Incidental Mutation 'R5081:Cnga4'
ID 387122
Institutional Source Beutler Lab
Gene Symbol Cnga4
Ensembl Gene ENSMUSG00000030897
Gene Name cyclic nucleotide gated channel alpha 4
Synonyms
MMRRC Submission 042670-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R5081 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 105053775-105057949 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 105056232 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 278 (I278T)
Ref Sequence ENSEMBL: ENSMUSP00000147387 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033187] [ENSMUST00000210344]
AlphaFold Q3UW12
Predicted Effect probably benign
Transcript: ENSMUST00000033187
AA Change: I381T

PolyPhen 2 Score 0.196 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000033187
Gene: ENSMUSG00000030897
AA Change: I381T

DomainStartEndE-ValueType
Pfam:Ion_trans 34 276 1.1e-28 PFAM
cNMP 348 472 1.54e-25 SMART
low complexity region 500 508 N/A INTRINSIC
low complexity region 514 523 N/A INTRINSIC
low complexity region 540 557 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000210344
AA Change: I278T

PolyPhen 2 Score 0.196 (Sensitivity: 0.92; Specificity: 0.87)
Meta Mutation Damage Score 0.3190 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.2%
Validation Efficiency 93% (65/70)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Inactivation of this gene results in odor adaptation defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agbl5 G A 5: 31,060,403 (GRCm39) R141Q probably damaging Het
AI593442 TGAGGAGGAGGAGGAGGA TGAGGAGGAGGAGGA 9: 52,589,114 (GRCm39) probably benign Het
Aig1 A G 10: 13,677,644 (GRCm39) I116T probably benign Het
Alox12 A T 11: 70,146,140 (GRCm39) probably null Het
Ap3s1 T A 18: 46,887,497 (GRCm39) D43E probably benign Het
Arhgap35 A G 7: 16,299,059 (GRCm39) M2T possibly damaging Het
Asah2 T A 19: 31,991,708 (GRCm39) E451V probably benign Het
Ash1l T G 3: 88,892,024 (GRCm39) I1301S probably damaging Het
Ass1 G A 2: 31,378,665 (GRCm39) probably null Het
Ccpg1 A G 9: 72,906,360 (GRCm39) T39A possibly damaging Het
Cd101 T A 3: 100,911,021 (GRCm39) Y879F possibly damaging Het
Cdc23 C A 18: 34,784,742 (GRCm39) V7L unknown Het
Cdh23 T C 10: 60,272,586 (GRCm39) T530A possibly damaging Het
Cep68 G T 11: 20,188,477 (GRCm39) Q643K probably damaging Het
Ces1c A G 8: 93,854,197 (GRCm39) S113P probably damaging Het
Col1a1 A G 11: 94,842,402 (GRCm39) D1440G unknown Het
Cspp1 A G 1: 10,117,691 (GRCm39) I48V possibly damaging Het
Ctsj T A 13: 61,151,664 (GRCm39) S85C possibly damaging Het
Cyp39a1 C A 17: 44,057,488 (GRCm39) D442E probably damaging Het
Dock3 A T 9: 106,868,292 (GRCm39) F664Y probably damaging Het
Gpcpd1 A T 2: 132,389,622 (GRCm39) H244Q probably benign Het
Gtf3a T A 5: 146,888,092 (GRCm39) V131E probably benign Het
Gtpbp3 A T 8: 71,943,026 (GRCm39) R147W probably damaging Het
H2-Oa A T 17: 34,313,344 (GRCm39) I132F probably damaging Het
Hsd17b8 G A 17: 34,246,552 (GRCm39) probably benign Het
Idi1 T A 13: 8,937,963 (GRCm39) C91* probably null Het
Itga11 A G 9: 62,662,478 (GRCm39) I484V probably benign Het
Kpna3 C T 14: 61,628,694 (GRCm39) S101N probably damaging Het
Larp4 G A 15: 99,870,898 (GRCm39) probably benign Het
Mink1 T C 11: 70,495,970 (GRCm39) L390P probably damaging Het
Morc1 T G 16: 48,322,715 (GRCm39) S337R probably benign Het
Myo10 A G 15: 25,786,026 (GRCm39) R1236G probably damaging Het
Nkx3-1 T C 14: 69,429,396 (GRCm39) I138T possibly damaging Het
Nnt T C 13: 119,502,936 (GRCm39) N489S probably damaging Het
Nrcam A T 12: 44,617,136 (GRCm39) I711F probably benign Het
Ntrk3 A G 7: 78,227,522 (GRCm39) S4P probably damaging Het
Obsl1 T C 1: 75,464,607 (GRCm39) T1605A possibly damaging Het
Or1j17 A G 2: 36,578,655 (GRCm39) I214V possibly damaging Het
Or7g32 A G 9: 19,408,557 (GRCm39) E171G probably benign Het
Pank1 T C 19: 34,856,316 (GRCm39) H54R probably benign Het
Pgm2l1 A G 7: 99,917,472 (GRCm39) I530V probably benign Het
Psmd2 A G 16: 20,480,405 (GRCm39) T709A probably benign Het
Qsox1 G T 1: 155,688,581 (GRCm39) probably benign Het
Rbm14 A G 19: 4,852,823 (GRCm39) S520P probably benign Het
Rbm15b G A 9: 106,762,120 (GRCm39) R683C probably benign Het
Rhbdd2 T A 5: 135,664,876 (GRCm39) V69D probably damaging Het
Sart1 T C 19: 5,438,576 (GRCm39) E27G possibly damaging Het
Scn4a G A 11: 106,239,553 (GRCm39) P153L probably damaging Het
Serpinb6d A T 13: 33,855,230 (GRCm39) R301S probably benign Het
Sf3a2 C A 10: 80,640,275 (GRCm39) probably benign Het
Syne1 T C 10: 4,997,767 (GRCm39) D400G probably benign Het
Tenm2 T C 11: 35,915,460 (GRCm39) S2025G possibly damaging Het
Ttc16 A T 2: 32,657,988 (GRCm39) D476E probably damaging Het
Ttc9c A T 19: 8,793,396 (GRCm39) C81* probably null Het
Ulk2 G A 11: 61,694,488 (GRCm39) P474L probably damaging Het
Vmn1r66 A G 7: 10,008,722 (GRCm39) C104R probably damaging Het
Vwa2 C T 19: 56,897,752 (GRCm39) H686Y probably damaging Het
Other mutations in Cnga4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01413:Cnga4 APN 7 105,054,169 (GRCm39) missense probably benign
IGL01418:Cnga4 APN 7 105,054,169 (GRCm39) missense probably benign
IGL02450:Cnga4 APN 7 105,054,955 (GRCm39) missense probably damaging 1.00
IGL02533:Cnga4 APN 7 105,057,168 (GRCm39) missense probably damaging 0.97
BB001:Cnga4 UTSW 7 105,057,028 (GRCm39) missense probably benign 0.00
BB011:Cnga4 UTSW 7 105,057,028 (GRCm39) missense probably benign 0.00
IGL03052:Cnga4 UTSW 7 105,053,932 (GRCm39) missense probably benign 0.21
R0020:Cnga4 UTSW 7 105,054,884 (GRCm39) missense probably damaging 1.00
R0135:Cnga4 UTSW 7 105,056,055 (GRCm39) missense probably damaging 1.00
R0281:Cnga4 UTSW 7 105,056,875 (GRCm39) missense probably damaging 1.00
R0506:Cnga4 UTSW 7 105,056,947 (GRCm39) missense probably damaging 1.00
R0599:Cnga4 UTSW 7 105,055,025 (GRCm39) missense probably damaging 1.00
R0646:Cnga4 UTSW 7 105,054,182 (GRCm39) missense possibly damaging 0.47
R0980:Cnga4 UTSW 7 105,057,213 (GRCm39) missense probably damaging 1.00
R1727:Cnga4 UTSW 7 105,054,961 (GRCm39) missense probably damaging 1.00
R3415:Cnga4 UTSW 7 105,056,325 (GRCm39) missense probably damaging 1.00
R3768:Cnga4 UTSW 7 105,056,887 (GRCm39) missense probably damaging 1.00
R4559:Cnga4 UTSW 7 105,054,892 (GRCm39) missense probably damaging 1.00
R4852:Cnga4 UTSW 7 105,054,937 (GRCm39) missense probably benign 0.01
R6232:Cnga4 UTSW 7 105,056,906 (GRCm39) nonsense probably null
R6234:Cnga4 UTSW 7 105,056,906 (GRCm39) nonsense probably null
R6235:Cnga4 UTSW 7 105,056,906 (GRCm39) nonsense probably null
R6824:Cnga4 UTSW 7 105,056,036 (GRCm39) missense probably benign
R6866:Cnga4 UTSW 7 105,056,952 (GRCm39) missense possibly damaging 0.95
R6997:Cnga4 UTSW 7 105,056,190 (GRCm39) missense probably damaging 1.00
R7019:Cnga4 UTSW 7 105,055,036 (GRCm39) missense probably benign 0.00
R7273:Cnga4 UTSW 7 105,056,172 (GRCm39) missense probably damaging 1.00
R7509:Cnga4 UTSW 7 105,056,097 (GRCm39) missense probably benign 0.32
R7522:Cnga4 UTSW 7 105,055,195 (GRCm39) missense probably damaging 0.99
R7545:Cnga4 UTSW 7 105,056,286 (GRCm39) missense probably damaging 1.00
R7873:Cnga4 UTSW 7 105,056,249 (GRCm39) missense probably damaging 0.99
R7924:Cnga4 UTSW 7 105,057,028 (GRCm39) missense probably benign 0.00
R7969:Cnga4 UTSW 7 105,055,253 (GRCm39) missense probably damaging 1.00
R8024:Cnga4 UTSW 7 105,056,042 (GRCm39) missense probably damaging 1.00
R8284:Cnga4 UTSW 7 105,057,239 (GRCm39) missense probably benign 0.17
R8743:Cnga4 UTSW 7 105,057,220 (GRCm39) missense probably benign
R9553:Cnga4 UTSW 7 105,054,977 (GRCm39) missense probably damaging 1.00
X0025:Cnga4 UTSW 7 105,054,427 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GTAGCCATCTTGCAGCACTTG -3'
(R):5'- CAAGGGCCAGATCTCCTAAATC -3'

Sequencing Primer
(F):5'- AGCACTTGCCTGAGCGG -3'
(R):5'- GGGCCAGATCTCCTAAATCTACATG -3'
Posted On 2016-06-06