Incidental Mutation 'R5037:Vmn1r89'
ID 389571
Institutional Source Beutler Lab
Gene Symbol Vmn1r89
Ensembl Gene ENSMUSG00000095629
Gene Name vomeronasal 1 receptor 89
Synonyms V1rj2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.121) question?
Stock # R5037 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 12953266-12954216 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 12953314 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 17 (C17R)
Ref Sequence ENSEMBL: ENSMUSP00000154359 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053008] [ENSMUST00000226717] [ENSMUST00000227176] [ENSMUST00000227239] [ENSMUST00000227276] [ENSMUST00000227319] [ENSMUST00000227390] [ENSMUST00000228587]
AlphaFold Q8R256
Predicted Effect possibly damaging
Transcript: ENSMUST00000053008
AA Change: C17R

PolyPhen 2 Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000096413
Gene: ENSMUSG00000095629
AA Change: C17R

DomainStartEndE-ValueType
Pfam:TAS2R 1 306 1.9e-15 PFAM
Pfam:7tm_1 25 295 1.1e-6 PFAM
Pfam:V1R 36 301 1.5e-34 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000226717
AA Change: C17R

PolyPhen 2 Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227176
AA Change: C17R

PolyPhen 2 Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227239
AA Change: C17R

PolyPhen 2 Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect probably benign
Transcript: ENSMUST00000227276
Predicted Effect probably benign
Transcript: ENSMUST00000227319
Predicted Effect probably benign
Transcript: ENSMUST00000227390
Predicted Effect possibly damaging
Transcript: ENSMUST00000228587
AA Change: C17R

PolyPhen 2 Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228795
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228825
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Btaf1 T C 19: 36,980,931 (GRCm39) V1584A probably damaging Het
Ccdc136 A T 6: 29,417,122 (GRCm39) S648C probably damaging Het
Ccna2 A G 3: 36,625,152 (GRCm39) probably benign Het
Cdc23 C A 18: 34,784,742 (GRCm39) V7L unknown Het
Cenpf T C 1: 189,416,043 (GRCm39) E94G probably damaging Het
Clic1 G A 17: 35,274,235 (GRCm39) V139I probably benign Het
Coasy A G 11: 100,975,648 (GRCm39) E327G probably damaging Het
Col6a5 C T 9: 105,805,337 (GRCm39) E1190K unknown Het
Cyp2c70 A G 19: 40,172,441 (GRCm39) V67A possibly damaging Het
Dglucy A G 12: 100,801,500 (GRCm39) S52G probably benign Het
Dync1h1 A G 12: 110,607,341 (GRCm39) N2644S probably benign Het
Eif4g2 A T 7: 110,676,239 (GRCm39) N347K probably benign Het
Epha10 T C 4: 124,809,178 (GRCm39) probably benign Het
Epm2aip1 T C 9: 111,101,218 (GRCm39) F64L probably benign Het
Eri2 G A 7: 119,384,897 (GRCm39) L535F probably benign Het
Garin5b T G 7: 4,761,575 (GRCm39) K379T possibly damaging Het
Gm17430 T C 18: 9,726,561 (GRCm39) E37G probably benign Het
Heatr5b T A 17: 79,131,939 (GRCm39) Q388L probably benign Het
Htr1f A G 16: 64,746,291 (GRCm39) W334R probably damaging Het
Icam4 A T 9: 20,940,937 (GRCm39) C717* probably null Het
Iqgap1 A C 7: 80,383,848 (GRCm39) L1072W probably damaging Het
Kbtbd11 G T 8: 15,077,886 (GRCm39) A162S probably benign Het
Kif13b T G 14: 64,996,038 (GRCm39) Y941* probably null Het
Kndc1 T C 7: 139,490,371 (GRCm39) V291A possibly damaging Het
Lrrn3 A T 12: 41,503,594 (GRCm39) I241N probably damaging Het
Macf1 A G 4: 123,349,312 (GRCm39) S2387P probably damaging Het
Msh5 A G 17: 35,251,369 (GRCm39) L451S possibly damaging Het
Mthfd1 T G 12: 76,340,914 (GRCm39) F258V probably damaging Het
Ncstn C T 1: 171,896,193 (GRCm39) R495H probably damaging Het
Or4k2 T G 14: 50,423,745 (GRCm39) T310P probably benign Het
Pkd1l3 T A 8: 110,392,268 (GRCm39) I1954N probably damaging Het
Ppox C A 1: 171,105,169 (GRCm39) V340L probably damaging Het
Prkag1 T C 15: 98,713,768 (GRCm39) T21A possibly damaging Het
Pygo1 C A 9: 72,852,199 (GRCm39) H129N probably damaging Het
Rad9a A T 19: 4,247,173 (GRCm39) C271S probably benign Het
Raph1 T C 1: 60,535,381 (GRCm39) probably null Het
Reln A G 5: 22,153,510 (GRCm39) F2265L probably damaging Het
Shc4 A G 2: 125,471,647 (GRCm39) I304T probably damaging Het
Slc35f3 T A 8: 127,116,011 (GRCm39) L313M probably damaging Het
Spata31g1 T A 4: 42,972,195 (GRCm39) H509Q probably benign Het
Spef1l A T 7: 139,558,587 (GRCm39) S3R possibly damaging Het
Sycp2l T A 13: 41,283,337 (GRCm39) M191K possibly damaging Het
Tmem132c C A 5: 127,630,199 (GRCm39) Q579K probably benign Het
Trbj2-5 A G 6: 41,520,394 (GRCm39) probably benign Het
Ttc38 A G 15: 85,728,741 (GRCm39) E231G probably benign Het
Utp20 A G 10: 88,611,192 (GRCm39) V1375A probably benign Het
Vcan T A 13: 89,852,096 (GRCm39) T955S probably damaging Het
Wnk1 A G 6: 119,942,696 (GRCm39) probably benign Het
Zfp667 T G 7: 6,308,949 (GRCm39) I539S possibly damaging Het
Zfp738 T A 13: 67,818,320 (GRCm39) H557L probably damaging Het
Other mutations in Vmn1r89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01569:Vmn1r89 APN 7 12,953,432 (GRCm39) missense probably benign 0.28
IGL02085:Vmn1r89 APN 7 12,953,465 (GRCm39) missense probably damaging 0.96
IGL02694:Vmn1r89 APN 7 12,954,056 (GRCm39) missense probably benign 0.12
IGL02709:Vmn1r89 APN 7 12,954,131 (GRCm39) missense probably damaging 1.00
PIT4142001:Vmn1r89 UTSW 7 12,953,515 (GRCm39) missense probably benign
R0765:Vmn1r89 UTSW 7 12,953,467 (GRCm39) missense probably benign 0.03
R1396:Vmn1r89 UTSW 7 12,953,938 (GRCm39) missense probably damaging 1.00
R2249:Vmn1r89 UTSW 7 12,954,187 (GRCm39) missense possibly damaging 0.90
R4296:Vmn1r89 UTSW 7 12,954,113 (GRCm39) missense possibly damaging 0.78
R4472:Vmn1r89 UTSW 7 12,953,799 (GRCm39) missense probably benign 0.04
R5267:Vmn1r89 UTSW 7 12,954,140 (GRCm39) missense probably damaging 1.00
R5352:Vmn1r89 UTSW 7 12,953,284 (GRCm39) missense probably benign
R5455:Vmn1r89 UTSW 7 12,954,194 (GRCm39) missense probably benign 0.01
R5595:Vmn1r89 UTSW 7 12,953,857 (GRCm39) missense possibly damaging 0.93
R5643:Vmn1r89 UTSW 7 12,954,146 (GRCm39) missense possibly damaging 0.94
R7493:Vmn1r89 UTSW 7 12,953,632 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTCGTCTCTGGACCTAAGA -3'
(R):5'- AACCGATATCATCCAGAAAATTTGGT -3'

Sequencing Primer
(F):5'- GATGGTGCACACATTAGTTCCCAG -3'
(R):5'- GGTACTCCAAAGGATAACATGATATC -3'
Posted On 2016-06-06