Mutagenetix > Incidental Mutation

Incidental Mutation 'R5057:Ncor2'

390915

Institutional Source

Beutler Lab

Gene Symbol

Ncor2

Ensembl Gene

ENSMUSG00000029478

Gene Name

nuclear receptor co-repressor 2

Synonyms

SMRTe, SMRT

MMRRC Submission

042647-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R5057 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

125094217-125256283 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 125125130 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glutamic Acid at position 307 (V307E)

Ref Sequence

ENSEMBL: ENSMUSP00000121588 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055256] [ENSMUST00000086083] [ENSMUST00000111393] [ENSMUST00000111394] [ENSMUST00000111398] [ENSMUST00000111402] [ENSMUST00000134404] [ENSMUST00000199561]

AlphaFold

Q9WU42

Predicted Effect

probably benign
Transcript: ENSMUST00000055256
AA Change: V893E

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000055954
Gene: ENSMUSG00000029478
AA Change: V893E

Domain	Start	End	E-Value	Type
low complexity region	147	154	N/A	INTRINSIC
coiled coil region	167	207	N/A	INTRINSIC
SANT	428	476	4.42e-6	SMART
coiled coil region	494	550	N/A	INTRINSIC
SANT	607	655	1.43e-14	SMART
low complexity region	668	686	N/A	INTRINSIC
low complexity region	699	726	N/A	INTRINSIC
low complexity region	768	813	N/A	INTRINSIC
low complexity region	822	828	N/A	INTRINSIC
low complexity region	848	860	N/A	INTRINSIC
low complexity region	867	874	N/A	INTRINSIC
low complexity region	905	919	N/A	INTRINSIC
low complexity region	935	944	N/A	INTRINSIC
low complexity region	989	1000	N/A	INTRINSIC
low complexity region	1011	1025	N/A	INTRINSIC
low complexity region	1027	1043	N/A	INTRINSIC
low complexity region	1086	1096	N/A	INTRINSIC
low complexity region	1100	1116	N/A	INTRINSIC
low complexity region	1366	1380	N/A	INTRINSIC
low complexity region	1481	1497	N/A	INTRINSIC
low complexity region	1616	1622	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1737	1754	N/A	INTRINSIC
low complexity region	1764	1776	N/A	INTRINSIC
low complexity region	1800	1807	N/A	INTRINSIC
low complexity region	1921	1939	N/A	INTRINSIC
low complexity region	1959	1975	N/A	INTRINSIC
low complexity region	2062	2076	N/A	INTRINSIC
PDB:2GPV\|I	2293	2314	8e-8	PDB
low complexity region	2324	2336	N/A	INTRINSIC
low complexity region	2433	2453	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000086083
AA Change: V893E

PolyPhen 2 Score 0.093 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000083250
Gene: ENSMUSG00000029478
AA Change: V893E

Domain	Start	End	E-Value	Type
low complexity region	147	154	N/A	INTRINSIC
coiled coil region	167	207	N/A	INTRINSIC
SANT	428	476	4.42e-6	SMART
coiled coil region	494	550	N/A	INTRINSIC
SANT	607	655	1.43e-14	SMART
low complexity region	668	686	N/A	INTRINSIC
low complexity region	699	726	N/A	INTRINSIC
low complexity region	768	813	N/A	INTRINSIC
low complexity region	822	828	N/A	INTRINSIC
low complexity region	848	860	N/A	INTRINSIC
low complexity region	867	874	N/A	INTRINSIC
low complexity region	905	919	N/A	INTRINSIC
low complexity region	935	944	N/A	INTRINSIC
low complexity region	988	999	N/A	INTRINSIC
low complexity region	1010	1024	N/A	INTRINSIC
low complexity region	1026	1042	N/A	INTRINSIC
low complexity region	1085	1095	N/A	INTRINSIC
low complexity region	1099	1115	N/A	INTRINSIC
low complexity region	1364	1378	N/A	INTRINSIC
low complexity region	1479	1495	N/A	INTRINSIC
low complexity region	1614	1620	N/A	INTRINSIC
low complexity region	1707	1724	N/A	INTRINSIC
low complexity region	1735	1752	N/A	INTRINSIC
low complexity region	1762	1774	N/A	INTRINSIC
low complexity region	1798	1805	N/A	INTRINSIC
low complexity region	1916	1934	N/A	INTRINSIC
low complexity region	1954	1970	N/A	INTRINSIC
low complexity region	2057	2071	N/A	INTRINSIC
PDB:2GPV\|I	2288	2309	8e-8	PDB
low complexity region	2319	2331	N/A	INTRINSIC
low complexity region	2428	2448	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111393
AA Change: V718E

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000107024
Gene: ENSMUSG00000029478
AA Change: V718E

Domain	Start	End	E-Value	Type
coiled coil region	1	32	N/A	INTRINSIC
SANT	253	301	4.42e-6	SMART
coiled coil region	319	375	N/A	INTRINSIC
SANT	432	480	1.43e-14	SMART
low complexity region	493	511	N/A	INTRINSIC
low complexity region	524	551	N/A	INTRINSIC
low complexity region	593	638	N/A	INTRINSIC
low complexity region	647	653	N/A	INTRINSIC
low complexity region	673	685	N/A	INTRINSIC
low complexity region	692	699	N/A	INTRINSIC
low complexity region	730	744	N/A	INTRINSIC
low complexity region	760	769	N/A	INTRINSIC
low complexity region	813	824	N/A	INTRINSIC
low complexity region	835	849	N/A	INTRINSIC
low complexity region	851	867	N/A	INTRINSIC
low complexity region	910	920	N/A	INTRINSIC
low complexity region	924	940	N/A	INTRINSIC
low complexity region	1225	1239	N/A	INTRINSIC
low complexity region	1340	1356	N/A	INTRINSIC
low complexity region	1475	1481	N/A	INTRINSIC
low complexity region	1568	1585	N/A	INTRINSIC
low complexity region	1596	1613	N/A	INTRINSIC
low complexity region	1623	1635	N/A	INTRINSIC
low complexity region	1659	1666	N/A	INTRINSIC
low complexity region	1780	1798	N/A	INTRINSIC
low complexity region	1818	1834	N/A	INTRINSIC
low complexity region	1921	1935	N/A	INTRINSIC
PDB:2GPV\|I	2152	2173	7e-8	PDB
low complexity region	2183	2195	N/A	INTRINSIC
low complexity region	2292	2312	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111394
AA Change: V674E

PolyPhen 2 Score 0.082 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000107025
Gene: ENSMUSG00000029478
AA Change: V674E

Domain	Start	End	E-Value	Type
SANT	209	257	4.42e-6	SMART
coiled coil region	275	331	N/A	INTRINSIC
SANT	388	436	1.43e-14	SMART
low complexity region	449	467	N/A	INTRINSIC
low complexity region	480	507	N/A	INTRINSIC
low complexity region	549	594	N/A	INTRINSIC
low complexity region	603	609	N/A	INTRINSIC
low complexity region	629	641	N/A	INTRINSIC
low complexity region	648	655	N/A	INTRINSIC
low complexity region	686	700	N/A	INTRINSIC
low complexity region	716	725	N/A	INTRINSIC
low complexity region	769	780	N/A	INTRINSIC
low complexity region	791	805	N/A	INTRINSIC
low complexity region	807	823	N/A	INTRINSIC
low complexity region	866	876	N/A	INTRINSIC
low complexity region	880	896	N/A	INTRINSIC
low complexity region	1146	1160	N/A	INTRINSIC
low complexity region	1261	1277	N/A	INTRINSIC
low complexity region	1396	1402	N/A	INTRINSIC
low complexity region	1489	1506	N/A	INTRINSIC
low complexity region	1517	1534	N/A	INTRINSIC
low complexity region	1544	1556	N/A	INTRINSIC
low complexity region	1580	1587	N/A	INTRINSIC
low complexity region	1701	1719	N/A	INTRINSIC
low complexity region	1739	1755	N/A	INTRINSIC
low complexity region	1842	1856	N/A	INTRINSIC
PDB:2GPV\|I	2073	2094	7e-8	PDB
low complexity region	2104	2116	N/A	INTRINSIC
low complexity region	2213	2233	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111398
AA Change: V893E

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000107029
Gene: ENSMUSG00000029478
AA Change: V893E

Domain	Start	End	E-Value	Type
low complexity region	147	154	N/A	INTRINSIC
coiled coil region	167	207	N/A	INTRINSIC
SANT	428	476	4.42e-6	SMART
coiled coil region	494	550	N/A	INTRINSIC
SANT	607	655	1.43e-14	SMART
low complexity region	668	686	N/A	INTRINSIC
low complexity region	699	726	N/A	INTRINSIC
low complexity region	768	813	N/A	INTRINSIC
low complexity region	822	828	N/A	INTRINSIC
low complexity region	848	860	N/A	INTRINSIC
low complexity region	867	874	N/A	INTRINSIC
low complexity region	905	919	N/A	INTRINSIC
low complexity region	935	944	N/A	INTRINSIC
low complexity region	988	999	N/A	INTRINSIC
low complexity region	1010	1024	N/A	INTRINSIC
low complexity region	1026	1042	N/A	INTRINSIC
low complexity region	1085	1095	N/A	INTRINSIC
low complexity region	1099	1115	N/A	INTRINSIC
low complexity region	1365	1379	N/A	INTRINSIC
low complexity region	1480	1496	N/A	INTRINSIC
low complexity region	1615	1621	N/A	INTRINSIC
low complexity region	1708	1725	N/A	INTRINSIC
low complexity region	1736	1753	N/A	INTRINSIC
low complexity region	1763	1775	N/A	INTRINSIC
low complexity region	1799	1806	N/A	INTRINSIC
low complexity region	1920	1938	N/A	INTRINSIC
low complexity region	1958	1974	N/A	INTRINSIC
low complexity region	2061	2075	N/A	INTRINSIC
PDB:2GPV\|I	2292	2313	8e-8	PDB
low complexity region	2323	2335	N/A	INTRINSIC
low complexity region	2432	2452	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111402
AA Change: V893E

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000107033
Gene: ENSMUSG00000029478
AA Change: V893E

Domain	Start	End	E-Value	Type
Pfam:GPS2_interact	141	229	4.9e-41	PFAM
SANT	428	476	4.42e-6	SMART
coiled coil region	494	550	N/A	INTRINSIC
SANT	607	655	1.43e-14	SMART
low complexity region	668	686	N/A	INTRINSIC
low complexity region	699	726	N/A	INTRINSIC
low complexity region	768	813	N/A	INTRINSIC
low complexity region	822	828	N/A	INTRINSIC
low complexity region	848	860	N/A	INTRINSIC
low complexity region	867	874	N/A	INTRINSIC
low complexity region	905	919	N/A	INTRINSIC
low complexity region	935	944	N/A	INTRINSIC
low complexity region	988	999	N/A	INTRINSIC
low complexity region	1010	1024	N/A	INTRINSIC
low complexity region	1026	1042	N/A	INTRINSIC
low complexity region	1085	1095	N/A	INTRINSIC
low complexity region	1099	1115	N/A	INTRINSIC
low complexity region	1400	1414	N/A	INTRINSIC
low complexity region	1515	1531	N/A	INTRINSIC
low complexity region	1650	1656	N/A	INTRINSIC
low complexity region	1743	1760	N/A	INTRINSIC
low complexity region	1771	1788	N/A	INTRINSIC
low complexity region	1798	1810	N/A	INTRINSIC
low complexity region	1834	1841	N/A	INTRINSIC
low complexity region	1955	1973	N/A	INTRINSIC
low complexity region	1993	2009	N/A	INTRINSIC
low complexity region	2096	2110	N/A	INTRINSIC
PDB:2GPV\|I	2327	2348	8e-8	PDB
low complexity region	2358	2370	N/A	INTRINSIC
low complexity region	2467	2487	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000134404
AA Change: V307E

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000121588
Gene: ENSMUSG00000029478
AA Change: V307E

Domain	Start	End	E-Value	Type
SANT	2	49	1.94e-2	SMART
low complexity region	84	100	N/A	INTRINSIC
low complexity region	113	140	N/A	INTRINSIC
low complexity region	182	227	N/A	INTRINSIC
low complexity region	236	242	N/A	INTRINSIC
low complexity region	262	274	N/A	INTRINSIC
low complexity region	281	288	N/A	INTRINSIC
low complexity region	319	333	N/A	INTRINSIC
low complexity region	349	358	N/A	INTRINSIC
low complexity region	402	413	N/A	INTRINSIC
low complexity region	424	438	N/A	INTRINSIC
low complexity region	440	456	N/A	INTRINSIC
low complexity region	499	509	N/A	INTRINSIC
low complexity region	513	529	N/A	INTRINSIC
low complexity region	813	827	N/A	INTRINSIC
low complexity region	928	944	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149968

Predicted Effect

probably benign
Transcript: ENSMUST00000199561

SMART Domains

Protein: ENSMUSP00000142862
Gene: ENSMUSG00000029478

Domain	Start	End	E-Value	Type
SANT	2	49	1.2e-4	SMART
low complexity region	62	80	N/A	INTRINSIC

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.2%
20x: 92.0%

Validation Efficiency

97% (118/122)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
PHENOTYPE: Mice homozygous for a null allele die before E16.5 of heart defects and exhibit neural defects. [provided by MGI curators]

Allele List at MGI

All alleles(145) : Targeted(2) Gene trapped(143)

Other mutations in this stock

Total: 120 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933427D14Rik	A	T	11: 72,057,581 (GRCm39)	H739Q	probably benign	Het
Acad12	T	A	5: 121,748,152 (GRCm39)	T89S	probably benign	Het
Adgb	A	G	10: 10,233,722 (GRCm39)	C1252R	probably benign	Het
Ankef1	A	G	2: 136,392,280 (GRCm39)		probably null	Het
Ankfy1	T	C	11: 72,650,745 (GRCm39)	L976P	probably damaging	Het
Ankib1	T	A	5: 3,784,011 (GRCm39)	I322F	possibly damaging	Het
Ankrd61	T	A	5: 143,831,613 (GRCm39)	T64S	probably benign	Het
Anxa6	T	G	11: 54,892,062 (GRCm39)	E298A	possibly damaging	Het
Apc2	A	G	10: 80,144,903 (GRCm39)	S605G	probably damaging	Het
Arih1	T	C	9: 59,393,515 (GRCm39)	N39S	unknown	Het
Bicc1	A	G	10: 70,783,713 (GRCm39)	S393P	possibly damaging	Het
Bptf	A	T	11: 106,973,354 (GRCm39)	F693L	probably damaging	Het
Cacng4	A	G	11: 107,685,197 (GRCm39)	Y32H	probably damaging	Het
Ccdc50	T	A	16: 27,257,092 (GRCm39)	D252E	probably benign	Het
Ccdc92b	C	A	11: 74,528,976 (GRCm39)	T160K	probably damaging	Het
Cd163	C	T	6: 124,302,247 (GRCm39)	T937I	probably damaging	Het
Cdh22	C	A	2: 164,958,063 (GRCm39)	V635F	probably damaging	Het
Cenpe	G	T	3: 134,926,074 (GRCm39)	A243S	probably benign	Het
Cep295	A	T	9: 15,233,979 (GRCm39)	H2272Q	probably benign	Het
Cgnl1	A	T	9: 71,632,076 (GRCm39)	V425D	probably damaging	Het
Clec4b2	A	T	6: 123,177,915 (GRCm39)	S77C	probably null	Het
Cntnap5a	C	T	1: 115,612,943 (GRCm39)	T26I	probably benign	Het
Col6a3	T	C	1: 90,743,852 (GRCm39)	K165R	possibly damaging	Het
Copb1	A	T	7: 113,825,997 (GRCm39)	N662K	probably benign	Het
Crybg1	T	A	10: 43,865,104 (GRCm39)	R1458*	probably null	Het
Cspp1	T	A	1: 10,145,186 (GRCm39)		probably benign	Het
Dhtkd1	A	G	2: 5,924,324 (GRCm39)	C430R	probably damaging	Het
Dlg5	T	C	14: 24,186,690 (GRCm39)	E1847G	probably damaging	Het
Dync2i1	A	T	12: 116,177,033 (GRCm39)	N856K	probably benign	Het
Eif1ad16	A	T	12: 87,985,481 (GRCm39)	S21T	unknown	Het
Ephb3	A	G	16: 21,039,197 (GRCm39)	D351G	probably damaging	Het
Exd2	T	A	12: 80,543,564 (GRCm39)	N582K	probably damaging	Het
Fam161a	T	A	11: 22,970,397 (GRCm39)	C192S	probably damaging	Het
Fbn1	A	G	2: 125,308,615 (GRCm39)	V149A	probably benign	Het
Fbxw16	A	G	9: 109,270,232 (GRCm39)	S170P	probably damaging	Het
Fndc1	T	A	17: 7,990,802 (GRCm39)	R965*	probably null	Het
Frem2	T	C	3: 53,442,617 (GRCm39)	D2640G	probably benign	Het
Gfm1	T	C	3: 67,380,877 (GRCm39)	V664A	probably damaging	Het
Gm10803	A	C	2: 93,394,517 (GRCm39)	L96F	probably damaging	Het
Gm14569	T	C	X: 35,694,470 (GRCm39)	D1413G	probably benign	Het
Gm44501	A	G	17: 40,889,563 (GRCm39)	T26A	probably benign	Het
Gpc4	G	A	X: 51,163,440 (GRCm39)	R148C	probably damaging	Het
Gpsm1	G	A	2: 26,215,369 (GRCm39)	R277Q	probably damaging	Het
Inmt	T	A	6: 55,151,883 (GRCm39)	H29L	probably benign	Het
Insrr	T	A	3: 87,722,572 (GRCm39)	C1265S	probably benign	Het
Kctd12	A	G	14: 103,219,045 (GRCm39)	F278L	possibly damaging	Het
Klk14	G	A	7: 43,341,501 (GRCm39)	C51Y	probably damaging	Het
Lag3	T	A	6: 124,882,318 (GRCm39)	I393F	possibly damaging	Het
Lama2	C	T	10: 27,040,982 (GRCm39)	C1447Y	probably damaging	Het
Lama3	G	A	18: 12,665,005 (GRCm39)	G2275S	probably null	Het
Lrrc17	A	T	5: 21,780,307 (GRCm39)	H427L	probably benign	Het
Med13l	T	A	5: 118,856,558 (GRCm39)	S164T	probably damaging	Het
Milr1	A	G	11: 106,657,791 (GRCm39)	D131G	possibly damaging	Het
Myo5c	A	T	9: 75,208,155 (GRCm39)	T1630S	probably damaging	Het
Nbeal2	A	T	9: 110,460,073 (GRCm39)	N1848K	probably damaging	Het
Ndufs3	C	A	2: 90,729,004 (GRCm39)	A161S	probably benign	Het
Neo1	T	C	9: 58,897,554 (GRCm39)	D134G	probably damaging	Het
Nexmif	A	T	X: 103,130,956 (GRCm39)	N320K	probably damaging	Het
Nipal3	T	A	4: 135,194,167 (GRCm39)	I289F	probably damaging	Het
Nrg4	A	G	9: 55,189,880 (GRCm39)		probably benign	Het
Nrxn3	A	T	12: 89,221,804 (GRCm39)	I528F	probably damaging	Het
Or11h23	A	C	14: 50,948,669 (GRCm39)	N294T	probably damaging	Het
Or3a10	T	A	11: 73,935,881 (GRCm39)	D73V	probably damaging	Het
Pate2	T	C	9: 35,597,407 (GRCm39)		probably benign	Het
Pcnx2	T	C	8: 126,581,930 (GRCm39)	I935M	possibly damaging	Het
Pik3c2a	G	T	7: 115,975,518 (GRCm39)	T683K	possibly damaging	Het
Pip5k1c	G	A	10: 81,146,723 (GRCm39)		probably null	Het
Pkd1l2	G	A	8: 117,781,747 (GRCm39)	T766I	probably benign	Het
Polr3c	C	A	3: 96,619,373 (GRCm39)	L508F	probably damaging	Het
Por	A	G	5: 135,759,756 (GRCm39)	D189G	probably damaging	Het
Potefam1	A	T	2: 111,055,766 (GRCm39)	F207I	probably benign	Het
Prim2	A	T	1: 33,669,441 (GRCm39)	L178*	probably null	Het
Prima1	C	A	12: 103,168,864 (GRCm39)		probably null	Het
Ptpn21	G	A	12: 98,645,666 (GRCm39)	R1091C	probably damaging	Het
Ptpn23	G	A	9: 110,217,624 (GRCm39)	T744I	probably benign	Het
Rad21	A	T	15: 51,830,102 (GRCm39)	I503K	probably benign	Het
Rbm12	A	T	2: 155,938,806 (GRCm39)	C489S	probably benign	Het
Rpl10a	A	T	17: 28,549,607 (GRCm39)	H140L	probably benign	Het
Rpl7-ps8	A	T	15: 59,083,004 (GRCm39)		noncoding transcript	Het
Rtbdn	T	C	8: 85,681,638 (GRCm39)	F143S	probably damaging	Het
Scamp3	T	A	3: 89,089,600 (GRCm39)		probably benign	Het
Setd5	A	G	6: 113,114,922 (GRCm39)	S848G	probably damaging	Het
Sez6	T	C	11: 77,863,979 (GRCm39)	V487A	probably damaging	Het
Shc2	G	A	10: 79,459,706 (GRCm39)	P413S	probably benign	Het
Sipa1l3	T	C	7: 29,070,618 (GRCm39)	N966S	probably damaging	Het
Slc39a8	A	G	3: 135,554,790 (GRCm39)	E78G	probably benign	Het
Slc8a3	A	G	12: 81,246,332 (GRCm39)	V900A	probably damaging	Het
Slitrk3	T	C	3: 72,957,981 (GRCm39)	T264A	probably benign	Het
Spire2	G	A	8: 124,084,940 (GRCm39)	R260H	probably damaging	Het
Stk39	T	A	2: 68,051,292 (GRCm39)	I518F	probably damaging	Het
Tardbp	T	A	4: 148,703,813 (GRCm39)		probably null	Het
Tep1	A	G	14: 51,066,456 (GRCm39)	Y2335H	probably benign	Het
Tesl1	G	A	X: 23,773,480 (GRCm39)	G327E	probably damaging	Het
Tll2	A	G	19: 41,105,705 (GRCm39)	V358A	probably benign	Het
Tmem268	C	G	4: 63,486,777 (GRCm39)	S100C	probably damaging	Het
Tnfsf9	A	G	17: 57,412,444 (GRCm39)	T5A	probably benign	Het
Trappc10	G	T	10: 78,052,994 (GRCm39)	F260L	possibly damaging	Het
Trim5	A	G	7: 103,914,630 (GRCm39)	Y480H	probably damaging	Het
Trmt112	T	C	19: 6,888,121 (GRCm39)	V91A	probably benign	Het
Ttn	T	A	2: 76,577,379 (GRCm39)	K22759*	probably null	Het
Ttn	C	A	2: 76,748,988 (GRCm39)	L4020F	probably benign	Het
Ubash3b	A	G	9: 40,948,755 (GRCm39)	C187R	possibly damaging	Het
Ube3b	T	C	5: 114,544,318 (GRCm39)	F572L	probably benign	Het
Ubr5	A	G	15: 38,004,353 (GRCm39)	V1332A	probably damaging	Het
Ubtd2	C	A	11: 32,466,320 (GRCm39)	R180S	probably damaging	Het
Ubtf	A	G	11: 102,197,913 (GRCm39)	S673P	probably damaging	Het
Ubtfl1	A	T	9: 18,320,487 (GRCm39)	D5V	possibly damaging	Het
Usp17la	G	A	7: 104,510,330 (GRCm39)	V312I	possibly damaging	Het
Usp17ld	G	T	7: 102,899,655 (GRCm39)	H426N	probably benign	Het
Usp34	A	G	11: 23,408,086 (GRCm39)		probably benign	Het
Vmn1r199	A	T	13: 22,567,575 (GRCm39)	T290S	possibly damaging	Het
Vmn1r33	T	C	6: 66,589,089 (GRCm39)	N155S	probably benign	Het
Vmn2r28	T	A	7: 5,489,463 (GRCm39)	I459L	probably benign	Het
Vmn2r6	T	A	3: 64,445,207 (GRCm39)	K839N	probably damaging	Het
Vmn2r65	A	G	7: 84,589,819 (GRCm39)	I699T	probably damaging	Het
Vps16	A	G	2: 130,281,372 (GRCm39)	S235G	probably benign	Het
Vwde	T	C	6: 13,192,641 (GRCm39)	I421V	possibly damaging	Het
Xiap	T	C	X: 41,183,342 (GRCm39)	F23L	probably benign	Het
Xkr7	A	G	2: 152,896,300 (GRCm39)	T385A	probably benign	Het
Znfx1	T	C	2: 166,881,746 (GRCm39)	Y217C	probably damaging	Het

Other mutations in Ncor2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00330:Ncor2	APN	5	125,119,807 (GRCm39)	critical splice donor site	probably null
IGL00519:Ncor2	APN	5	125,161,988 (GRCm39)	missense	unknown
IGL00900:Ncor2	APN	5	125,102,848 (GRCm39)	missense	probably damaging	1.00
IGL00950:Ncor2	APN	5	125,163,954 (GRCm39)	missense	unknown
IGL01320:Ncor2	APN	5	125,186,991 (GRCm39)	missense	probably benign	0.00
IGL01382:Ncor2	APN	5	125,132,837 (GRCm39)	missense	probably damaging	0.96
IGL01573:Ncor2	APN	5	125,162,090 (GRCm39)	missense	unknown
IGL01721:Ncor2	APN	5	125,128,001 (GRCm39)	missense	probably damaging	1.00
IGL01875:Ncor2	APN	5	125,142,934 (GRCm39)	missense	unknown
IGL02090:Ncor2	APN	5	125,111,467 (GRCm39)	missense	probably damaging	0.99
IGL02192:Ncor2	APN	5	125,101,301 (GRCm39)	missense	probably damaging	1.00
IGL02396:Ncor2	APN	5	125,114,978 (GRCm39)	missense	probably damaging	1.00
IGL02934:Ncor2	APN	5	125,102,621 (GRCm39)	missense	probably benign	0.33
IGL02997:Ncor2	APN	5	125,196,634 (GRCm39)	intron	probably benign
R0019:Ncor2	UTSW	5	125,196,545 (GRCm39)	critical splice donor site	probably null
R0331:Ncor2	UTSW	5	125,161,981 (GRCm39)	missense	unknown
R0333:Ncor2	UTSW	5	125,111,408 (GRCm39)	splice site	probably benign
R0403:Ncor2	UTSW	5	125,110,401 (GRCm39)	missense	possibly damaging	0.73
R0557:Ncor2	UTSW	5	125,183,369 (GRCm39)	nonsense	probably null
R0562:Ncor2	UTSW	5	125,162,093 (GRCm39)	missense	unknown
R0671:Ncor2	UTSW	5	125,126,451 (GRCm39)	missense	probably benign	0.13
R0699:Ncor2	UTSW	5	125,106,176 (GRCm39)	unclassified	probably benign
R0865:Ncor2	UTSW	5	125,116,046 (GRCm39)	missense	probably benign	0.17
R1183:Ncor2	UTSW	5	125,100,585 (GRCm39)	missense	possibly damaging	0.65
R1325:Ncor2	UTSW	5	125,195,844 (GRCm39)	intron	probably benign
R1344:Ncor2	UTSW	5	125,102,510 (GRCm39)	missense	probably damaging	1.00
R1433:Ncor2	UTSW	5	125,187,039 (GRCm39)	intron	probably benign
R1481:Ncor2	UTSW	5	125,104,202 (GRCm39)	nonsense	probably null
R1539:Ncor2	UTSW	5	125,187,003 (GRCm39)	missense	probably benign	0.07
R1558:Ncor2	UTSW	5	125,110,610 (GRCm39)	missense	probably damaging	1.00
R1585:Ncor2	UTSW	5	125,162,062 (GRCm39)	missense	unknown
R1611:Ncor2	UTSW	5	125,187,084 (GRCm39)	intron	probably benign
R1764:Ncor2	UTSW	5	125,105,679 (GRCm39)	missense	possibly damaging	0.91
R1789:Ncor2	UTSW	5	125,096,954 (GRCm39)	missense	probably damaging	1.00
R1809:Ncor2	UTSW	5	125,195,857 (GRCm39)	intron	probably benign
R1901:Ncor2	UTSW	5	125,102,489 (GRCm39)	missense	probably benign	0.39
R1946:Ncor2	UTSW	5	125,111,476 (GRCm39)	missense	probably damaging	1.00
R1970:Ncor2	UTSW	5	125,115,982 (GRCm39)	missense	probably damaging	0.99
R2048:Ncor2	UTSW	5	125,161,996 (GRCm39)	missense	unknown
R2137:Ncor2	UTSW	5	125,107,776 (GRCm39)	missense	probably damaging	1.00
R2270:Ncor2	UTSW	5	125,115,019 (GRCm39)	missense	probably benign	0.33
R2380:Ncor2	UTSW	5	125,113,144 (GRCm39)	missense	possibly damaging	0.89
R2570:Ncor2	UTSW	5	125,105,864 (GRCm39)	critical splice acceptor site	probably null
R2918:Ncor2	UTSW	5	125,102,824 (GRCm39)	missense	probably damaging	0.99
R2921:Ncor2	UTSW	5	125,132,855 (GRCm39)	missense	probably damaging	1.00
R2922:Ncor2	UTSW	5	125,132,855 (GRCm39)	missense	probably damaging	1.00
R2923:Ncor2	UTSW	5	125,132,855 (GRCm39)	missense	probably damaging	1.00
R3116:Ncor2	UTSW	5	125,101,230 (GRCm39)	missense	probably damaging	1.00
R3768:Ncor2	UTSW	5	125,105,751 (GRCm39)	missense	probably damaging	1.00
R3826:Ncor2	UTSW	5	125,195,756 (GRCm39)	intron	probably benign
R3829:Ncor2	UTSW	5	125,195,756 (GRCm39)	intron	probably benign
R3830:Ncor2	UTSW	5	125,195,756 (GRCm39)	intron	probably benign
R3951:Ncor2	UTSW	5	125,109,320 (GRCm39)	missense	possibly damaging	0.94
R4175:Ncor2	UTSW	5	125,128,020 (GRCm39)	missense	probably damaging	0.99
R4360:Ncor2	UTSW	5	125,106,036 (GRCm39)	missense	probably damaging	1.00
R4470:Ncor2	UTSW	5	125,179,705 (GRCm39)	critical splice donor site	probably null
R4490:Ncor2	UTSW	5	125,113,879 (GRCm39)	splice site	probably null
R4573:Ncor2	UTSW	5	125,132,889 (GRCm39)	missense	probably damaging	0.99
R4611:Ncor2	UTSW	5	125,107,923 (GRCm39)	missense	probably damaging	1.00
R4799:Ncor2	UTSW	5	125,114,124 (GRCm39)	critical splice donor site	probably null
R4851:Ncor2	UTSW	5	125,110,431 (GRCm39)	missense	possibly damaging	0.93
R4853:Ncor2	UTSW	5	125,158,247 (GRCm39)	missense	unknown
R4853:Ncor2	UTSW	5	125,102,169 (GRCm39)	missense	probably damaging	0.99
R4896:Ncor2	UTSW	5	125,126,404 (GRCm39)	critical splice donor site	probably null
R4997:Ncor2	UTSW	5	125,111,074 (GRCm39)	missense	probably damaging	0.99
R5253:Ncor2	UTSW	5	125,103,994 (GRCm39)	missense	probably benign	0.44
R5461:Ncor2	UTSW	5	125,104,177 (GRCm39)	missense	probably damaging	1.00
R5585:Ncor2	UTSW	5	125,144,975 (GRCm39)	nonsense	probably null
R5638:Ncor2	UTSW	5	125,125,364 (GRCm39)	missense	probably benign	0.33
R5879:Ncor2	UTSW	5	125,103,839 (GRCm39)	unclassified	probably benign
R5967:Ncor2	UTSW	5	125,146,048 (GRCm39)	missense	unknown
R5999:Ncor2	UTSW	5	125,110,505 (GRCm39)	missense	probably damaging	1.00
R6020:Ncor2	UTSW	5	125,097,075 (GRCm39)	missense	probably benign	0.14
R6109:Ncor2	UTSW	5	125,132,910 (GRCm39)	missense	probably damaging	1.00
R6423:Ncor2	UTSW	5	125,164,966 (GRCm39)	missense	unknown
R6462:Ncor2	UTSW	5	125,101,236 (GRCm39)	missense	probably damaging	1.00
R6478:Ncor2	UTSW	5	125,187,069 (GRCm39)	intron	probably benign
R7074:Ncor2	UTSW	5	125,126,430 (GRCm39)	nonsense	probably null
R7179:Ncor2	UTSW	5	125,132,847 (GRCm39)	missense	unknown
R7261:Ncor2	UTSW	5	125,187,143 (GRCm39)	splice site	probably null
R7263:Ncor2	UTSW	5	125,109,196 (GRCm39)	missense
R7273:Ncor2	UTSW	5	125,100,687 (GRCm39)	missense
R7282:Ncor2	UTSW	5	125,097,104 (GRCm39)	missense
R7570:Ncor2	UTSW	5	125,107,153 (GRCm39)	missense
R7725:Ncor2	UTSW	5	125,100,630 (GRCm39)	missense
R7747:Ncor2	UTSW	5	125,104,102 (GRCm39)	missense
R7748:Ncor2	UTSW	5	125,187,031 (GRCm39)	missense	unknown
R7825:Ncor2	UTSW	5	125,114,141 (GRCm39)	missense	possibly damaging	0.53
R8008:Ncor2	UTSW	5	125,144,983 (GRCm39)	missense	unknown
R8126:Ncor2	UTSW	5	125,183,268 (GRCm39)	missense	unknown
R8137:Ncor2	UTSW	5	125,114,957 (GRCm39)	missense
R8706:Ncor2	UTSW	5	125,145,010 (GRCm39)	missense	unknown
R8751:Ncor2	UTSW	5	125,115,964 (GRCm39)	missense
R8819:Ncor2	UTSW	5	125,106,291 (GRCm39)	missense
R8820:Ncor2	UTSW	5	125,106,291 (GRCm39)	missense
R8824:Ncor2	UTSW	5	125,195,821 (GRCm39)	missense
R8867:Ncor2	UTSW	5	125,179,739 (GRCm39)	missense	unknown
R8919:Ncor2	UTSW	5	125,106,253 (GRCm39)	missense
R8922:Ncor2	UTSW	5	125,163,939 (GRCm39)	missense	unknown
R9076:Ncor2	UTSW	5	125,111,086 (GRCm39)	missense
R9249:Ncor2	UTSW	5	125,186,988 (GRCm39)	missense	unknown
R9276:Ncor2	UTSW	5	125,113,150 (GRCm39)	missense
R9362:Ncor2	UTSW	5	125,095,265 (GRCm39)	missense
R9667:Ncor2	UTSW	5	125,125,545 (GRCm39)	missense	unknown
R9684:Ncor2	UTSW	5	125,102,139 (GRCm39)	missense
Z1088:Ncor2	UTSW	5	125,163,904 (GRCm39)	critical splice donor site	probably null
Z1088:Ncor2	UTSW	5	125,144,852 (GRCm39)	missense	unknown
Z1177:Ncor2	UTSW	5	125,113,913 (GRCm39)	missense
Z1177:Ncor2	UTSW	5	125,125,058 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- ACAGAGTCCATGGTAGGCAG -3'
(R):5'- TGCCAAGGAGCAGAAGTCTG -3'

Sequencing Primer
(F):5'- CCACCTGTGTTGTGGCAG -3'
(R):5'- TCTGAGGCCGAGGAGATC -3'

Posted On

2016-06-06