Incidental Mutation 'R0436:Or52s19'
ID 39007
Institutional Source Beutler Lab
Gene Symbol Or52s19
Ensembl Gene ENSMUSG00000109951
Gene Name olfactory receptor family 52 subfamily S member 19
Synonyms Olfr601, MOR24-3, GA_x6K02T2PBJ9-6068534-6067590
MMRRC Submission 038637-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.158) question?
Stock # R0436 (G1)
Quality Score 124
Status Validated
Chromosome 7
Chromosomal Location 103007431-103008420 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 103007948 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 151 (V151A)
Ref Sequence ENSEMBL: ENSMUSP00000150751 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080474] [ENSMUST00000210431] [ENSMUST00000214110] [ENSMUST00000217416]
AlphaFold A2RS33
Predicted Effect possibly damaging
Transcript: ENSMUST00000080474
AA Change: V151A

PolyPhen 2 Score 0.690 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000079328
Gene: ENSMUSG00000109951
AA Change: V151A

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 6.6e-102 PFAM
Pfam:7TM_GPCR_Srsx 37 187 1.2e-10 PFAM
Pfam:7tm_1 43 294 2.2e-15 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000210431
AA Change: V151A

PolyPhen 2 Score 0.690 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214110
AA Change: V151A

PolyPhen 2 Score 0.690 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217416
AA Change: V151A

PolyPhen 2 Score 0.690 (Sensitivity: 0.86; Specificity: 0.92)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 93.4%
Validation Efficiency 100% (66/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933430I17Rik T C 4: 62,461,682 (GRCm39) probably benign Het
Abcb10 C T 8: 124,697,740 (GRCm39) G195S probably benign Het
Adrb2 A G 18: 62,312,624 (GRCm39) V67A possibly damaging Het
Alx4 A T 2: 93,498,702 (GRCm39) K145* probably null Het
Arl8a G A 1: 135,074,718 (GRCm39) M1I probably null Het
Btbd16 G A 7: 130,387,783 (GRCm39) S134N probably benign Het
Ccdc136 T A 6: 29,414,933 (GRCm39) L474Q probably damaging Het
Cebpz A G 17: 79,243,079 (GRCm39) Y192H probably benign Het
Cep95 A G 11: 106,709,511 (GRCm39) Q109R probably null Het
Cfap54 G T 10: 92,874,837 (GRCm39) Q520K possibly damaging Het
Cog2 C T 8: 125,275,253 (GRCm39) probably benign Het
Cul1 A G 6: 47,500,707 (GRCm39) N702S probably benign Het
D430041D05Rik G C 2: 103,998,295 (GRCm39) P1836R probably damaging Het
Dmxl2 T C 9: 54,291,034 (GRCm39) D2472G probably damaging Het
Drgx T C 14: 32,330,040 (GRCm39) F81S probably damaging Het
Ect2 A G 3: 27,204,244 (GRCm39) F22L probably benign Het
Ehd4 A T 2: 119,932,822 (GRCm39) D201E probably damaging Het
Eif4ebp3 A G 18: 36,797,354 (GRCm39) probably null Het
Exd2 T C 12: 80,537,544 (GRCm39) probably benign Het
Gtf2a1 A C 12: 91,535,047 (GRCm39) probably null Het
H2-DMb1 A G 17: 34,378,630 (GRCm39) Y256C probably damaging Het
Haus6 T C 4: 86,504,044 (GRCm39) R527G probably benign Het
Helb C T 10: 119,930,117 (GRCm39) probably benign Het
Hhatl C T 9: 121,617,828 (GRCm39) A254T probably benign Het
Hk1 A T 10: 62,135,054 (GRCm39) probably benign Het
Hmcn2 A G 2: 31,295,624 (GRCm39) K2611R probably damaging Het
Hrc A G 7: 44,985,557 (GRCm39) H236R possibly damaging Het
Hunk T A 16: 90,261,042 (GRCm39) Y178N probably damaging Het
Iftap T C 2: 101,440,864 (GRCm39) probably benign Het
Jakmip2 G A 18: 43,691,234 (GRCm39) Q616* probably null Het
Kcnh4 C T 11: 100,637,758 (GRCm39) G633E probably benign Het
Msantd4 C T 9: 4,385,180 (GRCm39) R302C probably damaging Het
Nae1 T C 8: 105,249,868 (GRCm39) probably benign Het
Nek4 C T 14: 30,692,429 (GRCm39) L293F probably damaging Het
Odf2l C T 3: 144,831,877 (GRCm39) T44I possibly damaging Het
Otog G A 7: 45,915,360 (GRCm39) probably benign Het
Ppp1r21 C T 17: 88,873,117 (GRCm39) T425I possibly damaging Het
Prrc2b A G 2: 32,120,672 (GRCm39) E2204G probably damaging Het
Prrc2c A C 1: 162,532,883 (GRCm39) probably benign Het
Ptgs2 T C 1: 149,980,028 (GRCm39) probably benign Het
Slc12a8 T A 16: 33,371,455 (GRCm39) V197E probably damaging Het
Syne3 A G 12: 104,913,183 (GRCm39) W593R possibly damaging Het
Tmem63a A T 1: 180,800,298 (GRCm39) T696S probably benign Het
Tnks2 A G 19: 36,826,758 (GRCm39) D165G possibly damaging Het
Trim43a T C 9: 88,470,240 (GRCm39) W349R probably damaging Het
Unc45b T C 11: 82,820,393 (GRCm39) probably benign Het
Vmn1r4 T A 6: 56,933,947 (GRCm39) N150K probably damaging Het
Wdfy4 C A 14: 32,805,769 (GRCm39) probably benign Het
Wdr77 T A 3: 105,867,342 (GRCm39) D63E probably damaging Het
Zan T C 5: 137,463,164 (GRCm39) T672A unknown Het
Zdhhc17 A T 10: 110,817,851 (GRCm39) probably null Het
Other mutations in Or52s19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02825:Or52s19 APN 7 103,007,568 (GRCm39) missense probably benign 0.00
IGL03093:Or52s19 APN 7 103,007,446 (GRCm39) utr 3 prime probably benign
R0147:Or52s19 UTSW 7 103,007,613 (GRCm39) missense possibly damaging 0.67
R1486:Or52s19 UTSW 7 103,008,201 (GRCm39) missense possibly damaging 0.93
R2943:Or52s19 UTSW 7 103,007,658 (GRCm39) missense probably damaging 1.00
R4155:Or52s19 UTSW 7 103,008,363 (GRCm39) missense probably benign 0.00
R5335:Or52s19 UTSW 7 103,007,729 (GRCm39) missense probably damaging 1.00
R5378:Or52s19 UTSW 7 103,007,652 (GRCm39) missense probably damaging 1.00
R5840:Or52s19 UTSW 7 103,007,576 (GRCm39) missense probably damaging 1.00
R6961:Or52s19 UTSW 7 103,007,789 (GRCm39) missense possibly damaging 0.69
R7082:Or52s19 UTSW 7 103,007,495 (GRCm39) missense possibly damaging 0.84
R7497:Or52s19 UTSW 7 103,008,219 (GRCm39) missense probably damaging 0.97
R8154:Or52s19 UTSW 7 103,007,763 (GRCm39) missense probably benign
R9226:Or52s19 UTSW 7 103,008,092 (GRCm39) missense probably damaging 0.99
R9355:Or52s19 UTSW 7 103,008,125 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCACAGGAGCCGATGCCAAAAG -3'
(R):5'- TGGGGCCAGCTAATAAGTCGCAAC -3'

Sequencing Primer
(F):5'- GCAACACCAAGGCTGTAACG -3'
(R):5'- GGATGGCAGCTCATGATATTACC -3'
Posted On 2013-05-23