Incidental Mutation 'R5072:Ly75'
| ID |
388841 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ly75
|
| Ensembl Gene |
ENSMUSG00000026980 |
| Gene Name |
lymphocyte antigen 75 |
| Synonyms |
DEC-205, CD205 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5072 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
60122447-60213617 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 60206307 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 121
(Y121H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000108152
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028362]
[ENSMUST00000112533]
|
| AlphaFold |
Q60767 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000028362
AA Change: Y121H
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000028362
Gene: ENSMUSG00000026980
AA Change: Y121H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
RICIN
|
33 |
146 |
2.63e-17 |
SMART |
|
FN2
|
162 |
209 |
1.22e-23 |
SMART |
|
CLECT
|
216 |
341 |
7.36e-32 |
SMART |
|
CLECT
|
361 |
486 |
9.28e-29 |
SMART |
|
CLECT
|
501 |
624 |
1.11e-17 |
SMART |
|
CLECT
|
643 |
791 |
1.93e-26 |
SMART |
|
CLECT
|
811 |
932 |
7.94e-2 |
SMART |
|
CLECT
|
952 |
1091 |
5.81e-21 |
SMART |
|
CLECT
|
1104 |
1222 |
1.04e-22 |
SMART |
|
CLECT
|
1240 |
1382 |
3.48e-10 |
SMART |
|
CLECT
|
1395 |
1513 |
9.59e-22 |
SMART |
|
CLECT
|
1530 |
1661 |
7.79e-22 |
SMART |
|
transmembrane domain
|
1670 |
1692 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112533
AA Change: Y121H
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000108152
Gene: ENSMUSG00000026980
AA Change: Y121H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
RICIN
|
33 |
146 |
2.63e-17 |
SMART |
|
FN2
|
162 |
209 |
1.22e-23 |
SMART |
|
CLECT
|
216 |
341 |
7.36e-32 |
SMART |
|
CLECT
|
361 |
486 |
9.28e-29 |
SMART |
|
CLECT
|
501 |
624 |
1.11e-17 |
SMART |
|
CLECT
|
643 |
791 |
1.93e-26 |
SMART |
|
CLECT
|
811 |
932 |
7.94e-2 |
SMART |
|
CLECT
|
952 |
1091 |
5.81e-21 |
SMART |
|
CLECT
|
1104 |
1222 |
1.04e-22 |
SMART |
|
CLECT
|
1240 |
1382 |
3.48e-10 |
SMART |
|
CLECT
|
1395 |
1513 |
9.59e-22 |
SMART |
|
CLECT
|
1530 |
1661 |
7.79e-22 |
SMART |
|
transmembrane domain
|
1670 |
1692 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151984
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 95.9%
- 20x: 90.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele display abnormalities in CD8-positive T cell morphology and cytotoxic T cell physiology. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(7) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(5)
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930486L24Rik |
A |
T |
13: 61,001,414 (GRCm39) |
H104Q |
probably benign |
Het |
| 4933405L10Rik |
A |
G |
8: 106,436,201 (GRCm39) |
T158A |
possibly damaging |
Het |
| A1cf |
T |
C |
19: 31,895,385 (GRCm39) |
M156T |
probably benign |
Het |
| Abca15 |
A |
G |
7: 120,006,198 (GRCm39) |
Y1620C |
probably damaging |
Het |
| Abca3 |
C |
T |
17: 24,593,274 (GRCm39) |
R224C |
probably damaging |
Het |
| Ablim1 |
A |
G |
19: 57,062,285 (GRCm39) |
|
probably null |
Het |
| Acox2 |
A |
T |
14: 8,241,374 (GRCm38) |
Y579* |
probably null |
Het |
| Adnp |
A |
T |
2: 168,024,921 (GRCm39) |
S791R |
probably damaging |
Het |
| Agbl1 |
A |
G |
7: 76,071,665 (GRCm39) |
E329G |
probably damaging |
Het |
| Alx3 |
G |
T |
3: 107,512,109 (GRCm39) |
S249I |
possibly damaging |
Het |
| Apob |
A |
G |
12: 8,058,714 (GRCm39) |
T2366A |
probably benign |
Het |
| Apool |
C |
T |
X: 111,259,540 (GRCm39) |
Q60* |
probably null |
Het |
| Arid4a |
T |
C |
12: 71,091,853 (GRCm39) |
V213A |
probably benign |
Het |
| Atp7a |
A |
G |
X: 105,153,374 (GRCm39) |
D1092G |
probably benign |
Het |
| Bpifa5 |
A |
T |
2: 154,007,892 (GRCm39) |
E178V |
probably damaging |
Het |
| Car4 |
G |
A |
11: 84,854,193 (GRCm39) |
E47K |
probably benign |
Het |
| Catsper1 |
T |
C |
19: 5,390,074 (GRCm39) |
|
probably null |
Het |
| Ccdc63 |
T |
A |
5: 122,259,118 (GRCm39) |
Q260L |
probably benign |
Het |
| Ccdc83 |
A |
T |
7: 89,899,737 (GRCm39) |
F45Y |
probably damaging |
Het |
| Cct8l1 |
G |
A |
5: 25,721,881 (GRCm39) |
V199I |
probably benign |
Het |
| Cdc23 |
C |
A |
18: 34,784,742 (GRCm39) |
V7L |
unknown |
Het |
| Ces5a |
C |
T |
8: 94,261,296 (GRCm39) |
V44M |
probably damaging |
Het |
| Cltc |
A |
G |
11: 86,608,794 (GRCm39) |
I741T |
possibly damaging |
Het |
| Cnst |
C |
A |
1: 179,450,451 (GRCm39) |
D638E |
possibly damaging |
Het |
| Col13a1 |
A |
G |
10: 61,709,797 (GRCm39) |
|
silent |
Het |
| Cyp2a22 |
A |
T |
7: 26,631,906 (GRCm39) |
F450Y |
probably benign |
Het |
| Cyp2d10 |
C |
T |
15: 82,287,954 (GRCm39) |
R383H |
probably benign |
Het |
| Cyp4a29 |
A |
G |
4: 115,104,860 (GRCm39) |
T123A |
probably benign |
Het |
| Ddx20 |
A |
G |
3: 105,590,191 (GRCm39) |
|
probably null |
Het |
| Dnaja3 |
A |
T |
16: 4,514,289 (GRCm39) |
T274S |
probably damaging |
Het |
| Dot1l |
A |
G |
10: 80,620,480 (GRCm39) |
D514G |
possibly damaging |
Het |
| Dysf |
A |
T |
6: 84,114,254 (GRCm39) |
K1226M |
probably damaging |
Het |
| Epha4 |
T |
C |
1: 77,421,639 (GRCm39) |
Y281C |
probably damaging |
Het |
| Fbxo42 |
T |
C |
4: 140,926,256 (GRCm39) |
W313R |
probably damaging |
Het |
| Fign |
A |
T |
2: 63,810,037 (GRCm39) |
L411* |
probably null |
Het |
| Flt1 |
C |
A |
5: 147,620,749 (GRCm39) |
A132S |
probably benign |
Het |
| Fryl |
G |
A |
5: 73,232,110 (GRCm39) |
P1550L |
probably damaging |
Het |
| Gas2l3 |
CACTCGTCATACT |
CACT |
10: 89,266,820 (GRCm39) |
|
probably benign |
Het |
| Gprasp2 |
C |
T |
X: 134,743,346 (GRCm39) |
T235I |
possibly damaging |
Het |
| Gtf2ird1 |
G |
T |
5: 134,419,787 (GRCm39) |
|
probably null |
Het |
| H2ab3 |
T |
C |
X: 119,222,543 (GRCm39) |
T84A |
probably damaging |
Het |
| H2ac20 |
C |
T |
3: 96,128,099 (GRCm39) |
|
probably benign |
Het |
| Hal |
A |
T |
10: 93,349,904 (GRCm39) |
I555F |
probably damaging |
Het |
| Hdac6 |
A |
G |
X: 7,811,036 (GRCm39) |
F104L |
probably damaging |
Homo |
| Hspg2 |
T |
C |
4: 137,267,541 (GRCm39) |
S2050P |
probably damaging |
Het |
| Irgc |
T |
C |
7: 24,132,196 (GRCm39) |
D207G |
probably benign |
Het |
| Kif19a |
G |
A |
11: 114,658,053 (GRCm39) |
M37I |
probably benign |
Het |
| Kiss1r |
C |
A |
10: 79,754,596 (GRCm39) |
S30* |
probably null |
Het |
| Krtap1-4 |
C |
G |
11: 99,474,442 (GRCm39) |
|
probably benign |
Het |
| Lrrfip2 |
A |
G |
9: 111,028,872 (GRCm39) |
E365G |
probably damaging |
Het |
| Man2a1 |
G |
A |
17: 64,966,074 (GRCm39) |
|
probably null |
Het |
| Mllt10 |
C |
A |
2: 18,114,685 (GRCm39) |
H52N |
possibly damaging |
Het |
| Mrtfa |
A |
G |
15: 80,906,627 (GRCm39) |
V91A |
probably damaging |
Het |
| Myo1a |
T |
C |
10: 127,543,288 (GRCm39) |
|
probably null |
Het |
| Myo3b |
C |
A |
2: 69,925,593 (GRCm39) |
T20K |
possibly damaging |
Het |
| Nipsnap2 |
A |
T |
5: 129,816,644 (GRCm39) |
K62N |
probably damaging |
Het |
| Nr1i3 |
C |
T |
1: 171,044,382 (GRCm39) |
T169I |
probably benign |
Het |
| Numbl |
G |
A |
7: 26,980,415 (GRCm39) |
D466N |
probably damaging |
Het |
| Oprm1 |
A |
G |
10: 6,782,550 (GRCm39) |
S398G |
probably benign |
Het |
| Or14c46 |
A |
G |
7: 85,918,799 (GRCm39) |
I66T |
probably damaging |
Het |
| Or51k1 |
T |
A |
7: 103,661,325 (GRCm39) |
R195W |
probably damaging |
Het |
| Or6k2 |
A |
T |
1: 173,986,527 (GRCm39) |
I63F |
probably damaging |
Het |
| Or8h10 |
A |
T |
2: 86,808,666 (GRCm39) |
V158D |
possibly damaging |
Het |
| Pebp1 |
G |
T |
5: 117,421,475 (GRCm39) |
D156E |
probably benign |
Het |
| Pik3c2g |
T |
A |
6: 139,665,873 (GRCm39) |
C65S |
probably null |
Het |
| Pilra |
A |
G |
5: 137,833,674 (GRCm39) |
F131L |
probably damaging |
Het |
| Pitrm1 |
T |
C |
13: 6,603,226 (GRCm39) |
F91S |
probably damaging |
Het |
| Ppl |
A |
T |
16: 4,906,742 (GRCm39) |
S1184R |
probably benign |
Het |
| Prmt2 |
C |
T |
10: 76,058,390 (GRCm39) |
V140I |
probably damaging |
Het |
| Psg29 |
T |
A |
7: 16,945,763 (GRCm39) |
D444E |
probably damaging |
Het |
| Ptgs1 |
A |
T |
2: 36,141,272 (GRCm39) |
N573I |
probably damaging |
Het |
| Pygb |
C |
T |
2: 150,643,498 (GRCm39) |
T95M |
probably damaging |
Het |
| Rassf9 |
A |
G |
10: 102,381,766 (GRCm39) |
K383E |
probably damaging |
Het |
| Rfk |
T |
A |
19: 17,375,963 (GRCm39) |
F86I |
possibly damaging |
Het |
| Rims2 |
T |
C |
15: 39,325,986 (GRCm39) |
F773L |
probably benign |
Het |
| Sdcbp |
A |
G |
4: 6,393,019 (GRCm39) |
I218V |
probably benign |
Het |
| Slc4a2 |
G |
A |
5: 24,643,760 (GRCm39) |
S855N |
probably benign |
Het |
| Slc8a2 |
T |
C |
7: 15,884,508 (GRCm39) |
L626P |
possibly damaging |
Het |
| Snrpd3 |
G |
T |
10: 75,355,227 (GRCm39) |
C20F |
possibly damaging |
Het |
| Spen |
A |
T |
4: 141,249,613 (GRCm39) |
S58R |
unknown |
Het |
| St3gal2 |
T |
C |
8: 111,684,350 (GRCm39) |
C3R |
possibly damaging |
Het |
| Stab2 |
A |
T |
10: 86,699,422 (GRCm39) |
I481N |
probably benign |
Het |
| Stat5b |
T |
C |
11: 100,699,361 (GRCm39) |
|
probably null |
Het |
| Tmco3 |
G |
T |
8: 13,342,860 (GRCm39) |
E199* |
probably null |
Het |
| Tmem26 |
A |
G |
10: 68,611,178 (GRCm39) |
T216A |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,550,822 (GRCm39) |
|
probably null |
Het |
| Ttn |
A |
T |
2: 76,602,709 (GRCm39) |
|
probably null |
Het |
| Ttn |
C |
T |
2: 76,576,746 (GRCm39) |
V24716I |
probably damaging |
Het |
| Uba5 |
T |
C |
9: 103,931,626 (GRCm39) |
E202G |
probably damaging |
Het |
| Ufl1 |
A |
G |
4: 25,254,780 (GRCm39) |
Y559H |
probably benign |
Het |
| Utrn |
A |
T |
10: 12,259,948 (GRCm39) |
|
probably null |
Het |
| Vmn2r111 |
C |
A |
17: 22,767,022 (GRCm39) |
C825F |
probably damaging |
Het |
| Vmn2r113 |
T |
A |
17: 23,177,329 (GRCm39) |
C704* |
probably null |
Het |
| Vmn2r56 |
A |
G |
7: 12,427,983 (GRCm39) |
I761T |
probably benign |
Het |
| Vmn2r98 |
C |
T |
17: 19,286,306 (GRCm39) |
T268I |
probably benign |
Het |
| Zfp263 |
A |
G |
16: 3,564,704 (GRCm39) |
R240G |
possibly damaging |
Het |
| Zfp473 |
T |
A |
7: 44,381,943 (GRCm39) |
I797F |
probably damaging |
Het |
| Zfp68 |
A |
T |
5: 138,604,579 (GRCm39) |
D543E |
probably benign |
Het |
|
| Other mutations in Ly75 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00561:Ly75
|
APN |
2 |
60,206,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01072:Ly75
|
APN |
2 |
60,184,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01409:Ly75
|
APN |
2 |
60,152,036 (GRCm39) |
splice site |
probably null |
|
|
IGL01432:Ly75
|
APN |
2 |
60,206,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01626:Ly75
|
APN |
2 |
60,131,359 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01690:Ly75
|
APN |
2 |
60,168,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01862:Ly75
|
APN |
2 |
60,129,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01982:Ly75
|
APN |
2 |
60,142,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02075:Ly75
|
APN |
2 |
60,182,700 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02338:Ly75
|
APN |
2 |
60,184,796 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02364:Ly75
|
APN |
2 |
60,188,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02456:Ly75
|
APN |
2 |
60,124,125 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02474:Ly75
|
APN |
2 |
60,213,526 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL02608:Ly75
|
APN |
2 |
60,152,244 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02986:Ly75
|
APN |
2 |
60,138,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03015:Ly75
|
APN |
2 |
60,206,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03049:Ly75
|
APN |
2 |
60,182,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
euphues
|
UTSW |
2 |
60,129,389 (GRCm39) |
critical splice donor site |
probably null |
|
|
four_score
|
UTSW |
2 |
60,142,115 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
lyly
|
UTSW |
2 |
60,158,217 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
Witty
|
UTSW |
2 |
60,184,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
D605:Ly75
|
UTSW |
2 |
60,182,696 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0046:Ly75
|
UTSW |
2 |
60,169,801 (GRCm39) |
intron |
probably benign |
|
|
R0055:Ly75
|
UTSW |
2 |
60,152,262 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0055:Ly75
|
UTSW |
2 |
60,152,262 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0071:Ly75
|
UTSW |
2 |
60,152,163 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0071:Ly75
|
UTSW |
2 |
60,152,163 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0285:Ly75
|
UTSW |
2 |
60,148,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0387:Ly75
|
UTSW |
2 |
60,136,748 (GRCm39) |
missense |
probably benign |
0.20 |
|
R0492:Ly75
|
UTSW |
2 |
60,138,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0688:Ly75
|
UTSW |
2 |
60,146,565 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1367:Ly75
|
UTSW |
2 |
60,124,102 (GRCm39) |
splice site |
probably null |
|
|
R1463:Ly75
|
UTSW |
2 |
60,199,101 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1581:Ly75
|
UTSW |
2 |
60,158,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1663:Ly75
|
UTSW |
2 |
60,144,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1818:Ly75
|
UTSW |
2 |
60,142,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1881:Ly75
|
UTSW |
2 |
60,180,284 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2244:Ly75
|
UTSW |
2 |
60,180,257 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2905:Ly75
|
UTSW |
2 |
60,164,898 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3967:Ly75
|
UTSW |
2 |
60,158,217 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R3968:Ly75
|
UTSW |
2 |
60,158,217 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R4039:Ly75
|
UTSW |
2 |
60,183,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4406:Ly75
|
UTSW |
2 |
60,184,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4526:Ly75
|
UTSW |
2 |
60,161,117 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4647:Ly75
|
UTSW |
2 |
60,138,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4795:Ly75
|
UTSW |
2 |
60,180,284 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4796:Ly75
|
UTSW |
2 |
60,180,284 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4962:Ly75
|
UTSW |
2 |
60,182,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4979:Ly75
|
UTSW |
2 |
60,206,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5288:Ly75
|
UTSW |
2 |
60,133,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5373:Ly75
|
UTSW |
2 |
60,142,115 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5374:Ly75
|
UTSW |
2 |
60,142,115 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5384:Ly75
|
UTSW |
2 |
60,164,831 (GRCm39) |
nonsense |
probably null |
|
|
R5385:Ly75
|
UTSW |
2 |
60,133,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5395:Ly75
|
UTSW |
2 |
60,195,455 (GRCm39) |
missense |
probably benign |
0.41 |
|
R5531:Ly75
|
UTSW |
2 |
60,195,489 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5662:Ly75
|
UTSW |
2 |
60,182,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5667:Ly75
|
UTSW |
2 |
60,138,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5668:Ly75
|
UTSW |
2 |
60,184,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5671:Ly75
|
UTSW |
2 |
60,138,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5677:Ly75
|
UTSW |
2 |
60,129,426 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5764:Ly75
|
UTSW |
2 |
60,148,783 (GRCm39) |
missense |
probably benign |
|
|
R5896:Ly75
|
UTSW |
2 |
60,213,490 (GRCm39) |
missense |
probably benign |
|
|
R6025:Ly75
|
UTSW |
2 |
60,206,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6113:Ly75
|
UTSW |
2 |
60,199,217 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6448:Ly75
|
UTSW |
2 |
60,129,389 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6601:Ly75
|
UTSW |
2 |
60,148,720 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6745:Ly75
|
UTSW |
2 |
60,138,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6955:Ly75
|
UTSW |
2 |
60,158,217 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R6960:Ly75
|
UTSW |
2 |
60,136,749 (GRCm39) |
missense |
probably benign |
|
|
R7100:Ly75
|
UTSW |
2 |
60,136,778 (GRCm39) |
missense |
probably benign |
|
|
R7110:Ly75
|
UTSW |
2 |
60,206,528 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7203:Ly75
|
UTSW |
2 |
60,154,196 (GRCm39) |
nonsense |
probably null |
|
|
R7291:Ly75
|
UTSW |
2 |
60,160,337 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7308:Ly75
|
UTSW |
2 |
60,164,859 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7447:Ly75
|
UTSW |
2 |
60,164,818 (GRCm39) |
nonsense |
probably null |
|
|
R7512:Ly75
|
UTSW |
2 |
60,164,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7595:Ly75
|
UTSW |
2 |
60,124,171 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7976:Ly75
|
UTSW |
2 |
60,195,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8005:Ly75
|
UTSW |
2 |
60,163,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8171:Ly75
|
UTSW |
2 |
60,144,572 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R8392:Ly75
|
UTSW |
2 |
60,180,284 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8705:Ly75
|
UTSW |
2 |
60,148,729 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8714:Ly75
|
UTSW |
2 |
60,164,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8798:Ly75
|
UTSW |
2 |
60,154,270 (GRCm39) |
missense |
probably benign |
0.32 |
|
R8799:Ly75
|
UTSW |
2 |
60,178,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8834:Ly75
|
UTSW |
2 |
60,161,433 (GRCm39) |
missense |
probably benign |
|
|
R8990:Ly75
|
UTSW |
2 |
60,188,903 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9015:Ly75
|
UTSW |
2 |
60,146,442 (GRCm39) |
missense |
probably benign |
|
|
R9547:Ly75
|
UTSW |
2 |
60,161,069 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9628:Ly75
|
UTSW |
2 |
60,158,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9659:Ly75
|
UTSW |
2 |
60,168,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9660:Ly75
|
UTSW |
2 |
60,154,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9747:Ly75
|
UTSW |
2 |
60,136,672 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0025:Ly75
|
UTSW |
2 |
60,184,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ly75
|
UTSW |
2 |
60,182,477 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
Z1177:Ly75
|
UTSW |
2 |
60,180,348 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AAAGCTGTGCTGGGTATGGC -3'
(R):5'- ATCGTCCATGAAAACACTGGC -3'
Sequencing Primer
(F):5'- GCTGGGTATGGCATTTAAATGAAAC -3'
(R):5'- ACTGGCAAGTGCATCCAG -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation