Mutagenetix > Incidental Mutation

Incidental Mutation 'R5036:Vmn2r98'

389551

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r98

Ensembl Gene

ENSMUSG00000096717

Gene Name

vomeronasal 2, receptor 98

Synonyms

EG224552

MMRRC Submission

042627-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R5036 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

19273755-19301573 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19286419 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 306 (I306V)

Ref Sequence

ENSEMBL: ENSMUSP00000131261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170424]

AlphaFold

E9PZ56

Predicted Effect

probably benign
Transcript: ENSMUST00000170424
AA Change: I306V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: I306V

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	460	2.6e-35	PFAM
Pfam:NCD3G	509	562	7.4e-22	PFAM
Pfam:7tm_3	594	830	1.4e-52	PFAM
low complexity region	844	856	N/A	INTRINSIC

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.0%
3x: 98.2%
10x: 95.7%
20x: 90.1%

Validation Efficiency

100% (44/44)

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610021A01Rik	G	A	7: 41,275,578 (GRCm39)	G427D	possibly damaging	Het
Agbl5	G	A	5: 31,060,403 (GRCm39)	R141Q	probably damaging	Het
C4b	T	A	17: 34,959,419 (GRCm39)		probably null	Het
Cabyr	A	T	18: 12,884,303 (GRCm39)	E263D	probably damaging	Het
Car1	A	T	3: 14,841,299 (GRCm39)	D45E	possibly damaging	Het
Col25a1	T	C	3: 130,376,978 (GRCm39)		probably null	Het
Dnah6	G	T	6: 73,021,674 (GRCm39)	S3549R	probably benign	Het
Dync1h1	A	T	12: 110,596,969 (GRCm39)	I1639F	probably damaging	Het
Fhad1	A	T	4: 141,648,052 (GRCm39)	D271E	probably benign	Het
Gle1	T	C	2: 29,826,223 (GRCm39)	S101P	probably benign	Het
Gm4781	C	A	10: 100,232,851 (GRCm39)		noncoding transcript	Het
Gpatch3	A	G	4: 133,305,461 (GRCm39)	Y232C	probably damaging	Het
Gtf2ird2	A	G	5: 134,246,349 (GRCm39)	N869S	probably damaging	Het
Ifi204	G	A	1: 173,580,311 (GRCm39)	P400S	possibly damaging	Het
Ighv2-2	T	C	12: 113,552,092 (GRCm39)	T49A	possibly damaging	Het
Itsn1	T	A	16: 91,579,123 (GRCm39)		probably benign	Het
Mib2	A	T	4: 155,740,745 (GRCm39)	N626K	probably damaging	Het
Nf1	C	A	11: 79,337,690 (GRCm39)	Q1098K	probably damaging	Het
Odc1	C	A	12: 17,598,020 (GRCm39)	Q116K	probably damaging	Het
Otof	C	T	5: 30,541,783 (GRCm39)	E761K	possibly damaging	Het
Palld	A	T	8: 62,003,196 (GRCm39)	V301D	probably damaging	Het
Pask	A	T	1: 93,249,801 (GRCm39)	L533*	probably null	Het
Plekhh2	T	C	17: 84,879,189 (GRCm39)	S638P	probably damaging	Het
Scaf8	T	A	17: 3,214,537 (GRCm39)		probably benign	Het
Sdccag8	G	T	1: 176,839,541 (GRCm39)	R695L	probably damaging	Het
Serpina1c	A	G	12: 103,865,085 (GRCm39)	I187T	probably damaging	Het
Slitrk5	G	T	14: 111,918,316 (GRCm39)	G647W	possibly damaging	Het
Sycp1	T	A	3: 102,727,916 (GRCm39)	K899M	probably damaging	Het
Taok1	G	A	11: 77,440,157 (GRCm39)	R617C	probably benign	Het
Tbc1d32	A	C	10: 56,071,500 (GRCm39)	Y341*	probably null	Het
Tenm4	A	G	7: 96,343,997 (GRCm39)	N267D	probably damaging	Het
Tenm4	T	C	7: 96,501,768 (GRCm39)	V1287A	probably damaging	Het
Tsga10	A	T	1: 37,823,049 (GRCm39)	V488E	possibly damaging	Het
Ttc39c	G	T	18: 12,820,138 (GRCm39)		probably null	Het
Uck1	A	T	2: 32,148,478 (GRCm39)		probably benign	Het

Other mutations in Vmn2r98

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r98	APN	17	19,286,007 (GRCm39)	splice site	probably benign
IGL01296:Vmn2r98	APN	17	19,285,447 (GRCm39)	missense	probably damaging	1.00
IGL01363:Vmn2r98	APN	17	19,286,020 (GRCm39)	missense	probably benign	0.01
IGL01618:Vmn2r98	APN	17	19,285,521 (GRCm39)	missense	possibly damaging	0.93
IGL01746:Vmn2r98	APN	17	19,286,713 (GRCm39)	missense	probably damaging	1.00
IGL01747:Vmn2r98	APN	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
IGL01770:Vmn2r98	APN	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
IGL01868:Vmn2r98	APN	17	19,286,548 (GRCm39)	missense	probably benign
IGL02123:Vmn2r98	APN	17	19,300,941 (GRCm39)	missense	probably damaging	1.00
IGL02323:Vmn2r98	APN	17	19,286,113 (GRCm39)	missense	probably damaging	0.99
IGL02543:Vmn2r98	APN	17	19,286,083 (GRCm39)	missense	probably benign
IGL02650:Vmn2r98	APN	17	19,301,223 (GRCm39)	missense	probably benign	0.00
IGL02676:Vmn2r98	APN	17	19,285,521 (GRCm39)	missense	probably benign	0.00
IGL02803:Vmn2r98	APN	17	19,286,275 (GRCm39)	missense	probably benign
IGL02807:Vmn2r98	APN	17	19,301,283 (GRCm39)	missense	probably damaging	1.00
IGL03307:Vmn2r98	APN	17	19,286,242 (GRCm39)	missense	possibly damaging	0.62
IGL03396:Vmn2r98	APN	17	19,290,107 (GRCm39)	missense	possibly damaging	0.92
PIT4131001:Vmn2r98	UTSW	17	19,301,223 (GRCm39)	missense	probably benign	0.00
R0122:Vmn2r98	UTSW	17	19,286,662 (GRCm39)	missense	probably benign	0.06
R0329:Vmn2r98	UTSW	17	19,286,609 (GRCm39)	missense	probably benign	0.21
R0330:Vmn2r98	UTSW	17	19,286,609 (GRCm39)	missense	probably benign	0.21
R0368:Vmn2r98	UTSW	17	19,286,089 (GRCm39)	nonsense	probably null
R0545:Vmn2r98	UTSW	17	19,273,875 (GRCm39)	missense	probably benign	0.15
R0635:Vmn2r98	UTSW	17	19,300,759 (GRCm39)	missense	probably benign	0.00
R0689:Vmn2r98	UTSW	17	19,300,782 (GRCm39)	missense	possibly damaging	0.83
R1035:Vmn2r98	UTSW	17	19,301,011 (GRCm39)	missense	possibly damaging	0.90
R1243:Vmn2r98	UTSW	17	19,286,210 (GRCm39)	missense	possibly damaging	0.52
R1421:Vmn2r98	UTSW	17	19,285,440 (GRCm39)	missense	probably damaging	1.00
R1629:Vmn2r98	UTSW	17	19,287,645 (GRCm39)	missense	possibly damaging	0.94
R1643:Vmn2r98	UTSW	17	19,301,170 (GRCm39)	missense	probably damaging	1.00
R1795:Vmn2r98	UTSW	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
R1958:Vmn2r98	UTSW	17	19,286,680 (GRCm39)	missense	possibly damaging	0.70
R1962:Vmn2r98	UTSW	17	19,285,595 (GRCm39)	nonsense	probably null
R2165:Vmn2r98	UTSW	17	19,301,553 (GRCm39)	missense	unknown
R2238:Vmn2r98	UTSW	17	19,286,213 (GRCm39)	missense	probably damaging	1.00
R2252:Vmn2r98	UTSW	17	19,300,698 (GRCm39)	missense	probably benign	0.00
R2323:Vmn2r98	UTSW	17	19,286,081 (GRCm39)	missense	probably benign	0.18
R2887:Vmn2r98	UTSW	17	19,301,439 (GRCm39)	missense	possibly damaging	0.83
R2909:Vmn2r98	UTSW	17	19,287,664 (GRCm39)	missense	probably damaging	1.00
R3001:Vmn2r98	UTSW	17	19,286,125 (GRCm39)	missense	probably benign	0.01
R3002:Vmn2r98	UTSW	17	19,286,125 (GRCm39)	missense	probably benign	0.01
R3003:Vmn2r98	UTSW	17	19,286,125 (GRCm39)	missense	probably benign	0.01
R3788:Vmn2r98	UTSW	17	19,300,887 (GRCm39)	missense	probably benign	0.31
R4570:Vmn2r98	UTSW	17	19,286,354 (GRCm39)	missense	probably benign	0.11
R4706:Vmn2r98	UTSW	17	19,290,007 (GRCm39)	missense	probably damaging	1.00
R4723:Vmn2r98	UTSW	17	19,286,602 (GRCm39)	missense	probably benign	0.01
R5072:Vmn2r98	UTSW	17	19,286,306 (GRCm39)	missense	probably benign	0.07
R5121:Vmn2r98	UTSW	17	19,273,815 (GRCm39)	missense	probably benign	0.13
R5283:Vmn2r98	UTSW	17	19,300,981 (GRCm39)	missense	probably benign	0.05
R5294:Vmn2r98	UTSW	17	19,290,016 (GRCm39)	nonsense	probably null
R5371:Vmn2r98	UTSW	17	19,290,015 (GRCm39)	missense	probably damaging	1.00
R5532:Vmn2r98	UTSW	17	19,287,645 (GRCm39)	missense	possibly damaging	0.94
R5598:Vmn2r98	UTSW	17	19,301,161 (GRCm39)	missense	probably benign	0.37
R5800:Vmn2r98	UTSW	17	19,286,260 (GRCm39)	missense	probably benign	0.17
R6089:Vmn2r98	UTSW	17	19,286,336 (GRCm39)	missense	probably benign	0.29
R6155:Vmn2r98	UTSW	17	19,286,143 (GRCm39)	missense	possibly damaging	0.87
R6853:Vmn2r98	UTSW	17	19,286,063 (GRCm39)	missense	probably benign	0.00
R6920:Vmn2r98	UTSW	17	19,285,510 (GRCm39)	missense	probably damaging	0.98
R7012:Vmn2r98	UTSW	17	19,286,530 (GRCm39)	missense	probably benign	0.06
R7042:Vmn2r98	UTSW	17	19,301,184 (GRCm39)	missense	probably benign
R7068:Vmn2r98	UTSW	17	19,285,575 (GRCm39)	missense	probably benign
R7607:Vmn2r98	UTSW	17	19,287,570 (GRCm39)	missense	possibly damaging	0.95
R7763:Vmn2r98	UTSW	17	19,300,797 (GRCm39)	missense	probably benign	0.00
R7771:Vmn2r98	UTSW	17	19,287,460 (GRCm39)	splice site	probably null
R7915:Vmn2r98	UTSW	17	19,287,493 (GRCm39)	missense	probably benign	0.10
R8028:Vmn2r98	UTSW	17	19,273,912 (GRCm39)	missense	probably benign	0.00
R8205:Vmn2r98	UTSW	17	19,301,425 (GRCm39)	missense	probably damaging	0.99
R8241:Vmn2r98	UTSW	17	19,301,031 (GRCm39)	missense	probably damaging	0.99
R8906:Vmn2r98	UTSW	17	19,286,532 (GRCm39)	missense	probably benign
R8952:Vmn2r98	UTSW	17	19,285,531 (GRCm39)	missense	possibly damaging	0.76
R9147:Vmn2r98	UTSW	17	19,286,383 (GRCm39)	missense	probably benign	0.04
R9148:Vmn2r98	UTSW	17	19,286,383 (GRCm39)	missense	probably benign	0.04
R9187:Vmn2r98	UTSW	17	19,301,481 (GRCm39)	missense	probably damaging	1.00
R9344:Vmn2r98	UTSW	17	19,286,777 (GRCm39)	missense	probably benign	0.14
R9467:Vmn2r98	UTSW	17	19,287,517 (GRCm39)	missense	probably benign	0.01
R9487:Vmn2r98	UTSW	17	19,301,496 (GRCm39)	missense	possibly damaging	0.78
R9753:Vmn2r98	UTSW	17	19,285,665 (GRCm39)	missense	probably benign	0.27
Z1177:Vmn2r98	UTSW	17	19,287,685 (GRCm39)	nonsense	probably null
Z1177:Vmn2r98	UTSW	17	19,285,398 (GRCm39)	critical splice acceptor site	probably null

Predicted Primers

PCR Primer
(F):5'- TGGAGAGAAATGGCATCTGC -3'
(R):5'- GTTTCCCAACACATGACAATTAGTG -3'

Sequencing Primer
(F):5'- CTGCCTAGCTTTTGTAAAAATGACC -3'
(R):5'- TAGTGTCAGAAAATGAGCACTTG -3'

Posted On

2016-06-06