Incidental Mutation 'R5064:Vmn1r55'
| ID |
388258 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r55
|
| Ensembl Gene |
ENSMUSG00000074402 |
| Gene Name |
vomeronasal 1 receptor 55 |
| Synonyms |
LOC384522, V1rd5, LOC236535 |
| MMRRC Submission |
042654-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.050)
|
| Stock # |
R5064 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
5149489-5150421 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 5149928 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 165
(M165K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000096443
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098844]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098844
AA Change: M165K
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000096443
Gene: ENSMUSG00000074402
AA Change: M165K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
286 |
3.7e-14 |
PFAM |
|
Pfam:7tm_1
|
20 |
279 |
4e-8 |
PFAM |
|
Pfam:V1R
|
31 |
286 |
5.5e-17 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.3%
- 20x: 92.1%
|
| Validation Efficiency |
100% (44/44) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca12 |
A |
G |
1: 71,340,119 (GRCm39) |
V1082A |
probably damaging |
Het |
| Adamts7 |
T |
A |
9: 90,077,883 (GRCm39) |
Y1496N |
probably damaging |
Het |
| Ascl2 |
T |
C |
7: 142,521,996 (GRCm39) |
N151D |
possibly damaging |
Het |
| Asxl3 |
G |
T |
18: 22,649,076 (GRCm39) |
S355I |
probably benign |
Het |
| Cttnbp2 |
T |
C |
6: 18,448,278 (GRCm39) |
Q127R |
probably damaging |
Het |
| Efhc1 |
T |
A |
1: 21,045,187 (GRCm39) |
I401N |
possibly damaging |
Het |
| Eml6 |
C |
T |
11: 29,699,300 (GRCm39) |
V1818I |
probably benign |
Het |
| Grin1 |
G |
T |
2: 25,193,843 (GRCm39) |
|
probably benign |
Het |
| Ints2 |
C |
T |
11: 86,140,100 (GRCm39) |
R244H |
probably damaging |
Het |
| Mfng |
C |
T |
15: 78,648,588 (GRCm39) |
R163H |
probably benign |
Het |
| Mllt6 |
C |
A |
11: 97,564,775 (GRCm39) |
A527E |
probably damaging |
Het |
| Msh5 |
G |
T |
17: 35,262,759 (GRCm39) |
|
probably benign |
Het |
| Mypn |
T |
A |
10: 62,959,150 (GRCm39) |
D1057V |
possibly damaging |
Het |
| Nasp |
A |
G |
4: 116,469,167 (GRCm39) |
|
probably null |
Het |
| Nat8l |
T |
C |
5: 34,154,213 (GRCm39) |
V9A |
probably damaging |
Het |
| Niban1 |
A |
G |
1: 151,565,410 (GRCm39) |
I247V |
probably benign |
Het |
| Nr1h2 |
G |
A |
7: 44,201,073 (GRCm39) |
A219V |
possibly damaging |
Het |
| Nup155 |
C |
A |
15: 8,165,354 (GRCm39) |
H663Q |
probably damaging |
Het |
| Pikfyve |
A |
G |
1: 65,292,566 (GRCm39) |
Y1339C |
probably damaging |
Het |
| Plppr1 |
A |
T |
4: 49,319,974 (GRCm39) |
H200L |
probably benign |
Het |
| Por |
T |
C |
5: 135,762,649 (GRCm39) |
V421A |
probably benign |
Het |
| Pxylp1 |
T |
G |
9: 96,736,853 (GRCm39) |
|
probably benign |
Het |
| Serpina3a |
G |
A |
12: 104,082,448 (GRCm39) |
V74I |
probably benign |
Het |
| Sfxn1 |
T |
C |
13: 54,239,588 (GRCm39) |
I37T |
probably benign |
Het |
| Thsd7a |
G |
T |
6: 12,330,951 (GRCm39) |
T1397N |
possibly damaging |
Het |
| Tnrc6a |
T |
C |
7: 122,785,946 (GRCm39) |
|
probably null |
Het |
| Vmn2r58 |
A |
T |
7: 41,486,534 (GRCm39) |
M787K |
probably damaging |
Het |
| Vta1 |
G |
T |
10: 14,581,222 (GRCm39) |
|
probably benign |
Het |
| Wdr87-ps |
A |
G |
7: 29,235,080 (GRCm39) |
|
noncoding transcript |
Het |
| Zfp236 |
A |
G |
18: 82,709,701 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn1r55 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R1771:Vmn1r55
|
UTSW |
7 |
5,149,919 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2063:Vmn1r55
|
UTSW |
7 |
5,150,048 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2064:Vmn1r55
|
UTSW |
7 |
5,150,048 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2066:Vmn1r55
|
UTSW |
7 |
5,150,048 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2068:Vmn1r55
|
UTSW |
7 |
5,150,048 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R3737:Vmn1r55
|
UTSW |
7 |
5,150,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4409:Vmn1r55
|
UTSW |
7 |
5,150,075 (GRCm39) |
missense |
probably benign |
0.40 |
|
R4410:Vmn1r55
|
UTSW |
7 |
5,150,075 (GRCm39) |
missense |
probably benign |
0.40 |
|
R4700:Vmn1r55
|
UTSW |
7 |
5,149,587 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4700:Vmn1r55
|
UTSW |
7 |
5,149,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4755:Vmn1r55
|
UTSW |
7 |
5,150,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4945:Vmn1r55
|
UTSW |
7 |
5,150,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5186:Vmn1r55
|
UTSW |
7 |
5,149,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5394:Vmn1r55
|
UTSW |
7 |
5,149,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6487:Vmn1r55
|
UTSW |
7 |
5,149,554 (GRCm39) |
missense |
probably benign |
0.23 |
|
R7855:Vmn1r55
|
UTSW |
7 |
5,149,623 (GRCm39) |
missense |
probably benign |
|
|
R8204:Vmn1r55
|
UTSW |
7 |
5,150,285 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8376:Vmn1r55
|
UTSW |
7 |
5,149,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9586:Vmn1r55
|
UTSW |
7 |
5,149,770 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9688:Vmn1r55
|
UTSW |
7 |
5,149,669 (GRCm39) |
missense |
probably benign |
0.44 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTTCAGCATGGCCTCTGTTG -3'
(R):5'- GGCACAAACATGTGTTCTACC -3'
Sequencing Primer
(F):5'- CAGCATGGCCTCTGTTGCTTTG -3'
(R):5'- GCACAAACATGTGTTCTACCTGTGTC -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation