Incidental Mutation 'R5085:Gm14403'
ID 387353
Institutional Source Beutler Lab
Gene Symbol Gm14403
Ensembl Gene ENSMUSG00000094786
Gene Name predicted gene 14403
Synonyms
MMRRC Submission 042674-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R5085 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 177190008-177201556 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 177200282 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 76 (E76G)
Ref Sequence ENSEMBL: ENSMUSP00000104575 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108940] [ENSMUST00000108947]
AlphaFold A2BFU4
Predicted Effect probably benign
Transcript: ENSMUST00000108940
SMART Domains Protein: ENSMUSP00000104568
Gene: ENSMUSG00000094786

DomainStartEndE-ValueType
internal_repeat_1 1 73 1.34e-11 PROSPERO
internal_repeat_1 169 241 1.34e-11 PROSPERO
Predicted Effect probably benign
Transcript: ENSMUST00000108947
AA Change: E76G

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000104575
Gene: ENSMUSG00000094786
AA Change: E76G

DomainStartEndE-ValueType
KRAB 4 66 4.86e-13 SMART
ZnF_C2H2 76 97 2.31e2 SMART
ZnF_C2H2 103 125 1.2e-3 SMART
ZnF_C2H2 131 153 1.18e-2 SMART
ZnF_C2H2 159 179 4.57e0 SMART
ZnF_C2H2 187 209 5.59e-4 SMART
ZnF_C2H2 215 237 1.12e-3 SMART
ZnF_C2H2 243 265 1.18e-2 SMART
ZnF_C2H2 271 293 8.6e-5 SMART
ZnF_C2H2 299 321 3.16e-3 SMART
ZnF_C2H2 327 349 1.84e-4 SMART
ZnF_C2H2 355 377 3.44e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142549
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency 92% (69/75)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik A T 16: 4,653,837 (GRCm39) K129* probably null Het
Adamts6 A T 13: 104,443,751 (GRCm39) D162V probably damaging Het
Alms1 C A 6: 85,597,714 (GRCm39) P1316T possibly damaging Het
AU040320 A T 4: 126,722,664 (GRCm39) N394I possibly damaging Het
Cacng8 T C 7: 3,464,096 (GRCm39) L416P possibly damaging Het
Ccdc136 T A 6: 29,419,313 (GRCm39) N944K probably damaging Het
Clcn1 C T 6: 42,290,814 (GRCm39) T896I probably benign Het
Col16a1 A T 4: 129,947,964 (GRCm39) Y228F probably damaging Het
Cyfip1 A G 7: 55,548,083 (GRCm39) D561G probably benign Het
Ddr1 T A 17: 35,993,667 (GRCm39) probably null Het
Dedd2 A T 7: 24,918,411 (GRCm39) L48Q probably damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Dph3b-ps A G 13: 106,683,558 (GRCm39) noncoding transcript Het
Dppa3 T C 6: 122,606,891 (GRCm39) F127S probably damaging Het
Dpy19l4 C T 4: 11,265,943 (GRCm39) probably null Het
Flrt3 T C 2: 140,502,177 (GRCm39) T484A probably damaging Het
Gldc T C 19: 30,128,936 (GRCm39) E179G probably damaging Het
Gm6421 G A 13: 117,494,969 (GRCm39) noncoding transcript Het
Grk5 T C 19: 61,065,122 (GRCm39) V262A probably damaging Het
Grp A G 18: 66,013,230 (GRCm39) Q132R probably benign Het
Hap1 A G 11: 100,246,537 (GRCm39) F123L probably damaging Het
Hrc A G 7: 44,986,445 (GRCm39) D532G probably damaging Het
Igsf9b C A 9: 27,228,733 (GRCm39) F164L probably benign Het
Irag1 G T 7: 110,470,700 (GRCm39) L672I probably damaging Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Kansl1 C T 11: 104,315,168 (GRCm39) R290Q probably damaging Het
Kifc2 T A 15: 76,545,496 (GRCm39) L81Q probably damaging Het
Klrc3 T C 6: 129,616,538 (GRCm39) R160G probably damaging Het
Mal A G 2: 127,482,193 (GRCm39) M70T probably benign Het
Mep1a T G 17: 43,789,035 (GRCm39) R580S probably damaging Het
Methig1 A T 15: 100,251,130 (GRCm39) I14F probably damaging Het
Mtf1 T C 4: 124,715,101 (GRCm39) L242P probably damaging Het
Nfkb1 C A 3: 135,309,568 (GRCm39) A509S probably benign Het
Or2h2b-ps1 C G 17: 37,480,858 (GRCm39) S227T probably benign Het
Or2n1b G A 17: 38,460,003 (GRCm39) D175N probably damaging Het
Or5ac24 A T 16: 59,165,449 (GRCm39) I205K probably damaging Het
Or7a36 G T 10: 78,819,928 (GRCm39) M101I probably benign Het
Or8k23 A T 2: 86,186,318 (GRCm39) M136K probably damaging Het
Pabpc2 A T 18: 39,907,635 (GRCm39) N300I probably damaging Het
Peg10 C T 6: 4,755,864 (GRCm39) probably benign Het
Ppp1r3a T A 6: 14,719,603 (GRCm39) D437V probably damaging Het
Prickle1 A G 15: 93,398,783 (GRCm39) S682P probably damaging Het
Prkab2 T C 3: 97,580,308 (GRCm39) probably benign Het
Pus3 T A 9: 35,476,932 (GRCm39) L243Q possibly damaging Het
Relch A G 1: 105,605,905 (GRCm39) S182G probably damaging Het
Rgs19 G A 2: 181,331,336 (GRCm39) T99M possibly damaging Het
Ripk2 A G 4: 16,127,663 (GRCm39) S360P possibly damaging Het
Rock1 A G 18: 10,140,210 (GRCm39) I127T probably damaging Het
Serpinb10 T G 1: 107,469,947 (GRCm39) M143R probably damaging Het
Sipa1l3 G A 7: 29,048,000 (GRCm39) S247F probably damaging Het
Skint6 T A 4: 113,093,465 (GRCm39) Q226L probably damaging Het
Slc6a19 T C 13: 73,839,872 (GRCm39) M137V probably benign Het
Supv3l1 A T 10: 62,271,291 (GRCm39) N415K probably benign Het
Tekt4 A G 17: 25,692,749 (GRCm39) R192G probably damaging Het
Trgv7 A T 13: 19,362,598 (GRCm39) K96* probably null Het
Tshz1 T C 18: 84,032,053 (GRCm39) N785S probably benign Het
Usb1 A G 8: 96,070,679 (GRCm39) T202A probably damaging Het
Utp18 A T 11: 93,761,363 (GRCm39) D348E possibly damaging Het
Vmn1r42 T G 6: 89,821,598 (GRCm39) I324L probably benign Het
Wnt8a A T 18: 34,678,656 (GRCm39) R157* probably null Het
Ypel1 A G 16: 16,902,472 (GRCm39) probably null Het
Zfp235 A G 7: 23,836,546 (GRCm39) K31E probably damaging Het
Zhx2 G C 15: 57,686,089 (GRCm39) W486S probably damaging Het
Other mutations in Gm14403
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01835:Gm14403 APN 2 177,199,049 (GRCm39) missense probably damaging 0.99
IGL02660:Gm14403 APN 2 177,201,257 (GRCm39) missense probably damaging 1.00
R0492:Gm14403 UTSW 2 177,200,359 (GRCm39) missense probably benign 0.09
R0932:Gm14403 UTSW 2 177,198,810 (GRCm39) missense probably benign 0.01
R0975:Gm14403 UTSW 2 177,201,217 (GRCm39) missense probably damaging 1.00
R1468:Gm14403 UTSW 2 177,199,024 (GRCm39) splice site probably benign
R1853:Gm14403 UTSW 2 177,200,932 (GRCm39) missense probably damaging 1.00
R3011:Gm14403 UTSW 2 177,200,786 (GRCm39) missense probably benign
R3803:Gm14403 UTSW 2 177,200,569 (GRCm39) missense probably benign 0.04
R4589:Gm14403 UTSW 2 177,200,428 (GRCm39) missense probably benign 0.29
R4805:Gm14403 UTSW 2 177,200,492 (GRCm39) missense probably damaging 0.97
R5311:Gm14403 UTSW 2 177,201,448 (GRCm39) unclassified probably benign
R5425:Gm14403 UTSW 2 177,201,448 (GRCm39) unclassified probably benign
R5643:Gm14403 UTSW 2 177,199,054 (GRCm39) missense possibly damaging 0.87
R5644:Gm14403 UTSW 2 177,199,054 (GRCm39) missense possibly damaging 0.87
R5739:Gm14403 UTSW 2 177,201,040 (GRCm39) missense probably damaging 1.00
R5982:Gm14403 UTSW 2 177,200,345 (GRCm39) missense probably damaging 0.98
R6197:Gm14403 UTSW 2 177,201,448 (GRCm39) unclassified probably benign
R6198:Gm14403 UTSW 2 177,201,448 (GRCm39) unclassified probably benign
R6892:Gm14403 UTSW 2 177,201,040 (GRCm39) missense probably damaging 1.00
R7090:Gm14403 UTSW 2 177,201,114 (GRCm39) missense possibly damaging 0.87
R7168:Gm14403 UTSW 2 177,201,318 (GRCm39) missense probably damaging 0.96
R7510:Gm14403 UTSW 2 177,200,403 (GRCm39) missense probably benign 0.01
R7623:Gm14403 UTSW 2 177,200,405 (GRCm39) missense probably benign
R8049:Gm14403 UTSW 2 177,200,311 (GRCm39) missense probably benign 0.00
R8557:Gm14403 UTSW 2 177,201,354 (GRCm39) missense probably damaging 0.99
R9224:Gm14403 UTSW 2 177,200,336 (GRCm39) missense probably benign
R9333:Gm14403 UTSW 2 177,200,919 (GRCm39) missense probably benign 0.42
R9632:Gm14403 UTSW 2 177,201,421 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTGCAAGTACTGTGAGTTCGTCC -3'
(R):5'- CCACATTGGTTACATTCATAGGG -3'

Sequencing Primer
(F):5'- GTGAGCCAGATAATCAGTACTGTTCC -3'
(R):5'- TGACAGCTTCTTGCAAAGGC -3'
Posted On 2016-06-06