Incidental Mutation 'R5096:Or4p22'
ID 388024
Institutional Source Beutler Lab
Gene Symbol Or4p22
Ensembl Gene ENSMUSG00000051424
Gene Name olfactory receptor family 4 subfamily P member 22
Synonyms MOR225-3, GA_x6K02T2Q125-49974190-49975125, Olfr1184
MMRRC Submission 042685-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R5096 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 88317078-88318013 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 88317646 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 190 (T190I)
Ref Sequence ENSEMBL: ENSMUSP00000149649 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050038] [ENSMUST00000216675]
AlphaFold Q8VG86
Predicted Effect possibly damaging
Transcript: ENSMUST00000050038
AA Change: T190I

PolyPhen 2 Score 0.886 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000058679
Gene: ENSMUSG00000051424
AA Change: T190I

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.2e-47 PFAM
Pfam:7tm_1 39 285 2.3e-14 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216675
AA Change: T190I

PolyPhen 2 Score 0.886 (Sensitivity: 0.82; Specificity: 0.94)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 91.6%
Validation Efficiency 95% (61/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acin1 A T 14: 54,916,679 (GRCm39) probably benign Het
Adar T A 3: 89,654,598 (GRCm39) *728C probably null Het
Ap3b1 A G 13: 94,616,357 (GRCm39) R753G unknown Het
Atp9b C T 18: 80,805,399 (GRCm39) V720I probably benign Het
AY358078 A C 14: 52,063,575 (GRCm39) D407A probably benign Het
Ccdc185 A G 1: 182,576,354 (GRCm39) S112P possibly damaging Het
Cir1 A G 2: 73,134,105 (GRCm39) S155P probably damaging Het
Colq C T 14: 31,274,911 (GRCm39) E76K possibly damaging Het
Cthrc1 T A 15: 38,947,815 (GRCm39) I104N probably damaging Het
D930020B18Rik A T 10: 121,503,709 (GRCm39) I92L probably benign Het
Eif3i C T 4: 129,494,237 (GRCm39) E21K probably damaging Het
Fam114a1 T A 5: 65,137,234 (GRCm39) M59K probably benign Het
Fam163b A G 2: 27,002,761 (GRCm39) S79P probably benign Het
Fam181b T G 7: 92,730,452 (GRCm39) probably benign Het
Fsip2 G A 2: 82,821,460 (GRCm39) S5731N probably benign Het
Fzd9 C T 5: 135,278,713 (GRCm39) V391I probably damaging Het
Gbp5 A G 3: 142,207,122 (GRCm39) D97G probably damaging Het
Gm10715 T C 9: 3,038,157 (GRCm39) probably benign Het
Grhl1 A T 12: 24,653,049 (GRCm39) K418M probably damaging Het
H2-Q4 T A 17: 35,598,689 (GRCm39) probably benign Het
Hmcn1 C A 1: 150,486,420 (GRCm39) A4329S probably damaging Het
Hspa8 T C 9: 40,714,197 (GRCm39) probably benign Het
Ica1l T C 1: 60,067,313 (GRCm39) T26A possibly damaging Het
Ifi209 T A 1: 173,472,300 (GRCm39) N380K probably benign Het
Inpp5e G T 2: 26,289,537 (GRCm39) N482K probably damaging Het
Iqsec3 C T 6: 121,363,657 (GRCm39) V866M probably damaging Het
Kbtbd2 A G 6: 56,756,260 (GRCm39) V492A probably benign Het
Kcnb2 A G 1: 15,781,068 (GRCm39) R647G probably benign Het
Lcmt1 T G 7: 123,000,691 (GRCm39) V75G probably damaging Het
Lrp4 A G 2: 91,316,137 (GRCm39) I752V possibly damaging Het
Mmp17 C A 5: 129,682,627 (GRCm39) P422Q probably damaging Het
Myo3a A T 2: 22,464,254 (GRCm39) H165L probably benign Het
Nos3 C T 5: 24,576,955 (GRCm39) T494I probably damaging Het
Or1ak2 T C 2: 36,827,815 (GRCm39) V228A possibly damaging Het
Or51q1c T C 7: 103,652,667 (GRCm39) Y68H probably benign Het
Or8u8 A G 2: 86,012,276 (GRCm39) Y60H probably damaging Het
Pkn2 A C 3: 142,545,092 (GRCm39) V27G probably damaging Het
Scube2 T C 7: 109,398,451 (GRCm39) probably benign Het
Skint7 A G 4: 111,839,152 (GRCm39) I149V probably damaging Het
Smc4 T A 3: 68,928,612 (GRCm39) I412K probably damaging Het
Snx19 T A 9: 30,340,082 (GRCm39) C407S probably benign Het
Speer3 C G 5: 13,846,394 (GRCm39) A238G possibly damaging Het
Sytl2 T A 7: 90,025,290 (GRCm39) I426N possibly damaging Het
Tbce A T 13: 14,203,990 (GRCm39) probably benign Het
Tdpoz2 T C 3: 93,559,819 (GRCm39) E51G possibly damaging Het
Tmem221 A G 8: 72,011,353 (GRCm39) L34P probably damaging Het
Tmem92 T C 11: 94,669,862 (GRCm39) T90A probably benign Het
Tpr A G 1: 150,321,953 (GRCm39) D42G probably damaging Het
Wt1 A G 2: 104,973,470 (GRCm39) T237A probably damaging Het
Other mutations in Or4p22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01286:Or4p22 APN 2 88,317,592 (GRCm39) missense probably damaging 1.00
IGL01288:Or4p22 APN 2 88,317,592 (GRCm39) missense probably damaging 1.00
IGL01790:Or4p22 APN 2 88,317,270 (GRCm39) missense possibly damaging 0.65
IGL02070:Or4p22 APN 2 88,317,346 (GRCm39) missense probably damaging 1.00
IGL02247:Or4p22 APN 2 88,317,771 (GRCm39) missense probably benign 0.00
IGL02932:Or4p22 APN 2 88,317,519 (GRCm39) missense probably benign 0.01
IGL02997:Or4p22 APN 2 88,317,732 (GRCm39) missense probably damaging 0.99
IGL03161:Or4p22 APN 2 88,317,792 (GRCm39) missense probably benign 0.01
PIT4531001:Or4p22 UTSW 2 88,317,601 (GRCm39) missense possibly damaging 0.95
R3713:Or4p22 UTSW 2 88,317,787 (GRCm39) missense probably damaging 1.00
R3715:Or4p22 UTSW 2 88,317,787 (GRCm39) missense probably damaging 1.00
R4421:Or4p22 UTSW 2 88,317,585 (GRCm39) missense probably damaging 1.00
R4514:Or4p22 UTSW 2 88,317,709 (GRCm39) missense probably benign 0.05
R5661:Or4p22 UTSW 2 88,317,441 (GRCm39) missense probably damaging 0.98
R5851:Or4p22 UTSW 2 88,317,204 (GRCm39) missense possibly damaging 0.54
R6458:Or4p22 UTSW 2 88,317,562 (GRCm39) missense possibly damaging 0.90
R7073:Or4p22 UTSW 2 88,317,651 (GRCm39) missense probably benign 0.00
R7102:Or4p22 UTSW 2 88,317,492 (GRCm39) missense probably damaging 1.00
R7145:Or4p22 UTSW 2 88,317,721 (GRCm39) missense probably damaging 1.00
R7221:Or4p22 UTSW 2 88,317,973 (GRCm39) missense probably damaging 0.97
R8827:Or4p22 UTSW 2 88,317,165 (GRCm39) missense probably damaging 0.96
R9324:Or4p22 UTSW 2 88,317,787 (GRCm39) missense probably damaging 1.00
R9645:Or4p22 UTSW 2 88,317,373 (GRCm39) missense possibly damaging 0.89
X0063:Or4p22 UTSW 2 88,317,834 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- TCATCATGAGCAGAAGCAGG -3'
(R):5'- TGTCCTCAGGGAAAGTGGTAGG -3'

Sequencing Primer
(F):5'- AAGCAGGTGCCATATCCTGATCTG -3'
(R):5'- TGGTAGGAGGTCTAAGGTAAGC -3'
Posted On 2016-06-06