Incidental Mutation 'R4999:Iars1'
| ID |
389763 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Iars1
|
| Ensembl Gene |
ENSMUSG00000037851 |
| Gene Name |
isoleucyl-tRNA synthetase 1 |
| Synonyms |
Iars, 2510016L12Rik, E430001P04Rik |
| MMRRC Submission |
042593-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4999 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
49835606-49887743 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 49863137 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 530
(S530G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132082
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047363]
[ENSMUST00000164260]
[ENSMUST00000165316]
[ENSMUST00000171510]
|
| AlphaFold |
Q8BU30 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000047363
AA Change: S530G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000048096
Gene: ENSMUSG00000037851
AA Change: S530G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:tRNA-synt_1
|
17 |
639 |
9.2e-242 |
PFAM |
|
Pfam:tRNA-synt_1g
|
46 |
197 |
3.7e-6 |
PFAM |
|
Pfam:Anticodon_1
|
693 |
852 |
1.1e-23 |
PFAM |
|
low complexity region
|
1159 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1180 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1229 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000104172
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164260
AA Change: S530G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000126806
Gene: ENSMUSG00000037851
AA Change: S530G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:tRNA-synt_1
|
17 |
639 |
5.5e-238 |
PFAM |
|
Pfam:tRNA-synt_1g
|
46 |
205 |
5.2e-8 |
PFAM |
|
Pfam:tRNA-synt_1g
|
521 |
659 |
2.1e-5 |
PFAM |
|
Pfam:Anticodon_1
|
693 |
852 |
7.1e-24 |
PFAM |
|
low complexity region
|
1159 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1180 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1229 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000164275
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000165063
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000165316
AA Change: S530G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000132082
Gene: ENSMUSG00000037851
AA Change: S530G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:tRNA-synt_1
|
17 |
639 |
5.5e-238 |
PFAM |
|
Pfam:tRNA-synt_1g
|
46 |
205 |
5.2e-8 |
PFAM |
|
Pfam:tRNA-synt_1g
|
521 |
659 |
2.1e-5 |
PFAM |
|
Pfam:Anticodon_1
|
693 |
852 |
7.1e-24 |
PFAM |
|
low complexity region
|
1159 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1180 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1229 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171510
|
| SMART Domains |
Protein: ENSMUSP00000130204
Gene: ENSMUSG00000037851
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:tRNA-synt_1
|
1 |
96 |
5.6e-28 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.4%
- 20x: 92.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930444P10Rik |
A |
G |
1: 16,139,022 (GRCm39) |
|
probably null |
Het |
| Abca4 |
T |
A |
3: 121,899,019 (GRCm39) |
V667D |
probably damaging |
Het |
| Aco1 |
A |
G |
4: 40,176,507 (GRCm39) |
I224V |
probably damaging |
Het |
| Arel1 |
C |
T |
12: 84,978,541 (GRCm39) |
V364M |
probably damaging |
Het |
| Arhgap42 |
A |
G |
9: 9,009,435 (GRCm39) |
V484A |
probably damaging |
Het |
| Asap2 |
T |
C |
12: 21,302,766 (GRCm39) |
F681L |
probably benign |
Het |
| Atrn |
C |
A |
2: 130,817,874 (GRCm39) |
D809E |
probably damaging |
Het |
| Ccdc70 |
G |
A |
8: 22,463,266 (GRCm39) |
V19M |
possibly damaging |
Het |
| Ccp110 |
G |
T |
7: 118,329,235 (GRCm39) |
E73* |
probably null |
Het |
| Cfap57 |
A |
C |
4: 118,453,045 (GRCm39) |
S553A |
probably benign |
Het |
| Cftr |
A |
G |
6: 18,221,613 (GRCm39) |
K212E |
probably benign |
Het |
| Chkb |
A |
T |
15: 89,312,368 (GRCm39) |
Y216N |
probably damaging |
Het |
| Cntnap2 |
G |
T |
6: 45,897,768 (GRCm39) |
D149Y |
probably damaging |
Het |
| Cpd |
A |
G |
11: 76,737,048 (GRCm39) |
|
probably null |
Het |
| Creb3l1 |
C |
T |
2: 91,813,571 (GRCm39) |
D489N |
probably benign |
Het |
| Crhbp |
A |
G |
13: 95,578,753 (GRCm39) |
F123L |
