Incidental Mutation 'R5000:Wdr17'
| ID |
389831 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Wdr17
|
| Ensembl Gene |
ENSMUSG00000039375 |
| Gene Name |
WD repeat domain 17 |
| Synonyms |
B230207L18Rik, 3010002I12Rik |
| MMRRC Submission |
042594-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5000 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
55082316-55180014 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 55118161 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 512
(M512L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122326
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000127511]
[ENSMUST00000144482]
[ENSMUST00000144711]
[ENSMUST00000150488]
[ENSMUST00000175915]
|
| AlphaFold |
E9Q271 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126316
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000127511
AA Change: M536L
PolyPhen 2
Score 0.050 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000115550
Gene: ENSMUSG00000039375
AA Change: M536L
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
72 |
112 |
8.55e-8 |
SMART |
|
WD40
|
162 |
202 |
1.58e2 |
SMART |
|
WD40
|
205 |
252 |
4.26e1 |
SMART |
|
WD40
|
255 |
298 |
1.15e0 |
SMART |
|
WD40
|
383 |
422 |
1.59e-7 |
SMART |
|
WD40
|
425 |
465 |
2.39e0 |
SMART |
|
WD40
|
468 |
509 |
5.52e-2 |
SMART |
|
WD40
|
511 |
550 |
4.14e-6 |
SMART |
|
WD40
|
555 |
595 |
5.14e-11 |
SMART |
|
WD40
|
598 |
638 |
6.58e-9 |
SMART |
|
WD40
|
641 |
681 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144482
AA Change: M223L
PolyPhen 2
Score 0.098 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000134950
Gene: ENSMUSG00000039375
AA Change: M223L
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:WD40
|
16 |
65 |
2e-24 |
BLAST |
|
WD40
|
70 |
109 |
1.59e-7 |
SMART |
|
WD40
|
112 |
152 |
2.39e0 |
SMART |
|
WD40
|
155 |
196 |
5.52e-2 |
SMART |
|
WD40
|
198 |
237 |
4.14e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144711
AA Change: M519L
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000117710
Gene: ENSMUSG00000039375
AA Change: M519L
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
72 |
112 |
8.55e-8 |
SMART |
|
WD40
|
194 |
235 |
7.64e1 |
SMART |
|
WD40
|
238 |
281 |
1.15e0 |
SMART |
|
WD40
|
366 |
405 |
1.59e-7 |
SMART |
|
WD40
|
408 |
448 |
2.39e0 |
SMART |
|
WD40
|
451 |
492 |
5.52e-2 |
SMART |
|
WD40
|
494 |
533 |
4.14e-6 |
SMART |
|
WD40
|
538 |
578 |
5.14e-11 |
SMART |
|
WD40
|
581 |
621 |
6.58e-9 |
SMART |
|
WD40
|
624 |
664 |
6.28e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000150488
AA Change: M512L
PolyPhen 2
Score 0.823 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000122326
Gene: ENSMUSG00000039375
AA Change: M512L
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
274 |
1.15e0 |
SMART |
|
WD40
|
359 |
398 |
1.59e-7 |
SMART |
|
WD40
|
401 |
441 |
2.39e0 |
SMART |
|
WD40
|
444 |
485 |
5.52e-2 |
SMART |
|
WD40
|
487 |
526 |
4.14e-6 |
SMART |
|
WD40
|
531 |
571 |
5.14e-11 |
SMART |
|
WD40
|
574 |
614 |
6.58e-9 |
SMART |
|
WD40
|
617 |
657 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175915
AA Change: M512L
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000135805
Gene: ENSMUSG00000039375
AA Change: M512L
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
274 |
1.15e0 |
SMART |
|
WD40
|
359 |
398 |
1.59e-7 |
SMART |
|
WD40
|
401 |
441 |
2.39e0 |
SMART |
|
WD40
|
444 |
485 |
5.52e-2 |
SMART |
|
WD40
|
487 |
526 |
4.14e-6 |
SMART |
|
WD40
|
531 |
571 |
5.14e-11 |
SMART |
|
WD40
|
574 |
614 |
6.58e-9 |
SMART |
|
WD40
|
617 |
657 |
6.28e-6 |
SMART |
|
| Meta Mutation Damage Score |
0.1061 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.4%
|
| Validation Efficiency |
98% (97/99) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310022A10Rik |
T |
A |
7: 27,255,946 (GRCm39) |
F11Y |
probably benign |
Het |
| Abca5 |
A |
G |
11: 110,201,050 (GRCm39) |
L450P |
probably damaging |
Het |
| Abi1 |
T |
A |
2: 22,840,211 (GRCm39) |
R357W |
probably damaging |
Het |
| Acot7 |
G |
A |
4: 152,270,820 (GRCm39) |
G55R |
probably benign |
Het |
| Aicda |
G |
A |
6: 122,538,826 (GRCm39) |
V14I |
probably damaging |
Het |
| Anxa4 |
G |
T |
6: 86,742,766 (GRCm39) |
|
probably benign |
Het |
| Apobr |
T |
A |
7: 126,185,729 (GRCm39) |
D413E |
possibly damaging |
Het |
| Ash1l |
T |
C |
3: 88,965,941 (GRCm39) |
Y2448H |
probably damaging |
Het |
| Atf7ip |
A |
G |
6: 136,559,426 (GRCm39) |
E749G |
probably damaging |
Het |
| Atp8b3 |
A |
T |
10: 80,357,676 (GRCm39) |
N1114K |
possibly damaging |
Het |
| Bdnf |
C |
A |
2: 109,553,993 (GRCm39) |
N122K |
probably benign |
Het |
| Boc |
A |
T |
16: 44,310,517 (GRCm39) |
I801N |
probably damaging |
Het |
| Brap |
A |
T |
5: 121,800,089 (GRCm39) |
K37* |
probably null |
Het |
| Ccar1 |
C |
T |
10: 62,586,784 (GRCm39) |
E885K |
unknown |
Het |
| Ccdc103 |
A |
G |
11: 102,774,932 (GRCm39) |
N177S |
probably benign |
Het |
| Ccdc116 |
G |
A |
16: 16,959,657 (GRCm39) |
P344L |
possibly damaging |
Het |
| Cdca5 |
T |
C |
19: 6,135,463 (GRCm39) |
S28P |
possibly damaging |
Het |
| Ceacam20 |
T |
C |
7: 19,699,453 (GRCm39) |
I14T |
probably damaging |
Het |
| Chrnb1 |
A |
T |
11: 69,677,858 (GRCm39) |
V298E |
probably damaging |
Het |
| Cnksr3 |
G |
A |
10: 7,076,746 (GRCm39) |
Q149* |
probably null |
Het |
| Csnk1a1 |
T |
C |
18: 61,711,840 (GRCm39) |
F97L |
probably damaging |
Het |
| Dag1 |
A |
T |
9: 108,085,216 (GRCm39) |
S642T |
probably benign |
Het |
| Dedd2 |
A |
G |
7: 24,903,068 (GRCm39) |
V297A |
possibly damaging |
Het |
| Dhcr7 |
C |
T |
7: 143,395,060 (GRCm39) |
T189M |
possibly damaging |
Het |
| Dlgap1 |
T |
C |
17: 71,073,053 (GRCm39) |
S691P |
probably damaging |
Het |
| Dmgdh |
A |
C |
13: 93,825,046 (GRCm39) |
H123P |
probably damaging |
Het |
| Dnah6 |
C |
T |
6: 73,121,798 (GRCm39) |
V1395I |
probably benign |
Het |
| Dnah7a |
T |
C |
1: 53,606,201 (GRCm39) |
Y1273C |
probably damaging |
Het |
| Dnah7b |
T |
A |
1: 46,138,663 (GRCm39) |
L235* |
probably null |
Het |
| Elac2 |
T |
C |
11: 64,876,379 (GRCm39) |
F3L |
probably benign |
Het |
| Elovl7 |
A |
T |
13: 108,410,915 (GRCm39) |
K163N |
probably benign |
Het |
| Epg5 |
T |
C |
18: 77,997,376 (GRCm39) |
V413A |
probably benign |
Het |
| Espl1 |
T |
A |
15: 102,206,986 (GRCm39) |
L150Q |
probably damaging |
Het |
| F2rl3 |
T |
A |
8: 73,489,307 (GRCm39) |
L178Q |
probably damaging |
Het |
| Fam120a |
T |
C |
13: 49,051,143 (GRCm39) |
E754G |
probably damaging |
Het |
| Fam53b |
T |
C |
7: 132,317,730 (GRCm39) |
N304S |
probably benign |
Het |
| Fbxo41 |
T |
C |
6: 85,460,901 (GRCm39) |
E269G |
probably damaging |
Het |
| Fcrla |
T |
C |
1: 170,749,959 (GRCm39) |
T4A |
probably benign |
Het |
| Frmpd1 |
A |
T |
4: 45,261,931 (GRCm39) |
|
probably null |
Het |
| Gm9376 |
A |
G |
14: 118,504,702 (GRCm39) |
M45V |
probably benign |
Het |
| Gpr68 |
G |
A |
12: 100,844,596 (GRCm39) |
A316V |
probably benign |
Het |
| Hmgcl |
G |
A |
4: 135,689,511 (GRCm39) |
C323Y |
probably benign |
Het |
| Hnrnpu |
T |
C |
1: 178,156,941 (GRCm39) |
|
probably benign |
Het |
| Ier2 |
T |
A |
8: 85,389,353 (GRCm39) |
I10F |
probably damaging |
Het |
| Ip6k1 |
C |
T |
9: 107,922,798 (GRCm39) |
Q234* |
probably null |
Het |
| Llgl2 |
T |
C |
11: 115,735,728 (GRCm39) |
V108A |
probably benign |
Het |
| Lrfn3 |
T |
C |
7: 30,059,805 (GRCm39) |
N140S |
possibly damaging |
Het |
| Lrig1 |
T |
A |
6: 94,588,430 (GRCm39) |
H573L |
probably damaging |
Het |
| Lrrk2 |
T |
A |
15: 91,634,081 (GRCm39) |
W1393R |
probably damaging |
Het |
| Mrc1 |
T |
A |
2: 14,249,000 (GRCm39) |
Y179N |
probably damaging |
Het |
| Mtfr1 |
C |
T |
3: 19,265,743 (GRCm39) |
L93F |
probably damaging |
Het |
| Muc19 |
T |
C |
15: 91,757,429 (GRCm39) |
|
noncoding transcript |
Het |
| Ndst2 |
C |
T |
14: 20,774,975 (GRCm39) |
|
probably null |
Het |
| Nmd3 |
A |
T |
3: 69,624,735 (GRCm39) |
|
probably benign |
Het |
| Nsd3 |
A |
G |
8: 26,172,593 (GRCm39) |
Y784C |
probably damaging |
Het |
| Or4a27 |
A |
T |
2: 88,559,910 (GRCm39) |
I11N |
probably damaging |
Het |
| Or7a36 |
G |
A |
10: 78,820,514 (GRCm39) |
V297I |
probably benign |
Het |
| Papln |
A |
G |
12: 83,821,663 (GRCm39) |
Y297C |
probably damaging |
Het |
| Pdhx |
T |
C |
2: 102,871,385 (GRCm39) |
|
probably null |
Het |
| Pdpk1 |
T |
C |
17: 24,330,019 (GRCm39) |
T6A |
possibly damaging |
Het |
| Prcp |
T |
C |
7: 92,568,368 (GRCm39) |
W267R |
probably damaging |
Het |
| Prg2 |
T |
C |
2: 84,812,367 (GRCm39) |
S26P |
probably benign |
Het |
| Psg26 |
A |
T |
7: 18,214,057 (GRCm39) |
Y202N |
possibly damaging |
Het |
| Psrc1 |
T |
C |
3: 108,287,839 (GRCm39) |
|
probably benign |
Het |
| Rap1gds1 |
A |
T |
3: 138,662,011 (GRCm39) |
M366K |
probably damaging |
Het |
| Robo4 |
G |
T |
9: 37,319,664 (GRCm39) |
R527L |
probably benign |
Het |
| Sel1l3 |
G |
A |
5: 53,357,776 (GRCm39) |
T72M |
probably damaging |
Het |
| Selenoo |
G |
A |
15: 88,978,387 (GRCm39) |
R270H |
probably damaging |
Het |
| Sema3d |
A |
G |
5: 12,498,005 (GRCm39) |
T4A |
probably benign |
Het |
| Shroom1 |
A |
T |
11: 53,357,944 (GRCm39) |
|
probably benign |
Het |
| Slc25a19 |
T |
C |
11: 115,507,497 (GRCm39) |
|
probably null |
Het |
| Snx29 |
A |
C |
16: 11,221,371 (GRCm39) |
I266L |
probably damaging |
Het |
| Spo11 |
T |
C |
2: 172,831,193 (GRCm39) |
S255P |
probably damaging |
Het |
| Spock3 |
T |
C |
8: 63,698,158 (GRCm39) |
V167A |
possibly damaging |
Het |
| Tmc7 |
A |
G |
7: 118,158,077 (GRCm39) |
|
probably null |
Het |
| Tmtc4 |
A |
G |
14: 123,170,743 (GRCm39) |
V509A |
possibly damaging |
Het |
| Trim24 |
A |
G |
6: 37,935,547 (GRCm39) |
D880G |
probably benign |
Het |
| Ube2j2 |
G |
A |
4: 156,030,841 (GRCm39) |
M1I |
probably null |
Het |
| Ubr4 |
T |
A |
4: 139,163,480 (GRCm39) |
C2627S |
probably damaging |
Het |
| Unc5d |
A |
T |
8: 29,205,775 (GRCm39) |
M512K |
possibly damaging |
Het |
| Usp18 |
A |
G |
6: 121,229,479 (GRCm39) |
R33G |
possibly damaging |
Het |
| Utp23 |
T |
A |
15: 51,745,569 (GRCm39) |
V23D |
probably damaging |
Het |
| Wdr64 |
T |
A |
1: 175,553,941 (GRCm39) |
|
probably null |
Het |
| Zbtb6 |
T |
C |
2: 37,319,251 (GRCm39) |
T226A |
probably benign |
Het |
| Zc3hc1 |
T |
A |
6: 30,375,987 (GRCm39) |
H191L |
possibly damaging |
Het |
| Zdhhc4 |
C |
A |
5: 143,310,688 (GRCm39) |
C48F |
probably damaging |
Het |
| Zfp335 |
T |
A |
2: 164,736,588 (GRCm39) |
T1016S |
probably benign |
Het |
| Zfp583 |
A |
G |
7: 6,328,473 (GRCm39) |
Y39H |
probably damaging |
Het |
|
| Other mutations in Wdr17 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00309:Wdr17
|
APN |
8 |
55,140,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00496:Wdr17
|
APN |
8 |
55,112,614 (GRCm39) |
splice site |
probably benign |
|
|
IGL01318:Wdr17
|
APN |
8 |
55,125,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01347:Wdr17
|
APN |
8 |
55,104,380 (GRCm39) |
missense |
probably benign |
|
|
IGL01654:Wdr17
|
APN |
8 |
55,115,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02010:Wdr17
|
APN |
8 |
55,112,738 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02085:Wdr17
|
APN |
8 |
55,140,771 (GRCm39) |
nonsense |
probably null |
|
|
IGL02205:Wdr17
|
APN |
8 |
55,149,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02375:Wdr17
|
APN |
8 |
55,149,423 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02705:Wdr17
|
APN |
8 |
55,101,250 (GRCm39) |
splice site |
probably null |
|
|
IGL02719:Wdr17
|
APN |
8 |
55,146,089 (GRCm39) |
splice site |
probably null |
|
|
IGL03051:Wdr17
|
APN |
8 |
55,104,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03131:Wdr17
|
APN |
8 |
55,149,302 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03172:Wdr17
|
APN |
8 |
55,114,515 (GRCm39) |
missense |
probably damaging |
0.96 |
|
enthralled
|
UTSW |
8 |
55,112,716 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
riveted
|
UTSW |
8 |
55,085,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
thrilled
|
UTSW |
8 |
55,149,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03138:Wdr17
|
UTSW |
8 |
55,102,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4458001:Wdr17
|
UTSW |
8 |
55,126,614 (GRCm39) |
nonsense |
probably null |
|
|
R0011:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0011:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0124:Wdr17
|
UTSW |
8 |
55,088,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0226:Wdr17
|
UTSW |
8 |
55,116,043 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0270:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0271:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0288:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0321:Wdr17
|
UTSW |
8 |
55,149,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0464:Wdr17
|
UTSW |
8 |
55,123,427 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Wdr17
|
UTSW |
8 |
55,104,456 (GRCm39) |
splice site |
probably null |
|
|
R0488:Wdr17
|
UTSW |
8 |
55,146,087 (GRCm39) |
unclassified |
probably benign |
|
|
R0552:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0553:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0600:Wdr17
|
UTSW |
8 |
55,114,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0621:Wdr17
|
UTSW |
8 |
55,096,226 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0655:Wdr17
|
UTSW |
8 |
55,102,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0730:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0789:Wdr17
|
UTSW |
8 |
55,112,607 (GRCm39) |
splice site |
probably benign |
|
|
R0854:Wdr17
|
UTSW |
8 |
55,156,916 (GRCm39) |
missense |
probably benign |
|
|
R0879:Wdr17
|
UTSW |
8 |
55,114,516 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1462:Wdr17
|
UTSW |
8 |
55,123,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1462:Wdr17
|
UTSW |
8 |
55,123,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1497:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1589:Wdr17
|
UTSW |
8 |
55,156,942 (GRCm39) |
intron |
probably benign |
|
|
R1618:Wdr17
|
UTSW |
8 |
55,092,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1768:Wdr17
|
UTSW |
8 |
55,126,689 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1778:Wdr17
|
UTSW |
8 |
55,143,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1819:Wdr17
|
UTSW |
8 |
55,143,159 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1913:Wdr17
|
UTSW |
8 |
55,140,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2129:Wdr17
|
UTSW |
8 |
55,085,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Wdr17
|
UTSW |
8 |
55,125,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2309:Wdr17
|
UTSW |
8 |
55,096,283 (GRCm39) |
missense |
probably benign |
|
|
R3882:Wdr17
|
UTSW |
8 |
55,092,536 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4097:Wdr17
|
UTSW |
8 |
55,088,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4372:Wdr17
|
UTSW |
8 |
55,092,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4380:Wdr17
|
UTSW |
8 |
55,101,442 (GRCm39) |
intron |
probably benign |
|
|
R4480:Wdr17
|
UTSW |
8 |
55,117,999 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4654:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4656:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4669:Wdr17
|
UTSW |
8 |
55,143,083 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4719:Wdr17
|
UTSW |
8 |
55,092,911 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4912:Wdr17
|
UTSW |
8 |
55,082,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5073:Wdr17
|
UTSW |
8 |
55,143,271 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5176:Wdr17
|
UTSW |
8 |
55,106,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5194:Wdr17
|
UTSW |
8 |
