Mutagenetix > Incidental Mutation

Incidental Mutation 'R5073:Tenm2'

388999

Institutional Source

Beutler Lab

Gene Symbol

Tenm2

Ensembl Gene

ENSMUSG00000049336

Gene Name

teneurin transmembrane protein 2

Synonyms

D3Bwg1534e, Odz2, 9330187F13Rik, Ten-m2, 2610040L17Rik

MMRRC Submission

042662-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.569) question?

Stock #

R5073 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

35897483-37126791 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 35959208 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 1114 (T1114S)

Ref Sequence

ENSEMBL: ENSMUSP00000052014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057207] [ENSMUST00000102801] [ENSMUST00000163524]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000057207
AA Change: T1114S

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000052014
Gene: ENSMUSG00000049336
AA Change: T1114S

Domain	Start	End	E-Value	Type
Pfam:Ten_N	10	374	4.9e-177	PFAM
transmembrane domain	375	397	N/A	INTRINSIC
EGF	575	603	5.62e0	SMART
EGF_like	606	634	4.93e1	SMART
EGF	639	668	1.76e1	SMART
EGF	671	700	1.43e-1	SMART
EGF	705	735	1.2e1	SMART
EGF	738	766	9.63e0	SMART
EGF	769	797	1.25e1	SMART
EGF	800	832	1.4e0	SMART
low complexity region	1459	1475	N/A	INTRINSIC
low complexity region	2219	2230	N/A	INTRINSIC
Pfam:Tox-GHH	2681	2758	1.4e-34	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000102801
AA Change: T1113S

PolyPhen 2 Score 0.366 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000099865
Gene: ENSMUSG00000049336
AA Change: T1113S

Domain	Start	End	E-Value	Type
Pfam:Ten_N	9	374	2e-186	PFAM
transmembrane domain	375	397	N/A	INTRINSIC
EGF	575	603	5.62e0	SMART
EGF_like	606	634	4.93e1	SMART
EGF	639	668	1.76e1	SMART
EGF	671	700	1.43e-1	SMART
EGF	705	735	1.2e1	SMART
EGF	737	765	9.63e0	SMART
EGF	768	796	1.25e1	SMART
EGF	799	831	1.4e0	SMART
low complexity region	1458	1474	N/A	INTRINSIC
low complexity region	2218	2229	N/A	INTRINSIC
Pfam:Tox-GHH	2679	2757	2e-34	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000163524
AA Change: T1113S

PolyPhen 2 Score 0.366 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000129951
Gene: ENSMUSG00000049336
AA Change: T1113S

Domain	Start	End	E-Value	Type
Pfam:Ten_N	9	374	2e-186	PFAM
transmembrane domain	375	397	N/A	INTRINSIC
EGF	575	603	5.62e0	SMART
EGF_like	606	634	4.93e1	SMART
EGF	639	668	1.76e1	SMART
EGF	671	700	1.43e-1	SMART
EGF	705	735	1.2e1	SMART
EGF	737	765	9.63e0	SMART
EGF	768	796	1.25e1	SMART
EGF	799	831	1.4e0	SMART
low complexity region	1458	1474	N/A	INTRINSIC
low complexity region	2218	2229	N/A	INTRINSIC
Pfam:Tox-GHH	2679	2757	2e-34	PFAM

Meta Mutation Damage Score

0.0892

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.5%
20x: 92.6%

Validation Efficiency

100% (113/113)

MGI Phenotype

PHENOTYPE: Mice homozygous for a null allele show abnormalities in the laterality and mapping of ipsilateral retinal projections that lead to loss of ipsilateral drive, defects in binocular vision, and impaired performance on a visual discrimination task. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 104 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca3	C	T	17: 24,593,274 (GRCm39)	R224C	probably damaging	Het
Adcy8	A	T	15: 64,659,207 (GRCm39)	W528R	probably damaging	Het
Agbl5	G	A	5: 31,060,403 (GRCm39)	R141Q	probably damaging	Het
Ahnak	T	A	19: 8,980,595 (GRCm39)	H626Q	probably benign	Het
Ampd2	A	T	3: 107,986,549 (GRCm39)	M245K	probably damaging	Het
Apob	G	A	12: 8,055,219 (GRCm39)		probably null	Het
Apool	C	T	X: 111,259,540 (GRCm39)	Q60*	probably null	Het
Aqp1	A	T	6: 55,322,520 (GRCm39)	I172F	probably damaging	Het
Atp7a	A	G	X: 105,153,374 (GRCm39)	D1092G	probably benign	Het
Bcas3	A	G	11: 85,261,958 (GRCm39)	Y110C	probably damaging	Het
Brpf1	T	C	6: 113,287,215 (GRCm39)	S148P	probably damaging	Het
Capn3	A	G	2: 120,322,301 (GRCm39)	H339R	probably damaging	Het
Ccdc141	A	T	2: 76,954,722 (GRCm39)		probably null	Het
Ccl2	A	G	11: 81,927,984 (GRCm39)		probably benign	Het
Cct8l1	G	A	5: 25,721,881 (GRCm39)	V199I	probably benign	Het
Cdc23	C	A	18: 34,784,742 (GRCm39)	V7L	unknown	Het
Cit	T	A	5: 116,084,902 (GRCm39)	M811K	probably benign	Het
Crim1	T	C	17: 78,588,776 (GRCm39)	C284R	possibly damaging	Het
Cyp2d10	C	T	15: 82,287,954 (GRCm39)	R383H	probably benign	Het
Cyp4a29	A	G	4: 115,104,860 (GRCm39)	T123A	probably benign	Het
Dbndd2	A	G	2: 164,332,224 (GRCm39)		probably benign	Het
Dnaja3	A	T	16: 4,514,289 (GRCm39)	T274S	probably damaging	Het
Dot1l	A	G	10: 80,620,480 (GRCm39)	D514G	possibly damaging	Het
Dysf	A	T	6: 84,114,254 (GRCm39)	K1226M	probably damaging	Het
Eef1akmt1	A	G	14: 57,803,464 (GRCm39)	L30P	probably damaging	Het
Elavl1	A	G	8: 4,351,741 (GRCm39)	M125T	possibly damaging	Het
Eml4	C	A	17: 83,771,006 (GRCm39)	S723R	probably damaging	Het
Fgf15	A	C	7: 144,450,576 (GRCm39)	Y54S	possibly damaging	Het
Fign	A	T	2: 63,810,037 (GRCm39)	L411*	probably null	Het
Flt1	C	A	5: 147,620,749 (GRCm39)	A132S	probably benign	Het
Fryl	G	A	5: 73,232,110 (GRCm39)	P1550L	probably damaging	Het
Gas2l3	CACTCGTCATACT	CACT	10: 89,266,820 (GRCm39)		probably benign	Het
Gprasp2	C	T	X: 134,743,346 (GRCm39)	T235I	possibly damaging	Het
H2ab3	T	C	X: 119,222,543 (GRCm39)	T84A	probably damaging	Het
Hal	A	T	10: 93,349,904 (GRCm39)	I555F	probably damaging	Het
Hdac6	A	G	X: 7,811,036 (GRCm39)	F104L	probably damaging	Het
Hibadh	C	T	6: 52,597,079 (GRCm39)	V122M	possibly damaging	Het
Hmga1b	C	T	11: 120,654,012 (GRCm39)	Q100*	probably null	Het
Hydin	A	G	8: 111,265,105 (GRCm39)	N2763D	probably benign	Het
Ifi47	A	G	11: 48,986,361 (GRCm39)	T43A	probably benign	Het
Ifnlr1	A	G	4: 135,432,457 (GRCm39)	T298A	probably benign	Het
Impdh2	G	A	9: 108,440,535 (GRCm39)		probably null	Het
Insr	A	G	8: 3,209,475 (GRCm39)	F1203L	probably damaging	Het
Kcnq4	A	G	4: 120,574,714 (GRCm39)	S117P	probably damaging	Het
Kif19a	G	A	11: 114,658,053 (GRCm39)	M37I	probably benign	Het
Kif1a	T	C	1: 92,950,227 (GRCm39)	H1400R	probably damaging	Het
Kiss1r	C	A	10: 79,754,596 (GRCm39)	S30*	probably null	Het
Krt222	T	A	11: 99,134,796 (GRCm39)		probably benign	Het
Lekr1	A	T	3: 65,727,215 (GRCm39)		noncoding transcript	Het
Ltn1	A	G	16: 87,224,628 (GRCm39)	V32A	probably damaging	Het
Marchf1	T	A	8: 66,839,020 (GRCm39)	W21R	probably benign	Het
Marchf5	A	G	19: 37,188,207 (GRCm39)	N58S	possibly damaging	Het
Mast4	G	A	13: 102,875,391 (GRCm39)	Q1158*	probably null	Het
Mib2	C	G	4: 155,741,233 (GRCm39)	A535P	probably damaging	Het
Mrtfa	A	G	15: 80,906,627 (GRCm39)	V91A	probably damaging	Het
Msc	C	T	1: 14,824,537 (GRCm39)	V178M	probably benign	Het
Muc4	C	A	16: 32,754,529 (GRCm38)	H1468N	probably benign	Het
Muc5b	A	T	7: 141,412,999 (GRCm39)	T1982S	unknown	Het
Mvk	A	T	5: 114,591,013 (GRCm39)		probably benign	Het
Myo1a	T	C	10: 127,543,288 (GRCm39)		probably null	Het
Myo6	T	G	9: 80,195,290 (GRCm39)	S887A	probably benign	Het
Myo7a	G	A	7: 97,722,425 (GRCm39)	Q1167*	probably null	Het
Ncald	A	T	15: 37,397,478 (GRCm39)	H67Q	probably damaging	Het
Nmnat1	C	A	4: 149,553,595 (GRCm39)	M172I	probably benign	Het
Nudt1	G	T	5: 140,317,662 (GRCm39)		probably null	Het
Nudt5	T	A	2: 5,869,198 (GRCm39)	H141Q	probably benign	Het
Or1m1	T	C	9: 18,666,118 (GRCm39)	E271G	possibly damaging	Het
Or4e1	T	A	14: 52,701,032 (GRCm39)	M118L	probably damaging	Het
Or8h10	A	T	2: 86,808,666 (GRCm39)	V158D	possibly damaging	Het
Parp14	A	T	16: 35,655,077 (GRCm39)	I1798K	probably damaging	Het
Pcdhga7	A	G	18: 37,849,025 (GRCm39)	D344G	probably damaging	Het
Pck1	A	G	2: 172,998,770 (GRCm39)	T343A	probably benign	Het
Pik3c2g	T	A	6: 139,665,873 (GRCm39)	C65S	probably null	Het
Pilra	A	G	5: 137,833,674 (GRCm39)	F131L	probably damaging	Het
Ppl	A	T	16: 4,906,742 (GRCm39)	S1184R	probably benign	Het
Prmt2	C	T	10: 76,058,390 (GRCm39)	V140I	probably damaging	Het
Prpf38b	A	G	3: 108,818,484 (GRCm39)	F92S	probably damaging	Het
Psmc3	A	G	2: 90,884,915 (GRCm39)		probably benign	Het
Ptgs1	A	T	2: 36,141,272 (GRCm39)	N573I	probably damaging	Het
Rgs9	C	A	11: 109,118,157 (GRCm39)	A332S	probably benign	Het
Rptor	T	C	11: 119,787,305 (GRCm39)	I1290T	possibly damaging	Het
Slc38a7	C	A	8: 96,568,278 (GRCm39)	R369L	probably damaging	Het
Slc4a2	G	A	5: 24,643,760 (GRCm39)	S855N	probably benign	Het
Slco2a1	G	T	9: 102,923,925 (GRCm39)	L46F	probably damaging	Het
Snrpd3	G	T	10: 75,355,227 (GRCm39)	C20F	possibly damaging	Het
Stab2	A	T	10: 86,699,422 (GRCm39)	I481N	probably benign	Het
Tbc1d9	A	G	8: 83,960,176 (GRCm39)	E143G	probably damaging	Het
Tg	A	C	15: 66,607,101 (GRCm39)	M213L	probably benign	Het
Tnc	A	G	4: 63,938,648 (GRCm39)	C64R	probably damaging	Het
Tpd52l1	A	G	10: 31,233,916 (GRCm39)	L79S	probably damaging	Het
Tpp2	C	A	1: 43,993,896 (GRCm39)	S260R	possibly damaging	Het
Tppp2	G	A	14: 52,157,912 (GRCm39)	R119Q	probably benign	Het
Tshz2	A	T	2: 169,804,493 (GRCm39)		probably benign	Het
Tuba8	T	C	6: 121,199,862 (GRCm39)	V182A	probably damaging	Het
Ufl1	A	G	4: 25,254,780 (GRCm39)	Y559H	probably benign	Het
Usp53	A	T	3: 122,727,595 (GRCm39)	S996T	probably benign	Het
Vcam1	A	G	3: 115,918,037 (GRCm39)	V308A	probably damaging	Het
Wdr17	T	A	8: 55,143,271 (GRCm39)		probably null	Het
Wdr6	G	A	9: 108,451,565 (GRCm39)	H773Y	probably damaging	Het
Wnk4	T	G	11: 101,152,014 (GRCm39)	F173V	probably damaging	Het
Xrcc5	T	C	1: 72,378,188 (GRCm39)	Y395H	probably damaging	Het
Zcwpw1	T	A	5: 137,793,781 (GRCm39)	M1K	probably null	Het
Zfp263	A	G	16: 3,564,704 (GRCm39)	R240G	possibly damaging	Het
Zfp652	A	G	11: 95,640,890 (GRCm39)	I272V	possibly damaging	Het

Other mutations in Tenm2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00161:Tenm2	APN	11	36,097,726 (GRCm39)	splice site	probably benign
IGL00834:Tenm2	APN	11	35,915,085 (GRCm39)	missense	probably damaging	1.00
IGL00911:Tenm2	APN	11	35,899,560 (GRCm39)	nonsense	probably null
IGL00937:Tenm2	APN	11	35,915,450 (GRCm39)	missense	probably damaging	1.00
IGL01154:Tenm2	APN	11	35,932,371 (GRCm39)	missense	probably damaging	1.00
IGL01313:Tenm2	APN	11	35,915,075 (GRCm39)	missense	probably damaging	0.98
IGL01346:Tenm2	APN	11	35,918,232 (GRCm39)	nonsense	probably null
IGL01539:Tenm2	APN	11	35,997,654 (GRCm39)	missense	possibly damaging	0.89
IGL01629:Tenm2	APN	11	36,755,711 (GRCm39)	missense	probably damaging	0.98
IGL01780:Tenm2	APN	11	35,937,768 (GRCm39)	missense	probably benign
IGL01821:Tenm2	APN	11	35,914,710 (GRCm39)	missense	probably damaging	0.98
IGL01988:Tenm2	APN	11	35,918,078 (GRCm39)	missense	probably damaging	1.00
IGL02002:Tenm2	APN	11	36,097,922 (GRCm39)	missense	probably benign
IGL02449:Tenm2	APN	11	35,914,449 (GRCm39)	missense	probably damaging	0.99
IGL02505:Tenm2	APN	11	35,942,743 (GRCm39)	nonsense	probably null
IGL02649:Tenm2	APN	11	36,097,912 (GRCm39)	missense	possibly damaging	0.85
IGL02688:Tenm2	APN	11	35,959,285 (GRCm39)	missense	probably benign	0.05
IGL02801:Tenm2	APN	11	35,937,857 (GRCm39)	nonsense	probably null
IGL02928:Tenm2	APN	11	35,917,997 (GRCm39)	missense	possibly damaging	0.69
IGL02940:Tenm2	APN	11	35,932,471 (GRCm39)	missense	probably damaging	1.00
IGL03202:Tenm2	APN	11	35,915,375 (GRCm39)	missense	probably damaging	1.00
IGL03213:Tenm2	APN	11	35,914,157 (GRCm39)	missense	probably benign	0.05
IGL03276:Tenm2	APN	11	35,963,603 (GRCm39)	missense	possibly damaging	0.95
IGL03296:Tenm2	APN	11	35,942,852 (GRCm39)	splice site	probably null
IGL03381:Tenm2	APN	11	35,959,238 (GRCm39)	missense	probably benign	0.01
IGL03398:Tenm2	APN	11	35,915,370 (GRCm39)	missense	probably damaging	1.00
browser	UTSW	11	35,937,592 (GRCm39)	critical splice donor site	probably null
mosaic	UTSW	11	35,954,602 (GRCm39)	critical splice donor site	probably null
IGL02799:Tenm2	UTSW	11	36,164,235 (GRCm39)	missense	probably damaging	1.00
PIT4260001:Tenm2	UTSW	11	36,054,557 (GRCm39)	missense	probably damaging	1.00
PIT4382001:Tenm2	UTSW	11	35,954,729 (GRCm39)	missense	probably damaging	0.99
R0004:Tenm2	UTSW	11	35,914,184 (GRCm39)	missense	probably damaging	1.00
R0420:Tenm2	UTSW	11	36,097,951 (GRCm39)	splice site	probably benign
R0537:Tenm2	UTSW	11	36,054,557 (GRCm39)	missense	probably damaging	1.00
R0599:Tenm2	UTSW	11	35,915,607 (GRCm39)	missense	possibly damaging	0.93
R0636:Tenm2	UTSW	11	36,834,803 (GRCm39)	missense	probably damaging	1.00
R0693:Tenm2	UTSW	11	35,915,636 (GRCm39)	missense	probably damaging	1.00
R0991:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R0992:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1167:Tenm2	UTSW	11	36,755,511 (GRCm39)	missense	probably benign	0.30
R1177:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1178:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1179:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1180:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1181:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1193:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1194:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1195:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1195:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1195:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1259:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1265:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1267:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1268:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1269:Tenm2	UTSW	11	35,899,185 (GRCm39)	missense	possibly damaging	0.64
R1270:Tenm2	UTSW	11	35,932,486 (GRCm39)	missense	probably damaging	1.00
R1272:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1273:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1311:Tenm2	UTSW	11	35,959,421 (GRCm39)	splice site	probably benign
R1374:Tenm2	UTSW	11	35,899,281 (GRCm39)	missense	probably benign	0.00
R1542:Tenm2	UTSW	11	36,191,047 (GRCm39)	missense	probably damaging	0.99
R1573:Tenm2	UTSW	11	35,937,896 (GRCm39)	missense	probably damaging	1.00
R1579:Tenm2	UTSW	11	35,997,610 (GRCm39)	missense	probably damaging	1.00
R1697:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1722:Tenm2	UTSW	11	35,898,930 (GRCm39)	missense	probably damaging	1.00
R1756:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1793:Tenm2	UTSW	11	35,914,209 (GRCm39)	missense	probably damaging	0.99
R1950:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1954:Tenm2	UTSW	11	35,938,374 (GRCm39)	missense	possibly damaging	0.87
R2025:Tenm2	UTSW	11	35,938,091 (GRCm39)	nonsense	probably null
R2117:Tenm2	UTSW	11	35,915,681 (GRCm39)	missense	probably damaging	1.00
R2244:Tenm2	UTSW	11	36,755,689 (GRCm39)	missense	probably damaging	0.98
R2298:Tenm2	UTSW	11	35,937,604 (GRCm39)	missense	possibly damaging	0.62
R2432:Tenm2	UTSW	11	35,918,018 (GRCm39)	missense	probably damaging	1.00
R3014:Tenm2	UTSW	11	35,914,800 (GRCm39)	missense	probably damaging	1.00
R3115:Tenm2	UTSW	11	35,914,193 (GRCm39)	missense	probably damaging	1.00
R3684:Tenm2	UTSW	11	35,942,644 (GRCm39)	missense	probably benign	0.00
R3685:Tenm2	UTSW	11	35,942,644 (GRCm39)	missense	probably benign	0.00
R3705:Tenm2	UTSW	11	35,959,153 (GRCm39)	missense	probably damaging	0.97
R3820:Tenm2	UTSW	11	35,915,147 (GRCm39)	missense	probably damaging	0.98
R3821:Tenm2	UTSW	11	35,915,147 (GRCm39)	missense	probably damaging	0.98
R3822:Tenm2	UTSW	11	35,915,147 (GRCm39)	missense	probably damaging	0.98
R3844:Tenm2	UTSW	11	35,938,365 (GRCm39)	missense	probably damaging	0.98
R3878:Tenm2	UTSW	11	36,030,401 (GRCm39)	critical splice donor site	probably null
R4019:Tenm2	UTSW	11	35,937,901 (GRCm39)	missense	probably benign	0.04
R4062:Tenm2	UTSW	11	35,899,482 (GRCm39)	missense	probably damaging	1.00
R4367:Tenm2	UTSW	11	35,918,225 (GRCm39)	missense	probably benign
R4395:Tenm2	UTSW	11	35,915,451 (GRCm39)	missense	probably benign	0.23
R4508:Tenm2	UTSW	11	35,899,172 (GRCm39)	missense	possibly damaging	0.82
R4534:Tenm2	UTSW	11	35,953,931 (GRCm39)	missense	possibly damaging	0.64
R4539:Tenm2	UTSW	11	35,937,607 (GRCm39)	missense	probably damaging	1.00
R4644:Tenm2	UTSW	11	35,937,963 (GRCm39)	missense	probably benign	0.00
R4661:Tenm2	UTSW	11	35,915,275 (GRCm39)	missense	probably damaging	0.99
R4669:Tenm2	UTSW	11	35,901,314 (GRCm39)	missense	probably damaging	1.00
R4687:Tenm2	UTSW	11	35,939,924 (GRCm39)	missense	probably benign
R4711:Tenm2	UTSW	11	36,191,039 (GRCm39)	missense	probably damaging	0.98
R4816:Tenm2	UTSW	11	35,918,117 (GRCm39)	missense	probably damaging	1.00
R4843:Tenm2	UTSW	11	35,914,847 (GRCm39)	missense	probably damaging	1.00
R4850:Tenm2	UTSW	11	35,914,315 (GRCm39)	nonsense	probably null
R4870:Tenm2	UTSW	11	35,969,396 (GRCm39)	missense	probably damaging	1.00
R5058:Tenm2	UTSW	11	36,097,907 (GRCm39)	missense	possibly damaging	0.80
R5071:Tenm2	UTSW	11	35,959,208 (GRCm39)	missense	probably damaging	0.99
R5074:Tenm2	UTSW	11	35,959,208 (GRCm39)	missense	probably damaging	0.99
R5081:Tenm2	UTSW	11	35,915,460 (GRCm39)	missense	possibly damaging	0.95
R5093:Tenm2	UTSW	11	36,834,989 (GRCm39)	missense	probably damaging	1.00
R5170:Tenm2	UTSW	11	35,915,633 (GRCm39)	missense	probably damaging	0.98
R5253:Tenm2	UTSW	11	35,938,028 (GRCm39)	nonsense	probably null
R5343:Tenm2	UTSW	11	35,960,330 (GRCm39)	missense	probably benign	0.00
R5493:Tenm2	UTSW	11	36,755,503 (GRCm39)	missense	probably benign	0.01
R5600:Tenm2	UTSW	11	36,054,541 (GRCm39)	splice site	probably null
R5677:Tenm2	UTSW	11	36,032,510 (GRCm39)	missense	probably damaging	0.98
R5703:Tenm2	UTSW	11	35,914,626 (GRCm39)	missense	probably benign	0.34
R5707:Tenm2	UTSW	11	35,938,009 (GRCm39)	missense	possibly damaging	0.79
R6026:Tenm2	UTSW	11	35,963,556 (GRCm39)	critical splice donor site	probably null
R6063:Tenm2	UTSW	11	36,054,544 (GRCm39)	critical splice donor site	probably null
R6086:Tenm2	UTSW	11	35,899,473 (GRCm39)	missense	possibly damaging	0.64
R6151:Tenm2	UTSW	11	35,899,610 (GRCm39)	missense	probably damaging	1.00
R6169:Tenm2	UTSW	11	36,030,517 (GRCm39)	missense	probably damaging	0.99
R6193:Tenm2	UTSW	11	35,937,621 (GRCm39)	missense	probably damaging	1.00
R6405:Tenm2	UTSW	11	36,755,686 (GRCm39)	missense	probably benign	0.44
R6477:Tenm2	UTSW	11	35,901,334 (GRCm39)	critical splice acceptor site	probably null
R6607:Tenm2	UTSW	11	35,954,602 (GRCm39)	critical splice donor site	probably null
R6668:Tenm2	UTSW	11	35,937,592 (GRCm39)	critical splice donor site	probably null
R6825:Tenm2	UTSW	11	35,937,711 (GRCm39)	missense	probably benign	0.02
R6885:Tenm2	UTSW	11	35,914,407 (GRCm39)	missense	possibly damaging	0.95
R7017:Tenm2	UTSW	11	36,062,236 (GRCm39)	missense	probably damaging	0.98
R7115:Tenm2	UTSW	11	36,054,644 (GRCm39)	missense	probably damaging	0.99
R7153:Tenm2	UTSW	11	35,915,009 (GRCm39)	missense	probably damaging	0.98
R7173:Tenm2	UTSW	11	35,932,378 (GRCm39)	missense	probably damaging	0.99
R7199:Tenm2	UTSW	11	36,062,263 (GRCm39)	missense	probably damaging	1.00
R7205:Tenm2	UTSW	11	35,939,956 (GRCm39)	missense	probably damaging	0.99
R7250:Tenm2	UTSW	11	35,963,625 (GRCm39)	missense	probably damaging	1.00
R7290:Tenm2	UTSW	11	35,914,298 (GRCm39)	missense	probably damaging	1.00
R7366:Tenm2	UTSW	11	35,960,241 (GRCm39)	missense	probably benign	0.09
R7432:Tenm2	UTSW	11	36,755,768 (GRCm39)	missense	probably benign
R7504:Tenm2	UTSW	11	36,030,570 (GRCm39)	missense	probably damaging	1.00
R7513:Tenm2	UTSW	11	35,942,727 (GRCm39)	missense	probably benign	0.34
R7523:Tenm2	UTSW	11	35,969,408 (GRCm39)	splice site	probably null
R7527:Tenm2	UTSW	11	36,097,803 (GRCm39)	missense	probably damaging	1.00
R7648:Tenm2	UTSW	11	35,997,563 (GRCm39)	missense	probably damaging	1.00
R7653:Tenm2	UTSW	11	35,938,174 (GRCm39)	missense	probably benign	0.09
R7717:Tenm2	UTSW	11	36,755,762 (GRCm39)	missense	probably damaging	0.97
R7739:Tenm2	UTSW	11	35,960,388 (GRCm39)	missense	possibly damaging	0.50
R7762:Tenm2	UTSW	11	35,914,133 (GRCm39)	missense	possibly damaging	0.74
R7786:Tenm2	UTSW	11	35,901,276 (GRCm39)	missense	probably damaging	0.99
R7803:Tenm2	UTSW	11	35,937,943 (GRCm39)	missense	probably damaging	0.98
R7834:Tenm2	UTSW	11	35,915,681 (GRCm39)	missense	probably damaging	1.00
R7838:Tenm2	UTSW	11	35,997,626 (GRCm39)	missense	probably benign	0.02
R8073:Tenm2	UTSW	11	36,030,471 (GRCm39)	missense	possibly damaging	0.56
R8076:Tenm2	UTSW	11	35,918,048 (GRCm39)	missense	probably benign	0.23
R8109:Tenm2	UTSW	11	35,899,137 (GRCm39)	missense	probably benign
R8306:Tenm2	UTSW	11	35,960,196 (GRCm39)	missense	possibly damaging	0.52
R8352:Tenm2	UTSW	11	35,914,428 (GRCm39)	missense	probably damaging	0.98
R8452:Tenm2	UTSW	11	35,914,428 (GRCm39)	missense	probably damaging	0.98
R8864:Tenm2	UTSW	11	35,918,022 (GRCm39)	missense	possibly damaging	0.95
R8880:Tenm2	UTSW	11	35,942,788 (GRCm39)	missense	probably damaging	0.99
R8943:Tenm2	UTSW	11	36,834,861 (GRCm39)	missense	probably damaging	0.98
R8969:Tenm2	UTSW	11	35,942,688 (GRCm39)	missense	probably damaging	0.99
R9168:Tenm2	UTSW	11	35,930,722 (GRCm39)	missense	probably damaging	1.00
R9279:Tenm2	UTSW	11	35,959,303 (GRCm39)	missense	probably benign	0.00
R9294:Tenm2	UTSW	11	35,915,327 (GRCm39)	missense	probably damaging	0.98
R9320:Tenm2	UTSW	11	35,914,474 (GRCm39)	missense	probably damaging	0.99
R9373:Tenm2	UTSW	11	35,930,713 (GRCm39)	missense	probably damaging	1.00
R9408:Tenm2	UTSW	11	35,960,246 (GRCm39)	missense	probably damaging	1.00
R9410:Tenm2	UTSW	11	36,032,396 (GRCm39)	missense	probably damaging	0.99
R9454:Tenm2	UTSW	11	36,112,286 (GRCm39)	missense	probably benign
R9489:Tenm2	UTSW	11	36,834,791 (GRCm39)	missense	probably damaging	0.99
R9711:Tenm2	UTSW	11	35,915,341 (GRCm39)	missense	probably damaging	0.99
RF021:Tenm2	UTSW	11	35,915,030 (GRCm39)	missense	possibly damaging	0.95
X0018:Tenm2	UTSW	11	35,915,027 (GRCm39)	missense	probably damaging	1.00
X0063:Tenm2	UTSW	11	35,915,557 (GRCm39)	missense	probably benign
Z1088:Tenm2	UTSW	11	36,164,094 (GRCm39)	missense	probably damaging	1.00
Z1177:Tenm2	UTSW	11	36,191,162 (GRCm39)	missense	probably damaging	0.98
Z1177:Tenm2	UTSW	11	35,899,061 (GRCm39)	missense	possibly damaging	0.95
Z1177:Tenm2	UTSW	11	36,275,957 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- ACATAAGGCCCCTGGAAGAG -3'
(R):5'- GGTAGATCAACCATGTGTTTCCC -3'

Sequencing Primer
(F):5'- CCCCTGGAAGAGAGATTGTTG -3'
(R):5'- GAAATTGAGCTCCCTGGTACCAATG -3'

Posted On

2016-06-06