null Het
Itga11 A G 9: 62,662,478 (GRCm39) I484V probably benign Het
Kpna3 C T 14: 61,628,694 (GRCm39) S101N probably damaging Het
Larp4 G A 15: 99,870,898 (GRCm39) probably benign Het
Mink1 T C 11: 70,495,970 (GRCm39) L390P probably damaging Het
Morc1 T G 16: 48,322,715 (GRCm39) S337R probably benign Het
Myo10 A G 15: 25,786,026 (GRCm39) R1236G probably damaging Het
Nkx3-1 T C 14: 69,429,396 (GRCm39) I138T possibly damaging Het
Nnt T C 13: 119,502,936 (GRCm39) N489S probably damaging Het
Nrcam A T 12: 44,617,136 (GRCm39) I711F probably benign Het
Ntrk3 A G 7: 78,227,522 (GRCm39) S4P probably damaging Het
Obsl1 T C 1: 75,464,607 (GRCm39) T1605A possibly damaging Het
Or1j17 A G 2: 36,578,655 (GRCm39) I214V possibly damaging Het
Or7g32 A G 9: 19,408,557 (GRCm39) E171G probably benign Het
Pank1 T C 19: 34,856,316 (GRCm39) H54R probably benign Het
Pgm2l1 A G 7: 99,917,472 (GRCm39) I530V probably benign Het
Psmd2 A G 16: 20,480,405 (GRCm39) T709A probably benign Het
Qsox1 G T 1: 155,688,581 (GRCm39) probably benign Het
Rbm14 A G 19: 4,852,823 (GRCm39) S520P probably benign Het
Rbm15b G A 9: 106,762,120 (GRCm39) R683C probably benign Het
Rhbdd2 T A 5: 135,664,876 (GRCm39) V69D probably damaging Het
Sart1 T C 19: 5,438,576 (GRCm39) E27G possibly damaging Het
Scn4a G A 11: 106,239,553 (GRCm39) P153L probably damaging Het
Serpinb6d A T 13: 33,855,230 (GRCm39) R301S probably benign Het
Sf3a2 C A 10: 80,640,275 (GRCm39) probably benign Het
Syne1 T C 10: 4,997,767 (GRCm39) D400G probably benign Het
Tenm2 T C 11: 35,915,460 (GRCm39) S2025G possibly damaging Het
Ttc16 A T 2: 32,657,988 (GRCm39) D476E probably damaging Het
Ttc9c A T 19: 8,793,396 (GRCm39) C81* probably null Het
Ulk2 G A 11: 61,694,488 (GRCm39) P474L probably damaging Het
Vmn1r66 A G 7: 10,008,722 (GRCm39) C104R probably damaging Het
Vwa2 C T 19: 56,897,752 (GRCm39) H686Y probably damaging Het
Other mutations in Cd101
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Cd101 APN 3 100,911,018 (GRCm39) missense probably damaging 1.00
IGL01443:Cd101 APN 3 100,910,887 (GRCm39) missense probably benign
IGL02000:Cd101 APN 3 100,919,398 (GRCm39) missense probably benign 0.11
IGL02178:Cd101 APN 3 100,901,082 (GRCm39) missense probably damaging 1.00
IGL02224:Cd101 APN 3 100,924,318 (GRCm39) missense probably benign
IGL02450:Cd101 APN 3 100,901,054 (GRCm39) missense probably damaging 0.99
IGL02502:Cd101 APN 3 100,919,141 (GRCm39) missense probably damaging 0.99
IGL02536:Cd101 APN 3 100,910,913 (GRCm39) missense probably damaging 1.00
IGL02749:Cd101 APN 3 100,927,715 (GRCm39) missense probably damaging 1.00
IGL02818:Cd101 APN 3 100,919,245 (GRCm39) missense probably damaging 1.00
IGL02829:Cd101 APN 3 100,925,881 (GRCm39) splice site probably benign
IGL02902:Cd101 APN 3 100,926,310 (GRCm39) splice site probably benign
tax_day UTSW 3 100,911,021 (GRCm39) missense possibly damaging 0.86
R0069:Cd101 UTSW 3 100,915,533 (GRCm39) missense probably benign 0.08
R0069:Cd101 UTSW 3 100,915,533 (GRCm39) missense probably benign 0.08
R0411:Cd101 UTSW 3 100,925,843 (GRCm39) splice site probably null
R0486:Cd101 UTSW 3 100,915,408 (GRCm39) missense possibly damaging 0.94
R0556:Cd101 UTSW 3 100,927,970 (GRCm39) missense probably damaging 1.00
R0726:Cd101 UTSW 3 100,927,938 (GRCm39) missense possibly damaging 0.95
R0966:Cd101 UTSW 3 100,915,538 (GRCm39) missense probably benign 0.13
R1344:Cd101 UTSW 3 100,926,091 (GRCm39) nonsense probably null
R1418:Cd101 UTSW 3 100,926,091 (GRCm39) nonsense probably null
R1547:Cd101 UTSW 3 100,926,267 (GRCm39) missense possibly damaging 0.94
R1551:Cd101 UTSW 3 100,919,329 (GRCm39) missense probably damaging 0.99
R1845:Cd101 UTSW 3 100,936,764 (GRCm39) splice site probably null
R1919:Cd101 UTSW 3 100,926,233 (GRCm39) missense probably damaging 1.00
R1976:Cd101 UTSW 3 100,915,377 (GRCm39) missense probably damaging 0.96
R2260:Cd101 UTSW 3 100,924,261 (GRCm39) missense possibly damaging 0.82
R2679:Cd101 UTSW 3 100,901,079 (GRCm39) missense probably benign 0.00
R2873:Cd101 UTSW 3 100,911,164 (GRCm39) missense probably benign 0.00
R3606:Cd101 UTSW 3 100,927,913 (GRCm39) missense probably damaging 1.00
R4201:Cd101 UTSW 3 100,926,001 (GRCm39) missense probably damaging 1.00
R4202:Cd101 UTSW 3 100,926,001 (GRCm39) missense probably damaging 1.00
R4205:Cd101 UTSW 3 100,926,001 (GRCm39) missense probably damaging 1.00
R4349:Cd101 UTSW 3 100,920,630 (GRCm39) missense possibly damaging 0.93
R4574:Cd101 UTSW 3 100,920,469 (GRCm39) missense probably benign 0.02
R4601:Cd101 UTSW 3 100,901,204 (GRCm39) missense possibly damaging 0.84
R4820:Cd101 UTSW 3 100,929,471 (GRCm39) missense probably benign 0.01
R4910:Cd101 UTSW 3 100,901,205 (GRCm39) missense probably benign 0.13
R5014:Cd101 UTSW 3 100,911,139 (GRCm39) missense probably damaging 0.99
R5396:Cd101 UTSW 3 100,926,126 (GRCm39) missense probably damaging 1.00
R5425:Cd101 UTSW 3 100,926,002 (GRCm39) missense probably damaging 1.00
R6193:Cd101 UTSW 3 100,927,778 (GRCm39) missense probably damaging 1.00
R6210:Cd101 UTSW 3 100,925,959 (GRCm39) missense probably damaging 1.00
R6732:Cd101 UTSW 3 100,915,515 (GRCm39) missense probably benign 0.01
R6830:Cd101 UTSW 3 100,901,012 (GRCm39) missense probably benign 0.12
R6897:Cd101 UTSW 3 100,920,376 (GRCm39) missense probably damaging 1.00
R6940:Cd101 UTSW 3 100,911,018 (GRCm39) missense probably damaging 1.00
R7335:Cd101 UTSW 3 100,926,045 (GRCm39) missense probably benign 0.01
R7565:Cd101 UTSW 3 100,926,108 (GRCm39) missense probably benign 0.00
R7880:Cd101 UTSW 3 100,915,182 (GRCm39) missense probably benign 0.00
R8121:Cd101 UTSW 3 100,927,898 (GRCm39) missense probably damaging 1.00
R8233:Cd101 UTSW 3 100,900,989 (GRCm39) missense unknown
R8900:Cd101 UTSW 3 100,926,062 (GRCm39) missense probably benign 0.19
R8960:Cd101 UTSW 3 100,910,817 (GRCm39) missense probably benign 0.01
R9260:Cd101 UTSW 3 100,920,599 (GRCm39) missense probably benign 0.16
R9335:Cd101 UTSW 3 100,915,431 (GRCm39) missense probably benign 0.18
R9663:Cd101 UTSW 3 100,911,222 (GRCm39) missense probably benign 0.21
X0018:Cd101 UTSW 3 100,925,948 (GRCm39) missense possibly damaging 0.95
X0023:Cd101 UTSW 3 100,926,171 (GRCm39) missense probably benign
X0058:Cd101 UTSW 3 100,927,737 (GRCm39) missense probably damaging 1.00
Z1177:Cd101 UTSW 3 100,924,456 (GRCm39) missense probably benign 0.02
Z1177:Cd101 UTSW 3 100,919,232 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- AGCACCATTCGTTGCGACTC -3'
(R):5'- TTGGACAGGAAACGCTACCG -3'

Sequencing Primer
(F):5'- CCTGAGGCTTGGTTGATCC -3'
(R):5'- CAGGAAACGCTACCGAGTATG -3'
Posted On 2016-06-06