Incidental Mutation 'R0427:Mplkipl1'
ID 38795
Institutional Source Beutler Lab
Gene Symbol Mplkipl1
Ensembl Gene ENSMUSG00000094649
Gene Name M-phase specific PLK1 intereacting protein like 1
Synonyms Gm7102
MMRRC Submission 038629-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.141) question?
Stock # R0427 (G1)
Quality Score 165
Status Not validated
Chromosome 19
Chromosomal Location 61163124-61164747 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 61163908 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 176 (Y176H)
Ref Sequence ENSEMBL: ENSMUSP00000137574 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000180168]
AlphaFold J3QQ10
Predicted Effect probably damaging
Transcript: ENSMUST00000180168
AA Change: Y176H

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000137574
Gene: ENSMUSG00000094649
AA Change: Y176H

DomainStartEndE-ValueType
Pfam:MPLKIP 31 170 8.9e-27 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34 T G 8: 44,105,493 (GRCm39) T51P probably benign Het
Alpk1 A T 3: 127,464,720 (GRCm39) V1186E probably damaging Het
Ankfn1 T C 11: 89,296,423 (GRCm39) D102G probably damaging Het
Armc2 A G 10: 41,876,406 (GRCm39) I127T possibly damaging Het
Atp6v1b2 T C 8: 69,554,084 (GRCm39) L87P probably damaging Het
Atp9a T A 2: 168,482,617 (GRCm39) probably null Het
BC048679 C G 7: 81,144,993 (GRCm39) V123L probably benign Het
Birc7 G A 2: 180,571,307 (GRCm39) probably null Het
Btbd9 C T 17: 30,493,916 (GRCm39) D492N possibly damaging Het
Cacna1d T A 14: 30,068,774 (GRCm39) N155I probably damaging Het
Cd300lg T C 11: 101,933,852 (GRCm39) V33A probably damaging Het
Cep290 A G 10: 100,352,041 (GRCm39) D742G probably benign Het
Cep95 A G 11: 106,681,578 (GRCm39) N14S probably benign Het
Cfap74 A T 4: 155,525,734 (GRCm39) M728L probably benign Het
Ctsll3 T A 13: 60,949,205 (GRCm39) T9S probably benign Het
Cyp3a44 A G 5: 145,716,412 (GRCm39) S393P possibly damaging Het
Dmbt1 T A 7: 130,642,632 (GRCm39) L150* probably null Het
Dnah2 A G 11: 69,343,705 (GRCm39) I2868T probably damaging Het
Dop1a A G 9: 86,389,585 (GRCm39) H505R probably damaging Het
Exo1 A G 1: 175,733,519 (GRCm39) K781R probably damaging Het
Fam184a A G 10: 53,566,211 (GRCm39) Y459H probably damaging Het
Foxp1 C T 6: 98,907,164 (GRCm39) D540N probably damaging Het
Fstl5 T A 3: 76,615,034 (GRCm39) Y698* probably null Het
Gm5141 T C 13: 62,922,525 (GRCm39) K215E probably damaging Het
Grik5 C A 7: 24,757,923 (GRCm39) R386L probably benign Het
Ikbke A T 1: 131,185,647 (GRCm39) S620R possibly damaging Het
Kcnh3 A T 15: 99,131,180 (GRCm39) M518L probably benign Het
Lrrcc1 G T 3: 14,623,416 (GRCm39) A748S probably damaging Het
Mbd5 T G 2: 49,169,091 (GRCm39) S1191A probably benign Het
Med27 T C 2: 29,390,283 (GRCm39) I70T probably damaging Het
Myh4 A G 11: 67,149,479 (GRCm39) D1737G probably damaging Het
Myo5a A G 9: 75,081,478 (GRCm39) D1021G probably benign Het
Ncor1 T C 11: 62,301,746 (GRCm39) E212G probably damaging Het
Neb A T 2: 52,133,896 (GRCm39) N3362K possibly damaging Het
Neb A G 2: 52,134,081 (GRCm39) S3301P probably damaging Het
Neurod1 T G 2: 79,284,526 (GRCm39) K286Q probably damaging Het
Noc3l T C 19: 38,778,095 (GRCm39) Q773R probably benign Het
Nup205 T A 6: 35,171,398 (GRCm39) N420K probably benign Het
Olfml3 A T 3: 103,644,330 (GRCm39) V113E probably benign Het
Opa1 T C 16: 29,430,279 (GRCm39) V439A probably damaging Het
Or13c7 A G 4: 43,854,417 (GRCm39) Y36C probably damaging Het
Or14j7 A T 17: 38,234,520 (GRCm39) H21L probably benign Het
Or1j14 C T 2: 36,417,994 (GRCm39) S190L probably damaging Het
Or1o11 T A 17: 37,756,593 (GRCm39) D60E probably damaging Het
Pcdhb11 T C 18: 37,555,818 (GRCm39) S383P probably damaging Het
Pkd1 T C 17: 24,812,476 (GRCm39) V3803A probably damaging Het
Plekhg1 A G 10: 3,914,235 (GRCm39) D1319G probably benign Het
Polq T A 16: 36,882,355 (GRCm39) C1227* probably null Het
Pramel22 A T 4: 143,380,993 (GRCm39) N343K probably benign Het
Psmc1 T C 12: 100,085,487 (GRCm39) F283L probably damaging Het
Psmd8 T C 7: 28,875,552 (GRCm39) N189S probably damaging Het
Ptger4 G A 15: 5,272,382 (GRCm39) T104I probably benign Het
Ptpro T G 6: 137,345,294 (GRCm39) V100G possibly damaging Het
Rab11fip1 T A 8: 27,644,520 (GRCm39) T422S probably damaging Het
Rad54l2 A G 9: 106,570,891 (GRCm39) L1143P possibly damaging Het
Rnf148 A G 6: 23,654,072 (GRCm39) M308T probably damaging Het
Sbsn T A 7: 30,451,523 (GRCm39) probably benign Het
Scube2 T A 7: 109,424,044 (GRCm39) T487S probably benign Het
Sema4c C A 1: 36,592,892 (GRCm39) E109* probably null Het
Sipa1l2 A T 8: 126,207,071 (GRCm39) L544Q probably damaging Het
Slc28a2 A G 2: 122,288,702 (GRCm39) T603A probably benign Het
Tbc1d7 T A 13: 43,306,563 (GRCm39) T138S probably benign Het
Timd4 A T 11: 46,710,084 (GRCm39) T239S probably benign Het
Trp53bp1 A G 2: 121,066,498 (GRCm39) S743P probably damaging Het
Tspan10 T A 11: 120,335,120 (GRCm39) Y77N probably damaging Het
Ttc14 T C 3: 33,857,633 (GRCm39) S245P probably damaging Het
Ttf1 T A 2: 28,955,054 (GRCm39) S139R probably benign Het
Tubd1 C A 11: 86,448,616 (GRCm39) Q279K possibly damaging Het
Twnk A G 19: 44,996,026 (GRCm39) E153G probably benign Het
Ush2a A G 1: 188,132,478 (GRCm39) D900G probably damaging Het
Usp54 A G 14: 20,620,432 (GRCm39) V691A probably benign Het
Usp8 T C 2: 126,559,952 (GRCm39) probably benign Het
Vmn1r231 C T 17: 21,110,490 (GRCm39) V142I probably benign Het
Vmn2r15 C T 5: 109,434,953 (GRCm39) A584T probably damaging Het
Vmn2r6 A G 3: 64,467,008 (GRCm39) S164P probably damaging Het
Vps16 A G 2: 130,280,770 (GRCm39) Y233C probably benign Het
Vwf C G 6: 125,650,902 (GRCm39) H2511D probably benign Het
Wipf3 T G 6: 54,460,882 (GRCm39) L110R possibly damaging Het
Zfp945 T A 17: 23,084,226 (GRCm39) N11I probably benign Het
Other mutations in Mplkipl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01718:Mplkipl1 APN 19 61,164,199 (GRCm39) missense probably damaging 0.98
IGL02958:Mplkipl1 APN 19 61,164,118 (GRCm39) missense possibly damaging 0.83
R1886:Mplkipl1 UTSW 19 61,164,136 (GRCm39) missense probably damaging 0.97
R4576:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R4578:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R4615:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R4616:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R4617:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R4621:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R4622:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R4623:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R4826:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R4827:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R4829:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R4830:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R4870:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R4871:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R4951:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R5112:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R5301:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R5317:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R5335:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R5397:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R5399:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R5591:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R5592:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R5594:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R5616:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R5884:Mplkipl1 UTSW 19 61,164,364 (GRCm39) missense unknown
R5919:Mplkipl1 UTSW 19 61,163,907 (GRCm39) missense probably damaging 1.00
R7003:Mplkipl1 UTSW 19 61,164,319 (GRCm39) missense possibly damaging 0.93
R7112:Mplkipl1 UTSW 19 61,163,997 (GRCm39) missense probably damaging 1.00
R7266:Mplkipl1 UTSW 19 61,163,973 (GRCm39) missense possibly damaging 0.84
R8489:Mplkipl1 UTSW 19 61,164,085 (GRCm39) missense probably damaging 0.98
R8979:Mplkipl1 UTSW 19 61,164,169 (GRCm39) missense probably damaging 1.00
Z1177:Mplkipl1 UTSW 19 61,164,188 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- ACACACTCCCAGATAGCGAAATACTGT -3'
(R):5'- GGGTTCTCCAAGGACATCTACACCA -3'

Sequencing Primer
(F):5'- AATGAACGCCTATCATTTTCGCTG -3'
(R):5'- TACACCATTTGGATCAGGGC -3'
Posted On 2013-05-23