55,140,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5270:Wdr17
|
UTSW |
8 |
55,096,221 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5300:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5325:Wdr17
|
UTSW |
8 |
55,112,716 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5336:Wdr17
|
UTSW |
8 |
55,085,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5394:Wdr17
|
UTSW |
8 |
55,092,524 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5424:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5425:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5426:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5548:Wdr17
|
UTSW |
8 |
55,156,886 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5681:Wdr17
|
UTSW |
8 |
55,115,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5722:Wdr17
|
UTSW |
8 |
55,113,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5894:Wdr17
|
UTSW |
8 |
55,149,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5906:Wdr17
|
UTSW |
8 |
55,092,503 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6038:Wdr17
|
UTSW |
8 |
55,085,346 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6038:Wdr17
|
UTSW |
8 |
55,085,346 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6391:Wdr17
|
UTSW |
8 |
55,114,495 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6605:Wdr17
|
UTSW |
8 |
55,134,559 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6892:Wdr17
|
UTSW |
8 |
55,126,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7019:Wdr17
|
UTSW |
8 |
55,134,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7257:Wdr17
|
UTSW |
8 |
55,085,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7481:Wdr17
|
UTSW |
8 |
55,114,371 (GRCm39) |
missense |
probably benign |
|
|
R7868:Wdr17
|
UTSW |
8 |
55,149,302 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7939:Wdr17
|
UTSW |
8 |
55,140,677 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7962:Wdr17
|
UTSW |
8 |
55,113,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8017:Wdr17
|
UTSW |
8 |
55,091,403 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8122:Wdr17
|
UTSW |
8 |
55,118,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8226:Wdr17
|
UTSW |
8 |
55,146,155 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8251:Wdr17
|
UTSW |
8 |
55,110,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8413:Wdr17
|
UTSW |
8 |
55,115,953 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8534:Wdr17
|
UTSW |
8 |
55,101,265 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8708:Wdr17
|
UTSW |
8 |
55,093,127 (GRCm39) |
intron |
probably benign |
|
|
R9116:Wdr17
|
UTSW |
8 |
55,114,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9258:Wdr17
|
UTSW |
8 |
55,112,654 (GRCm39) |
nonsense |
probably null |
|
|
R9351:Wdr17
|
UTSW |
8 |
55,143,057 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9475:Wdr17
|
UTSW |
8 |
55,088,512 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9546:Wdr17
|
UTSW |
8 |
55,112,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9547:Wdr17
|
UTSW |
8 |
55,112,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9635:Wdr17
|
UTSW |
8 |
55,101,375 (GRCm39) |
missense |
probably damaging |
0.98 |
|
V5088:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
V5622:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
V5622:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
X0022:Wdr17
|
UTSW |
8 |
55,092,529 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0066:Wdr17
|
UTSW |
8 |
55,126,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Wdr17
|
UTSW |
8 |
55,123,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Wdr17
|
UTSW |
8 |
55,096,220 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACACATGCATTTCTGGGAAACTG -3'
(R):5'- CTTACTGAAATAGTCCTTTTCAGCC -3'
Sequencing Primer
(F):5'- GAACACTCTTGCTGTGTG -3'
(R):5'- CTGAAATAGTCCTTTTCAGCCATAAG -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation