Incidental Mutation 'R5100:Spred2'
ID 388226
Institutional Source Beutler Lab
Gene Symbol Spred2
Ensembl Gene ENSMUSG00000045671
Gene Name sprouty-related EVH1 domain containing 2
Synonyms Spred-2
MMRRC Submission 042689-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.442) question?
Stock # R5100 (G1)
Quality Score 144
Status Not validated
Chromosome 11
Chromosomal Location 19874442-19974026 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 19971291 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 386 (C386*)
Ref Sequence ENSEMBL: ENSMUSP00000090988 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093298] [ENSMUST00000093299] [ENSMUST00000123036]
AlphaFold Q924S7
Predicted Effect probably null
Transcript: ENSMUST00000093298
AA Change: C359*
SMART Domains Protein: ENSMUSP00000090987
Gene: ENSMUSG00000045671
AA Change: C359*

DomainStartEndE-ValueType
Pfam:WH1 6 119 4.7e-13 PFAM
Pfam:Sprouty 298 403 3.8e-44 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000093299
AA Change: C386*
SMART Domains Protein: ENSMUSP00000090988
Gene: ENSMUSG00000045671
AA Change: C386*

DomainStartEndE-ValueType
Pfam:WH1 91 146 4.1e-10 PFAM
Pfam:Sprouty 325 430 8.6e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000123036
SMART Domains Protein: ENSMUSP00000115103
Gene: ENSMUSG00000045671

DomainStartEndE-ValueType
Pfam:WH1 120 175 1.5e-10 PFAM
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Homozygous null mice are fertile and display increased hematopoietic cell formation in culture. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427D14Rik A T 11: 72,057,477 (GRCm39) M774K probably damaging Het
Adamts3 G A 5: 89,856,502 (GRCm39) T357I probably damaging Het
Ap3m2 T A 8: 23,279,404 (GRCm39) M408L probably benign Het
Apaf1 A T 10: 90,833,149 (GRCm39) N1116K probably benign Het
Arhgap31 A T 16: 38,421,821 (GRCm39) I1415N probably damaging Het
Arhgef17 A T 7: 100,530,963 (GRCm39) D1374E possibly damaging Het
Asxl1 C G 2: 153,239,851 (GRCm39) N546K probably damaging Het
Cobll1 T A 2: 64,956,245 (GRCm39) T337S probably benign Het
Depdc1a A T 3: 159,221,157 (GRCm39) I163L probably benign Het
Flrt3 T A 2: 140,513,304 (GRCm39) probably null Het
Foxn4 A T 5: 114,394,820 (GRCm39) L369H possibly damaging Het
Gm11992 T C 11: 9,011,290 (GRCm39) S244P probably damaging Het
Gm14412 C T 2: 177,006,908 (GRCm39) C329Y probably damaging Het
Gm4787 G C 12: 81,424,604 (GRCm39) T518S probably benign Het
Gm5113 G A 7: 29,878,076 (GRCm39) V55M probably damaging Het
Grhl3 A G 4: 135,269,986 (GRCm39) I599T probably benign Het
H2-Q6 G C 17: 35,644,296 (GRCm39) E93Q probably benign Het
Hk3 T C 13: 55,156,843 (GRCm39) T570A probably damaging Het
Hspb8 T C 5: 116,553,468 (GRCm39) I143M probably damaging Het
Kif15 A G 9: 122,821,059 (GRCm39) T655A probably damaging Het
Lpin2 G A 17: 71,550,965 (GRCm39) W708* probably null Het
Lrit1 T A 14: 36,784,171 (GRCm39) C500S possibly damaging Het
Macf1 A C 4: 123,368,261 (GRCm39) C602G probably benign Het
Mesd C T 7: 83,546,977 (GRCm39) R147C probably damaging Het
Mfge8 A T 7: 78,793,048 (GRCm39) D139E probably benign Het
Ncoa3 G A 2: 165,892,017 (GRCm39) R131Q probably damaging Het
Ncoa5 A G 2: 164,851,309 (GRCm39) I188T probably damaging Het
Ngp T C 9: 110,249,069 (GRCm39) L47P probably damaging Het
Nhlrc1 T C 13: 47,167,897 (GRCm39) H120R probably benign Het
Otos T A 1: 92,572,107 (GRCm39) H73L probably damaging Het
Pcsk5 C T 19: 17,492,499 (GRCm39) probably null Het
Phc3 T C 3: 30,976,348 (GRCm39) E740G possibly damaging Het
Pla2g7 T C 17: 43,922,267 (GRCm39) L382P probably damaging Het
Plcd3 C A 11: 102,969,175 (GRCm39) R264L probably benign Het
Pms2 A G 5: 143,865,006 (GRCm39) D696G probably damaging Het
Ptchd4 A T 17: 42,814,567 (GRCm39) I823F possibly damaging Het
Scn9a T C 2: 66,364,463 (GRCm39) R828G probably damaging Het
Terb1 A T 8: 105,221,805 (GRCm39) L165* probably null Het
Tgm2 A T 2: 157,969,084 (GRCm39) S430R probably benign Het
Tnxb A T 17: 34,929,902 (GRCm39) I2879F probably damaging Het
Trpm3 T G 19: 22,896,130 (GRCm39) V977G probably damaging Het
Wnt5b A C 6: 119,417,449 (GRCm39) S139A probably benign Het
Zfp820 C A 17: 22,040,054 (GRCm39) V52L possibly damaging Het
Zfyve26 T A 12: 79,326,832 (GRCm39) R764* probably null Het
Other mutations in Spred2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0512:Spred2 UTSW 11 19,958,485 (GRCm39) splice site probably benign
R0944:Spred2 UTSW 11 19,951,104 (GRCm39) splice site probably benign
R1467:Spred2 UTSW 11 19,968,109 (GRCm39) missense probably benign 0.00
R1467:Spred2 UTSW 11 19,968,109 (GRCm39) missense probably benign 0.00
R2156:Spred2 UTSW 11 19,971,241 (GRCm39) missense probably damaging 1.00
R2915:Spred2 UTSW 11 19,948,215 (GRCm39) missense probably damaging 1.00
R3433:Spred2 UTSW 11 19,948,277 (GRCm39) nonsense probably null
R4839:Spred2 UTSW 11 19,948,233 (GRCm39) missense possibly damaging 0.53
R5353:Spred2 UTSW 11 19,968,155 (GRCm39) missense possibly damaging 0.82
R5529:Spred2 UTSW 11 19,971,301 (GRCm39) missense probably damaging 1.00
R5709:Spred2 UTSW 11 19,971,415 (GRCm39) missense probably damaging 1.00
R6978:Spred2 UTSW 11 19,948,254 (GRCm39) missense possibly damaging 0.73
R7345:Spred2 UTSW 11 19,874,958 (GRCm39) critical splice donor site probably null
R8073:Spred2 UTSW 11 19,958,422 (GRCm39) missense probably benign 0.45
R8847:Spred2 UTSW 11 19,951,064 (GRCm39) missense probably benign 0.03
R8888:Spred2 UTSW 11 19,951,019 (GRCm39) missense probably benign 0.11
R8895:Spred2 UTSW 11 19,951,019 (GRCm39) missense probably benign 0.11
X0025:Spred2 UTSW 11 19,948,234 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AGTGTGATCAAGACACAGCCG -3'
(R):5'- AAGAGACAAGTTGCCCGTGG -3'

Sequencing Primer
(F):5'- ACGGTCGCGGTGTGTGTAC -3'
(R):5'- TGGCCGTGGATGGAGAAGC -3'
Posted On 2016-06-06