Incidental Mutation 'R5084:Tas2r114'
ID 387303
Institutional Source Beutler Lab
Gene Symbol Tas2r114
Ensembl Gene ENSMUSG00000063478
Gene Name taste receptor, type 2, member 114
Synonyms mt2r46, mGR14, T2R14, Tas2r14
MMRRC Submission 042673-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R5084 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 131666097-131667026 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 131666251 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 259 (L259*)
Ref Sequence ENSEMBL: ENSMUSP00000079453 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053652] [ENSMUST00000072404] [ENSMUST00000080619]
AlphaFold Q7M722
Predicted Effect probably benign
Transcript: ENSMUST00000053652
SMART Domains Protein: ENSMUSP00000058006
Gene: ENSMUSG00000051153

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 9.4e-109 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000072404
SMART Domains Protein: ENSMUSP00000072237
Gene: ENSMUSG00000061977

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 8.3e-102 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000080619
AA Change: L259*
SMART Domains Protein: ENSMUSP00000079453
Gene: ENSMUSG00000063478
AA Change: L259*

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 8.1e-104 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.3%
  • 20x: 92.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp3 T A 9: 104,204,116 (GRCm39) E59D probably damaging Het
Akap7 T A 10: 25,155,640 (GRCm39) probably benign Het
Anpep C A 7: 79,476,618 (GRCm39) probably null Het
Aste1 T A 9: 105,274,886 (GRCm39) Y314* probably null Het
Ccdc183 G A 2: 25,498,802 (GRCm39) T497I probably damaging Het
Cd4 A T 6: 124,847,402 (GRCm39) I254N probably damaging Het
Crot G T 5: 9,019,994 (GRCm39) H449Q probably damaging Het
Dact2 A T 17: 14,418,214 (GRCm39) W164R possibly damaging Het
Dapk3 C A 10: 81,026,152 (GRCm39) probably null Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Fbrsl1 G A 5: 110,527,272 (GRCm39) probably benign Het
Flg T C 3: 93,184,922 (GRCm39) F15L probably damaging Het
Fscn2 A G 11: 120,252,686 (GRCm39) D51G probably damaging Het
H2-Ob G T 17: 34,460,102 (GRCm39) G71V probably damaging Het
Hmgcs1 T C 13: 120,161,520 (GRCm39) V104A possibly damaging Het
Hs3st4 G T 7: 123,996,518 (GRCm39) D395Y probably damaging Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Ldlrad3 G A 2: 101,900,329 (GRCm39) R58C probably damaging Het
Lpin1 A G 12: 16,626,983 (GRCm39) S188P probably damaging Het
Mamdc2 G T 19: 23,336,516 (GRCm39) T331K possibly damaging Het
Matr3 G A 18: 35,715,135 (GRCm39) S195N probably damaging Het
Nktr T C 9: 121,577,176 (GRCm39) Y390H possibly damaging Het
Notch3 C T 17: 32,376,864 (GRCm39) probably null Het
Olfm3 T C 3: 114,698,202 (GRCm39) probably null Het
Or10ak11 A G 4: 118,686,767 (GRCm39) V290A probably damaging Het
Or2a20 T C 6: 43,194,594 (GRCm39) L249P probably damaging Het
Or5h25 C T 16: 58,930,436 (GRCm39) C179Y possibly damaging Het
Or7e173 T A 9: 19,938,551 (GRCm39) I228F probably damaging Het
Or7g17 T A 9: 18,768,632 (GRCm39) M237K probably benign Het
Pask A G 1: 93,249,819 (GRCm39) V527A probably benign Het
Pcdha6 A T 18: 37,102,016 (GRCm39) N403I probably damaging Het
Peg3 T C 7: 6,710,848 (GRCm39) E1458G probably damaging Het
Pip4k2b G A 11: 97,610,569 (GRCm39) T386M probably damaging Het
Pkd1l1 T C 11: 8,892,004 (GRCm39) M272V probably benign Het
Plcb4 A G 2: 135,844,571 (GRCm39) E163G probably damaging Het
Plk5 C A 10: 80,194,723 (GRCm39) R149S possibly damaging Het
Pou4f3 A T 18: 42,528,933 (GRCm39) Y292F probably damaging Het
Rasgef1c A G 11: 49,860,332 (GRCm39) K272E probably damaging Het
Rbl2 C T 8: 91,841,759 (GRCm39) T942M probably benign Het
Sipa1l3 G A 7: 29,048,000 (GRCm39) S247F probably damaging Het
Smarca4 T C 9: 21,572,059 (GRCm39) L777P probably damaging Het
Smpd1 T C 7: 105,206,185 (GRCm39) Y438H probably damaging Het
Sorl1 T C 9: 41,887,673 (GRCm39) K2052R probably benign Het
Spata31d1c C A 13: 65,182,944 (GRCm39) P162Q probably damaging Het
Spmip9 A G 6: 70,892,688 (GRCm39) S20P possibly damaging Het
Ston1 A T 17: 88,944,002 (GRCm39) E469D probably benign Het
Syde2 AGTTC AGTTCGTTC 3: 145,707,164 (GRCm39) probably null Het
Syde2 CAGTT CAGTTAGTT 3: 145,707,163 (GRCm39) probably null Het
Taar5 T A 10: 23,846,836 (GRCm39) L78Q probably damaging Het
Topaz1 T A 9: 122,577,883 (GRCm39) H264Q probably benign Het
Vcl G T 14: 21,059,027 (GRCm39) V548L possibly damaging Het
Vmn2r57 C A 7: 41,075,974 (GRCm39) probably null Het
Vmn2r92 A G 17: 18,405,439 (GRCm39) *861W probably null Het
Ylpm1 T G 12: 85,076,095 (GRCm39) V940G probably damaging Het
Zfp236 A G 18: 82,627,556 (GRCm39) S1500P probably damaging Het
Zfp384 G T 6: 125,000,642 (GRCm39) probably benign Het
Zfp786 T C 6: 47,796,953 (GRCm39) M662V probably benign Het
Other mutations in Tas2r114
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01777:Tas2r114 APN 6 131,666,664 (GRCm39) nonsense probably null
IGL02971:Tas2r114 APN 6 131,666,243 (GRCm39) missense probably benign 0.00
R0561:Tas2r114 UTSW 6 131,666,758 (GRCm39) missense probably benign 0.30
R3034:Tas2r114 UTSW 6 131,666,611 (GRCm39) missense probably benign 0.15
R3687:Tas2r114 UTSW 6 131,666,231 (GRCm39) missense probably benign 0.25
R4411:Tas2r114 UTSW 6 131,666,585 (GRCm39) missense probably benign 0.06
R4826:Tas2r114 UTSW 6 131,666,800 (GRCm39) missense probably damaging 0.99
R4889:Tas2r114 UTSW 6 131,666,758 (GRCm39) missense probably damaging 0.96
R5258:Tas2r114 UTSW 6 131,666,504 (GRCm39) missense probably benign 0.03
R6038:Tas2r114 UTSW 6 131,666,444 (GRCm39) missense possibly damaging 0.89
R6038:Tas2r114 UTSW 6 131,666,444 (GRCm39) missense possibly damaging 0.89
R6499:Tas2r114 UTSW 6 131,666,099 (GRCm39) makesense probably null
R7164:Tas2r114 UTSW 6 131,666,728 (GRCm39) missense possibly damaging 0.74
R7276:Tas2r114 UTSW 6 131,666,310 (GRCm39) missense probably damaging 0.96
R7745:Tas2r114 UTSW 6 131,666,401 (GRCm39) missense probably damaging 1.00
R7851:Tas2r114 UTSW 6 131,666,888 (GRCm39) missense probably damaging 1.00
R8002:Tas2r114 UTSW 6 131,666,102 (GRCm39) missense probably damaging 1.00
R8901:Tas2r114 UTSW 6 131,666,914 (GRCm39) missense probably damaging 0.99
R9297:Tas2r114 UTSW 6 131,666,287 (GRCm39) missense probably damaging 0.96
R9380:Tas2r114 UTSW 6 131,666,381 (GRCm39) missense probably benign 0.00
R9402:Tas2r114 UTSW 6 131,666,894 (GRCm39) missense possibly damaging 0.49
R9473:Tas2r114 UTSW 6 131,666,104 (GRCm39) missense probably benign
R9513:Tas2r114 UTSW 6 131,666,746 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GCATAGTGCAAGTGAAAAGATCTTC -3'
(R):5'- TCACTTTGGAGACATCGCAG -3'

Sequencing Primer
(F):5'- CAATTCCAGATTGCATGTGTTCCAG -3'
(R):5'- CATCGCAGGCAGATGGAATC -3'
Posted On 2016-06-06