Mutagenetix > Incidental Mutation

Incidental Mutation 'R5072:Stab2'

388898

Institutional Source

Beutler Lab

Gene Symbol

Stab2

Ensembl Gene

ENSMUSG00000035459

Gene Name

stabilin 2

Synonyms

FEEL-2, STAB-2

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5072 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

86677062-86843889 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 86699422 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 481 (I481N)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035288]

AlphaFold

Q8R4U0

Predicted Effect

probably benign
Transcript: ENSMUST00000035288
AA Change: I1932N

PolyPhen 2 Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000048309
Gene: ENSMUSG00000035459
AA Change: I1932N

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
EGF	119	156	1.85e0	SMART
EGF	167	201	2.43e1	SMART
EGF	206	244	1.43e-1	SMART
EGF	248	284	3.82e-2	SMART
EGF	333	370	2.02e-1	SMART
FAS1	414	515	1.06e-8	SMART
FAS1	561	662	3.54e-19	SMART
EGF	746	783	6.76e-3	SMART
EGF	836	873	1.31e0	SMART
EGF	877	917	2.99e-4	SMART
EGF	921	960	3.51e-1	SMART
EGF	964	1002	1.99e0	SMART
FAS1	1038	1138	1.73e-13	SMART
FAS1	1181	1276	1.83e-12	SMART
EGF	1354	1391	6.92e0	SMART
EGF	1401	1435	1.11e1	SMART
EGF	1442	1477	3.01e0	SMART
EGF	1481	1519	1.64e-1	SMART
EGF	1523	1561	1.14e0	SMART
EGF	1565	1603	5.62e0	SMART
FAS1	1638	1734	2.23e-25	SMART
FAS1	1785	1891	6.92e-22	SMART
EGF	1966	2006	1.95e1	SMART
EGF_like	1977	2017	2.46e-1	SMART
EGF	2016	2050	1.14e0	SMART
EGF	2058	2089	1.56e1	SMART
EGF	2093	2130	1.36e1	SMART
EGF	2134	2173	2.13e0	SMART
LINK	2204	2298	2.08e-29	SMART
FAS1	2363	2455	3.19e-12	SMART
transmembrane domain	2467	2489	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159445

Predicted Effect

probably benign
Transcript: ENSMUST00000161560
AA Change: I481N

PolyPhen 2 Score 0.233 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000125263
Gene: ENSMUSG00000035459
AA Change: I481N

Domain	Start	End	E-Value	Type
EGF	30	68	1.64e-1	SMART
EGF	72	110	1.14e0	SMART
EGF	114	152	5.62e0	SMART
FAS1	187	283	2.23e-25	SMART
FAS1	334	440	6.92e-22	SMART
EGF	515	555	1.95e1	SMART
EGF_like	526	566	2.46e-1	SMART
EGF	565	599	1.14e0	SMART
EGF	607	638	1.56e1	SMART
EGF	643	680	1.36e1	SMART
EGF	684	723	2.13e0	SMART
LINK	754	848	2.08e-29	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000219341
AA Change: I480N

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 95.9%
20x: 90.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for knock-out alleles exhibit no gross abnormaities. Mice homozygous for one null allele display elevated serum hyaluronic acid levels and decreased metastasis. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 98 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930486L24Rik	A	T	13: 61,001,414 (GRCm39)	H104Q	probably benign	Het
4933405L10Rik	A	G	8: 106,436,201 (GRCm39)	T158A	possibly damaging	Het
A1cf	T	C	19: 31,895,385 (GRCm39)	M156T	probably benign	Het
Abca15	A	G	7: 120,006,198 (GRCm39)	Y1620C	probably damaging	Het
Abca3	C	T	17: 24,593,274 (GRCm39)	R224C	probably damaging	Het
Ablim1	A	G	19: 57,062,285 (GRCm39)		probably null	Het
Acox2	A	T	14: 8,241,374 (GRCm38)	Y579*	probably null	Het
Adnp	A	T	2: 168,024,921 (GRCm39)	S791R	probably damaging	Het
Agbl1	A	G	7: 76,071,665 (GRCm39)	E329G	probably damaging	Het
Alx3	G	T	3: 107,512,109 (GRCm39)	S249I	possibly damaging	Het
Apob	A	G	12: 8,058,714 (GRCm39)	T2366A	probably benign	Het
Apool	C	T	X: 111,259,540 (GRCm39)	Q60*	probably null	Het
Arid4a	T	C	12: 71,091,853 (GRCm39)	V213A	probably benign	Het
Atp7a	A	G	X: 105,153,374 (GRCm39)	D1092G	probably benign	Het
Bpifa5	A	T	2: 154,007,892 (GRCm39)	E178V	probably damaging	Het
Car4	G	A	11: 84,854,193 (GRCm39)	E47K	probably benign	Het
Catsper1	T	C	19: 5,390,074 (GRCm39)		probably null	Het
Ccdc63	T	A	5: 122,259,118 (GRCm39)	Q260L	probably benign	Het
Ccdc83	A	T	7: 89,899,737 (GRCm39)	F45Y	probably damaging	Het
Cct8l1	G	A	5: 25,721,881 (GRCm39)	V199I	probably benign	Het
Cdc23	C	A	18: 34,784,742 (GRCm39)	V7L	unknown	Het
Ces5a	C	T	8: 94,261,296 (GRCm39)	V44M	probably damaging	Het
Cltc	A	G	11: 86,608,794 (GRCm39)	I741T	possibly damaging	Het
Cnst	C	A	1: 179,450,451 (GRCm39)	D638E	possibly damaging	Het
Col13a1	A	G	10: 61,709,797 (GRCm39)		silent	Het
Cyp2a22	A	T	7: 26,631,906 (GRCm39)	F450Y	probably benign	Het
Cyp2d10	C	T	15: 82,287,954 (GRCm39)	R383H	probably benign	Het
Cyp4a29	A	G	4: 115,104,860 (GRCm39)	T123A	probably benign	Het
Ddx20	A	G	3: 105,590,191 (GRCm39)		probably null	Het
Dnaja3	A	T	16: 4,514,289 (GRCm39)	T274S	probably damaging	Het
Dot1l	A	G	10: 80,620,480 (GRCm39)	D514G	possibly damaging	Het
Dysf	A	T	6: 84,114,254 (GRCm39)	K1226M	probably damaging	Het
Epha4	T	C	1: 77,421,639 (GRCm39)	Y281C	probably damaging	Het
Fbxo42	T	C	4: 140,926,256 (GRCm39)	W313R	probably damaging	Het
Fign	A	T	2: 63,810,037 (GRCm39)	L411*	probably null	Het
Flt1	C	A	5: 147,620,749 (GRCm39)	A132S	probably benign	Het
Fryl	G	A	5: 73,232,110 (GRCm39)	P1550L	probably damaging	Het
Gas2l3	CACTCGTCATACT	CACT	10: 89,266,820 (GRCm39)		probably benign	Het
Gprasp2	C	T	X: 134,743,346 (GRCm39)	T235I	possibly damaging	Het
Gtf2ird1	G	T	5: 134,419,787 (GRCm39)		probably null	Het
H2ab3	T	C	X: 119,222,543 (GRCm39)	T84A	probably damaging	Het
H2ac20	C	T	3: 96,128,099 (GRCm39)		probably benign	Het
Hal	A	T	10: 93,349,904 (GRCm39)	I555F	probably damaging	Het
Hdac6	A	G	X: 7,811,036 (GRCm39)	F104L	probably damaging	Homo
Hspg2	T	C	4: 137,267,541 (GRCm39)	S2050P	probably damaging	Het
Irgc	T	C	7: 24,132,196 (GRCm39)	D207G	probably benign	Het
