Incidental Mutation 'R5006:Vmn1r235'
| ID |
390179 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r235
|
| Ensembl Gene |
ENSMUSG00000050102 |
| Gene Name |
vomeronasal 1 receptor 235 |
| Synonyms |
V1rf2 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.051)
|
| Stock # |
R5006 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
21480689-21483125 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 21482467 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Threonine
at position 264
(M264T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000061689
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060603]
|
| AlphaFold |
A0A494B9T5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000060603
AA Change: M264T
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000061689
Gene: ENSMUSG00000050102
AA Change: M264T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
52 |
322 |
2.1e-19 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcf2 |
C |
A |
5: 24,781,535 (GRCm39) |
E51* |
probably null |
Het |
| Bcl11a |
T |
A |
11: 24,114,989 (GRCm39) |
Y777* |
probably null |
Het |
| C2cd4c |
T |
A |
10: 79,448,341 (GRCm39) |
T269S |
probably benign |
Het |
| Ciao2a |
G |
A |
9: 66,043,634 (GRCm39) |
|
probably null |
Het |
| Efcab3 |
T |
A |
11: 104,620,503 (GRCm39) |
|
probably null |
Het |
| Foxp1 |
A |
C |
6: 99,139,819 (GRCm39) |
V54G |
probably damaging |
Het |
| Il2ra |
T |
G |
2: 11,679,157 (GRCm39) |
L39R |
possibly damaging |
Het |
| Klk1b9 |
A |
T |
7: 43,628,711 (GRCm39) |
K72* |
probably null |
Het |
| Lmo7 |
A |
G |
14: 102,163,673 (GRCm39) |
|
probably benign |
Het |
| Mfng |
C |
T |
15: 78,648,588 (GRCm39) |
R163H |
probably benign |
Het |
| Nebl |
T |
A |
2: 17,393,582 (GRCm39) |
|
probably null |
Het |
| Or6b6 |
C |
T |
7: 106,570,808 (GRCm39) |
V248I |
probably damaging |
Het |
| Or7e169 |
G |
T |
9: 19,757,567 (GRCm39) |
A116E |
probably benign |
Het |
| Or7g30 |
A |
G |
9: 19,352,545 (GRCm39) |
N112S |
probably benign |
Het |
| Ralgapa1 |
A |
T |
12: 55,764,899 (GRCm39) |
C918S |
probably benign |
Het |
| Rasd2 |
G |
T |
8: 75,945,234 (GRCm39) |
R21L |
probably damaging |
Het |
| Sema4a |
A |
G |
3: 88,344,091 (GRCm39) |
M720T |
probably benign |
Het |
| Susd3 |
A |
G |
13: 49,392,181 (GRCm39) |
|
probably benign |
Het |
| Wls |
A |
G |
3: 159,617,428 (GRCm39) |
I368V |
possibly damaging |
Het |
| Ypel4 |
A |
G |
2: 84,567,182 (GRCm39) |
D5G |
probably benign |
Het |
| Zbtb38 |
C |
T |
9: 96,567,704 (GRCm39) |
G1127S |
probably damaging |
Het |
|
| Other mutations in Vmn1r235 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0138:Vmn1r235
|
UTSW |
17 |
21,482,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Vmn1r235
|
UTSW |
17 |
21,482,257 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1780:Vmn1r235
|
UTSW |
17 |
21,481,999 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1918:Vmn1r235
|
UTSW |
17 |
21,482,659 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1944:Vmn1r235
|
UTSW |
17 |
21,481,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2151:Vmn1r235
|
UTSW |
17 |
21,482,628 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4296:Vmn1r235
|
UTSW |
17 |
21,482,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4408:Vmn1r235
|
UTSW |
17 |
21,481,854 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4689:Vmn1r235
|
UTSW |
17 |
21,482,623 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5033:Vmn1r235
|
UTSW |
17 |
21,482,550 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R5303:Vmn1r235
|
UTSW |
17 |
21,482,268 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5512:Vmn1r235
|
UTSW |
17 |
21,481,677 (GRCm39) |
start codon destroyed |
probably benign |
0.09 |
|
R6999:Vmn1r235
|
UTSW |
17 |
21,482,127 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7133:Vmn1r235
|
UTSW |
17 |
21,482,292 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7471:Vmn1r235
|
UTSW |
17 |
21,482,658 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7552:Vmn1r235
|
UTSW |
17 |
21,481,713 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7577:Vmn1r235
|
UTSW |
17 |
21,481,881 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R8716:Vmn1r235
|
UTSW |
17 |
21,482,554 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R8725:Vmn1r235
|
UTSW |
17 |
21,482,056 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8727:Vmn1r235
|
UTSW |
17 |
21,482,056 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8729:Vmn1r235
|
UTSW |
17 |
21,481,875 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8732:Vmn1r235
|
UTSW |
17 |
21,482,439 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9016:Vmn1r235
|
UTSW |
17 |
21,481,969 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9072:Vmn1r235
|
UTSW |
17 |
21,482,271 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9350:Vmn1r235
|
UTSW |
17 |
21,482,190 (GRCm39) |
missense |
probably benign |
0.17 |
|
R9633:Vmn1r235
|
UTSW |
17 |
21,482,330 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9633:Vmn1r235
|
UTSW |
17 |
21,482,329 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9712:Vmn1r235
|
UTSW |
17 |
21,481,960 (GRCm39) |
missense |
probably benign |
0.14 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCTCTGTTTGTCTTGACAAAACTG -3'
(R):5'- CTCATGCAAGGAACACAGTGG -3'
Sequencing Primer
(F):5'- GTCTTGACAAAACTGGACAAATCCTG -3'
(R):5'- CACAGTGGCTAGATGCTATGG -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation