Incidental Mutation 'R5021:Decr2'
ID 389209
Institutional Source Beutler Lab
Gene Symbol Decr2
Ensembl Gene ENSMUSG00000036775
Gene Name 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal
Synonyms
MMRRC Submission 042612-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5021 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 26300182-26309096 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 26301980 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 250 (L250Q)
Ref Sequence ENSEMBL: ENSMUSP00000045621 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040907]
AlphaFold Q9WV68
Predicted Effect probably damaging
Transcript: ENSMUST00000040907
AA Change: L250Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000045621
Gene: ENSMUSG00000036775
AA Change: L250Q

DomainStartEndE-ValueType
Blast:NDK 1 28 5e-9 BLAST
Pfam:adh_short 29 224 3.6e-44 PFAM
Pfam:KR 30 208 3.8e-11 PFAM
Pfam:adh_short_C2 35 271 6.4e-30 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123056
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134696
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137672
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150534
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 89.8%
Validation Efficiency 95% (39/41)
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano5 A T 7: 51,205,933 (GRCm39) T242S probably benign Het
B3gnt4 G C 5: 123,649,010 (GRCm39) R125P probably damaging Het
Blvrb A C 7: 27,147,543 (GRCm39) M1L probably benign Het
Cep112 T A 11: 108,361,154 (GRCm39) H169Q possibly damaging Het
Clcn1 A T 6: 42,287,922 (GRCm39) K718* probably null Het
Clhc1 A G 11: 29,510,627 (GRCm39) N226S probably benign Het
Cpne1 T C 2: 155,940,193 (GRCm39) probably benign Het
Cspg4 G A 9: 56,805,014 (GRCm39) V1942I probably benign Het
Depdc5 A G 5: 33,136,758 (GRCm39) T1343A probably damaging Het
Eed A T 7: 89,621,513 (GRCm39) L45M probably damaging Het
Ep300 T A 15: 81,524,224 (GRCm39) S1351T unknown Het
Fam184b T A 5: 45,730,604 (GRCm39) Q476L probably benign Het
Gm10722 A C 9: 3,001,041 (GRCm39) Y39S probably benign Het
Herc1 A T 9: 66,377,608 (GRCm39) K3458M possibly damaging Het
Ift122 A G 6: 115,841,333 (GRCm39) D39G probably benign Het
Igf2bp1 A G 11: 95,864,832 (GRCm39) Y206H probably damaging Het
Ighv1-19 T C 12: 114,672,686 (GRCm39) I6V probably benign Het
Itm2c T C 1: 85,833,059 (GRCm39) I131T probably damaging Het
Kcnd3 A T 3: 105,566,070 (GRCm39) D417V probably damaging Het
Klf4 T C 4: 55,530,970 (GRCm39) E38G probably damaging Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lct T C 1: 128,228,302 (GRCm39) M1064V probably benign Het
Map4 C T 9: 109,867,157 (GRCm39) Q265* probably null Het
Mcf2l T G 8: 13,061,808 (GRCm39) V893G probably damaging Het
Mlst8 C T 17: 24,696,193 (GRCm39) D179N possibly damaging Het
Mup6 T A 4: 59,964,352 (GRCm39) N18K probably damaging Het
Nbeal2 G A 9: 110,466,531 (GRCm39) R764W probably damaging Het
Ncoa6 A T 2: 155,248,869 (GRCm39) S1478R probably benign Het
Pcdhga1 C A 18: 37,796,876 (GRCm39) R627S probably damaging Het
Sacm1l A G 9: 123,411,393 (GRCm39) D394G probably damaging Het
Schip1 A G 3: 68,402,585 (GRCm39) T221A probably benign Het
Slc35c1 A G 2: 92,289,366 (GRCm39) Y47H possibly damaging Het
Tspan32 A G 7: 142,568,715 (GRCm39) D70G probably damaging Het
Vmn2r68 T C 7: 84,882,942 (GRCm39) Y270C possibly damaging Het
Zfp777 A G 6: 48,019,061 (GRCm39) V291A probably damaging Het
Other mutations in Decr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01657:Decr2 APN 17 26,301,926 (GRCm39) missense probably damaging 1.00
IGL02023:Decr2 APN 17 26,306,354 (GRCm39) missense probably benign 0.01
R0003:Decr2 UTSW 17 26,302,027 (GRCm39) missense probably benign 0.00
R0003:Decr2 UTSW 17 26,302,027 (GRCm39) missense probably benign 0.00
R1583:Decr2 UTSW 17 26,301,998 (GRCm39) missense probably damaging 0.99
R1588:Decr2 UTSW 17 26,302,002 (GRCm39) missense possibly damaging 0.91
R1903:Decr2 UTSW 17 26,306,387 (GRCm39) missense probably damaging 0.99
R1968:Decr2 UTSW 17 26,302,053 (GRCm39) missense probably benign 0.00
R2269:Decr2 UTSW 17 26,302,858 (GRCm39) missense probably benign 0.03
R4758:Decr2 UTSW 17 26,307,914 (GRCm39) missense probably damaging 0.96
R5174:Decr2 UTSW 17 26,306,443 (GRCm39) splice site probably null
R6608:Decr2 UTSW 17 26,302,858 (GRCm39) missense probably benign 0.30
R6661:Decr2 UTSW 17 26,302,561 (GRCm39) missense possibly damaging 0.53
R8036:Decr2 UTSW 17 26,301,962 (GRCm39) missense probably damaging 0.97
R8799:Decr2 UTSW 17 26,307,911 (GRCm39) missense possibly damaging 0.94
R8969:Decr2 UTSW 17 26,306,355 (GRCm39) missense probably benign
R9706:Decr2 UTSW 17 26,302,869 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ATCCAAGGACATGGGGATCC -3'
(R):5'- CATCATGTGGGTTCAGTGTCAG -3'

Sequencing Primer
(F):5'- TCCCGAGAAGTGGGAACAACAC -3'
(R):5'- TTGGCCTTGATAGAGCAACC -3'
Posted On 2016-06-06