Incidental Mutation 'R5066:Igkv8-21'
ID 388324
Institutional Source Beutler Lab
Gene Symbol Igkv8-21
Ensembl Gene ENSMUSG00000076586
Gene Name immunoglobulin kappa variable 8-21
Synonyms
MMRRC Submission 042656-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R5066 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 70291879-70292436 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 70292427 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 4 (Q4*)
Ref Sequence ENSEMBL: ENSMUSP00000100188 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103387]
AlphaFold A0A140T8P7
Predicted Effect probably null
Transcript: ENSMUST00000103387
AA Change: Q4*
SMART Domains Protein: ENSMUSP00000100188
Gene: ENSMUSG00000076586
AA Change: Q4*

DomainStartEndE-ValueType
IGv 38 116 6.58e-22 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency 100% (45/45)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930544D05Rik A T 11: 70,507,417 (GRCm39) Y154F probably benign Het
Abca5 A T 11: 110,200,176 (GRCm39) probably benign Het
Agtpbp1 T A 13: 59,622,364 (GRCm39) D11V probably damaging Het
Aldh1a2 G A 9: 71,188,982 (GRCm39) A299T possibly damaging Het
Apc T A 18: 34,449,158 (GRCm39) V1984D probably damaging Het
Asxl3 C G 18: 22,658,356 (GRCm39) A2122G possibly damaging Het
Atp13a2 G A 4: 140,732,449 (GRCm39) V905M probably damaging Het
Atp1a1 C T 3: 101,489,420 (GRCm39) G731R probably damaging Het
Atrn T C 2: 130,836,113 (GRCm39) V1131A possibly damaging Het
Bcl2l13 T A 6: 120,863,982 (GRCm39) V312E possibly damaging Het
Chic2 A G 5: 75,187,817 (GRCm39) V81A possibly damaging Het
Drg1 A T 11: 3,209,353 (GRCm39) I122N possibly damaging Het
Efcab3 A G 11: 104,611,490 (GRCm39) D444G probably benign Het
Flt4 A G 11: 49,524,990 (GRCm39) N612S possibly damaging Het
Hadhb T C 5: 30,369,094 (GRCm39) probably benign Het
Heg1 G T 16: 33,559,041 (GRCm39) R856S probably benign Het
Ice2 A C 9: 69,315,573 (GRCm39) N143T probably benign Het
Lrfn2 T C 17: 49,403,448 (GRCm39) S524P probably damaging Het
Mndal C A 1: 173,703,229 (GRCm39) A59S probably damaging Het
Mpp7 T C 18: 7,513,002 (GRCm39) E33G possibly damaging Het
Msantd5l A G 11: 51,145,251 (GRCm39) F112S probably damaging Het
Nedd4 T A 9: 72,617,801 (GRCm39) D187E probably damaging Het
Nfx1 A G 4: 40,991,868 (GRCm39) I519V probably benign Het
Or10p22 G A 10: 128,826,660 (GRCm39) R293Q probably damaging Het
Or6c204 T C 10: 129,022,433 (GRCm39) I286V possibly damaging Het
Padi1 T C 4: 140,556,748 (GRCm39) N153S probably damaging Het
Parp10 A G 15: 76,125,146 (GRCm39) probably benign Het
Setbp1 A T 18: 78,900,514 (GRCm39) M1051K probably damaging Het
Slc2a7 T A 4: 150,244,573 (GRCm39) M347K probably damaging Het
Slc45a2 C A 15: 11,012,693 (GRCm39) T232K probably benign Het
Snd1 C A 6: 28,888,239 (GRCm39) N891K probably damaging Het
Spata13 T C 14: 60,987,538 (GRCm39) Y899H possibly damaging Het
Sult1c2 T A 17: 54,281,026 (GRCm39) I26F probably damaging Het
Sybu A G 15: 44,541,040 (GRCm39) C341R probably damaging Het
Syk T A 13: 52,796,018 (GRCm39) S538T possibly damaging Het
Syne2 A G 12: 76,013,325 (GRCm39) T2840A probably benign Het
Thsd4 A G 9: 59,883,615 (GRCm39) C924R probably damaging Het
Tle1 A G 4: 72,076,504 (GRCm39) S175P probably benign Het
Tmbim4 C T 10: 120,053,537 (GRCm39) T112M probably benign Het
Tmprss11a A G 5: 86,567,859 (GRCm39) probably null Het
Tnc C A 4: 63,893,466 (GRCm39) D1698Y probably damaging Het
Ypel1 A G 16: 16,927,539 (GRCm39) Y18H probably benign Het
Other mutations in Igkv8-21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01388:Igkv8-21 APN 6 70,292,153 (GRCm39) missense probably benign 0.18
IGL01838:Igkv8-21 APN 6 70,292,009 (GRCm39) missense probably damaging 1.00
R4246:Igkv8-21 UTSW 6 70,292,436 (GRCm39) start codon destroyed possibly damaging 0.75
R4614:Igkv8-21 UTSW 6 70,292,141 (GRCm39) missense probably benign 0.05
R4616:Igkv8-21 UTSW 6 70,292,141 (GRCm39) missense probably benign 0.05
R4825:Igkv8-21 UTSW 6 70,292,410 (GRCm39) missense probably benign
R5758:Igkv8-21 UTSW 6 70,292,009 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- CCCCACAGGTACCTGAAATAAGTAG -3'
(R):5'- GACTGTTGATTGACACCAGCC -3'

Sequencing Primer
(F):5'- TAGAAAGTGAACATGCATACATACAC -3'
(R):5'- GTTGATTGACACCAGCCACTCTC -3'
Posted On 2016-06-06