Incidental Mutation 'R5092:Cnot1'
ID |
387833 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cnot1
|
Ensembl Gene |
ENSMUSG00000036550 |
Gene Name |
CCR4-NOT transcription complex, subunit 1 |
Synonyms |
6030411K04Rik |
MMRRC Submission |
042681-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R5092 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
8 |
Chromosomal Location |
96446079-96534092 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 96479396 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Arginine to Serine
at position 875
(R875S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000148735
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068452]
[ENSMUST00000098473]
[ENSMUST00000211887]
[ENSMUST00000213006]
[ENSMUST00000213046]
|
AlphaFold |
no structure available at present |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000068452
AA Change: R870S
PolyPhen 2
Score 0.867 (Sensitivity: 0.83; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000063565 Gene: ENSMUSG00000036550 AA Change: R870S
Domain | Start | End | E-Value | Type |
low complexity region
|
181 |
189 |
N/A |
INTRINSIC |
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
low complexity region
|
779 |
796 |
N/A |
INTRINSIC |
PDB:4J8S|A
|
798 |
999 |
1e-137 |
PDB |
low complexity region
|
1011 |
1028 |
N/A |
INTRINSIC |
low complexity region
|
1031 |
1055 |
N/A |
INTRINSIC |
PDB:4CT4|C
|
1056 |
1295 |
1e-148 |
PDB |
low complexity region
|
1296 |
1308 |
N/A |
INTRINSIC |
low complexity region
|
1328 |
1345 |
N/A |
INTRINSIC |
Pfam:DUF3819
|
1381 |
1530 |
2.5e-56 |
PFAM |
low complexity region
|
1634 |
1648 |
N/A |
INTRINSIC |
Pfam:Not1
|
1991 |
2305 |
2.4e-125 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000083277
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000098473
AA Change: R875S
PolyPhen 2
Score 0.839 (Sensitivity: 0.84; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000096073 Gene: ENSMUSG00000036550 AA Change: R875S
Domain | Start | End | E-Value | Type |
low complexity region
|
181 |
189 |
N/A |
INTRINSIC |
Pfam:CNOT1_HEAT
|
500 |
656 |
2.4e-57 |
PFAM |
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
low complexity region
|
779 |
796 |
N/A |
INTRINSIC |
Pfam:CNOT1_TTP_bind
|
812 |
1004 |
1.4e-87 |
PFAM |
low complexity region
|
1016 |
1033 |
N/A |
INTRINSIC |
low complexity region
|
1036 |
1060 |
N/A |
INTRINSIC |
Pfam:CNOT1_CAF1_bind
|
1087 |
1313 |
5.7e-99 |
PFAM |
low complexity region
|
1333 |
1350 |
N/A |
INTRINSIC |
Pfam:DUF3819
|
1387 |
1534 |
2.3e-57 |
PFAM |
low complexity region
|
1639 |
1653 |
N/A |
INTRINSIC |
Pfam:Not1
|
1998 |
2357 |
5.7e-157 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000196326
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197815
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000211887
AA Change: R868S
PolyPhen 2
Score 0.905 (Sensitivity: 0.82; Specificity: 0.94)
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000211937
|
Predicted Effect |
unknown
Transcript: ENSMUST00000211973
AA Change: R342S
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000213006
AA Change: R875S
PolyPhen 2
Score 0.914 (Sensitivity: 0.81; Specificity: 0.94)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000213046
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.9%
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice hmozygous for a conditional allele activated in cardiomyocytes exhibit postnatal lethality, decreased cardiac muscle contractility, prolonged QT interval and cardiac muscle cell death. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 93 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930433I11Rik |
C |
T |
7: 40,637,091 (GRCm39) |
|
probably benign |
Het |
Abca13 |
T |
A |
11: 9,208,535 (GRCm39) |
L236Q |
probably damaging |
Het |
Acp2 |
A |
T |
2: 91,038,391 (GRCm39) |
T255S |
probably benign |
Het |
Acsf3 |
A |
C |
8: 123,544,131 (GRCm39) |
R536S |
probably benign |
Het |
Adgrb1 |
T |
G |
15: 74,401,664 (GRCm39) |
V220G |
probably benign |
Het |
Anks6 |
C |
T |
4: 47,030,795 (GRCm39) |
G601S |
probably damaging |
Het |
Atp5f1b |
A |
G |
10: 127,919,854 (GRCm39) |
Q74R |
probably benign |
Het |
Bltp1 |
A |
T |
3: 37,054,234 (GRCm39) |
M3118L |
probably benign |
Het |
Brf1 |
G |
A |
12: 112,943,352 (GRCm39) |
T166M |
probably damaging |
Het |
Capn9 |
A |
G |
8: 125,324,264 (GRCm39) |
K188R |
probably damaging |
Het |
Casp8 |
A |
T |
1: 58,883,835 (GRCm39) |
N381Y |
possibly damaging |
Het |
Ccdc88b |
A |
G |
19: 6,825,600 (GRCm39) |
S1218P |
probably damaging |
Het |
Cdc42bpg |
C |
T |
19: 6,363,250 (GRCm39) |
P403S |
probably benign |
Het |
Cdkal1 |
T |
A |
13: 30,030,222 (GRCm39) |
Y91F |
probably damaging |
Het |
Cdyl2 |
T |
C |
8: 117,350,679 (GRCm39) |
N151D |
possibly damaging |
Het |
Cpd |
A |
G |
11: 76,702,530 (GRCm39) |
S613P |
possibly damaging |
Het |
Cyp2e1 |
G |
T |
7: 140,354,648 (GRCm39) |
R492L |
probably damaging |
Het |
D5Ertd579e |
G |
A |
5: 36,760,047 (GRCm39) |
T1371M |
probably benign |
Het |
Dcaf8 |
A |
G |
1: 172,014,476 (GRCm39) |
T394A |
probably benign |
Het |
Dgka |
T |
C |
10: 128,571,702 (GRCm39) |
E117G |
probably damaging |
Het |
Dock4 |
G |
A |
12: 40,894,440 (GRCm39) |
V1867I |
probably benign |
Het |
E2f2 |
G |
T |
4: 135,914,248 (GRCm39) |
A333S |
probably benign |
Het |
Eif3l |
T |
C |
15: 78,968,354 (GRCm39) |
S208P |
probably benign |
Het |
Elovl3 |
A |
T |
19: 46,122,961 (GRCm39) |
H179L |
probably damaging |
Het |
Eml5 |
T |
C |
12: 98,758,875 (GRCm39) |
D1766G |
probably damaging |
Het |
Eno4 |
A |
G |
19: 58,934,023 (GRCm39) |
T75A |
probably benign |
Het |
Fam135a |
C |
T |
1: 24,067,888 (GRCm39) |
D94N |
probably benign |
Het |
Fasn |
G |
T |
11: 120,705,862 (GRCm39) |
Q1136K |
probably benign |
Het |
Fcer1a |
T |
G |
1: 173,053,022 (GRCm39) |
N58T |
probably damaging |
Het |
Frmd4b |
T |
A |
6: 97,272,941 (GRCm39) |
D763V |
probably damaging |
Het |
Gm43518 |
A |
G |
5: 124,076,297 (GRCm39) |
T115A |
probably damaging |
Het |
Gria4 |
C |
T |
9: 4,472,176 (GRCm39) |
E438K |
probably benign |
Het |
Grin2d |
T |
C |
7: 45,503,692 (GRCm39) |
E681G |
probably damaging |
Het |
Gtf3c5 |
G |
T |
2: 28,472,885 (GRCm39) |
N35K |
possibly damaging |
Het |
Hydin |
A |
G |
8: 111,309,300 (GRCm39) |
T4031A |
probably benign |
Het |
Igfn1 |
G |
T |
1: 135,892,564 (GRCm39) |
N2185K |
probably benign |
Het |
Il17rb |
T |
C |
14: 29,724,333 (GRCm39) |
T174A |
probably benign |
Het |
Kdm3b |
T |
A |
18: 34,946,515 (GRCm39) |
C835S |
probably benign |
Het |
Lgi2 |
A |
T |
5: 52,695,429 (GRCm39) |
I510N |
probably damaging |
Het |
Map3k6 |
A |
G |
4: 132,979,054 (GRCm39) |
E1164G |
probably benign |
Het |
Mpv17l |
T |
A |
16: 13,758,537 (GRCm39) |
M1K |
probably null |
Het |
Myoc |
T |
A |
1: 162,467,203 (GRCm39) |
L124Q |
probably damaging |
Het |
Nbeal2 |
C |
A |
9: 110,455,796 (GRCm39) |
|
probably null |
Het |
Nek10 |
A |
G |
14: 14,820,851 (GRCm38) |
K13E |
possibly damaging |
Het |
Nt5dc2 |
A |
G |
14: 30,860,989 (GRCm39) |
H491R |
possibly damaging |
Het |
Or4f61 |
A |
C |
2: 111,922,452 (GRCm39) |
M198R |
possibly damaging |
Het |
Or51b6 |
T |
A |
7: 103,556,406 (GRCm39) |
Y250* |
probably null |
Het |
Or8k21 |
T |
C |
2: 86,144,706 (GRCm39) |
Q308R |
probably benign |
Het |
Pclo |
T |
A |
5: 14,727,322 (GRCm39) |
|
probably benign |
Het |
Pgm2 |
A |
T |
5: 64,265,092 (GRCm39) |
N371I |
possibly damaging |
Het |
Phf20l1 |
T |
A |
15: 66,508,762 (GRCm39) |
S873T |
possibly damaging |
Het |
Plch1 |
T |
C |
3: 63,606,131 (GRCm39) |
T1249A |
probably benign |
Het |
Plekhn1 |
A |
T |
4: 156,309,222 (GRCm39) |
I228N |
possibly damaging |
Het |
Ppp1r12a |
A |
T |
10: 108,103,263 (GRCm39) |
|
probably null |
Het |
Ptchd3 |
T |
C |
11: 121,721,972 (GRCm39) |
Y282H |
probably damaging |
Het |
Ptprk |
T |
A |
10: 28,468,769 (GRCm39) |
N1396K |
probably damaging |
Het |
Rap1gap2 |
T |
C |
11: 74,329,121 (GRCm39) |
E81G |
probably damaging |
Het |
Rpf2 |
T |
C |
10: 40,122,971 (GRCm39) |
M1V |
probably null |
Het |
Rpgrip1l |
G |
A |
8: 91,948,012 (GRCm39) |
Q1224* |
probably null |
Het |
Rreb1 |
A |
G |
13: 38,112,254 (GRCm39) |
D286G |
probably benign |
Het |
Rufy4 |
T |
C |
1: 74,186,822 (GRCm39) |
C537R |
probably damaging |
Het |
Senp5 |
A |
T |
16: 31,807,960 (GRCm39) |
N431K |
probably benign |
Het |
Serpina1f |
A |
C |
12: 103,659,809 (GRCm39) |
S158A |
probably damaging |
Het |
Sertad3 |
T |
A |
7: 27,176,145 (GRCm39) |
I193N |
probably damaging |
Het |
Slc22a8 |
T |
A |
19: 8,571,528 (GRCm39) |
N86K |
probably damaging |
Het |
Slc6a2 |
T |
C |
8: 93,721,347 (GRCm39) |
V492A |
possibly damaging |
Het |
Slf2 |
T |
A |
19: 44,940,523 (GRCm39) |
D773E |
probably benign |
Het |
Slmap |
A |
C |
14: 26,184,744 (GRCm39) |
L272R |
probably damaging |
Het |
Smyd5 |
T |
C |
6: 85,422,185 (GRCm39) |
|
probably benign |
Het |
Snx21 |
