Incidental Mutation 'R5004:Siglec1'
| ID |
390027 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Siglec1
|
| Ensembl Gene |
ENSMUSG00000027322 |
| Gene Name |
sialic acid binding Ig-like lectin 1, sialoadhesin |
| Synonyms |
Sn, CD169, Siglec-1 |
| MMRRC Submission |
042597-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.076)
|
| Stock # |
R5004 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
130911140-130928685 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 130915331 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Glutamine
at position 1420
(L1420Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105856
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028794]
[ENSMUST00000110227]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000028794
AA Change: L1420Q
PolyPhen 2
Score 0.421 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000028794
Gene: ENSMUSG00000027322
AA Change: L1420Q
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IG
|
32 |
142 |
2.92e-5 |
SMART |
|
Pfam:C2-set_2
|
148 |
235 |
9.4e-18 |
PFAM |
|
IGc2
|
260 |
319 |
8.78e-9 |
SMART |
|
IGc2
|
344 |
404 |
4.07e-4 |
SMART |
|
IGc2
|
431 |
505 |
3.3e-4 |
SMART |
|
IGc2
|
529 |
589 |
5.75e-4 |
SMART |
|
IGc2
|
622 |
698 |
3.54e-4 |
SMART |
|
low complexity region
|
700 |
705 |
N/A |
INTRINSIC |
|
IG
|
716 |
795 |
3.35e-5 |
SMART |
|
IG
|
804 |
896 |
6.51e-3 |
SMART |
|
IGc2
|
909 |
969 |
4.13e-5 |
SMART |
|
IG_like
|
1001 |
1076 |
6.78e-2 |
SMART |
|
low complexity region
|
1077 |
1088 |
N/A |
INTRINSIC |
|
IG
|
1094 |
1171 |
4.32e-8 |
SMART |
|
IG_like
|
1185 |
1250 |
1.94e-2 |
SMART |
|
IG
|
1268 |
1345 |
1.36e-5 |
SMART |
|
IG_like
|
1354 |
1447 |
1.45e1 |
SMART |
|
IG_like
|
1365 |
1435 |
4.51e-2 |
SMART |
|
IG
|
1454 |
1534 |
4.56e-7 |
SMART |
|
IG_like
|
1549 |
1624 |
1.21e-1 |
SMART |
|
transmembrane domain
|
1647 |
1669 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000110227
AA Change: L1420Q
PolyPhen 2
Score 0.874 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000105856
Gene: ENSMUSG00000027322
AA Change: L1420Q
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IG
|
32 |
142 |
2.92e-5 |
SMART |
|
Pfam:C2-set_2
|
148 |
235 |
7e-17 |
PFAM |
|
IGc2
|
260 |
319 |
8.78e-9 |
SMART |
|
IGc2
|
344 |
404 |
4.07e-4 |
SMART |
|
IGc2
|
431 |
505 |
3.3e-4 |
SMART |
|
IGc2
|
529 |
589 |
5.75e-4 |
SMART |
|
IGc2
|
622 |
698 |
3.54e-4 |
SMART |
|
low complexity region
|
700 |
705 |
N/A |
INTRINSIC |
|
IG
|
716 |
795 |
3.35e-5 |
SMART |
|
IG
|
804 |
896 |
6.51e-3 |
SMART |
|
IGc2
|
909 |
969 |
4.13e-5 |
SMART |
|
IG_like
|
1001 |
1076 |
6.78e-2 |
SMART |
|
low complexity region
|
1077 |
1088 |
N/A |
INTRINSIC |
|
IG
|
1094 |
1171 |
4.32e-8 |
SMART |
|
IG_like
|
1185 |
1250 |
1.94e-2 |
SMART |
|
IG
|
1268 |
1345 |
1.36e-5 |
SMART |
|
IG_like
|
1354 |
1447 |
1.45e1 |
SMART |
|
IG_like
|
1365 |
1435 |
4.51e-2 |
SMART |
|
IG
|
1454 |
1534 |
4.56e-7 |
SMART |
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a disruption in this gene display subtle changes in B- and T-cell populations and decreased IgM levels. Mice homozygous for a knock-out or knock-in allele exhibit impaired phagocytosis of sialylated C. jejuni. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700029H14Rik |
A |
C |
8: 13,605,927 (GRCm39) |
D189E |
possibly damaging |
Het |
| Abca5 |
C |
T |
11: 110,170,202 (GRCm39) |
E1298K |
probably damaging |
Het |
| Actg1 |
C |
A |
11: 120,238,986 (GRCm39) |
|
probably benign |
Het |
| Add2 |
A |
G |
6: 86,073,728 (GRCm39) |
T206A |
probably benign |
Het |
| Alox12e |
A |
G |
11: 70,212,330 (GRCm39) |
V116A |
probably benign |
Het |
| Ankrd27 |
T |
A |
7: 35,307,800 (GRCm39) |
D346E |
probably damaging |
Het |
| Arfgap3 |
T |
A |
15: 83,194,497 (GRCm39) |
S391C |
possibly damaging |
Het |
| Bcor |
C |
T |
X: 11,906,725 (GRCm39) |
R1551Q |
probably damaging |
Het |
| Cars2 |
C |
T |
8: 11,568,956 (GRCm39) |
|
probably null |
Het |
| Cav3 |
A |
G |
6: 112,436,885 (GRCm39) |
K38R |
probably damaging |
Het |
| Ccdc159 |
G |
A |
9: 21,844,241 (GRCm39) |
R101H |
probably damaging |
Het |
| Cops7b |
A |
G |
1: 86,515,132 (GRCm39) |
|
probably benign |
Het |
| Cyp4a12b |
C |
T |
4: 115,295,310 (GRCm39) |
T472I |
probably benign |
Het |
| Cyp4a32 |
T |
C |
4: 115,458,238 (GRCm39) |
S23P |
probably damaging |
Het |
| Cyp4f13 |
T |
G |
17: 33,144,760 (GRCm39) |
I275L |
probably benign |
Het |
| Dlgap1 |
T |
A |
17: 71,025,222 (GRCm39) |
|
probably null |
Het |
| Dnajc12 |
A |
T |
10: 63,222,486 (GRCm39) |
I4L |
probably benign |
Het |
| Ephb2 |
T |
A |
4: 136,387,010 (GRCm39) |
D739V |
possibly damaging |
Het |
| Fam169a |
A |
G |
13: 97,234,100 (GRCm39) |
Y124C |
probably damaging |
Het |
| Fbln5 |
T |
A |
12: 101,727,080 (GRCm39) |
N303I |
probably damaging |
Het |
| Fdxr |
T |
C |
11: 115,160,399 (GRCm39) |
E352G |
probably benign |
Het |
| Fhad1 |
T |
G |
4: 141,729,910 (GRCm39) |
|
probably null |
Het |
| Fhod1 |
C |
T |
8: 106,063,577 (GRCm39) |
|
probably benign |
Het |
| Fndc7 |
G |
A |
3: 108,790,789 (GRCm39) |
T79M |
probably damaging |
Het |
| Fry |
A |
G |
5: 150,357,069 (GRCm39) |
Q1872R |
probably benign |
Het |
| Gbx1 |
T |
C |
5: 24,709,837 (GRCm39) |
H336R |
probably damaging |
Het |
| Gkn3 |
C |
T |
6: 87,360,507 (GRCm39) |
A163T |
probably damaging |
Het |
| Gpr15lg |
A |
T |
14: 36,824,622 (GRCm39) |
C60S |
probably damaging |
Het |
| Hacl1 |
C |
A |
14: 31,340,996 (GRCm39) |
C346F |
probably benign |
Het |
| Hectd4 |
C |
A |
5: 121,466,262 (GRCm39) |
|
probably null |
Het |
| Hectd4 |
C |
T |
5: 121,467,628 (GRCm39) |
P2526S |
possibly damaging |
Het |
| Il3ra |
A |
T |
14: 14,355,381 (GRCm38) |
E289D |
probably benign |
Het |
| Itih4 |
T |
G |
14: 30,614,629 (GRCm39) |
L497R |
probably damaging |
Het |
| Kcnh3 |
A |
T |
15: 99,124,383 (GRCm39) |
K91* |
probably null |
Het |
| Kiz |
C |
G |
2: 146,811,899 (GRCm39) |
D669E |
possibly damaging |
Het |
| Klhl30 |
T |
A |
1: 91,287,046 (GRCm39) |
|
probably null |
Het |
| Kndc1 |
C |
A |
7: 139,512,792 (GRCm39) |
C1514* |
probably null |
Het |
| Lipo2 |
A |
G |
19: 33,699,076 (GRCm39) |
|
probably null |
Het |
| Macf1 |
T |
C |
4: 123,279,268 (GRCm39) |
D5921G |
probably damaging |
Het |
| Mau2 |
A |
G |
8: 70,478,537 (GRCm39) |
Y394H |
probably damaging |
Het |
| Mctp1 |
T |
A |
13: 76,789,923 (GRCm39) |
S50R |
possibly damaging |
Het |
| Mllt10 |
T |
C |
2: 18,175,079 (GRCm39) |
Y3H |
probably damaging |
Het |
| Mon1b |
T |
C |
8: 114,365,859 (GRCm39) |
S396P |
probably damaging |
Het |
| Mrgpra4 |
A |
C |
7: 47,631,535 (GRCm39) |
L22R |
probably benign |
Het |
| Msln |
T |
G |
17: 25,973,193 (GRCm39) |
M1L |
possibly damaging |
Het |
| Myh15 |
T |
A |
16: 48,952,411 (GRCm39) |
I827N |
probably damaging |
Het |
| Myh7 |
T |
C |
14: 55,209,140 (GRCm39) |
D1866G |
probably damaging |
Het |
| Myo5b |
T |
G |
18: 74,877,844 (GRCm39) |
|
probably null |
Het |
| Nlrc5 |
T |
G |
8: 95,247,844 (GRCm39) |
|
probably benign |
Het |
| Nup210l |
A |
T |
3: 90,087,472 (GRCm39) |
R1082* |
probably null |
Het |
| Or12k7 |
A |
G |
2: 36,958,422 (GRCm39) |
Y35C |
probably damaging |
Het |
| Or4f4b |
G |
A |
2: 111,314,005 (GRCm39) |
V105I |
possibly damaging |
Het |
| Or5p63 |
T |
A |
7: 107,811,323 (GRCm39) |
K138* |
probably null |
Het |
| Or7e169 |
T |
C |
9: 19,757,398 (GRCm39) |
I172M |
probably benign |
Het |
| Pi4ka |
A |
T |
16: 17,195,033 (GRCm39) |
C122S |
probably damaging |
Het |
| Pkd2l1 |
G |
T |
19: 44,138,016 (GRCm39) |
A690E |
probably benign |
Het |
| Pramel22 |
T |
C |
4: 143,380,706 (GRCm39) |
Q439R |
probably benign |
Het |
| Prickle2 |
A |
T |
6: 92,393,736 (GRCm39) |
D312E |
probably benign |
Het |
| Prrc2a |
T |
A |
17: 35,368,974 (GRCm39) |
N2021Y |
probably benign |
Het |
| Prss3 |
T |
C |
6: 41,350,836 (GRCm39) |
Y218C |
probably damaging |
Het |
| Psg20 |
T |
C |
7: 18,414,837 (GRCm39) |
T350A |
probably damaging |
Het |
| Ptprg |
A |
T |
14: 12,220,667 (GRCm38) |
I1235F |
probably damaging |
Het |
| Ptprk |
T |
A |
10: 28,462,059 (GRCm39) |
D1181E |
possibly damaging |
Het |
| Rcc2 |
T |
A |
4: 140,444,977 (GRCm39) |
S415T |
possibly damaging |
Het |
| Ripor1 |
CAA |
CA |
8: 106,345,452 (GRCm39) |
|
probably null |
Het |
| Rnf31 |
T |
C |
14: 55,829,639 (GRCm39) |
L68P |
probably damaging |
Het |
| Rsph6a |
A |
T |
7: 18,791,665 (GRCm39) |
E278V |
possibly damaging |
Het |
| Rubcnl |
C |
T |
14: 75,269,617 (GRCm39) |
Q92* |
probably null |
Het |
| Scfd1 |
A |
G |
12: 51,491,777 (GRCm39) |
R580G |
probably benign |
Het |
| Sec31a |
A |
T |
5: 100,516,192 (GRCm39) |
N967K |
probably damaging |
Het |
| Sema4b |
C |
A |
7: 79,866,093 (GRCm39) |
T154N |
probably benign |
Het |
| Septin14 |
T |
A |
5: 129,770,040 (GRCm39) |
I219F |
possibly damaging |
Het |
| Serpinb9c |
A |
T |
13: 33,334,338 (GRCm39) |
S235T |
probably benign |
Het |
| Setd4 |
G |
T |
16: 93,388,133 (GRCm39) |
H118N |
probably benign |
Het |
| Soat2 |
T |
A |
15: 102,069,546 (GRCm39) |
H402Q |
probably damaging |
Het |
| Sp3 |
A |
T |
2: 72,768,633 (GRCm39) |
V666D |
probably benign |
Het |
| Spef2 |
T |
G |
15: 9,578,413 (GRCm39) |
S1704R |
probably benign |
Het |
| Spidr |
A |
T |
16: 15,936,806 (GRCm39) |
W100R |
possibly damaging |
Het |
| Steap1 |
G |
T |
5: 5,792,829 (GRCm39) |
Y27* |
probably null |
Het |
| Svep1 |
G |
T |
4: 58,087,751 (GRCm39) |
T1776K |
probably benign |
Het |
| Tdpoz1 |
T |
A |
3: 93,578,440 (GRCm39) |
T115S |
probably benign |
Het |
| Tet2 |
A |
T |
3: 133,193,140 (GRCm39) |
H431Q |
possibly damaging |
Het |
| Tnrc6c |
T |
G |
11: 117,611,872 (GRCm39) |
V170G |
probably benign |
Het |
| Tom1 |
T |
C |
8: 75,778,630 (GRCm39) |
L99P |
probably damaging |
Het |
| Trim11 |
C |
A |
11: 58,872,164 (GRCm39) |
|
probably benign |
Het |
| Trio |
T |
C |
15: 27,755,264 (GRCm39) |
K955R |
probably damaging |
Het |
| Tubd1 |
C |
T |
11: 86,452,146 (GRCm39) |
T371I |
probably damaging |
Het |
| Usp17lb |
C |
T |
7: 104,490,884 (GRCm39) |
M13I |
probably benign |
Het |
| Usp29 |
A |
G |
7: 6,965,158 (GRCm39) |
M334V |
probably benign |
Het |
| Usp34 |
A |
G |
11: 23,414,586 (GRCm39) |
Y2843C |
probably damaging |
Het |
| Utp20 |
A |
T |
10: 88,584,135 (GRCm39) |
I2674N |
probably damaging |
Het |
| Vmn2r14 |
T |
G |
5: 109,368,246 (GRCm39) |
T249P |
probably benign |
Het |
| Vmn2r43 |
A |
T |
7: 8,247,848 (GRCm39) |
F772I |
probably damaging |
Het |
| Vmn2r51 |
T |
A |
7: 9,821,932 (GRCm39) |
E584D |
probably benign |
Het |
| Zbtb22 |
G |
T |
17: 34,136,217 (GRCm39) |
A121S |
probably benign |
Het |
| Zfp273 |
A |
T |
13: 67,973,673 (GRCm39) |
H267L |
probably damaging |
Het |
| Zkscan2 |
C |
T |
7: 123,089,267 (GRCm39) |
V335M |
probably damaging |
Het |
|
| Other mutations in Siglec1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00482:Siglec1
|
APN |
2 |
130,921,245 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01092:Siglec1
|
APN |
2 |
130,921,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01115:Siglec1
|
APN |
2 |
130,916,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01324:Siglec1
|
APN |
2 |
130,927,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01330:Siglec1
|
APN |
2 |
130,916,925 (GRCm39) |
nonsense |
probably null |
|
|
IGL01330:Siglec1
|
APN |
2 |
130,925,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01558:Siglec1
|
APN |
2 |
130,920,419 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01632:Siglec1
|
APN |
2 |
130,925,740 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01768:Siglec1
|
APN |
2 |
130,916,314 (GRCm39) |
missense |
probably benign |
|
|
IGL02399:Siglec1
|
APN |
2 |
130,913,098 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02558:Siglec1
|
APN |
2 |
130,916,915 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02794:Siglec1
|
APN |
2 |
130,917,889 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02839:Siglec1
|
APN |
2 |
130,926,852 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
aggressor
|
UTSW |
2 |
130,925,861 (GRCm39) |
nonsense |
probably null |
|
|
boris
|
UTSW |
2 |
130,921,297 (GRCm39) |
nonsense |
probably null |
|
|
espia
|
UTSW |
2 |
130,914,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
hoodlum
|
UTSW |
2 |
130,914,667 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
microfische
|
UTSW |
2 |
130,928,015 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
K3955:Siglec1
|
UTSW |
2 |
130,923,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
P0038:Siglec1
|
UTSW |
2 |
130,923,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4576001:Siglec1
|
UTSW |
2 |
130,920,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4677001:Siglec1
|
UTSW |
2 |
130,914,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0003:Siglec1
|
UTSW |
2 |
130,916,980 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0048:Siglec1
|
UTSW |
2 |
130,915,317 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0048:Siglec1
|
UTSW |
2 |
130,915,317 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0243:Siglec1
|
