Incidental Mutation 'R5088:Vmn2r108'
ID 387604
Institutional Source Beutler Lab
Gene Symbol Vmn2r108
Ensembl Gene ENSMUSG00000091805
Gene Name vomeronasal 2, receptor 108
Synonyms EG627805
MMRRC Submission 042677-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R5088 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 20682635-20701498 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 20690454 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 459 (N459K)
Ref Sequence ENSEMBL: ENSMUSP00000130373 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167314]
AlphaFold E9PYS0
Predicted Effect possibly damaging
Transcript: ENSMUST00000167314
AA Change: N459K

PolyPhen 2 Score 0.456 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: N459K

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 83 467 6e-33 PFAM
Pfam:NCD3G 510 563 9.2e-22 PFAM
Pfam:7tm_3 593 831 2.2e-51 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.9%
Validation Efficiency 99% (72/73)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik A T 5: 109,883,939 (GRCm39) C640S probably damaging Het
4931429L15Rik T C 9: 46,217,038 (GRCm39) R246G probably benign Het
Aak1 T C 6: 86,921,462 (GRCm39) probably null Het
Abcc5 A G 16: 20,195,412 (GRCm39) L695P probably damaging Het
Alcam T A 16: 52,109,290 (GRCm39) T328S probably damaging Het
Alpk1 A G 3: 127,478,969 (GRCm39) probably benign Het
Arel1 A G 12: 84,970,889 (GRCm39) L642P probably damaging Het
Atrip T C 9: 108,888,964 (GRCm39) D741G probably damaging Het
Bmp1 T C 14: 70,723,659 (GRCm39) T726A possibly damaging Het
Bnip3 A G 7: 138,496,337 (GRCm39) probably null Het
Cacng5 C G 11: 107,768,215 (GRCm39) C264S possibly damaging Het
Calr4 T A 4: 109,101,859 (GRCm39) probably benign Het
Cdhr1 T A 14: 36,811,422 (GRCm39) T230S probably benign Het
Cdk16 T C X: 20,562,566 (GRCm39) probably benign Het
Cenpj T C 14: 56,791,148 (GRCm39) E337G probably damaging Het
Chd9 A G 8: 91,704,147 (GRCm39) I694V possibly damaging Het
Chsy3 T A 18: 59,312,607 (GRCm39) V360D probably damaging Het
Col16a1 C T 4: 129,972,988 (GRCm39) T643M probably benign Het
Col5a1 G A 2: 27,908,614 (GRCm39) W67* probably null Het
Cyp20a1 A T 1: 60,402,509 (GRCm39) H198L probably damaging Het
Dnai1 T A 4: 41,597,630 (GRCm39) S38T probably benign Het
Dnai1 T G 4: 41,632,251 (GRCm39) S562A probably benign Het
Dpy19l4 G T 4: 11,303,357 (GRCm39) T188K probably damaging Het
Ergic2 A G 6: 148,084,621 (GRCm39) V304A probably damaging Het
Fam83a A G 15: 57,873,196 (GRCm39) T342A probably benign Het
Fbxo7 A G 10: 85,857,784 (GRCm39) probably benign Het
Gins4 T C 8: 23,727,084 (GRCm39) E3G possibly damaging Het
Glis3 G A 19: 28,508,979 (GRCm39) P335L probably benign Het
Golph3l A T 3: 95,524,501 (GRCm39) T251S possibly damaging Het
Hnf4g C T 3: 3,722,181 (GRCm39) A445V probably benign Het
Hykk A G 9: 54,853,763 (GRCm39) I362V probably benign Het
Il6st G A 13: 112,627,089 (GRCm39) V294M probably damaging Het
Itpr1 A G 6: 108,366,348 (GRCm39) I92V probably damaging Het
Kdm4c T C 4: 74,252,936 (GRCm39) L501P probably benign Het
Mpi G A 9: 57,457,887 (GRCm39) T105M probably damaging Het
Mrpl37 A T 4: 106,921,919 (GRCm39) L132H probably damaging Het
Muc5ac A T 7: 141,350,056 (GRCm39) T600S possibly damaging Het
Npl A T 1: 153,384,890 (GRCm39) I249N possibly damaging Het
Or10j27 C T 1: 172,958,606 (GRCm39) M59I probably damaging Het
Or7g30 A G 9: 19,353,067 (GRCm39) N286S probably damaging Het
Pkd1 A G 17: 24,809,812 (GRCm39) K3497E possibly damaging Het
Ptprt T C 2: 162,080,095 (GRCm39) N235D probably benign Het
Rangap1 A C 15: 81,594,664 (GRCm39) D388E probably benign Het
Rcvrn A T 11: 67,586,340 (GRCm39) Q33L probably benign Het
Rif1 A T 2: 51,982,307 (GRCm39) K524I possibly damaging Het
Rnf139 A T 15: 58,771,790 (GRCm39) N605I possibly damaging Het
Ryr2 C A 13: 11,727,129 (GRCm39) G2411* probably null Het
Scn3a A T 2: 65,302,643 (GRCm39) S1268T probably damaging Het
Sema6a T A 18: 47,382,196 (GRCm39) I784F probably damaging Het
Sgms2 C T 3: 131,124,005 (GRCm39) V232M probably benign Het
Skint7 T C 4: 111,837,627 (GRCm39) I135T possibly damaging Het
Smchd1 A T 17: 71,738,343 (GRCm39) N507K possibly damaging Het
Spata31d1a A C 13: 59,848,966 (GRCm39) probably null Het
Spata7 A T 12: 98,635,761 (GRCm39) D527V probably benign Het
Srcap A G 7: 127,140,833 (GRCm39) T1477A probably benign Het
Srl C A 16: 4,300,633 (GRCm39) D375Y probably damaging Het
Stk4 A T 2: 163,925,608 (GRCm39) K58* probably null Het
Svep1 T G 4: 58,120,648 (GRCm39) H795P possibly damaging Het
Trak2 T A 1: 58,974,967 (GRCm39) Q75L probably benign Het
Ubxn2a T A 12: 4,933,904 (GRCm39) N169I probably damaging Het
Vmn1r216 T A 13: 23,283,473 (GRCm39) L52* probably null Het
Vstm5 A G 9: 15,168,601 (GRCm39) D55G possibly damaging Het
Wdr24 T A 17: 26,047,181 (GRCm39) probably null Het
Zfp13 C A 17: 23,796,035 (GRCm39) E179* probably null Het
Zfp839 T C 12: 110,834,610 (GRCm39) S546P probably damaging Het
Other mutations in Vmn2r108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00903:Vmn2r108 APN 17 20,682,774 (GRCm39) missense probably damaging 0.98
IGL01143:Vmn2r108 APN 17 20,682,727 (GRCm39) missense possibly damaging 0.82
IGL01311:Vmn2r108 APN 17 20,682,939 (GRCm39) nonsense probably null
IGL01411:Vmn2r108 APN 17 20,691,282 (GRCm39) missense probably benign 0.01
IGL01414:Vmn2r108 APN 17 20,691,942 (GRCm39) missense probably benign 0.00
IGL01536:Vmn2r108 APN 17 20,683,543 (GRCm39) missense probably damaging 1.00
IGL01748:Vmn2r108 APN 17 20,683,476 (GRCm39) missense probably benign 0.03
IGL01769:Vmn2r108 APN 17 20,691,280 (GRCm39) missense probably benign 0.02
IGL02022:Vmn2r108 APN 17 20,691,987 (GRCm39) missense possibly damaging 0.77
IGL02041:Vmn2r108 APN 17 20,683,398 (GRCm39) missense probably damaging 1.00
IGL02049:Vmn2r108 APN 17 20,691,608 (GRCm39) missense probably benign 0.00
IGL02344:Vmn2r108 APN 17 20,689,405 (GRCm39) missense probably damaging 1.00
IGL02939:Vmn2r108 APN 17 20,691,545 (GRCm39) missense probably benign 0.05
IGL03202:Vmn2r108 APN 17 20,691,319 (GRCm39) nonsense probably null
PIT4498001:Vmn2r108 UTSW 17 20,683,279 (GRCm39) missense probably damaging 1.00
R0112:Vmn2r108 UTSW 17 20,691,897 (GRCm39) missense probably benign 0.07
R0505:Vmn2r108 UTSW 17 20,683,096 (GRCm39) missense possibly damaging 0.77
R0833:Vmn2r108 UTSW 17 20,691,721 (GRCm39) missense probably benign
R0836:Vmn2r108 UTSW 17 20,691,721 (GRCm39) missense probably benign
R0943:Vmn2r108 UTSW 17 20,691,397 (GRCm39) nonsense probably null
R1411:Vmn2r108 UTSW 17 20,683,107 (GRCm39) missense probably damaging 0.98
R1442:Vmn2r108 UTSW 17 20,692,623 (GRCm39) nonsense probably null
R1587:Vmn2r108 UTSW 17 20,692,383 (GRCm39) missense probably damaging 1.00
R1751:Vmn2r108 UTSW 17 20,682,786 (GRCm39) missense probably damaging 1.00
R1773:Vmn2r108 UTSW 17 20,689,335 (GRCm39) missense probably damaging 1.00
R2021:Vmn2r108 UTSW 17 20,691,252 (GRCm39) missense probably benign 0.00
R2159:Vmn2r108 UTSW 17 20,689,363 (GRCm39) missense probably benign 0.41
R2224:Vmn2r108 UTSW 17 20,701,295 (GRCm39) nonsense probably null
R2226:Vmn2r108 UTSW 17 20,701,295 (GRCm39) nonsense probably null
R2517:Vmn2r108 UTSW 17 20,692,577 (GRCm39) missense probably damaging 1.00
R3710:Vmn2r108 UTSW 17 20,682,932 (GRCm39) missense probably benign
R4470:Vmn2r108 UTSW 17 20,682,990 (GRCm39) missense probably damaging 1.00
R4686:Vmn2r108 UTSW 17 20,691,636 (GRCm39) missense probably damaging 0.99
R4729:Vmn2r108 UTSW 17 20,692,632 (GRCm39) missense probably damaging 0.99
R4799:Vmn2r108 UTSW 17 20,682,891 (GRCm39) missense probably damaging 1.00
R4993:Vmn2r108 UTSW 17 20,701,449 (GRCm39) missense probably benign 0.04
R5213:Vmn2r108 UTSW 17 20,691,755 (GRCm39) missense probably benign 0.00
R5289:Vmn2r108 UTSW 17 20,691,866 (GRCm39) missense probably damaging 1.00
R5290:Vmn2r108 UTSW 17 20,691,665 (GRCm39) missense probably benign 0.00
R5713:Vmn2r108 UTSW 17 20,691,290 (GRCm39) missense probably damaging 1.00
R5753:Vmn2r108 UTSW 17 20,683,179 (GRCm39) missense probably damaging 0.99
R5792:Vmn2r108 UTSW 17 20,683,398 (GRCm39) missense probably damaging 0.99
R5798:Vmn2r108 UTSW 17 20,692,545 (GRCm39) missense probably benign 0.39
R5897:Vmn2r108 UTSW 17 20,691,580 (GRCm39) missense probably benign 0.01
R6018:Vmn2r108 UTSW 17 20,683,268 (GRCm39) missense possibly damaging 0.83
R6093:Vmn2r108 UTSW 17 20,701,402 (GRCm39) missense probably benign 0.00
R6156:Vmn2r108 UTSW 17 20,692,447 (GRCm39) missense probably benign 0.03
R6199:Vmn2r108 UTSW 17 20,682,644 (GRCm39) missense probably benign 0.01
R6259:Vmn2r108 UTSW 17 20,683,371 (GRCm39) missense possibly damaging 0.95
R6309:Vmn2r108 UTSW 17 20,691,660 (GRCm39) missense probably damaging 0.98
R6324:Vmn2r108 UTSW 17 20,691,977 (GRCm39) nonsense probably null
R6364:Vmn2r108 UTSW 17 20,691,260 (GRCm39) missense probably benign 0.00
R6446:Vmn2r108 UTSW 17 20,692,609 (GRCm39) nonsense probably null
R6541:Vmn2r108 UTSW 17 20,701,480 (GRCm39) missense probably benign 0.02
R7025:Vmn2r108 UTSW 17 20,691,345 (GRCm39) missense possibly damaging 0.67
R7063:Vmn2r108 UTSW 17 20,701,410 (GRCm39) missense probably damaging 1.00
R7092:Vmn2r108 UTSW 17 20,701,338 (GRCm39) missense probably benign 0.10
R7096:Vmn2r108 UTSW 17 20,682,762 (GRCm39) missense probably damaging 1.00
R7203:Vmn2r108 UTSW 17 20,683,038 (GRCm39) missense probably benign 0.12
R7458:Vmn2r108 UTSW 17 20,692,532 (GRCm39) missense probably benign 0.17
R7619:Vmn2r108 UTSW 17 20,692,457 (GRCm39) missense probably benign 0.02
R7841:Vmn2r108 UTSW 17 20,690,305 (GRCm39) critical splice donor site probably null
R7944:Vmn2r108 UTSW 17 20,691,890 (GRCm39) missense probably damaging 0.99
R8048:Vmn2r108 UTSW 17 20,691,762 (GRCm39) missense probably benign 0.29
R8213:Vmn2r108 UTSW 17 20,690,350 (GRCm39) missense probably benign 0.03
R8218:Vmn2r108 UTSW 17 20,683,465 (GRCm39) missense probably damaging 1.00
R8507:Vmn2r108 UTSW 17 20,683,195 (GRCm39) nonsense probably null
R8708:Vmn2r108 UTSW 17 20,682,687 (GRCm39) missense probably damaging 0.98
R8845:Vmn2r108 UTSW 17 20,691,361 (GRCm39) missense probably benign 0.03
R9030:Vmn2r108 UTSW 17 20,690,312 (GRCm39) missense probably benign 0.01
R9226:Vmn2r108 UTSW 17 20,691,330 (GRCm39) missense probably benign
R9278:Vmn2r108 UTSW 17 20,692,561 (GRCm39) missense probably benign 0.11
X0022:Vmn2r108 UTSW 17 20,691,371 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r108 UTSW 17 20,691,375 (GRCm39) missense probably benign 0.01
Z1177:Vmn2r108 UTSW 17 20,691,219 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AGAGTGATGGGCCTTAAATCAG -3'
(R):5'- TGGTATCCAAAACACTCAGACATTC -3'

Sequencing Primer
(F):5'- TGATGGGCCTTAAATCAGAAAAC -3'
(R):5'- ATAGCTTCATTCACTTGACTTTCAC -3'
Posted On 2016-06-06