G |
T |
2: 164,628,666 (GRCm39) |
R103L |
probably damaging |
Het |
Sphk2 |
T |
A |
7: 45,361,777 (GRCm39) |
|
probably null |
Het |
Stab1 |
T |
C |
14: 30,867,812 (GRCm39) |
K1653E |
probably benign |
Het |
Syde1 |
A |
G |
10: 78,425,252 (GRCm39) |
V253A |
probably benign |
Het |
Sympk |
G |
T |
7: 18,776,584 (GRCm39) |
R492L |
probably benign |
Het |
Taar7f |
T |
C |
10: 23,925,451 (GRCm39) |
I15T |
probably benign |
Het |
Tas2r140 |
A |
G |
6: 40,468,200 (GRCm39) |
D10G |
probably benign |
Het |
Tbcc |
A |
G |
17: 47,202,600 (GRCm39) |
S329G |
probably benign |
Het |
Teddm3 |
G |
A |
16: 20,971,900 (GRCm39) |
T223M |
probably benign |
Het |
Tex14 |
G |
T |
11: 87,405,668 (GRCm39) |
C860F |
probably benign |
Het |
Thada |
A |
T |
17: 84,751,896 (GRCm39) |
L360Q |
probably damaging |
Het |
Thop1 |
C |
A |
10: 80,916,412 (GRCm39) |
H473Q |
probably damaging |
Het |
Tln2 |
T |
C |
9: 67,163,310 (GRCm39) |
D1075G |
probably benign |
Het |
Tmem130 |
G |
A |
5: 144,680,528 (GRCm39) |
T292I |
probably benign |
Het |
Tmem198b |
T |
C |
10: 128,637,305 (GRCm39) |
N278S |
probably benign |
Het |
Ttc21a |
A |
T |
9: 119,771,731 (GRCm39) |
T177S |
probably benign |
Het |
Ubr2 |
A |
T |
17: 47,280,173 (GRCm39) |
C659S |
probably damaging |
Het |
Vmn2r4 |
T |
C |
3: 64,298,373 (GRCm39) |
K585R |
probably benign |
Het |
Vmn2r86 |
A |
G |
10: 130,282,456 (GRCm39) |
I720T |
probably damaging |
Het |
Wdr35 |
G |
T |
12: 9,037,327 (GRCm39) |
W311L |
probably damaging |
Het |
Zfp39 |
A |
T |
11: 58,782,028 (GRCm39) |
F245I |
possibly damaging |
Het |
Zftraf1 |
A |
T |
15: 76,530,512 (GRCm39) |
F269L |
probably benign |
Het |
Zmym5 |
G |
A |
14: 57,034,236 (GRCm39) |
T325I |
probably benign |
Het |
Zng1 |
A |
T |
19: 24,898,383 (GRCm39) |
|
probably null |
Het |
|
Other mutations in Cnot1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00516:Cnot1
|
APN |
8 |
96,452,707 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01340:Cnot1
|
APN |
8 |
96,487,165 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01457:Cnot1
|
APN |
8 |
96,467,637 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01505:Cnot1
|
APN |
8 |
96,455,346 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02401:Cnot1
|
APN |
8 |
96,482,761 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02693:Cnot1
|
APN |
8 |
96,500,113 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02696:Cnot1
|
APN |
8 |
96,471,645 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02754:Cnot1
|
APN |
8 |
96,481,706 (GRCm39) |
missense |
probably benign |
0.03 |
IGL03092:Cnot1
|
APN |
8 |
96,496,243 (GRCm39) |
intron |
probably benign |
|
IGL03174:Cnot1
|
APN |
8 |
96,487,983 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03310:Cnot1
|
APN |
8 |
96,462,308 (GRCm39) |
splice site |
probably benign |
|
IGL03371:Cnot1
|
APN |
8 |
96,501,344 (GRCm39) |
missense |
possibly damaging |
0.85 |
Affiliate
|
UTSW |
8 |
96,491,753 (GRCm39) |
missense |
probably damaging |
0.99 |
Barge
|
UTSW |
8 |
96,460,757 (GRCm39) |
missense |
probably benign |
0.13 |
Byproduct
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
Chairman
|
UTSW |
8 |
96,491,655 (GRCm39) |
missense |
possibly damaging |
0.95 |
cohort
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
Director
|
UTSW |
8 |
96,491,690 (GRCm39) |
missense |
probably benign |
0.15 |
kowloon
|
UTSW |
8 |
96,515,286 (GRCm39) |
missense |
probably damaging |
1.00 |
Quorum
|
UTSW |
8 |
96,452,746 (GRCm39) |
missense |
probably damaging |
1.00 |
tugboat
|
UTSW |
8 |
96,500,246 (GRCm39) |
missense |
probably damaging |
0.99 |
Xiao
|
UTSW |
8 |
96,457,048 (GRCm39) |
missense |
probably damaging |
1.00 |
BB001:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
BB003:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
BB011:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
BB013:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R0008:Cnot1
|
UTSW |
8 |
96,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
R0008:Cnot1
|
UTSW |
8 |
96,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
R0091:Cnot1
|
UTSW |
8 |
96,489,772 (GRCm39) |
missense |
probably damaging |
1.00 |
R0335:Cnot1
|
UTSW |
8 |
96,498,628 (GRCm39) |
missense |
probably benign |
0.02 |
R0409:Cnot1
|
UTSW |
8 |
96,475,483 (GRCm39) |
missense |
probably damaging |
0.96 |
R0445:Cnot1
|
UTSW |
8 |
96,486,836 (GRCm39) |
missense |
probably damaging |
1.00 |
R1505:Cnot1
|
UTSW |
8 |
96,455,295 (GRCm39) |
missense |
probably damaging |
1.00 |
R1517:Cnot1
|
UTSW |
8 |
96,469,841 (GRCm39) |
missense |
probably benign |
0.38 |
R1640:Cnot1
|
UTSW |
8 |
96,496,460 (GRCm39) |
missense |
probably damaging |
0.98 |
R1737:Cnot1
|
UTSW |
8 |
96,474,904 (GRCm39) |
missense |
probably damaging |
0.98 |
R1755:Cnot1
|
UTSW |
8 |
96,451,205 (GRCm39) |
missense |
probably damaging |
1.00 |
R1901:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1902:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1903:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1988:Cnot1
|
UTSW |
8 |
96,468,572 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2051:Cnot1
|
UTSW |
8 |
96,451,221 (GRCm39) |
missense |
possibly damaging |
0.47 |
R2054:Cnot1
|
UTSW |
8 |
96,466,469 (GRCm39) |
missense |
possibly damaging |
0.55 |
R2072:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2074:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2075:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2093:Cnot1
|
UTSW |
8 |
96,501,986 (GRCm39) |
missense |
probably damaging |
1.00 |
R2116:Cnot1
|
UTSW |
8 |
96,452,781 (GRCm39) |
missense |
probably damaging |
1.00 |
R2191:Cnot1
|
UTSW |
8 |
96,488,054 (GRCm39) |
missense |
probably damaging |
0.98 |
R2238:Cnot1
|
UTSW |
8 |
96,496,149 (GRCm39) |
missense |
probably benign |
0.04 |
R2239:Cnot1
|
UTSW |
8 |
96,496,149 (GRCm39) |
missense |
probably benign |
0.04 |
R2251:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
R2252:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
R2253:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
R2315:Cnot1
|
UTSW |
8 |
96,475,690 (GRCm39) |
missense |
probably damaging |
1.00 |
R2431:Cnot1
|
UTSW |
8 |
96,501,280 (GRCm39) |
missense |
probably damaging |
1.00 |
R2988:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R2989:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R3108:Cnot1
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
R3109:Cnot1
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
R3114:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R3115:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R3153:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R3154:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
R4112:Cnot1
|
UTSW |
8 |
96,500,246 (GRCm39) |
missense |
probably damaging |
0.99 |
R4359:Cnot1
|
UTSW |
8 |
96,466,476 (GRCm39) |
missense |
probably damaging |
1.00 |
R4382:Cnot1
|
UTSW |
8 |
96,496,407 (GRCm39) |
missense |
probably damaging |
0.97 |
R4747:Cnot1
|
UTSW |
8 |
96,501,310 (GRCm39) |
missense |
probably benign |
0.27 |
R4910:Cnot1
|
UTSW |
8 |
96,459,859 (GRCm39) |
missense |
probably benign |
0.43 |
R4913:Cnot1
|
UTSW |
8 |
96,489,695 (GRCm39) |
missense |
possibly damaging |
0.63 |
R4971:Cnot1
|
UTSW |
8 |
96,448,254 (GRCm39) |
missense |
probably damaging |
1.00 |
R5056:Cnot1
|
UTSW |
8 |
96,467,636 (GRCm39) |
missense |
probably damaging |
1.00 |
R5101:Cnot1
|
UTSW |
8 |
96,486,815 (GRCm39) |
missense |
possibly damaging |
0.90 |
R5498:Cnot1
|
UTSW |
8 |
96,483,983 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5719:Cnot1
|
UTSW |
8 |
96,470,924 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5850:Cnot1
|
UTSW |
8 |
96,460,775 (GRCm39) |
nonsense |
probably null |
|
R5956:Cnot1
|
UTSW |
8 |
96,481,606 (GRCm39) |
critical splice donor site |
probably null |
|
R5981:Cnot1
|
UTSW |
8 |
96,515,293 (GRCm39) |
missense |
probably damaging |
1.00 |
R6093:Cnot1
|
UTSW |
8 |
96,475,522 (GRCm39) |
missense |
probably benign |
0.03 |
R6108:Cnot1
|
UTSW |
8 |
96,457,048 (GRCm39) |
missense |
probably damaging |
1.00 |
R6261:Cnot1
|
UTSW |
8 |
96,468,549 (GRCm39) |
missense |
probably benign |
0.00 |
R6632:Cnot1
|
UTSW |
8 |
96,499,895 (GRCm39) |
intron |
probably benign |
|
R6882:Cnot1
|
UTSW |
8 |
96,447,054 (GRCm39) |
missense |
possibly damaging |
0.85 |
R6966:Cnot1
|
UTSW |
8 |
96,451,160 (GRCm39) |
missense |
probably damaging |
1.00 |
R6985:Cnot1
|
UTSW |
8 |
96,460,757 (GRCm39) |
missense |
probably benign |
0.13 |
R7210:Cnot1
|
UTSW |
8 |
96,515,286 (GRCm39) |
missense |
probably damaging |
1.00 |
R7410:Cnot1
|
UTSW |
8 |
96,459,787 (GRCm39) |
missense |
possibly damaging |
0.77 |
R7623:Cnot1
|
UTSW |
8 |
96,454,276 (GRCm39) |
missense |
probably damaging |
1.00 |
R7624:Cnot1
|
UTSW |
8 |
96,478,447 (GRCm39) |
missense |
probably damaging |
1.00 |
R7695:Cnot1
|
UTSW |
8 |
96,497,260 (GRCm39) |
missense |
probably benign |
0.03 |
R7703:Cnot1
|
UTSW |
8 |
96,486,726 (GRCm39) |
critical splice donor site |
probably null |
|
R7771:Cnot1
|
UTSW |
8 |
96,491,753 (GRCm39) |
missense |
probably damaging |
0.99 |
R7800:Cnot1
|
UTSW |
8 |
96,491,690 (GRCm39) |
missense |
probably benign |
0.15 |
R7809:Cnot1
|
UTSW |
8 |
96,478,406 (GRCm39) |
missense |
probably damaging |
1.00 |
R7857:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R7914:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R7924:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R7926:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
R7981:Cnot1
|
UTSW |
8 |
96,489,797 (GRCm39) |
missense |
probably damaging |
1.00 |
R8004:Cnot1
|
UTSW |
8 |
96,479,380 (GRCm39) |
missense |
probably benign |
0.03 |
R8061:Cnot1
|
UTSW |
8 |
96,491,655 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8185:Cnot1
|
UTSW |
8 |
96,487,979 (GRCm39) |
missense |
probably damaging |
1.00 |
R8269:Cnot1
|
UTSW |
8 |
96,478,389 (GRCm39) |
missense |
probably damaging |
1.00 |
R8306:Cnot1
|
UTSW |
8 |
96,473,649 (GRCm39) |
missense |
probably benign |
0.05 |
R8322:Cnot1
|
UTSW |
8 |
96,496,472 (GRCm39) |
missense |
probably benign |
0.00 |
R8427:Cnot1
|
UTSW |
8 |
96,460,952 (GRCm39) |
missense |
probably benign |
0.01 |
R8723:Cnot1
|
UTSW |
8 |
96,462,907 (GRCm39) |
missense |
probably benign |
0.00 |
R8934:Cnot1
|
UTSW |
8 |
96,491,695 (GRCm39) |
missense |
probably benign |
0.04 |
R9025:Cnot1
|
UTSW |
8 |
96,475,660 (GRCm39) |
missense |
probably benign |
|
R9179:Cnot1
|
UTSW |
8 |
96,500,054 (GRCm39) |
missense |
probably benign |
0.16 |
R9280:Cnot1
|
UTSW |
8 |
96,497,227 (GRCm39) |
missense |
probably benign |
0.15 |
R9285:Cnot1
|
UTSW |
8 |
96,452,746 (GRCm39) |
missense |
probably damaging |
1.00 |
R9299:Cnot1
|
UTSW |
8 |
96,468,448 (GRCm39) |
missense |
probably damaging |
1.00 |
R9337:Cnot1
|
UTSW |
8 |
96,468,448 (GRCm39) |
missense |
probably damaging |
1.00 |
R9480:Cnot1
|
UTSW |
8 |
96,497,338 (GRCm39) |
missense |
possibly damaging |
0.94 |
R9548:Cnot1
|
UTSW |
8 |
96,482,854 (GRCm39) |
missense |
probably benign |
0.02 |
R9601:Cnot1
|
UTSW |
8 |
96,482,835 (GRCm39) |
missense |
probably benign |
0.02 |
R9629:Cnot1
|
UTSW |
8 |
96,455,874 (GRCm39) |
missense |
probably damaging |
0.98 |
R9752:Cnot1
|
UTSW |
8 |
96,488,019 (GRCm39) |
missense |
probably damaging |
1.00 |
R9764:Cnot1
|
UTSW |
8 |
96,496,209 (GRCm39) |
missense |
probably benign |
0.00 |
R9789:Cnot1
|
UTSW |
8 |
96,455,772 (GRCm39) |
missense |
probably damaging |
1.00 |
X0050:Cnot1
|
UTSW |
8 |
96,469,726 (GRCm39) |
splice site |
probably null |
|
Z1176:Cnot1
|
UTSW |
8 |
96,474,905 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
Predicted Primers |
PCR Primer
(F):5'- CCAATGCCATGTAAGTGACCAG -3'
(R):5'- TGAGGTGAGTGTCTAGGATCCC -3'
Sequencing Primer
(F):5'- AGTGACCAGTCCTTTTTCAATTATGC -3'
(R):5'- TGAGTGTCTAGGATCCCTAATTTC -3'
|
Posted On |
2016-06-06 |