Kif19a	G	A	11: 114,658,053 (GRCm39)	M37I	probably benign	Het
Kiss1r	C	A	10: 79,754,596 (GRCm39)	S30*	probably null	Het
Krtap1-4	C	G	11: 99,474,442 (GRCm39)		probably benign	Het
Lrrfip2	A	G	9: 111,028,872 (GRCm39)	E365G	probably damaging	Het
Ly75	A	G	2: 60,206,307 (GRCm39)	Y121H	probably damaging	Het
Man2a1	G	A	17: 64,966,074 (GRCm39)		probably null	Het
Mllt10	C	A	2: 18,114,685 (GRCm39)	H52N	possibly damaging	Het
Mrtfa	A	G	15: 80,906,627 (GRCm39)	V91A	probably damaging	Het
Myo1a	T	C	10: 127,543,288 (GRCm39)		probably null	Het
Myo3b	C	A	2: 69,925,593 (GRCm39)	T20K	possibly damaging	Het
Nipsnap2	A	T	5: 129,816,644 (GRCm39)	K62N	probably damaging	Het
Nr1i3	C	T	1: 171,044,382 (GRCm39)	T169I	probably benign	Het
Numbl	G	A	7: 26,980,415 (GRCm39)	D466N	probably damaging	Het
Oprm1	A	G	10: 6,782,550 (GRCm39)	S398G	probably benign	Het
Or14c46	A	G	7: 85,918,799 (GRCm39)	I66T	probably damaging	Het
Or51k1	T	A	7: 103,661,325 (GRCm39)	R195W	probably damaging	Het
Or6k2	A	T	1: 173,986,527 (GRCm39)	I63F	probably damaging	Het
Or8h10	A	T	2: 86,808,666 (GRCm39)	V158D	possibly damaging	Het
Pebp1	G	T	5: 117,421,475 (GRCm39)	D156E	probably benign	Het
Pik3c2g	T	A	6: 139,665,873 (GRCm39)	C65S	probably null	Het
Pilra	A	G	5: 137,833,674 (GRCm39)	F131L	probably damaging	Het
Pitrm1	T	C	13: 6,603,226 (GRCm39)	F91S	probably damaging	Het
Ppl	A	T	16: 4,906,742 (GRCm39)	S1184R	probably benign	Het
Prmt2	C	T	10: 76,058,390 (GRCm39)	V140I	probably damaging	Het
Psg29	T	A	7: 16,945,763 (GRCm39)	D444E	probably damaging	Het
Ptgs1	A	T	2: 36,141,272 (GRCm39)	N573I	probably damaging	Het
Pygb	C	T	2: 150,643,498 (GRCm39)	T95M	probably damaging	Het
Rassf9	A	G	10: 102,381,766 (GRCm39)	K383E	probably damaging	Het
Rfk	T	A	19: 17,375,963 (GRCm39)	F86I	possibly damaging	Het
Rims2	T	C	15: 39,325,986 (GRCm39)	F773L	probably benign	Het
Sdcbp	A	G	4: 6,393,019 (GRCm39)	I218V	probably benign	Het
Slc4a2	G	A	5: 24,643,760 (GRCm39)	S855N	probably benign	Het
Slc8a2	T	C	7: 15,884,508 (GRCm39)	L626P	possibly damaging	Het
Snrpd3	G	T	10: 75,355,227 (GRCm39)	C20F	possibly damaging	Het
Spen	A	T	4: 141,249,613 (GRCm39)	S58R	unknown	Het
St3gal2	T	C	8: 111,684,350 (GRCm39)	C3R	possibly damaging	Het
Stat5b	T	C	11: 100,699,361 (GRCm39)		probably null	Het
Tmco3	G	T	8: 13,342,860 (GRCm39)	E199*	probably null	Het
Tmem26	A	G	10: 68,611,178 (GRCm39)	T216A	probably damaging	Het
Ttn	A	G	2: 76,550,822 (GRCm39)		probably null	Het
Ttn	A	T	2: 76,602,709 (GRCm39)		probably null	Het
Ttn	C	T	2: 76,576,746 (GRCm39)	V24716I	probably damaging	Het
Uba5	T	C	9: 103,931,626 (GRCm39)	E202G	probably damaging	Het
Ufl1	A	G	4: 25,254,780 (GRCm39)	Y559H	probably benign	Het
Utrn	A	T	10: 12,259,948 (GRCm39)		probably null	Het
Vmn2r111	C	A	17: 22,767,022 (GRCm39)	C825F	probably damaging	Het
Vmn2r113	T	A	17: 23,177,329 (GRCm39)	C704*	probably null	Het
Vmn2r56	A	G	7: 12,427,983 (GRCm39)	I761T	probably benign	Het
Vmn2r98	C	T	17: 19,286,306 (GRCm39)	T268I	probably benign	Het
Zfp263	A	G	16: 3,564,704 (GRCm39)	R240G	possibly damaging	Het
Zfp473	T	A	7: 44,381,943 (GRCm39)	I797F	probably damaging	Het
Zfp68	A	T	5: 138,604,579 (GRCm39)	D543E	probably benign	Het

Other mutations in Stab2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Stab2	APN	10	86,705,070 (GRCm39)	splice site	probably null
IGL00809:Stab2	APN	10	86,684,038 (GRCm39)	splice site	probably benign
IGL00911:Stab2	APN	10	86,805,617 (GRCm39)	missense	probably damaging	1.00
IGL01347:Stab2	APN	10	86,737,567 (GRCm39)	splice site	probably null
IGL01411:Stab2	APN	10	86,815,872 (GRCm39)	splice site	probably benign
IGL01503:Stab2	APN	10	86,776,477 (GRCm39)	splice site	probably benign
IGL01599:Stab2	APN	10	86,758,759 (GRCm39)	missense	probably damaging	1.00
IGL01635:Stab2	APN	10	86,816,992 (GRCm39)	missense	probably benign	0.04
IGL01640:Stab2	APN	10	86,790,035 (GRCm39)	missense	probably benign	0.09
IGL01671:Stab2	APN	10	86,805,141 (GRCm39)	missense	possibly damaging	0.80
IGL02023:Stab2	APN	10	86,707,695 (GRCm39)	missense	possibly damaging	0.67
IGL02075:Stab2	APN	10	86,803,514 (GRCm39)	missense	possibly damaging	0.71
IGL02174:Stab2	APN	10	86,695,606 (GRCm39)	splice site	probably null
IGL02600:Stab2	APN	10	86,790,123 (GRCm39)	missense	probably damaging	1.00
IGL02666:Stab2	APN	10	86,686,766 (GRCm39)	missense	possibly damaging	0.67
IGL02668:Stab2	APN	10	86,682,027 (GRCm39)	splice site	probably benign
IGL02709:Stab2	APN	10	86,682,029 (GRCm39)	splice site	probably benign
IGL02728:Stab2	APN	10	86,692,420 (GRCm39)	missense	possibly damaging	0.95
IGL02803:Stab2	APN	10	86,786,133 (GRCm39)	splice site	probably benign
IGL02938:Stab2	APN	10	86,707,785 (GRCm39)	missense	possibly damaging	0.77
IGL03033:Stab2	APN	10	86,832,667 (GRCm39)	critical splice donor site	probably null
IGL03238:Stab2	APN	10	86,690,985 (GRCm39)	missense	probably damaging	1.00
IGL03402:Stab2	APN	10	86,805,165 (GRCm39)	missense	probably benign	0.03
prospector	UTSW	10	86,737,431 (GRCm39)	splice site	probably null
songbird	UTSW	10	86,694,016 (GRCm39)	missense	probably damaging	1.00
3-1:Stab2	UTSW	10	86,705,041 (GRCm39)	missense	probably damaging	0.96
F6893:Stab2	UTSW	10	86,691,035 (GRCm39)	missense	probably damaging	1.00
K7371:Stab2	UTSW	10	86,779,153 (GRCm39)	critical splice donor site	probably null
PIT4142001:Stab2	UTSW	10	86,703,039 (GRCm39)	missense	possibly damaging	0.94
PIT4362001:Stab2	UTSW	10	86,697,299 (GRCm39)	nonsense	probably null
R0015:Stab2	UTSW	10	86,679,481 (GRCm39)	missense	probably benign
R0254:Stab2	UTSW	10	86,733,824 (GRCm39)	missense	probably benign
R0310:Stab2	UTSW	10	86,803,477 (GRCm39)	splice site	probably benign
R0333:Stab2	UTSW	10	86,677,491 (GRCm39)	missense	probably benign
R0391:Stab2	UTSW	10	86,783,008 (GRCm39)	missense	probably benign	0.27
R0400:Stab2	UTSW	10	86,708,474 (GRCm39)	missense	probably damaging	1.00
R0433:Stab2	UTSW	10	86,679,355 (GRCm39)	splice site	probably benign
R0440:Stab2	UTSW	10	86,785,792 (GRCm39)	missense	probably benign	0.23
R0743:Stab2	UTSW	10	86,723,759 (GRCm39)	missense	probably damaging	1.00
R0847:Stab2	UTSW	10	86,805,735 (GRCm39)	missense	probably benign	0.00
R0883:Stab2	UTSW	10	86,760,314 (GRCm39)	splice site	probably benign
R1078:Stab2	UTSW	10	86,742,997 (GRCm39)	splice site	probably null
R1118:Stab2	UTSW	10	86,721,582 (GRCm39)	splice site	probably null
R1119:Stab2	UTSW	10	86,695,619 (GRCm39)	missense	possibly damaging	0.51
R1179:Stab2	UTSW	10	86,786,165 (GRCm39)	missense	probably damaging	0.98
R1440:Stab2	UTSW	10	86,697,231 (GRCm39)	splice site	probably null
R1550:Stab2	UTSW	10	86,714,790 (GRCm39)	missense	probably benign	0.01
R1616:Stab2	UTSW	10	86,721,582 (GRCm39)	splice site	probably null
R1728:Stab2	UTSW	10	86,773,903 (GRCm39)	missense	probably benign	0.41
R1768:Stab2	UTSW	10	86,838,872 (GRCm39)	missense	probably damaging	1.00
R1772:Stab2	UTSW	10	86,790,098 (GRCm39)	missense	probably benign	0.06
R1776:Stab2	UTSW	10	86,793,680 (GRCm39)	missense	possibly damaging	0.92
R1784:Stab2	UTSW	10	86,773,903 (GRCm39)	missense	probably benign	0.41
R1892:Stab2	UTSW	10	86,773,913 (GRCm39)	missense	probably damaging	0.99
R1957:Stab2	UTSW	10	86,697,334 (GRCm39)	missense	probably benign	0.13
R1972:Stab2	UTSW	10	86,796,180 (GRCm39)	missense	probably damaging	0.99
R1975:Stab2	UTSW	10	86,732,360 (GRCm39)	critical splice donor site	probably null
R1976:Stab2	UTSW	10	86,732,360 (GRCm39)	critical splice donor site	probably null
R1996:Stab2	UTSW	10	86,838,895 (GRCm39)	missense	probably damaging	1.00
R2085:Stab2	UTSW	10	86,790,023 (GRCm39)	missense	probably damaging	1.00
R2149:Stab2	UTSW	10	86,700,904 (GRCm39)	nonsense	probably null
R2169:Stab2	UTSW	10	86,723,726 (GRCm39)	missense	probably damaging	1.00
R2201:Stab2	UTSW	10	86,776,503 (GRCm39)	missense	probably benign	0.22
R2296:Stab2	UTSW	10	86,790,338 (GRCm39)	critical splice acceptor site	probably null
R2297:Stab2	UTSW	10	86,790,338 (GRCm39)	critical splice acceptor site	probably null
R2298:Stab2	UTSW	10	86,790,338 (GRCm39)	critical splice acceptor site	probably null
R2326:Stab2	UTSW	10	86,790,338 (GRCm39)	critical splice acceptor site	probably null
R2434:Stab2	UTSW	10	86,805,183 (GRCm39)	missense	possibly damaging	0.78
R2519:Stab2	UTSW	10	86,770,704 (GRCm39)	splice site	probably benign
R2696:Stab2	UTSW	10	86,697,363 (GRCm39)	missense	probably benign	0.45
R2883:Stab2	UTSW	10	86,803,550 (GRCm39)	missense	possibly damaging	0.92
R2923:Stab2	UTSW	10	86,697,325 (GRCm39)	missense	probably damaging	1.00
R3711:Stab2	UTSW	10	86,702,572 (GRCm39)	missense	probably damaging	1.00
R3787:Stab2	UTSW	10	86,805,141 (GRCm39)	missense	possibly damaging	0.50
R3834:Stab2	UTSW	10	86,785,776 (GRCm39)	missense	possibly damaging	0.87
R3970:Stab2	UTSW	10	86,714,750 (GRCm39)	missense	probably damaging	0.97
R3979:Stab2	UTSW	10	86,699,320 (GRCm39)	missense	possibly damaging	0.56
R4003:Stab2	UTSW	10	86,693,988 (GRCm39)	missense	probably damaging	1.00
R4088:Stab2	UTSW	10	86,758,049 (GRCm39)	missense	probably damaging	1.00
R4151:Stab2	UTSW	10	86,838,847 (GRCm39)	missense	probably benign	0.12
R4190:Stab2	UTSW	10	86,714,808 (GRCm39)	missense	probably damaging	0.98
R4556:Stab2	UTSW	10	86,803,543 (GRCm39)	missense	possibly damaging	0.95
R4773:Stab2	UTSW	10	86,743,235 (GRCm39)	nonsense	probably null
R4825:Stab2	UTSW	10	86,783,011 (GRCm39)	missense	probably benign	0.08
R4865:Stab2	UTSW	10	86,679,364 (GRCm39)	splice site	probably null
R4871:Stab2	UTSW	10	86,778,099 (GRCm39)	missense	probably damaging	0.99
R4943:Stab2	UTSW	10	86,790,026 (GRCm39)	missense	probably damaging	0.99
R4981:Stab2	UTSW	10	86,796,087 (GRCm39)	missense	probably benign
R4994:Stab2	UTSW	10	86,785,771 (GRCm39)	missense	probably benign
R4999:Stab2	UTSW	10	86,773,773 (GRCm39)	missense	probably damaging	0.97
R5061:Stab2	UTSW	10	86,743,249 (GRCm39)	missense	probably damaging	1.00
R5073:Stab2	UTSW	10	86,699,422 (GRCm39)	missense	probably benign	0.23
R5074:Stab2	UTSW	10	86,699,422 (GRCm39)	missense	probably benign	0.23
R5134:Stab2	UTSW	10	86,707,674 (GRCm39)	splice site	probably null
R5213:Stab2	UTSW	10	86,743,061 (GRCm39)	missense	probably damaging	0.99
R5508:Stab2	UTSW	10	86,796,143 (GRCm39)	missense	probably benign	0.01
R5530:Stab2	UTSW	10	86,783,026 (GRCm39)	missense	probably benign	0.04
R5540:Stab2	UTSW	10	86,683,989 (GRCm39)	missense	probably benign	0.30
R5839:Stab2	UTSW	10	86,708,555 (GRCm39)	missense	probably damaging	0.97
R5949:Stab2	UTSW	10	86,805,713 (GRCm39)	missense	possibly damaging	0.87
R6015:Stab2	UTSW	10	86,773,906 (GRCm39)	missense	probably damaging	0.99
R6019:Stab2	UTSW	10	86,838,886 (GRCm39)	missense	probably benign	0.00
R6116:Stab2	UTSW	10	86,743,054 (GRCm39)	missense	probably damaging	1.00
R6131:Stab2	UTSW	10	86,719,642 (GRCm39)	splice site	probably null
R6209:Stab2	UTSW	10	86,758,867 (GRCm39)	missense	possibly damaging	0.94
R6243:Stab2	UTSW	10	86,743,025 (GRCm39)	missense	probably damaging	1.00
R6433:Stab2	UTSW	10	86,737,431 (GRCm39)	splice site	probably null
R6787:Stab2	UTSW	10	86,754,948 (GRCm39)	missense	probably benign	0.07
R6841:Stab2	UTSW	10	86,778,054 (GRCm39)	missense	probably damaging	1.00
R6873:Stab2	UTSW	10	86,697,230 (GRCm39)	critical splice donor site	probably null
R7025:Stab2	UTSW	10	86,686,701 (GRCm39)	missense	probably damaging	1.00
R7043:Stab2	UTSW	10	86,706,110 (GRCm39)	missense	probably damaging	0.99
R7047:Stab2	UTSW	10	86,694,016 (GRCm39)	missense	probably damaging	1.00
R7107:Stab2	UTSW	10	86,741,456 (GRCm39)	missense	possibly damaging	0.96
R7214:Stab2	UTSW	10	86,735,705 (GRCm39)	missense	probably damaging	0.99
R7271:Stab2	UTSW	10	86,838,972 (GRCm39)	splice site	probably null
R7291:Stab2	UTSW	10	86,782,084 (GRCm39)	missense	probably damaging	0.96
R7336:Stab2	UTSW	10	86,805,049 (GRCm39)	nonsense	probably null
R7432:Stab2	UTSW	10	86,721,547 (GRCm39)	missense	probably damaging	0.99
R7580:Stab2	UTSW	10	86,705,028 (GRCm39)	missense	probably benign	0.00
R7622:Stab2	UTSW	10	86,709,766 (GRCm39)	missense	possibly damaging	0.65
R7629:Stab2	UTSW	10	86,719,646 (GRCm39)	critical splice donor site	probably null
R7658:Stab2	UTSW	10	86,816,999 (GRCm39)	missense	probably benign	0.12
R7798:Stab2	UTSW	10	86,793,776 (GRCm39)	missense	probably damaging	0.98
R7835:Stab2	UTSW	10	86,708,483 (GRCm39)	missense	probably benign	0.06
R7845:Stab2	UTSW	10	86,832,758 (GRCm39)	missense	probably benign	0.09
R7863:Stab2	UTSW	10	86,808,745 (GRCm39)	missense	probably benign	0.30
R7885:Stab2	UTSW	10	86,714,776 (GRCm39)	missense	probably benign	0.03
R7904:Stab2	UTSW	10	86,790,056 (GRCm39)	nonsense	probably null
R7947:Stab2	UTSW	10	86,681,897 (GRCm39)	missense	probably benign	0.31
R7963:Stab2	UTSW	10	86,683,887 (GRCm39)	critical splice donor site	probably null
R8014:Stab2	UTSW	10	86,686,767 (GRCm39)	missense	possibly damaging	0.78
R8021:Stab2	UTSW	10	86,741,403 (GRCm39)	missense	possibly damaging	0.69
R8024:Stab2	UTSW	10	86,681,916 (GRCm39)	missense	probably benign	0.34
R8097:Stab2	UTSW	10	86,704,959 (GRCm39)	missense	possibly damaging	0.86
R8281:Stab2	UTSW	10	86,709,728 (GRCm39)	missense	probably damaging	0.98
R8462:Stab2	UTSW	10	86,803,598 (GRCm39)	missense	possibly damaging	0.79
R8670:Stab2	UTSW	10	86,776,587 (GRCm39)	missense	probably damaging	1.00
R8692:Stab2	UTSW	10	86,808,794 (GRCm39)	missense	probably damaging	0.99
R8744:Stab2	UTSW	10	86,805,213 (GRCm39)	missense	probably benign	0.32
R8745:Stab2	UTSW	10	86,805,213 (GRCm39)	missense	probably benign	0.32
R8782:Stab2	UTSW	10	86,735,685 (GRCm39)	missense	probably benign	0.00
R8875:Stab2	UTSW	10	86,832,728 (GRCm39)	missense	probably damaging	1.00
R8978:Stab2	UTSW	10	86,785,782 (GRCm39)	missense	possibly damaging	0.64
R9141:Stab2	UTSW	10	86,704,911 (GRCm39)	missense	probably damaging	1.00
R9248:Stab2	UTSW	10	86,727,481 (GRCm39)	missense	probably damaging	0.98
R9326:Stab2	UTSW	10	86,791,010 (GRCm39)	missense	probably damaging	1.00
R9426:Stab2	UTSW	10	86,704,911 (GRCm39)	missense	probably damaging	1.00
R9568:Stab2	UTSW	10	86,699,420 (GRCm39)	missense	probably damaging	1.00
R9627:Stab2	UTSW	10	86,793,704 (GRCm39)	missense	probably damaging	0.98
R9635:Stab2	UTSW	10	86,686,651 (GRCm39)	nonsense	probably null
R9648:Stab2	UTSW	10	86,692,561 (GRCm39)	frame shift	probably null
R9649:Stab2	UTSW	10	86,692,561 (GRCm39)	frame shift	probably null
R9650:Stab2	UTSW	10	86,692,561 (GRCm39)	frame shift	probably null
R9726:Stab2	UTSW	10	86,790,095 (GRCm39)	missense	probably benign	0.00
R9756:Stab2	UTSW	10	86,803,553 (GRCm39)	missense	possibly damaging	0.50
R9786:Stab2	UTSW	10	86,757,997 (GRCm39)	missense	probably benign	0.03
RF061:Stab2	UTSW	10	86,702,622 (GRCm39)	critical splice acceptor site	probably benign
X0023:Stab2	UTSW	10	86,758,062 (GRCm39)	critical splice acceptor site	probably null
X0025:Stab2	UTSW	10	86,723,680 (GRCm39)	missense	probably damaging	1.00
Z1176:Stab2	UTSW	10	86,785,778 (GRCm39)	missense	probably damaging	0.99
Z1177:Stab2	UTSW	10	86,732,460 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACAACTGTTCAGTGAGCTGG -3'
(R):5'- AGTTCAGCGTTCCTGGTCTG -3'

Sequencing Primer
(F):5'- GGGTGGAGTTTCCCTACCTC -3'
(R):5'- GCCCATCTACTCCCTTGAAAATC -3'

Posted On

2016-06-06