probably damaging |
Het |
| Cryab |
T |
C |
9: 50,665,909 (GRCm39) |
V100A |
possibly damaging |
Het |
| Csmd2 |
T |
C |
4: 128,415,723 (GRCm39) |
I2684T |
probably benign |
Het |
| Ctbp2 |
G |
T |
7: 132,616,378 (GRCm39) |
P186T |
possibly damaging |
Het |
| Ctnna2 |
T |
C |
6: 76,892,745 (GRCm39) |
N814S |
possibly damaging |
Het |
| Dntt |
T |
C |
19: 41,028,295 (GRCm39) |
V197A |
probably damaging |
Het |
| Fam135a |
G |
A |
1: 24,059,758 (GRCm39) |
A1187V |
possibly damaging |
Het |
| Filip1l |
A |
T |
16: 57,390,778 (GRCm39) |
Q455H |
probably benign |
Het |
| Grm2 |
T |
C |
9: 106,531,189 (GRCm39) |
E100G |
probably damaging |
Het |
| Gtf2ird2 |
G |
A |
5: 134,246,306 (GRCm39) |
V855M |
probably damaging |
Het |
| Heatr9 |
A |
T |
11: 83,409,618 (GRCm39) |
I118N |
possibly damaging |
Het |
| Htra3 |
T |
C |
5: 35,828,469 (GRCm39) |
H137R |
probably benign |
Het |
| Klhdc4 |
T |
A |
8: 122,523,342 (GRCm39) |
M510L |
probably benign |
Het |
| Lipc |
T |
C |
9: 70,724,013 (GRCm39) |
T204A |
probably benign |
Het |
| Lrp1 |
A |
G |
10: 127,389,648 (GRCm39) |
V3129A |
probably damaging |
Het |
| Macf1 |
G |
A |
4: 123,388,702 (GRCm39) |
T1120I |
probably benign |
Het |
| Maco1 |
A |
G |
4: 134,555,444 (GRCm39) |
I343T |
probably benign |
Het |
| Map4 |
T |
C |
9: 109,867,445 (GRCm39) |
|
probably benign |
Het |
| Mbtps1 |
A |
T |
8: 120,260,087 (GRCm39) |
V420D |
probably damaging |
Het |
| Mta2 |
G |
T |
19: 8,927,747 (GRCm39) |
D523Y |
probably benign |
Het |
| Mtcl2 |
C |
T |
2: 156,864,776 (GRCm39) |
G1144D |
probably benign |
Het |
| Muc4 |
A |
G |
16: 32,576,670 (GRCm39) |
|
probably benign |
Het |
| Mug1 |
C |
T |
6: 121,855,902 (GRCm39) |
Q965* |
probably null |
Het |
| Myo1e |
T |
A |
9: 70,260,594 (GRCm39) |
I584N |
probably damaging |
Het |
| Nolc1 |
T |
C |
19: 46,067,359 (GRCm39) |
V80A |
probably damaging |
Het |
| Nop56 |
G |
T |
2: 130,117,645 (GRCm39) |
V91L |
probably benign |
Het |
| Or5b99 |
A |
T |
19: 12,976,583 (GRCm39) |
M78L |
probably benign |
Het |
| Or5h23 |
A |
T |
16: 58,906,765 (GRCm39) |
L27Q |
probably damaging |
Het |
| Or6f2 |
T |
C |
7: 139,756,933 (GRCm39) |
V300A |
probably damaging |
Het |
| Osbpl3 |
T |
C |
6: 50,313,277 (GRCm39) |
E107G |
probably damaging |
Het |
| Pde3a |
T |
A |
6: 141,195,751 (GRCm39) |
C146S |
probably benign |
Het |
| Pfkm |
A |
G |
15: 98,026,123 (GRCm39) |
M573V |
probably damaging |
Het |
| Pkd1l2 |
C |
T |
8: 117,774,113 (GRCm39) |
|
probably null |
Het |
| Plekhg3 |
T |
C |
12: 76,612,021 (GRCm39) |
I374T |
possibly damaging |
Het |
| Ppig |
T |
A |
2: 69,571,830 (GRCm39) |
V183D |
unknown |
Het |
| Prom1 |
T |
G |
5: 44,194,876 (GRCm39) |
I290L |
probably benign |
Het |
| Rufy3 |
T |
A |
5: 88,785,085 (GRCm39) |
M387K |
probably damaging |
Het |
| Selenoo |
G |
A |
15: 88,978,387 (GRCm39) |
R270H |
probably damaging |
Het |
| Sema3d |
T |
A |
5: 12,558,054 (GRCm39) |
|
probably null |
Het |
| Sema6c |
C |
T |
3: 95,075,674 (GRCm39) |
T175I |
probably damaging |
Het |
| Serpina3k |
T |
C |
12: 104,307,305 (GRCm39) |
I179T |
probably damaging |
Het |
| Sf3b3 |
T |
C |
8: 111,567,835 (GRCm39) |
T207A |
probably benign |
Het |
| Slc22a26 |
C |
A |
19: 7,779,546 (GRCm39) |
R90L |
probably damaging |
Het |
| Slitrk5 |
T |
C |
14: 111,917,648 (GRCm39) |
V424A |
probably damaging |
Het |
| Smarca2 |
G |
T |
19: 26,698,255 (GRCm39) |
E89* |
probably null |
Het |
| Stab2 |
T |
A |
10: 86,773,773 (GRCm39) |
S853C |
probably damaging |
Het |
| Stk17b |
A |
T |
1: 53,800,306 (GRCm39) |
|
probably null |
Het |
| Taar5 |
T |
A |
10: 23,847,445 (GRCm39) |
I281N |
possibly damaging |
Het |
| Tars3 |
A |
T |
7: 65,308,683 (GRCm39) |
E284D |
probably damaging |
Het |
| Tbx15 |
C |
A |
3: 99,223,649 (GRCm39) |
T279K |
probably damaging |
Het |
| Tfr2 |
G |
A |
5: 137,585,187 (GRCm39) |
V740I |
probably benign |
Het |
| Tlr12 |
T |
C |
4: 128,511,473 (GRCm39) |
E259G |
probably benign |
Het |
| Tmem145 |
A |
G |
7: 25,008,459 (GRCm39) |
T302A |
probably benign |
Het |
| Trappc14 |
T |
A |
5: 138,259,884 (GRCm39) |
T391S |
probably damaging |
Het |
| Trpa1 |
G |
T |
1: 14,946,085 (GRCm39) |
H1015Q |
probably benign |
Het |
| Tspan8 |
A |
G |
10: 115,653,534 (GRCm39) |
Y10C |
possibly damaging |
Het |
| Ttll7 |
A |
G |
3: 146,600,224 (GRCm39) |
N44S |
probably damaging |
Het |
| Uba7 |
T |
C |
9: 107,857,038 (GRCm39) |
|
probably null |
Het |
| Ube2j2 |
G |
A |
4: 156,030,841 (GRCm39) |
M1I |
probably null |
Het |
| Ubr5 |
C |
A |
15: 38,009,912 (GRCm39) |
A1022S |
probably benign |
Het |
| Usf1 |
T |
G |
1: 171,243,331 (GRCm39) |
I36S |
probably damaging |
Het |
| Vmn1r181 |
A |
T |
7: 23,683,790 (GRCm39) |
D85V |
probably damaging |
Het |
| Vmn1r3 |
A |
T |
4: 3,185,009 (GRCm39) |
Y99* |
probably null |
Het |
| Vmn1r72 |
T |
C |
7: 11,404,300 (GRCm39) |
I49M |
possibly damaging |
Het |
| Vmn2r99 |
A |
G |
17: 19,582,397 (GRCm39) |
M1V |
probably null |
Het |
| Vsig10 |
T |
A |
5: 117,482,040 (GRCm39) |
V410E |
probably damaging |
Het |
| Zc3h7b |
A |
G |
15: 81,663,334 (GRCm39) |
Y442C |
probably damaging |
Het |
| Zfyve26 |
G |
T |
12: 79,327,159 (GRCm39) |
Y730* |
probably null |
Het |
|
| Other mutations in Iars1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00697:Iars1
|
APN |
13 |
49,863,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00764:Iars1
|
APN |
13 |
49,865,303 (GRCm39) |
missense |
probably benign |
0.34 |
|
IGL01153:Iars1
|
APN |
13 |
49,865,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01481:Iars1
|
APN |
13 |
49,882,174 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01596:Iars1
|
APN |
13 |
49,856,652 (GRCm39) |
missense |
probably benign |
|
|
IGL01682:Iars1
|
APN |
13 |
49,863,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01885:Iars1
|
APN |
13 |
49,844,975 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL01907:Iars1
|
APN |
13 |
49,863,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02023:Iars1
|
APN |
13 |
49,841,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02121:Iars1
|
APN |
13 |
49,878,172 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02365:Iars1
|
APN |
13 |
49,844,975 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02704:Iars1
|
APN |
13 |
49,874,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02838:Iars1
|
APN |
13 |
49,843,965 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02975:Iars1
|
APN |
13 |
49,858,325 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02982:Iars1
|
APN |
13 |
49,863,185 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03034:Iars1
|
APN |
13 |
49,843,965 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03060:Iars1
|
APN |
13 |
49,843,923 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL03156:Iars1
|
APN |
13 |
49,856,655 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03206:Iars1
|
APN |
13 |
49,846,546 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03343:Iars1
|
APN |
13 |
49,878,223 (GRCm39) |
missense |
probably benign |
0.12 |
|
gannett_peak
|
UTSW |
13 |
49,861,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
missouri
|
UTSW |
13 |
49,841,752 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
spacex
|
UTSW |
13 |
49,876,478 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
wind_river
|
UTSW |
13 |
49,855,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Iars1
|
UTSW |
13 |
49,846,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Iars1
|
UTSW |
13 |
49,846,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0184:Iars1
|
UTSW |
13 |
49,875,688 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0200:Iars1
|
UTSW |
13 |
49,879,678 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R0356:Iars1
|
UTSW |
13 |
49,856,709 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0383:Iars1
|
UTSW |
13 |
49,885,818 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0657:Iars1
|
UTSW |
13 |
49,855,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1005:Iars1
|
UTSW |
13 |
49,840,921 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1427:Iars1
|
UTSW |
13 |
49,857,745 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1449:Iars1
|
UTSW |
13 |
49,887,186 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1647:Iars1
|
UTSW |
13 |
49,876,478 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1648:Iars1
|
UTSW |
13 |
49,876,478 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1664:Iars1
|
UTSW |
13 |
49,865,251 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1763:Iars1
|
UTSW |
13 |
49,876,553 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2192:Iars1
|
UTSW |
13 |
49,841,605 (GRCm39) |
splice site |
probably null |
|
|
R2203:Iars1
|
UTSW |
13 |
49,876,151 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2357:Iars1
|
UTSW |
13 |
49,841,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3724:Iars1
|
UTSW |
13 |
49,840,860 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4785:Iars1
|
UTSW |
13 |
49,878,139 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4934:Iars1
|
UTSW |
13 |
49,871,460 (GRCm39) |
missense |
probably benign |
0.17 |
|
R5048:Iars1
|
UTSW |
13 |
49,841,713 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5268:Iars1
|
UTSW |
13 |
49,843,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5394:Iars1
|
UTSW |
13 |
49,875,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5486:Iars1
|
UTSW |
13 |
49,863,049 (GRCm39) |
splice site |
probably null |
|
|
R5960:Iars1
|
UTSW |
13 |
49,878,113 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5972:Iars1
|
UTSW |
13 |
49,863,108 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5978:Iars1
|
UTSW |
13 |
49,876,469 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6031:Iars1
|
UTSW |
13 |
49,859,307 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6031:Iars1
|
UTSW |
13 |
49,859,307 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6092:Iars1
|
UTSW |
13 |
49,861,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6167:Iars1
|
UTSW |
13 |
49,876,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6313:Iars1
|
UTSW |
13 |
49,861,921 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6358:Iars1
|
UTSW |
13 |
49,880,619 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R6385:Iars1
|
UTSW |
13 |
49,855,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6403:Iars1
|
UTSW |
13 |
49,840,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6575:Iars1
|
UTSW |
13 |
49,878,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6675:Iars1
|
UTSW |
13 |
49,873,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6957:Iars1
|
UTSW |
13 |
49,875,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7207:Iars1
|
UTSW |
13 |
49,841,791 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7254:Iars1
|
UTSW |
13 |
49,876,554 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7354:Iars1
|
UTSW |
13 |
49,857,796 (GRCm39) |
missense |
probably benign |
|
|
R7397:Iars1
|
UTSW |
13 |
49,882,153 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7696:Iars1
|
UTSW |
13 |
49,860,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7799:Iars1
|
UTSW |
13 |
49,876,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7828:Iars1
|
UTSW |
13 |
49,878,748 (GRCm39) |
missense |
probably benign |
|
|
R8679:Iars1
|
UTSW |
13 |
49,856,675 (GRCm39) |
unclassified |
probably benign |
|
|
R8768:Iars1
|
UTSW |
13 |
49,878,102 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8797:Iars1
|
UTSW |
13 |
49,841,738 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8906:Iars1
|
UTSW |
13 |
49,882,177 (GRCm39) |
missense |
probably benign |
|
|
R8990:Iars1
|
UTSW |
13 |
49,841,752 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9134:Iars1
|
UTSW |
13 |
49,855,323 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9137:Iars1
|
UTSW |
13 |
49,855,350 (GRCm39) |
missense |
probably benign |
|
|
R9394:Iars1
|
UTSW |
13 |
49,883,536 (GRCm39) |
missense |
probably benign |
|
|
R9668:Iars1
|
UTSW |
13 |
49,840,885 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9741:Iars1
|
UTSW |
13 |
49,844,978 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Iars1
|
UTSW |
13 |
49,874,564 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CTCACCAAAGTACTGTAGCATGAC -3'
(R):5'- AGGCATGTGGGCATTTAGAAAC -3'
Sequencing Primer
(F):5'- GTACTGTAGCATGACACATGAATG -3'
(R):5'- TAGAAACTCATGCTTGGCGC -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation