Incidental Mutation 'R5013:Or5ac25'
ID 390675
Institutional Source Beutler Lab
Gene Symbol Or5ac25
Ensembl Gene ENSMUSG00000095706
Gene Name olfactory receptor family 5 subfamily AC member 25
Synonyms MOR182-6, GA_x54KRFPKG5P-55580232-55579315, MOR182-6, Olfr207, MOR182-9, Olfr208, GA_x54KRFPKG5P-55570276-55569359, Olfr209, GA_x54KRFPKG5P-55590495-55589578
MMRRC Submission 042604-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # R5013 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 59181587-59182603 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 59182067 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 171 (N171K)
Ref Sequence ENSEMBL: ENSMUSP00000147068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055868] [ENSMUST00000208246] [ENSMUST00000208875] [ENSMUST00000213779]
AlphaFold L7N1X3
Predicted Effect probably damaging
Transcript: ENSMUST00000055868
AA Change: N171K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000053192
Gene: ENSMUSG00000095706
AA Change: N171K

DomainStartEndE-ValueType
Pfam:7tm_4 30 304 1.3e-49 PFAM
Pfam:7TM_GPCR_Srsx 34 303 1.3e-6 PFAM
Pfam:7tm_1 40 289 6.2e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208246
Predicted Effect probably damaging
Transcript: ENSMUST00000208875
AA Change: N171K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably benign
Transcript: ENSMUST00000213779
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.3%
Validation Efficiency 100% (86/86)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A G 1: 71,303,926 (GRCm39) L2117P probably damaging Het
Ago3 A T 4: 126,262,391 (GRCm39) S386R probably benign Het
Agxt T C 1: 93,069,779 (GRCm39) probably benign Het
Ahctf1 A T 1: 179,611,675 (GRCm39) I565N possibly damaging Het
Ank1 C T 8: 23,572,300 (GRCm39) T70I probably damaging Het
Anxa1 A G 19: 20,360,287 (GRCm39) V108A probably benign Het
Aqp3 A G 4: 41,093,819 (GRCm39) F225L probably damaging Het
Atp11b T G 3: 35,888,532 (GRCm39) I934R possibly damaging Het
Atp13a5 A T 16: 29,169,566 (GRCm39) L42Q probably damaging Het
Bcr A G 10: 74,960,898 (GRCm39) D443G probably benign Het
Cbfa2t3 G T 8: 123,365,598 (GRCm39) D211E possibly damaging Het
Ccdc146 A T 5: 21,538,036 (GRCm39) L96Q probably damaging Het
Cdh16 A G 8: 105,343,660 (GRCm39) I612T probably damaging Het
Clcn2 G A 16: 20,525,965 (GRCm39) P785S probably damaging Het
Dennd5a A G 7: 109,513,983 (GRCm39) I743T possibly damaging Het
Dnah12 T A 14: 26,431,326 (GRCm39) D381E probably benign Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Dnajc2 G A 5: 21,962,771 (GRCm39) R521* probably null Het
Dst T C 1: 34,289,728 (GRCm39) V5776A probably damaging Het
Eddm13 G A 7: 6,269,332 (GRCm39) probably benign Het
Eif1ad19 T A 12: 87,740,512 (GRCm39) K16* probably null Het
Ercc4 G A 16: 12,941,445 (GRCm39) probably benign Het
Eya1 T A 1: 14,254,582 (GRCm39) N417Y probably damaging Het
Fam149b T A 14: 20,413,439 (GRCm39) H219Q possibly damaging Het
Fam227b G A 2: 125,958,043 (GRCm39) P241S probably damaging Het
Fbxw17 C T 13: 50,586,506 (GRCm39) R403C probably benign Het
Fer1l4 T C 2: 155,873,135 (GRCm39) Y1315C probably damaging Het
Gatd1 G T 7: 140,988,861 (GRCm39) probably benign Het
Gm10330 A T 12: 23,829,961 (GRCm39) Y73* probably null Het
Grn C A 11: 102,321,380 (GRCm39) probably benign Het
Gsn T A 2: 35,188,933 (GRCm39) Y440N probably damaging Het
Hdc C T 2: 126,446,220 (GRCm39) E180K probably benign Het
Ilk A G 7: 105,391,456 (GRCm39) D374G probably damaging Het
Invs G A 4: 48,421,807 (GRCm39) R813Q probably damaging Het
Itln1 T A 1: 171,360,958 (GRCm39) K45* probably null Het
Ivd A G 2: 118,710,946 (GRCm39) Y385C probably damaging Het
Klk1b4 A G 7: 43,860,492 (GRCm39) N170S probably benign Het
Klk1b9 A C 7: 43,445,419 (GRCm39) D203A probably damaging Het
Lamtor3 A T 3: 137,630,909 (GRCm39) R27S probably damaging Het
Lcn6 T A 2: 25,567,082 (GRCm39) probably null Het
Lrriq1 T C 10: 103,025,784 (GRCm39) D946G probably damaging Het
Morc1 A G 16: 48,322,699 (GRCm39) D332G probably benign Het
Myo15a T C 11: 60,382,493 (GRCm39) I1523T probably damaging Het
Nagpa A T 16: 5,013,743 (GRCm39) M365K probably benign Het
Nckap5l G T 15: 99,324,457 (GRCm39) P682Q probably benign Het
Nfix A G 8: 85,498,713 (GRCm39) F87L possibly damaging Het
Nup155 C A 15: 8,153,722 (GRCm39) T421K probably benign Het
Or5ae2 T C 7: 84,505,646 (GRCm39) V23A probably damaging Het
Or7c74 A G 2: 37,160,937 (GRCm39) noncoding transcript Het
Or8k53 A T 2: 86,177,647 (GRCm39) F154L probably benign Het
Pate14 T C 9: 36,549,120 (GRCm39) N47D probably benign Het
Pds5a A C 5: 65,792,680 (GRCm39) V751G probably benign Het
Podnl1 G T 8: 84,852,965 (GRCm39) C45F probably damaging Het
Psme2b C T 11: 48,836,654 (GRCm39) E98K probably benign Het
Ptprk T A 10: 28,427,713 (GRCm39) I764N probably damaging Het
Rbm33 A T 5: 28,547,409 (GRCm39) Q193L probably benign Het
Rnasel C A 1: 153,629,677 (GRCm39) H64Q probably damaging Het
Ryr1 G A 7: 28,802,234 (GRCm39) probably null Het
Scamp3 A G 3: 89,088,216 (GRCm39) probably benign Het
Sema6b C T 17: 56,439,497 (GRCm39) probably null Het
Six4 A C 12: 73,150,400 (GRCm39) I715R probably benign Het
Slc28a2 T C 2: 122,288,371 (GRCm39) M554T possibly damaging Het
Snhg11 T C 2: 158,218,872 (GRCm39) probably benign Het
Spdya A T 17: 71,869,499 (GRCm39) Y98F possibly damaging Het
Tert T C 13: 73,794,428 (GRCm39) probably null Het
Tex22 G A 12: 113,052,104 (GRCm39) C54Y probably damaging Het
Tmem198b C T 10: 128,637,942 (GRCm39) R207H probably damaging Het
Trbv13-1 C T 6: 41,093,189 (GRCm39) Q42* probably null Het
Trcg1 T C 9: 57,149,562 (GRCm39) L378P probably damaging Het
Trpv5 T G 6: 41,636,647 (GRCm39) D433A probably damaging Het
Ube3b A G 5: 114,545,702 (GRCm39) N654D probably damaging Het
Vmn1r17 A G 6: 57,337,828 (GRCm39) V130A probably benign Het
Vwa7 A T 17: 35,241,709 (GRCm39) Y448F probably damaging Het
Zan A C 5: 137,382,099 (GRCm39) D5149E unknown Het
Zfp106 A G 2: 120,341,015 (GRCm39) W1832R probably damaging Het
Zfp189 G A 4: 49,530,438 (GRCm39) G514S probably damaging Het
Zhx1 G A 15: 57,917,538 (GRCm39) T236I possibly damaging Het
Other mutations in Or5ac25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01083:Or5ac25 APN 16 59,182,198 (GRCm39) missense probably damaging 1.00
IGL01137:Or5ac25 APN 16 59,182,335 (GRCm39) missense probably benign 0.01
IGL01383:Or5ac25 APN 16 59,182,316 (GRCm39) missense probably benign 0.10
IGL01913:Or5ac25 APN 16 59,182,294 (GRCm39) missense probably damaging 1.00
IGL01914:Or5ac25 APN 16 59,182,294 (GRCm39) missense probably damaging 1.00
IGL02125:Or5ac25 APN 16 59,181,879 (GRCm39) missense probably benign
IGL02414:Or5ac25 APN 16 59,182,077 (GRCm39) missense probably damaging 1.00
IGL02512:Or5ac25 APN 16 59,182,171 (GRCm39) missense possibly damaging 0.95
PIT4495001:Or5ac25 UTSW 16 59,181,871 (GRCm39) missense probably damaging 0.99
R0029:Or5ac25 UTSW 16 59,181,904 (GRCm39) missense probably benign 0.00
R0531:Or5ac25 UTSW 16 59,182,171 (GRCm39) missense probably damaging 0.99
R1799:Or5ac25 UTSW 16 59,182,243 (GRCm39) missense probably benign 0.01
R1901:Or5ac25 UTSW 16 59,182,526 (GRCm39) missense probably benign 0.03
R1902:Or5ac25 UTSW 16 59,182,526 (GRCm39) missense probably benign 0.03
R1903:Or5ac25 UTSW 16 59,182,526 (GRCm39) missense probably benign 0.03
R1972:Or5ac25 UTSW 16 59,182,476 (GRCm39) missense probably damaging 0.96
R2471:Or5ac25 UTSW 16 59,181,944 (GRCm39) missense possibly damaging 0.79
R5160:Or5ac25 UTSW 16 59,182,129 (GRCm39) missense probably damaging 1.00
R5883:Or5ac25 UTSW 16 59,182,078 (GRCm39) missense probably damaging 1.00
R6272:Or5ac25 UTSW 16 59,181,948 (GRCm39) missense possibly damaging 0.76
R6296:Or5ac25 UTSW 16 59,181,769 (GRCm39) missense probably benign 0.06
R6741:Or5ac25 UTSW 16 59,181,918 (GRCm39) missense probably damaging 1.00
R6928:Or5ac25 UTSW 16 59,181,826 (GRCm39) missense probably damaging 1.00
R7982:Or5ac25 UTSW 16 59,181,927 (GRCm39) missense probably benign
R8254:Or5ac25 UTSW 16 59,182,534 (GRCm39) missense probably benign 0.00
R8429:Or5ac25 UTSW 16 59,181,990 (GRCm39) missense possibly damaging 0.89
R8857:Or5ac25 UTSW 16 59,182,041 (GRCm39) missense probably damaging 1.00
R9596:Or5ac25 UTSW 16 59,181,942 (GRCm39) missense possibly damaging 0.50
R9611:Or5ac25 UTSW 16 59,182,242 (GRCm39) missense probably benign 0.04
R9658:Or5ac25 UTSW 16 59,182,106 (GRCm39) missense probably damaging 1.00
X0017:Or5ac25 UTSW 16 59,182,002 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- GAGAAGGCTTTGTTTCTGCC -3'
(R):5'- TAAGTGCAACTGCGGAATGTTTC -3'

Sequencing Primer
(F):5'- CCCTCTCAGACTTTGTTCTCAGGATG -3'
(R):5'- CAACTGCGGAATGTTTCATCCTGG -3'
Posted On 2016-06-06