Mutagenetix > Incidental Mutation

Incidental Mutation 'R5099:Ptprv'

388161

Institutional Source

Beutler Lab

Gene Symbol

Ptprv

Ensembl Gene

ENSMUSG00000097993

Gene Name

protein tyrosine phosphatase receptor type V

Synonyms

Esp, OST, mOST-PTP, OST-PTP

MMRRC Submission

042688-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5099 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

135036236-135060313 bp(-) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

T to C at 135046592 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183317

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.2%

Validation Efficiency

98% (41/42)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased resistance to diet-induced obesity, decreased circulating glucose levels, and decreased suseptibility to death induced by streptozotocin treatment. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arsa	A	G	15: 89,359,542 (GRCm39)	L80P	probably damaging	Het
Bdkrb1	A	G	12: 105,570,533 (GRCm39)	D33G	probably benign	Het
Ccdc178	A	T	18: 22,238,648 (GRCm39)	V323E	probably benign	Het
Ceacam5	T	C	7: 17,479,513 (GRCm39)	V210A	probably damaging	Het
Dcdc2a	A	G	13: 25,291,681 (GRCm39)	E222G	probably benign	Het
Gbp9	A	T	5: 105,242,379 (GRCm39)	L120Q	probably damaging	Het
Gm4787	G	C	12: 81,424,604 (GRCm39)	T518S	probably benign	Het
Gsr	T	A	8: 34,161,556 (GRCm39)	I121N	probably damaging	Het
Ift140	T	A	17: 25,309,674 (GRCm39)	M1068K	probably damaging	Het
Jakmip2	A	G	18: 43,701,173 (GRCm39)	I414T	probably benign	Het
Lpin2	G	A	17: 71,550,965 (GRCm39)	W708*	probably null	Het
Mecom	A	G	3: 30,039,465 (GRCm39)		probably benign	Het
Mff	C	T	1: 82,728,192 (GRCm39)		probably benign	Het
Ms4a20	T	C	19: 11,089,825 (GRCm39)		probably null	Het
Neb	C	T	2: 52,085,460 (GRCm39)	C1545Y	probably damaging	Het
Or5ac24	C	T	16: 59,165,266 (GRCm39)	G266D	probably benign	Het
Or5p5	A	G	7: 107,413,809 (GRCm39)	H6R	probably benign	Het
Or8k36-ps1	A	T	2: 86,437,560 (GRCm39)	N118K	unknown	Het
Ppm1n	A	T	7: 19,011,903 (GRCm39)	L392Q	possibly damaging	Het
Prr22	T	C	17: 57,078,467 (GRCm39)	F207L	probably benign	Het
Rin2	G	A	2: 145,720,821 (GRCm39)	C718Y	probably damaging	Het
Rpgrip1l	G	A	8: 91,975,350 (GRCm39)	T1089I	probably benign	Het
Scn1a	A	G	2: 66,108,145 (GRCm39)	V1510A	probably damaging	Het
Slfn3	A	T	11: 83,105,764 (GRCm39)	Y587F	probably damaging	Het
Sp2	T	C	11: 96,852,175 (GRCm39)	K250E	probably damaging	Het
Ssu2	A	G	6: 112,336,585 (GRCm39)	S333P	probably benign	Het
Strbp	T	C	2: 37,493,030 (GRCm39)	T419A	probably damaging	Het
Tada2b	A	T	5: 36,633,744 (GRCm39)	M203K	probably benign	Het
Tmem176b	T	C	6: 48,811,463 (GRCm39)	Y62C	probably benign	Het
Tox	G	T	4: 6,688,958 (GRCm39)	Q469K	probably benign	Het
Trgv5	G	T	13: 19,376,886 (GRCm39)	C111F	probably damaging	Het
Tyw5	T	C	1: 57,427,864 (GRCm39)	N243D	probably damaging	Het
Ube2q2	T	A	9: 55,113,307 (GRCm39)		probably benign	Het
Ufl1	C	T	4: 25,275,914 (GRCm39)	R83Q	probably damaging	Het
Unk	A	G	11: 115,949,936 (GRCm39)	Q701R	probably benign	Het
Vmn1r60	A	T	7: 5,547,816 (GRCm39)	C95S	probably damaging	Het
Vmn1r81	A	G	7: 11,994,248 (GRCm39)	I120T	possibly damaging	Het

Other mutations in Ptprv

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL02449:Ptprv	APN	1	135,039,074 (GRCm39)	exon	noncoding transcript
R4077:Ptprv	UTSW	1	135,038,168 (GRCm39)	exon	noncoding transcript
R4079:Ptprv	UTSW	1	135,038,168 (GRCm39)	exon	noncoding transcript
R4229:Ptprv	UTSW	1	135,053,945 (GRCm39)	unclassified	noncoding transcript
R4433:Ptprv	UTSW	1	135,042,308 (GRCm39)	exon	noncoding transcript
R4624:Ptprv	UTSW	1	135,051,869 (GRCm39)	exon	noncoding transcript
R4975:Ptprv	UTSW	1	135,046,586 (GRCm39)	exon	noncoding transcript
R5023:Ptprv	UTSW	1	135,052,244 (GRCm39)	unclassified	noncoding transcript
R5260:Ptprv	UTSW	1	135,039,998 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- CCCATTGCATATCTCCTGGG -3'
(R):5'- CATGACATGTGAGTTCTGGGC -3'

Sequencing Primer
(F):5'- CATATCTCCTGGGTGTTGTCACAG -3'
(R):5'- TCTGGGCTTGCAAGGGC -3'

Posted On

2016-06-06