UTSW |
2 |
130,927,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0276:Siglec1
|
UTSW |
2 |
130,925,861 (GRCm39) |
nonsense |
probably null |
|
|
R0379:Siglec1
|
UTSW |
2 |
130,916,445 (GRCm39) |
splice site |
probably benign |
|
|
R0464:Siglec1
|
UTSW |
2 |
130,921,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0507:Siglec1
|
UTSW |
2 |
130,916,445 (GRCm39) |
splice site |
probably benign |
|
|
R0560:Siglec1
|
UTSW |
2 |
130,912,266 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0620:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0621:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0853:Siglec1
|
UTSW |
2 |
130,926,942 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1079:Siglec1
|
UTSW |
2 |
130,921,297 (GRCm39) |
nonsense |
probably null |
|
|
R1169:Siglec1
|
UTSW |
2 |
130,916,747 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1205:Siglec1
|
UTSW |
2 |
130,922,384 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1293:Siglec1
|
UTSW |
2 |
130,915,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1470:Siglec1
|
UTSW |
2 |
130,912,307 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1470:Siglec1
|
UTSW |
2 |
130,912,307 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1533:Siglec1
|
UTSW |
2 |
130,918,078 (GRCm39) |
missense |
probably benign |
|
|
R1717:Siglec1
|
UTSW |
2 |
130,925,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1717:Siglec1
|
UTSW |
2 |
130,915,876 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1744:Siglec1
|
UTSW |
2 |
130,923,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1852:Siglec1
|
UTSW |
2 |
130,923,420 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1941:Siglec1
|
UTSW |
2 |
130,920,051 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2011:Siglec1
|
UTSW |
2 |
130,925,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Siglec1
|
UTSW |
2 |
130,925,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2128:Siglec1
|
UTSW |
2 |
130,922,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2278:Siglec1
|
UTSW |
2 |
130,913,257 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2403:Siglec1
|
UTSW |
2 |
130,916,395 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2449:Siglec1
|
UTSW |
2 |
130,920,645 (GRCm39) |
missense |
probably benign |
0.44 |
|
R2885:Siglec1
|
UTSW |
2 |
130,914,667 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4213:Siglec1
|
UTSW |
2 |
130,916,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4274:Siglec1
|
UTSW |
2 |
130,927,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4679:Siglec1
|
UTSW |
2 |
130,915,331 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4715:Siglec1
|
UTSW |
2 |
130,916,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4782:Siglec1
|
UTSW |
2 |
130,917,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4896:Siglec1
|
UTSW |
2 |
130,911,789 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4993:Siglec1
|
UTSW |
2 |
130,915,281 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5004:Siglec1
|
UTSW |
2 |
130,911,789 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5105:Siglec1
|
UTSW |
2 |
130,922,320 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5137:Siglec1
|
UTSW |
2 |
130,923,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5153:Siglec1
|
UTSW |
2 |
130,927,497 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5311:Siglec1
|
UTSW |
2 |
130,921,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5600:Siglec1
|
UTSW |
2 |
130,927,503 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5682:Siglec1
|
UTSW |
2 |
130,925,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5732:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5870:Siglec1
|
UTSW |
2 |
130,914,767 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5898:Siglec1
|
UTSW |
2 |
130,915,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5909:Siglec1
|
UTSW |
2 |
130,919,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6488:Siglec1
|
UTSW |
2 |
130,923,227 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6920:Siglec1
|
UTSW |
2 |
130,919,997 (GRCm39) |
nonsense |
probably null |
|
|
R7064:Siglec1
|
UTSW |
2 |
130,925,834 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7270:Siglec1
|
UTSW |
2 |
130,923,471 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7355:Siglec1
|
UTSW |
2 |
130,922,371 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7400:Siglec1
|
UTSW |
2 |
130,928,015 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7470:Siglec1
|
UTSW |
2 |
130,917,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7568:Siglec1
|
UTSW |
2 |
130,914,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7781:Siglec1
|
UTSW |
2 |
130,923,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7853:Siglec1
|
UTSW |
2 |
130,923,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Siglec1
|
UTSW |
2 |
130,913,083 (GRCm39) |
missense |
probably benign |
0.28 |
|
R8191:Siglec1
|
UTSW |
2 |
130,927,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8274:Siglec1
|
UTSW |
2 |
130,925,830 (GRCm39) |
missense |
probably benign |
|
|
R8345:Siglec1
|
UTSW |
2 |
130,920,498 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8670:Siglec1
|
UTSW |
2 |
130,923,387 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8814:Siglec1
|
UTSW |
2 |
130,914,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9102:Siglec1
|
UTSW |
2 |
130,915,389 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9311:Siglec1
|
UTSW |
2 |
130,916,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9416:Siglec1
|
UTSW |
2 |
130,925,390 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9462:Siglec1
|
UTSW |
2 |
130,916,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9521:Siglec1
|
UTSW |
2 |
130,915,246 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9683:Siglec1
|
UTSW |
2 |
130,921,236 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9799:Siglec1
|
UTSW |
2 |
130,915,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0024:Siglec1
|
UTSW |
2 |
130,922,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Siglec1
|
UTSW |
2 |
130,922,444 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Z1176:Siglec1
|
UTSW |
2 |
130,920,665 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTGAGAGCCATGCCTTCTTAAG -3'
(R):5'- CATGGTCGTGATTCAGTGCAC -3'
Sequencing Primer
(F):5'- CCATGCCTTCTTAAGCAGATTAGGG -3'
(R):5'- TGATTCAGTGCACCGTGGAC -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation